Environmental cadmium exposure may cause male reproductive dysfunction through the renal-testis axis
Cadmium exposure may harm male fertility and kidney health
This narrative review of 40 animal studies synthesizes evidence on environmental cadmium exposure and its impact on male reproduction. The a…
Environmental cadmium exposure can damage the male reproductive system and kidneys, potentially leading to lower semen quality and other iss…
Narrative review explores potential links between BPA exposure and male infertility risks
Plastic Chemicals May Hurt Male Fertility Through Gut Changes
This narrative review examines the association between transgenerational exposure to plastics-derived endocrine-disrupting bisphenol A and i…
New research suggests plastic chemicals might harm male fertility by altering gut bacteria and gene activity in ways that could last for gen…
Umbrella review identifies risk factors and protective factors for male infertility and semen quality
New study lists many things that hurt male fertility and health
This umbrella review of 43 studies synthesizes evidence on risk factors for male infertility and abnormal semen parameters.
A new review shows that obesity, smoking, and certain illnesses can hurt sperm, but healthy habits might fix the problem.
Systematic review of antioxidant and anti-inflammatory strategies for male infertility and immune-mediated testicular disorders
Sperm Health Tied to Immune System in New Way
This systematic review synthesizes evidence on targeted antioxidant and anti-inflammatory interventions for male infertility and related imm…
John and Maria tried for years to have a baby.
Cross-sectional study finds low knowledge and negative attitudes toward male infertility among undergraduates
Do young adults understand male infertility? A new study finds concerning gaps
A descriptive cross-sectional study of 300 undergraduates at Osun State University found low overall knowledge (47.7%) and negative attitude…
Young adults often lack knowledge about male infertility, with over half expressing negative attitudes that may fuel stigma and silence the …
AI technologies outperform traditional methods for semen analysis in male infertility
Can AI help diagnose male infertility better than traditional methods?
A narrative review of AI applications in male infertility found AI algorithms outperform traditional methods for semen analysis.
Artificial intelligence is outperforming traditional methods for analyzing sperm samples, offering faster and more consistent diagnoses for …
Research across Infertility
Related studies from across the Infertility family.
Recurrent implantation failure worsens quality of life and raises depression, anxiety in IVF patients
Recurrent Implantation Failure Linked to Higher Anxiety and Depression
This meta-analysis of 28 studies in couples undergoing ICSI/IVF found that recurrent implantation failure (RIF) is associated with worse qua…
Couples facing repeated pregnancy failures during IVF may experience higher levels of anxiety, depression, and lower quality of life.
The Faster-Fewer-and-Finished approach aims to maximize time-to-first-live birth for women of advanced reproductive age
New 3F Approach Aims to Speed Fertility Treatment for Women
This expert consensus guideline proposes the Faster-Fewer-and-Finished (3F) approach to optimize treatment for women of advanced reproductiv…
A new 3F approach aims to speed up fertility treatments for women of advanced reproductive age to help them achieve their goals faster.
Therapeutic LH window of 1 to 10 IU/L supports optimal follicular development in IVF patients
Finding the right hormone levels for successful IVF pregnancies
This narrative review synthesizes literature from 1985 to 2025 regarding the impact of LH levels on ovarian stimulation for normogonadotropi…
New research identifies a specific window of LH hormone levels that may help improve follicle growth and pregnancy success in IVF treatments…
Ultra-processed food intake not significantly tied to infertility risk, meta-analysis finds
Ultra-Processed Foods May Raise Infertility Risk, But Evidence Weak
This meta-analysis of 8,769 adults found no statistically significant association between higher ultra-processed food consumption and infert…
A new meta-analysis suggests a possible link between ultra-processed foods and infertility, but the evidence is not strong enough to confirm…
Total testosterone and BMI predict clomiphene citrate resistance in 6.8% of women with PCOS
High Testosterone and BMI Predict Clomiphene Resistance in PCOS
This post-hoc analysis of a multicenter randomized controlled trial involving 471 infertile women with polycystic ovary syndrome (PCOS) iden…
New analysis shows that high testosterone levels and higher body mass index can help predict if clomiphene citrate will work for women with …
Myo-inositol and clomiphene with sildenafil are associated with improved pregnancy outcomes in women with infertility
New findings show specific treatments may improve fertility outcomes
This meta-analysis evaluates various interventions for infertility, including hormonal therapies, ART strategies, and investigational adjunc…
Certain supplements and stress management programs show promise for women struggling with infertility, though more data is needed on safety.
Leptin expression in seminal plasma is significantly higher in infertile patients with varicocele than controls
Infertile men with varicocele have higher leptin in their semen than healthy controls
This systematic review and meta-analysis examined leptin expression in seminal plasma and serum leptin levels in infertile patients with var…
A new analysis shows men with varicocele have significantly higher leptin in their semen. This finding might help explain why some struggle …
Meta-analysis finds modest melanoma risk increase among infertile women using fertility treatments
Fertility Drugs Linked to Slight Rise in Melanoma Risk
This systematic review and meta-analysis evaluated melanoma incidence in infertile women exposed to fertility treatments compared to untreat…
A large review finds fertility drugs may raise melanoma risk slightly, but the increase is small and more research is needed.
HA-ICSI may slightly reduce miscarriage risk in IVF, but live birth and pregnancy rates show little difference
Advanced sperm selection shows mixed results for IVF success
This Cochrane systematic review of 5 RCTs with 3752 women found that HA-ICSI probably slightly decreases miscarriage risk compared to standa…
A review of trials finds one advanced sperm method may slightly lower miscarriage risk during IVF, but most techniques show uncertain benefi…
Ethical analysis of non-oncological fertility preservation reviews challenges in reproductive autonomy and social justice
Fertility preservation ethics face real risks for women and transgender people
This narrative review analyzes 56 scientific articles regarding non-oncological fertility preservation. The authors synthesize ethical chall…
Fertility preservation for non-cancer patients faces ethical challenges like decisional pressure and unequal access that need attention now.
Narrative review on semen and vaginal microbiota links to infertility outcomes
Understanding how partner microbes might influence fertility outcomes for couples seeking treatment
This narrative mini review synthesizes evidence on semen and vaginal microbiota and couple-associated microbial patterns in infertility. The…
Current research suggests that microbes found in the vagina and on male genitals may play a role in fertility. However, scientists warn that…
Narrative review explores nesfatin-1 in infertility, pregnancy, and lactation
Nesfatin-1 May Explain Infertility, Pregnancy Problems, and Milk Supply
This narrative review examines the role of nesfatin-1 in infertility, pregnancy complications, and lactation. The authors find heterogeneous…
A body chemical called nesfatin-1 may tie together stress, metabolism, and fertility, offering clues for infertility, pregnancy problems, an…
Questions about Male Infertility
Can anti-inflammatory interventions be used to treat male infertility effectively?
Anti-inflammatory interventions show promise for treating male infertility, particularly in cases involving varicocele or immune-mediated testicular disorders, though more clinical trials are needed to confirm their full effectiveness.
Full answer →Are there links between transgenerational plastic exposure and male infertility risks?
Research suggests that exposure to plastic chemicals like BPA can alter gut health and gene activity, potentially leading to male infertility that may affect future generations.
Full answer →Does knowing about male infertility help reduce negative attitudes toward the condition?
Increasing knowledge about male infertility is linked to more positive attitudes, as students with formal education on the topic showed better understanding and fewer negative views.
Full answer →What antioxidant strategies might help treat male infertility and immune disorders?
Antioxidant strategies like flavonoids and anti-inflammatory treatments target immune pathways in the testis to improve sperm quality and treat male infertility.
Full answer →