Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Conditions › Helicobacter pylori infection

Helicobacter pylori infection

16 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Helicobacter pylori infection

25 trials tracked for Helicobacter pylori infection: 11 in phase 3 or 4 and 3 with published results. The most-cited published study has 284 citations.

25Trials tracked
11Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 6 Phase 3 5 Phase 2 2 Phase 1 3 Other / NA 9
  1. Phase 3 Efficacy and Safety of Vonoprazan Compared to Lansoprazole in Participants With Helicobacter Pylori Infection Completed · 284 cited
  2. Phase 3 ERADICATE Hp2 - Treating Helicobacter Pylori With RHB-105 Compared to Active Comparator Completed · 86 cited
  3. Phase 3 ERADICATE Hp - Treating Helicobacter Pylori With RHB-105 Completed · 10 cited
  4. Phase 4 Comparison Between Quadruple Regimens for Helicobacter Pylori Infection in Egypt Completed
  5. Phase 4 High Dose Dual Therapy vs Clarithromycin Triple Therapy for Treatment Naive H Pylori Infection in an Urban Population Completed
  6. Phase 4 Sequential and Hybrid Therapies for H Pylori Infection Completed
Show 19 more trials
  1. Phase 4 Clarithromycin Resistant Tailored Therapy Completed
  2. Phase 4 Concomitant, Sequential, and Standard Triple Therapy for H. Pylori Infection Completed
  3. Phase 4 13-C Urea Breath Test Using BreathID System and PPIs (Proton Pump Inhibitors) Completed
  4. Phase 3 Exalenz Lab Mode System Compared to Biopsy for H.Pylori Detection Completed
  5. Phase 3 Urea Breath Test (UBT) With Breath Hp System /BreathID Hp Lab System Pediatrics Completed
  6. Phase 2 A Study to Evaluate Preliminary Helicobacter Pylori Eradication After Multiple Doses of TNP-2198 Capsules Combined With Rabeprazole Sodium Enteric-coated Tablets, or Rabeprazole Sodium Enteric-coated Tablets and Amoxicillin Capsules Completed
  7. Phase 2 Efficacy and Safety After Multiple Doses of TNP-2198 Capsules, Rabeprazole Sodium Enteric-coated Tablets and Amoxicillin Capsules in Helicobacter Pylori Infected-positive Participants Completed
  8. Phase 1 Efficacy and Safety of an H.Pylori Vaccine in H.Pylori-Negative Adults Completed
  9. Phase 1 A Study to Evaluate Vonoprazan Concentrations in Breast Milk of Healthy Lactating Women Receiving Vonoprazan 20 mg Once Daily or Vonoprazan 20 mg Twice Daily Completed
  10. Phase 1 A Phase 1 Study to Evaluate PK Profile of Multiple Oral Administrations of TNP-2092 Capsules in Healthy Subjects Completed
  11. N/A Compare Sequential and Quadruple Therapy for the Eradication of Helicobacter Pylori in Korea Completed
  12. N/A Levofloxacin-containing Therapies In Second Line Helicobacter Pylori Eradication Completed
  13. N/A Comparing the Efficacy of Reverse Hybrid Therapy and Concomitant Therapy Completed
  14. N/A Comparison of Hybrid and Bismuth Quadruple Therapies for Helicobacter Pylori Eradication Completed
  15. N/A Lactobacillus Reuteri in Management of Helicobacter Pylori Infection in Dyspeptic Patients Completed
  16. N/A Comparison of Two Rescue Therapies for Helicobacter Pylori Infection Completed
  17. N/A Comparison of 12-day Reverse Hybrid Therapy and 12-day Standard Triple Therapy for Helicobacter Pylori Infection Completed
  18. N/A Levofloxacin Triple and Bismuth Quadruple Therapies for Rescue Treatment of H Pylori Infection Completed
  19. N/A Comparing the Efficacy of Reverse Hybrid Therapy and Bismuth Quadruple Therapy Completed

Showing the 25 most-cited and recently-updated of 25 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Meta-analysis of 19,941 participants shows 83.0% eradication rates for Helicobacter pylori antibiotic regimens
Infectious Disease Meta-analysis
Meta-analysis of 19,941 participants shows 83.0% eradication rates for Helicobacter pylori antibiotic regimens How Well Today's Antibiotics Still Clear the Stomach Bug Behind Ulcers
This systematic review and meta-analysis evaluated antibiotic regimens for Helicobacter pylori eradication across 57 studies involving 19,94…
Current antibiotics clear the ulcer-causing stomach bug in about 83% of patients, meaning roughly 1 in 6 people still need a second round of…
Frontiers Apr 13, 2026
Vonoprazan-based regimens show higher H. pylori eradication rates than rabeprazole dual therapy in Chinese cohort
Anesthesiology & Pain Medicine Cohort
Vonoprazan-based regimens show higher H. pylori eradication rates than rabeprazole dual therapy in Chinese cohort A New Stomach Infection Treatment Works Where Old Ones Often Fail
A retrospective cohort study of 598 H. pylori-positive outpatients in Guizhou, China, found vonoprazan-based regimens achieved eradication r…
For millions struggling with a common and stubborn stomach bug, a new treatment approach just proved it can succeed where standard care freq…
Frontiers Apr 11, 2026
H. pylori eradication reduces gastric cancer risk by up to 44%, per guideline review
Gastroenterology Guideline
H. pylori eradication reduces gastric cancer risk by up to 44%, per guideline review Review finds H. pylori eradication reduces risk of stomach cancer and ulcers
A narrative review of global evidence indicates H.
Treating a common stomach bacteria infection can lower future cancer risk by up to 44% and prevent recurring ulcers.
Frontiers Apr 3, 2026
Genetic study links H. pylori susceptibility to HLA and innate immunity genes, suggests causal disease relationships
Gastroenterology Meta-analysis
Genetic study links H. pylori susceptibility to HLA and innate immunity genes, suggests causal disease relationships Large genetic study finds links between H. pylori infection susceptibility and autoimmune diseases
A meta-analysis of up to 140,863 Japanese and European individuals identified significant genetic associations for H.
A large genetic study reveals specific immune system genes linked to H. pylori infection and autoimmune diseases like type 1 diabetes and Ha…
medRxiv Apr 2, 2026

Questions about Helicobacter pylori infection

How does clarithromycin resistance affect the success of treating Helicobacter pylori infection in pediatric patients?

Clarithromycin resistance significantly lowers H. pylori eradication success in children, but bismuth-based quadruple therapy or tailored regimens can overcome this resistance.

Full answer →
Which antibiotic regimens are being compared to treat Helicobacter pylori infection in children aged 4 to 13 years?

In children aged 4–13 years, studies compare triple therapy (PPI + amoxicillin + clarithromycin or PPI + metronidazole + clarithromycin) versus bismuth-containing quadruple therapy (adding bismuth).

Full answer →
Do vonoprazan-based therapies cure Helicobacter pylori infection in 94% of Asian patients according to recent studies?

Yes, a 2025 meta-analysis found vonoprazan-based therapies achieve 94% eradication in Asian patients, but real-world rates vary.

Full answer →
Can a stool antigen test accurately find Helicobacter pylori infection in patients with chronic atrophic gastritis?

Yes, a monoclonal stool antigen test is a reliable non-invasive tool for detecting H. pylori in chronic atrophic gastritis, with high specificity and strong diagnostic consistency.

Full answer →
Does bismuth quadruple therapy work better than triple therapy for kids with Helicobacter pylori infection?

Yes, bismuth quadruple therapy works better than triple therapy for H. pylori eradication in children, with higher success rates especially when clarithromycin resistance is present.

Full answer →
See all 5 questions about Helicobacter pylori infection →