Mode
Text Size
Log in / Sign up

Male Infertility

Part of Infertility

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Male Infertility

13 trials tracked for Male Infertility: 1 in phase 3 or 4.

13Trials tracked
1Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 4 1 Phase 2 4 Other / NA 8
  1. Phase 4 Post-operative Pain Control of Testicular Sperm Extraction Using Liposomal Bupivacaine Completed
  2. Phase 2 RA-2 13-cis Retinoic Acid (Isotretinoin) Completed
  3. Phase 2 Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication Administration Completed
  4. Phase 2 Impact of Duloxetine on Male Fertility Completed
  5. Phase 2 Males, Antioxidants, and Infertility Trial Completed
  6. N/A Impact of Sperm DNA Integrity on In Vitro Cycles Completed
Show 7 more trials
  1. N/A Retrospective Study on the Use, Efficiency, and Safety of the At-home Mosie Kit Completed
  2. N/A Fertility Preservation in Male AYA With Cancer Completed
  3. N/A Sperm Selection by Microfluidic Separation Improves Embryo Quality Completed
  4. N/A Investigating the Physiological Effects of Weight Loss on Male Fertility Completed
  5. N/A Impact of DNA Fragmentation in Sperm on Pregnancy Outcome After Intra-uterine Insemination in a Spontaneous Cycle Completed
  6. N/A Assessment of TetraSOD® Efficacy to Improve Semen Parameters in Men With Idiopathic Infertility Completed
  7. N/A HOP-2A - Intratesticular Hormone Levels Completed

Showing the 13 most-cited and recently-updated of 13 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Infertility

Related studies from across the Infertility family.

Myo-inositol and clomiphene with sildenafil are associated with improved pregnancy outcomes in women with infertility
Diabetes & Endocrinology Meta-analysis
Myo-inositol and clomiphene with sildenafil are associated with improved pregnancy outcomes in women with infertility New findings show specific treatments may improve fertility outcomes
This meta-analysis evaluates various interventions for infertility, including hormonal therapies, ART strategies, and investigational adjunc…
Certain supplements and stress management programs show promise for women struggling with infertility, though more data is needed on safety.
Leptin expression in seminal plasma is significantly higher in infertile patients with varicocele than controls
Urology Meta-analysis
Leptin expression in seminal plasma is significantly higher in infertile patients with varicocele than controls Infertile men with varicocele have higher leptin in their semen than healthy controls
This systematic review and meta-analysis examined leptin expression in seminal plasma and serum leptin levels in infertile patients with var…
A new analysis shows men with varicocele have significantly higher leptin in their semen. This finding might help explain why some struggle …
Meta-analysis finds modest melanoma risk increase among infertile women using fertility treatments
Oncology Meta-analysis
Meta-analysis finds modest melanoma risk increase among infertile women using fertility treatments Fertility Drugs Linked to Slight Rise in Melanoma Risk
This systematic review and meta-analysis evaluated melanoma incidence in infertile women exposed to fertility treatments compared to untreat…
A large review finds fertility drugs may raise melanoma risk slightly, but the increase is small and more research is needed.
HA-ICSI may slightly reduce miscarriage risk in IVF, but live birth and pregnancy rates show little difference
OB/GYN & Women's Health Sys. Review
HA-ICSI may slightly reduce miscarriage risk in IVF, but live birth and pregnancy rates show little difference Advanced sperm selection shows mixed results for IVF success
This Cochrane systematic review of 5 RCTs with 3752 women found that HA-ICSI probably slightly decreases miscarriage risk compared to standa…
A review of trials finds one advanced sperm method may slightly lower miscarriage risk during IVF, but most techniques show uncertain benefi…
Narrative review on semen and vaginal microbiota links to infertility outcomes
OB/GYN & Women's Health Sys. Review
Narrative review on semen and vaginal microbiota links to infertility outcomes Understanding how partner microbes might influence fertility outcomes for couples seeking treatment
This narrative mini review synthesizes evidence on semen and vaginal microbiota and couple-associated microbial patterns in infertility. The…
Current research suggests that microbes found in the vagina and on male genitals may play a role in fertility. However, scientists warn that…
Narrative review explores nesfatin-1 in infertility, pregnancy, and lactation
Diabetes & Endocrinology Sys. Review
Narrative review explores nesfatin-1 in infertility, pregnancy, and lactation Nesfatin-1 May Explain Infertility, Pregnancy Problems, and Milk Supply
This narrative review examines the role of nesfatin-1 in infertility, pregnancy complications, and lactation. The authors find heterogeneous…
A body chemical called nesfatin-1 may tie together stress, metabolism, and fertility, offering clues for infertility, pregnancy problems, an…
Systematic review of induction methods for pelvic inflammatory disease animal models
OB/GYN & Women's Health Sys. Review
Systematic review of induction methods for pelvic inflammatory disease animal models New animal models reveal hidden causes of pelvic pain
This systematic review evaluates various methods used to construct animal models for pelvic inflammatory disease. The authors categorize ind…
Chronic pelvic pain affects millions of women, and new research reveals how animal models are uncovering hidden triggers of pelvic inflammat…
Higher body mass index associated with increased oxidative stress in women undergoing IVF
OB/GYN & Women's Health Cohort
Higher body mass index associated with increased oxidative stress in women undergoing IVF Higher BMI linked to oxidative stress in infertility treatment
In this prospective observational cross-sectional study, researchers examined the relationship between body mass index and oxidative stress …
A new study shows that a higher BMI may trigger oxidative stress, a chemical imbalance that could impact women undergoing IVF.
Large ART cohort shows clinical pregnancy rates around 34% and live birth rates near 25%
OB/GYN & Women's Health Cohort
Large ART cohort shows clinical pregnancy rates around 34% and live birth rates near 25% A new database reveals how IVF success rates vary across Europe
This retrospective observational cohort study analyzed 64,081 ovarian stimulation cycles from 18 IVF/ICSI centers in Italy and Germany.
This huge new database tracks real IVF cycles to help doctors understand current success rates and treatment patterns across Europe.
Narrative review links ultra-processed food to obesity and multiple metabolic conditions
Nutrition & Obesity Medicine Sys. Review
Narrative review links ultra-processed food to obesity and multiple metabolic conditions Is Ultra-Processed Food Driving Obesity And Infertility
This narrative review examines the association between ultra-processed food (UPF) consumption and adverse health outcomes.
Ultra-processed foods might hurt your health by causing weight gain or by acting directly on your body without weight gain at all.
Vaginal and semen microbiota parameters in 475 infertile couples undergoing IVF
Infectious Disease Cohort
Vaginal and semen microbiota parameters in 475 infertile couples undergoing IVF Microbes in semen and vaginal fluid do not match up for IVF success
This retrospective cohort study evaluated baseline clinical, biochemical, and microbiological parameters in 475 infertile couples undergoing…
New data shows that the germs living in a woman and man do not match up, which could change how doctors predict IVF success rates for patien…
Systematic review and meta-analysis of Zishen Yutai Pill for IVF-ET outcomes
Drug Pipeline Meta-analysis
Systematic review and meta-analysis of Zishen Yutai Pill for IVF-ET outcomes Zishen Pill Boosts IVF Success Rates
This systematic review and meta-analysis of 5,660 participants undergoing IVF-ET found that Zishen Yutai Pill was associated with significan…
Imagine waiting months for a pregnancy test.

Questions about Male Infertility

Can anti-inflammatory interventions be used to treat male infertility effectively?

Anti-inflammatory interventions show promise for treating male infertility, particularly in cases involving varicocele or immune-mediated testicular disorders, though more clinical trials are needed to confirm their full effectiveness.

Full answer →
Are there links between transgenerational plastic exposure and male infertility risks?

Research suggests that exposure to plastic chemicals like BPA can alter gut health and gene activity, potentially leading to male infertility that may affect future generations.

Full answer →
Does knowing about male infertility help reduce negative attitudes toward the condition?

Increasing knowledge about male infertility is linked to more positive attitudes, as students with formal education on the topic showed better understanding and fewer negative views.

Full answer →
What antioxidant strategies might help treat male infertility and immune disorders?

Antioxidant strategies like flavonoids and anti-inflammatory treatments target immune pathways in the testis to improve sperm quality and treat male infertility.

Full answer →