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Intracerebral hemorrhage

Part of Intracranial Hemorrhage

21 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Intracerebral hemorrhage

17 trials tracked for Intracerebral hemorrhage: 1 in phase 3 or 4 and 1 with published results. The most-cited published study has 12 citations.

17Trials tracked
1Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 3 1 Phase 2 8 Phase 1 3 Other / NA 5
  1. Phase 3 Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase III Completed · 12 cited
  2. Phase 2 Improving Platelet Activity for Cerebral Hemorrhage Treatment - DDAVP Proof of Concept Completed
  3. Phase 2 Minimally Invasive Surgery and rtPA for Intracerebral Hemorrhage Evacuation Completed
  4. Phase 2 Near Infrared Spectroscopy (NIRS) as Transfusion Indicator in Neurocritical Patients Completed
  5. Phase 2 Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury Completed
  6. Phase 2 Intracerebral Hemorrhage Deferoxamine Trial - iDEF Ttrial Completed
Show 11 more trials
  1. Phase 2 Normobaric Hyperoxia for Intracerebral Hemorrhage Completed
  2. Phase 2 A Pilot Study of Minocycline in Intracerebral Hemorrhage Patients Completed
  3. Phase 2 The Spot Sign for Predicting and Treating ICH Growth Study Completed
  4. Phase 1 Fingolimod as a Treatment of Cerebral Edema After Intracerebral Hemorrhage Completed
  5. Phase 1 Antihypertensive Treatment in Acute Cerebral Hemorrhage Completed
  6. Phase 1 Conivaptan for the Reduction of Cerebral Edema in Intracerebral Hemorrhage- A Safety and Tolerability Study Completed
  7. N/A Biologic Mechanisms of Early Exercise After Intracerebral Hemorrhage Completed
  8. N/A MIND: Artemis in the Removal of Intracerebral Hemorrhage Completed
  9. N/A A Study to Test the SENSE Device in Patients With Intracranial Hemorrhage Completed
  10. N/A Remote Ischemic Conditioning in Patients With Acute Stroke (RESIST) Completed
  11. N/A The Second Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial Completed

Showing the 17 most-cited and recently-updated of 17 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Intracerebral hemorrhage: what the trials found

In a Phase 3 trial, the administration of rt-PA did not result in statistically significant differences in functional outcomes (mRS 0-3 vs. 4-6) at 365 days post-ictus (p=0.73) or in the proportion of patients with favorable outcomes on the extended Glasgow Outcome Scale (eGOS) (p=0.55). Additionally, all-cause mortality from ictus to 365 days did not reach statistical significance following rt-PA treatment (p=0.08).

A new trial evaluating Artemis combined with medical management reported functional outcomes measured via the Modified Rankin Score (mRS) and Utility Weighted Modified Rankin Score.

Recent results — preliminary, needs further review

  • Artemis + Medical Management: Reported mRS scores of 32, 20, 4, 2, 5, 1 and utility-weighted mRS scores of 0.41 and 0.38 1.

For the clinician treating this condition

  • rt-PA treatment for intracerebral hemorrhage did not demonstrate significant differences in long-term functional outcomes or mortality rates at one year 2.
  • The Artemis plus medical management intervention is a newly reported regimen with associated functional outcome data 1.

AI synthesis of 2 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Intracranial Hemorrhage

Related studies from across the Intracranial Hemorrhage family.

MRSE Brain Abscess After Stent-Assisted Coiling for Ruptured Aneurysm Treated With Drainage
Allergy & Immunology Sys. Review
MRSE Brain Abscess After Stent-Assisted Coiling for Ruptured Aneurysm Treated With Drainage Treatment Strategy for Rare Brain Abscess After Aneurysm Surgery
Single case report and literature review describing a 49-year-old man who developed a methicillin-resistant Staphylococcus epidermidis (ST2)…
A case report describes a specific treatment path for a patient who developed a rare brain abscess following a procedure for a ruptured aneu…
Antiseizure medication prophylaxis shows no significant difference in mortality or functional outcomes in aneurysmal subarachnoid hemorrhage
Emergency Medicine Meta-analysis
Antiseizure medication prophylaxis shows no significant difference in mortality or functional outcomes in aneurysmal subarachnoid hemorrhage Antiseizure medications show mixed results for brain bleed patients
This meta-analysis evaluates antiseizure medication (ASM) prophylaxis for adults with aneurysmal subarachnoid hemorrhage. The analysis found…
New data shows that while some antiseizure drugs may lower seizure risk after a brain bleed, they do not change overall survival rates.
Deep Learning Models Show Promise for Detecting Cerebral Microbleeds on MRI
Radiology & Imaging Meta-analysis
Deep Learning Models Show Promise for Detecting Cerebral Microbleeds on MRI Deep Learning Shows Promise for Spotting Brain Microbleeds
A meta-analysis of five patient-level studies finds deep learning models can detect cerebral microbleeds on MRI with strong diagnostic accur…
A new meta-analysis suggests deep learning can help detect tiny brain bleeds on MRI, but the evidence is still early.
Efficacy of Pressure-Controlled Active CSF Irrigation in Managing Aneurysmal Subarachnoid Hemorrhage
Neurology Meta-analysis
Efficacy of Pressure-Controlled Active CSF Irrigation in Managing Aneurysmal Subarachnoid Hemorrhage Pressure controlled irrigation may reduce brain damage after brain bleeds
Meta-analysis suggests pressure-controlled active CSF irrigation significantly reduces the odds of delayed cerebral infarction and symptomat…
A review of over 2,000 cases suggests that pressure-controlled irrigation can lower the risk of brain tissue death after a ruptured aneurysm…
Hydrocephalus and high Fisher grade blood distribution are strongly associated with post-procedural seizures in SAH
Neurology Meta-analysis
Hydrocephalus and high Fisher grade blood distribution are strongly associated with post-procedural seizures in SAH Specific brain conditions linked to seizures after aneurysm surgery
This meta-analysis of patients undergoing endovascular aneurysm exclusion for subarachnoid hemorrhage identifies hydrocephalus (OR 3.91) and…
New data identifies specific markers, like hydrocephalus, that strongly link to a higher risk of seizures after aneurysm surgery.
Lumbar puncture identifies subarachnoid blood while CT angiography facilitates rapid vascular assessment in SAH
Emergency Medicine Guideline
Lumbar puncture identifies subarachnoid blood while CT angiography facilitates rapid vascular assessment in SAH Lumbar Puncture and CT Angiography Help Diagnose Brain Bleeding
This clinical guideline addresses the management of patients with suspected subarachnoid hemorrhage (SAH) and non-diagnostic head CT scans. …
Doctors use different imaging tools to find brain bleeds when initial scans are unclear, balancing the need for speed against accuracy.
Higher FIB-4 scores are associated with increased odds of poor stroke outcomes and mortality
Neurology Meta-analysis
Higher FIB-4 scores are associated with increased odds of poor stroke outcomes and mortality Higher Fibrosis Scores Linked to Worse Stroke Outcomes
This meta-analysis of 20 cohort studies and 2 cross-sectional studies examines the association between the Fibrosis-4 index (FIB-4) and vari…
A liver health score called FIB-4 shows a link to higher risks of stroke, poor recovery, and death in patients with brain injuries.
Tranexamic acid does not improve mortality or neurological outcomes in acute brain injury
Neurology Meta-analysis
Tranexamic acid does not improve mortality or neurological outcomes in acute brain injury Tranexamic acid does not improve survival in acute brain injuries
This meta-analysis of over 12,000 patients found that tranexamic acid did not significantly impact short-term or long-term mortality or func…
A large review of over 12,000 patients shows that tranexamic acid does not improve survival or recovery after a serious brain injury.
Blood product removal reduces permanent shunting risk and mortality in infants with posthemorrhagic hydrocephalus
Pediatrics Meta-analysis
Blood product removal reduces permanent shunting risk and mortality in infants with posthemorrhagic hydrocephalus Blood Product Removal Shows Lower Risks for Preterm Infants
This meta-analysis of 256 preterm infants with intraventricular hemorrhage and posthemorrhagic hydrocephalus found that blood product remova…
A meta-analysis suggests blood product removal may lower mortality and infection rates in preterm infants with specific brain conditions.
Higher aneurysm treatment rates are associated with improved outcomes and lower mortality in poor-grade aSAH
Neurology Meta-analysis
Higher aneurysm treatment rates are associated with improved outcomes and lower mortality in poor-grade aSAH Higher Treatment Rates Linked to Better Outcomes in Brain Hemorrhages
This meta-analysis of 7,726 patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH) found that higher treatment rates correlate w…
Research shows that higher treatment rates for severe brain bleeds are linked to better survival and functional recovery for patients.
Women critically ill adults on EEG have higher intracranial hemorrhage and seizure discharge rates than men
Emergency Medicine RCT
Women critically ill adults on EEG have higher intracranial hemorrhage and seizure discharge rates than men Trial finds women with impaired consciousness have different outcomes
This post hoc analysis of a multicenter randomized trial included 364 critically ill adults requiring electroencephalography. Women showed h…
A trial of critically ill adults found women with impaired consciousness had higher rates of brain bleeding and seizures but similar surviva…
IVIG and platelet transfusions managed immune thrombocytopenia in a very preterm infant with intraventricular hemorrhage
Pediatrics Sys. Review
IVIG and platelet transfusions managed immune thrombocytopenia in a very preterm infant with intraventricular hemorrhage A preterm baby with low platelets improved after IVIG and transfusions
This case report and literature review describes management of immune thrombocytopenia in a very preterm male infant born to a mother with i…
A very preterm male infant born to a mother with immune thrombocytopenia improved after receiving intravenous immunoglobulin and platelet tr…

Questions about Intracerebral hemorrhage

Does chronic kidney disease increase my death risk after intracerebral hemorrhage?

Yes, chronic kidney disease (CKD) is linked to higher death risk after intracerebral hemorrhage, with studies showing increased mortality at 30 days, 90 days, and 1 year.

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Is having a lobar intracerebral hemorrhage linked to higher readmission or dementia risk?

Yes, lobar intracerebral hemorrhage is linked to higher 1-year readmission and dementia risk compared to deep ICH, based on a large Scottish cohort study.

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Can a computer model predict my recovery after intracerebral hemorrhage or other strokes?

Yes, computer models can predict recovery after intracerebral hemorrhage, with some achieving over 90% accuracy, but they are not yet standard in clinical care.

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Does swelling around the bleeding spot make my intracerebral hemorrhage outcome worse?

Yes, swelling (perihematomal edema) growth after intracerebral hemorrhage is linked to worse functional outcomes and higher death or dependence risk.

Full answer →