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Home › Conditions › Dental Caries

Dental Caries

16 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Dental Caries

75 trials tracked for Dental Caries: 14 in phase 3 or 4 and 4 with published results. The most-cited published study has 366 citations.

75Trials tracked
14Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 3 Phase 3 11 Phase 2 12 Phase 1 2 Other / NA 47
  1. Phase 4 MI Varnish and MI Paste Plus in a Caries Prevention and Remineralization Study Completed · 366 cited
  2. Phase 3 Prevention of Adult Caries Study (PACS) Completed · 34 cited
  3. Phase 4 Effect of Dentifrice Usage Regime on Delivery and Efficacy of Fluoride Completed · 23 cited
  4. Phase 3 Preventing and Arresting Dental Root Surface Caries in Community-dwelling Older Adults Completed · 23 cited
  5. Phase 4 Enamel Remineralization Potential of Dentifrices in Situ Completed
  6. Phase 3 Reducing Bacteria That Cause Tooth Decay Completed
Show 44 more trials
  1. Phase 3 Stopping Cavities Study: Diammine Silver Fluoride Completed
  2. Phase 3 Antibacterial Effect of Nano Silver Fluoride vs Chlorhexidine on Occlusal Carious Molars Treated With Partial Caries Removal Technique Completed
  3. Phase 3 Fluoride Release,Compressive Strength and Clinical Performance of a Bioactive Restorative Material in ART Completed
  4. Phase 3 Fluoride Varnish Randomized Clinical Trial Completed
  5. Phase 3 Healozone Study to Evaluate the Safety and Efficacy of the Use of Ozone for Management of Dental Caries Completed
  6. Phase 3 Evaluation of Plaque Fluid Fluoride Retention From Fluoride Toothpastes Completed
  7. Phase 3 Effect of pH and Fluoride Concentration of Dentifrices on Caries Control Completed
  8. Phase 3 A Clinical Study to Evaluate Experimental Children's Toothpastes in an In-Situ Caries Model Completed
  9. Phase 2 Glass Ionomer Sealant and Fluoride Varnish Study to Prevent Early Childhood Caries Completed
  10. Phase 2 A Study to Evaluate the Safety and Microbiology of C16G2 Varnish Administered in Multiple Doses to Dental Subjects Completed
  11. Phase 2 A Study to Evaluate the Microbiology, Safety and Tolerability of C16G2 Dental Strip Application Completed
  12. Phase 2 A Phase 2 Study to Evaluate the Microbiology, Safety and Tolerability of C16G2 Varnish and Strip in Adolescent and Adult Subjects Completed
  13. Phase 2 Evaluation of Oral Plaque Removal Utilizing an Adjunct Enzyme Pre-rinse Completed
  14. Phase 2 MTA/FS Pulpotomy for Vital Primary Incisors: A Randomized Controlled Trial Completed
  15. Phase 2 Self Assembling Peptide P11-4 in Patients With Early Occlusal Carious Lesions Completed
  16. Phase 2 Pharmacokinetics of Advantage Anti-Caries Varnish Completed
  17. Phase 2 Effect of CPP-ACP Paste on Dental Caries in Primary Teeth Completed
  18. Phase 2 Pharmacokinetics of Advantage Arrest Completed
  19. Phase 2 Pharmacokinetics of Advantage Arrest in Children Completed
  20. Phase 2 Efficacy Of A PVP-I Fluoride Varnish Completed
  21. Phase 1 Safety Evaluation of Advantage Anti-Caries Varnish Completed
  22. Phase 1 Effect of Calcium Glycerophosphate (CaGP) - Fluoride Dentifrice on Dental Biofilm pH Completed
  23. N/A Validation of Near-infrared Light Transillumination for Interproximal Enamel Caries Detection Completed
  24. N/A Treatment of Interproximal Cavities on Primary Molar Teeth With Silver Diamine Fluoride Completed
  25. N/A Nobio Clinical Study - Demineralization Prevention With a New Antibacterial Restorative Composite Completed
  26. N/A Silver Diamine Fluoride and Papain-Based Gel for Management of MIH-affected Molar in Paediatric Patients Completed
  27. N/A Ecological Effect of Arginine Dentifrice on Oral Microbiota Completed
  28. N/A Implementing a Participatory, Multi-level Intervention to Improve Asian American Health Study Completed
  29. N/A Composites and Urinary Bisphenol-A Study Completed
  30. N/A Providers Against Cavities in Children's Teeth Completed
  31. N/A Healthy Hydration Pilot in Elementary Schools Completed
  32. N/A A Comparison of the Accurate Diagnosis of the Horizontal & Vertical Bitewing Images Completed
  33. N/A Evaluation of Oral Hygiene Products in an In Situ Caries Model Completed
  34. N/A Assessment of Caries Diagnosis and Caries Treatment in Dental PBRN Japan Completed
  35. N/A Clinical Evaluation of a Bulk Fill Resin Composite Completed
  36. N/A Prevention of Enamel Demineralization by Use of K18-smooth Surface Sealant Completed
  37. N/A European Study on Three Different Approaches to Managing Class 2 Cavities in Primary Teeth Completed
  38. N/A Conventional Bite Wing Radiography Versus Stationary Intraoral Tomosynthesis, a Comparison Study Completed
  39. N/A A Comparative Study of Papacarie® and the Conventional Method for Dental Caries Treatment Completed
  40. N/A Clinical Performance of Chairside CAD/CAM Restorations Completed
  41. N/A Clinical Performance of Incremental and Bulk Fill Composites in Class II Restorations Completed
  42. N/A Older Adult Effectiveness of 2 Treatments Completed
  43. N/A In Vivo Comparison of Salivary Fluoride Levels Following the Application of Different 5% NaF Varnishes Completed
  44. N/A Clinical Investigation of the F-Composite 2 System in Direct Filling Therapy Completed

Showing the 50 most-cited and recently-updated of 75 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Dental Caries: what the trials found

Fluoride-based interventions demonstrate significant efficacy in improving enamel properties and reducing caries incidence. Specifically, fluoride varnishes have been shown to significantly reduce the number of new caries cases compared to other treatments 13. Research on various fluoride formulations indicates that NaF (1450ppmF) provides superior surface microhardness recovery (%SMHR) and higher enamel fluoride uptake compared to SnF/NaF or NaMFP/NaF combinations 3. Furthermore, specific fluoride dentifrices have been shown to improve surface microhardness relative to placebo 10 and increase the concentration of fluoride incorporated into biofilm over a 6-month period 12.

Clinical studies on caries progression show that high-concentration fluoride dentifrices are associated with lower rates of caries progression in children compared to low-fluoride or specific alternative formulations 12. Additionally, evidence suggests that the duration and quantity of brushing with certain experimental dentifrices significantly impact surface microhardness recovery 2. Other interventions, such as CPP-ACP 5% sodium fluoride varnish combined with 900ppm fluoride paste, were evaluated for white spot lesion scores 1.

Several other treatments have been evaluated in clinical trials without showing statistically significant differences in primary outcomes. Chlorhexidine acetate coating did not show a significant difference in total net or crude caries increments 4. Ozone treatment showed no significant difference in ICDAS severity values or lesion activity, though it did show a significant difference in the progression of radiographic scores at 12 months 14. Additionally, studies on Fuji IX EXTRA and certain fluoride-based materials for primary teeth did not show statistically significant differences in success rates 6, while iodine treatment did not result in significantly different microbial levels 9.

Recent results — preliminary, needs further review

  • Bromelain was associated with a statistically significant difference in composite plaque scores 20.
  • A test varnish showed a statistically significant difference in the number of primary molars that were sound at baseline, though results for all primary teeth and child response to first treatment did not reach statistical significance 21.

For the clinician treating this condition

  • Fluoride varnishes are effective in reducing the incidence of new caries cases 13.
  • High-concentration fluoride dentifrices (e.g., 1450ppmF) provide superior enamel microhardness recovery and fluoride uptake compared to some alternative combinations [3, 10].
  • The choice of fluoride concentration in dentifrices can significantly impact the amount of fluoride incorporated into biofilm and the subsequent rate of caries progression in children 12.

AI synthesis of 12 cited trials, updated Jun 23, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Cross-sectional study of dental caries awareness among Uttarakhand healthcare professionals
Primary Care & Family Medicine
Cross-sectional study of dental caries awareness among Uttarakhand healthcare professionals Most doctors don't link kids' liquid medicines to tooth decay
This cross-sectional study assessed awareness and practices regarding sugar-free paediatric liquid medicines among 431 healthcare profession…
Only 20% of doctors in India connect sugary liquid medicines to dental caries, even as 83% know sugar-free options exist.
medRxiv Apr 23, 2026
Digital and strip-based salivary pH measurements assessed for caries risk in 66 school-aged children
Pediatrics Cohort
Digital and strip-based salivary pH measurements assessed for caries risk in 66 school-aged children Digital pH Meter Beats Strips for Kids' Tooth Health
This observational clinical evidence study evaluated salivary pH measurement methods in 66 children aged 6–12 years.
Checking saliva with a digital tool is better than strips, but your daily habits are the real drivers of cavity risk.
Frontiers Apr 22, 2026
Behavioral oral health interventions improve knowledge and hygiene but not calculus in children
Pediatrics Meta-analysis
Behavioral oral health interventions improve knowledge and hygiene but not calculus in children Do Oral Health Lessons Actually Help Kids' Teeth?
A meta-analysis of 44 quasi-experimental studies in children found behavior-based oral health interventions significantly improved knowledge…
A review of 44 studies shows that teaching kids about oral health really does improve their brushing habits and gum health, but hardened bui…
Apr 14, 2026
Report examines performance of U.S. water systems in safely fluoridating community water
Infectious Disease
Report examines performance of U.S. water systems in safely fluoridating community water How well are U.S. water systems safely adding fluoride to prevent cavities?
A report describes the performance of U.S.
A new report examines how well U.S. water systems safely add fluoride to drinking water to prevent cavities, but it does not share its main …
CDC Apr 5, 2026

Questions about Dental Caries

Does drinking fluoridated water from U.S. systems help prevent dental caries?

Yes, fluoridated water helps prevent cavities by strengthening enamel and reducing acid damage, though many U.S. systems face challenges in maintaining optimal levels.

Full answer →
Can using an 8% arginine toothpaste reduce dental caries in teenagers?

Using an 8% arginine toothpaste significantly reduces dental caries in teenagers aged 10 to 14 by lowering decay scores compared to standard fluoride toothpaste.

Full answer →