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Heart Failure

Subtypes of Heart Failure

Heart Failure with Reduced Ejection Fraction 12 Heart Failure with Preserved Ejection Fraction 11 Acute Decompensated Heart Failure 4 Heart failure with mildly reduced ejection fraction 4 Acute Decompensated Heart Failure with Reduced Ejection Fraction 1 Cardiorenal Syndrome 1 End-stage heart failure 1 Heart failure-related cardiogenic shock 1 Pulmonary hypertension with left heart failure 1

213 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Heart Failure

697 trials tracked for Heart Failure: 177 in phase 3 or 4 and 67 with published results. The most-cited published study has 1502 citations.

697Trials tracked
177Phase 3 & 4
0Recruiting
67With published results
Phase distribution
Phase 4 76 Phase 3 101 Phase 2 118 Phase 1 20 Other / NA 382
  1. Phase 4 Determining Genetic Role in Treatment Response to Anti-Platelet Interventions (The PAPI Study) Completed · 1,502 cited
  2. Phase 3 A Study to Test the Effect of Empagliflozin in Patients Who Are in Hospital for Acute Heart Failure Completed · 886 cited
  3. Phase 4 Study to Compare Ferric Carboxymaltose With Placebo in Patients With Acute Heart Failure and Iron Deficiency Completed · 757 cited
  4. Phase 3 Oral Iron Repletion Effects On Oxygen Uptake in Heart Failure Completed · 450 cited
  5. Phase 4 Ancillary Effects of Dexmedetomidine Sedation After Cardiac Surgery Completed · 301 cited
  6. Phase 4 Empagliflozin Impact on Hemodynamics in Patients With Heart Failure Completed · 272 cited
Show 44 more trials
  1. Phase 3 Dapagliflozin Effects on Cardiometabolic Outcomes in Patients With an Acute Heart Attack. Completed · 267 cited
  2. Phase 3 Inhaled Beta-adrenergic Agonists to Treat Pulmonary Vascular Disease in Heart Failure With Preserved EF (BEAT HFpEF): A Randomized Controlled Trial Completed · 253 cited
  3. Phase 4 SGLT2 Inhibition in Combination With Diuretics in Heart Failure Completed · 250 cited
  4. Phase 3 Interleukin-1 Blockade in Recently Decompensated Heart Failure Completed · 235 cited
  5. Phase 3 A Study on Impact of Canagliflozin on Health Status, Quality of Life, and Functional Status in Heart Failure Completed · 235 cited
  6. Phase 3 Targeting Acute Congestion With Tolvaptan in Congestive Heart Failure Completed · 234 cited
  7. Phase 3 Randomized Placebo-controlled Trial of FCM as Treatment for Heart Failure With Iron Deficiency / and Sub-Study Completed · 213 cited
  8. Phase 4 Reducing Total Cardiovascular Risk in an Urban Community Completed · 192 cited
  9. Phase 3 TRANSFORM-HF: ToRsemide compArisoN With furoSemide FORManagement of Heart Failure Completed · 180 cited
  10. Phase 4 Comparison of Oral or Intravenous Thiazides vs Tolvaptan in Diuretic Resistant Decompensated Heart Failure Completed · 179 cited
  11. Phase 4 EntrestoTM (LCZ696) In Advanced Heart Failure (LIFE Study) Completed · 175 cited
  12. Phase 3 Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40% Completed · 130 cited
  13. Phase 4 INfluenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure Completed · 129 cited
  14. Phase 3 Efficacy and Safety of Dapagliflozin in Acute Heart Failure Completed · 121 cited
  15. Phase 4 Acetazolamide and Spironolactone to Increase Natriuresis in Congestive Heart Failure Completed · 117 cited
  16. Phase 3 A Study That Looks at the Function of the Heart in Patients With Heart Failure Who Take Empagliflozin Completed · 106 cited
  17. Phase 3 A Study to Assess the Effectiveness and Safety of Rivaroxaban in Reducing the Risk of Death, Myocardial Infarction or Stroke in Participants With Heart Failure and Coronary Artery Disease Following an Episode of Decompensated Heart Failure Completed · 97 cited
  18. Phase 3 A Study of RO4607381 in Stable Coronary Heart Disease Patients With Recent Acute Coronary Syndrome Completed · 95 cited
  19. Phase 3 A Study of Vericiguat in Participants With Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-001) Completed · 88 cited
  20. Phase 4 Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode. Completed · 87 cited
  21. Phase 3 Efficacy and Safety of Allogeneic Mesenchymal Precursor Cells (Rexlemestrocel-L) for the Treatment of Heart Failure Completed · 84 cited
  22. Phase 3 Ranolazine Implantable Cardioverter-Defibrillator Trial Completed · 80 cited
  23. Phase 3 MultiPoint Pacing IDE Study Completed · 80 cited
  24. Phase 4 Myocardial Dysfunction in Type 2 Diabetes Mellitus (T2DM) Completed · 63 cited
  25. Phase 4 ISCHEMIA-Chronic Kidney Disease Trial Completed · 63 cited
  26. Phase 3 A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients Completed · 63 cited
  27. Phase 3 The Effects of Sacubitril/Valsartan Compared to Valsartan on LV Remodelling in Asymptomatic LV Systolic Dysfunction After MI Completed · 61 cited
  28. Phase 4 Mechanistic Evaluation of Glucose-lowering Strategies in Patients With Heart Failure Completed · 58 cited
  29. Phase 3 This Study Tests Empagliflozin in Patients With Chronic Heart Failure With Preserved Ejection Fraction (HFpEF). The Study Looks at How Far Patients Can Walk in 6 Minutes and at Their Heart Failure Symptoms. Completed · 58 cited
  30. Phase 3 This Study Tests Empagliflozin in Patients With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF). The Study Looks at How Far Patients Can Walk in 6 Minutes and at Their Heart Failure Symptoms Completed · 58 cited
  31. Phase 4 Effects of Sacubitril/Valsartan Therapy on Biomarkers, Myocardial Remodeling and Outcomes. Completed · 46 cited
  32. Phase 3 Efficacy and Safety of Aliskiren and Aliskiren/Enalapril Combination on Morbidity-mortality in Patients With Chronic Heart Failure Completed · 46 cited
  33. Phase 3 Metformin to Reduce Heart Failure After Myocardial Infarction Completed · 42 cited
  34. Phase 3 Intravenous Thyroxine for Heart-Eligible Organ Donors Completed · 42 cited
  35. Phase 3 Chronic Kidney Disease (CKD) Platelet Study Completed · 40 cited
  36. Phase 3 Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LCZ696 Followed by a 52-week, Double-blind Study of LCZ696 Compared With Enalapril in Pediatric Patients With Heart Failure Completed · 40 cited
  37. Phase 3 Supplementation of Glutamine and Fish Oil Versus Placebo in Patients With Heart Failure Completed · 38 cited
  38. Phase 3 Clinical Study Of Eplerenone In Japanese Patients With Chronic Heart Failure Completed · 38 cited
  39. Phase 4 Effects of Aliskiren on Patient With Heart Failure and a Normal Ejection Fraction Completed · 37 cited
  40. Phase 3 Micronutrient Supplementation in Patients With Heart Failure Completed · 32 cited
  41. Phase 3 Intracardiac CrYoablation for AtrioVentricular Nodal Reentrant Tachycardia Completed · 26 cited
  42. Phase 3 EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction (EMPEROR-Reduced) Completed · 26 cited
  43. Phase 3 Heart And Lung Failure - Pediatric INsulin Titration Trial Completed · 25 cited
  44. Phase 3 EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved) Completed · 25 cited

Showing the 50 most-cited and recently-updated of 697 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

Heart Failure: current evidence & treatments

In heart failure, SGLT2 inhibitors (empagliflozin, dapagliflozin) demonstrate robust prognostic benefits in both HFrEF and HFpEF populations 3. Adding SGLT2 inhibitors or ARNIs to standard neurohormonal therapy modestly reduces the composite risk of cardiovascular death or heart failure hospitalization in severe HFrEF 7. Conduction system pacing (CSP) improves LVEF by 4.22% and reduces heart failure hospitalization risk (RR 0.65) compared to biventricular pacing 5, while left bundle branch area pacing (LBBAP) also lowers all-cause mortality (RR 0.68) and heart failure hospitalization versus biventricular pacing 18. Two-lead CRT-D with atrial sensing is noninferior to three-lead systems for a composite of mortality, cardiovascular hospitalization, and lead complications 12.

Exercise interventions show variable benefits: resistance training yields the largest LVEF gains (mean difference 9.9 percentage points) 6, high-intensity interval aerobic exercise improves brachial flow-mediated dilation 4, but exercise rehabilitation in HFpEF does not reduce all-cause mortality (RR 1.13) while lowering rehospitalization risk (RR 0.52) 24. Natriuresis-guided diuretic protocols improve fluid removal and shorten hospital stays in acute decompensated heart failure 8, and lung ultrasound-guided decongestion reduces heart failure hospitalization and all-cause mortality (RR 0.72) 16. Lower VExUS grades (≤1) predict reduced in-hospital mortality (1.9% vs 14.1%) in acute heart failure 19. Remote monitoring algorithms (HeartLogic, TriageHF, HeartInsight) may predict heart failure events and reduce hospitalizations 22.

In pediatric heart failure, pre-transplant ventricular assist device support shows no survival benefit but increases stroke risk 20. Structural cerebral abnormalities in congenital heart disease increase from 23.1% prenatally to 50.3% postoperatively 14. Left atrial strain predicts major cardiovascular events (HR 0.91) in the general population 15. Acute kidney function decline timing predicts mortality and heart failure outcomes in hospitalized patients 17. Oral traditional Chinese medicines containing Astragalus, particularly Astragalus Granule plus Western medicine, rank best for overall clinical efficacy in heart failure 21. Breast arterial calcification is associated with increased cardiovascular mortality risk 25.

Key drugs in the evidence

dapagliflozin 12 SGLT2 inhibitors 9 semaglutide 7 beta-blockers 5 sodium-glucose cotransporter 2 inhibitors 5 empagliflozin 3 dulaglutide 2 angiotensin receptor-neprilysin inhibitors 2 furosemide 2 lixisenatide 2

Latest findings

AI-generated synthesis of 17 cited studies, updated Jun 12, 2026. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Questions about Heart Failure

Are SGLT2 inhibitors effective for treating heart failure with mildly reduced ejection fraction?

Yes, SGLT2 inhibitors are effective for treating heart failure with mildly reduced ejection fraction, reducing heart failure hospitalizations and improving outcomes.

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Does finerenone help patients with heart failure with mildly reduced ejection fraction?

Yes, finerenone reduces cardiovascular death and worsening heart failure events in patients with heart failure with mildly reduced ejection fraction, based on a network meta-analysis and the FINEARTS-HF trial.

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Can erythropoiesis-stimulating agents help adults with chronic heart failure and anaemia?

Erythropoiesis-stimulating agents (ESAs) reduce total heart failure hospitalizations and improve exercise tolerance in adults with chronic heart failure and anaemia, but do not lower mortality risk.

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Do alternative loop diuretics reduce hospitalizations for patients with chronic heart failure?

No, alternative loop diuretics (torsemide, azosemide, piretanide) do not reduce hospitalizations compared to furosemide in chronic heart failure, based on a systematic review of 23 trials.

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What are the main themes in coping experiences for chronic heart failure patients and caregivers?

Coping experiences for CHF patients and caregivers center on differing views of illness, emotional exhaustion, strained relationships, and a need for support to find new meaning.

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Does taking Qishen Yiqi dropping pills plus Western medicine improve chronic heart failure efficacy?

A 2024 trial found that adding Qishen Yiqi dropping pills to standard Western medicine improved clinical effectiveness and heart function in chronic heart failure patients.

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Does having higher levels of EPA in my blood increase my risk of ischemic heart disease?

Higher EPA levels may slightly increase ischemic heart disease risk, according to genetic studies, but the evidence is not definitive.

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What side effects or benefits did levosimendan show for patients with acute heart failure?

Levosimendan improves symptoms and heart function in acute heart failure, but can cause hypotension and tachycardia; benefits may vary by BMI.

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See all 20 questions about Heart Failure →