Staged revascularization shows no significant difference versus immediate revascularization for major adverse cardiovascular events in STEMI and MVD patients
Timing of heart surgery does not change survival for a specific heart attack group
This meta-analysis reviewed 5077 patients with ST-segment elevation myocardial infarction and multivessel coronary artery disease comparing …
A large review found that waiting for staged heart surgery did not improve survival or reduce heart attacks compared to immediate surgery fo…
Five-year economic and quality of life outcomes favor PCI with zotarolimus stents over CABG in 3-vessel CAD
Five-year follow-up reveals lower costs and better employment for PCI over surgery in complex heart disease
This randomized trial compared fractional flow reserve-guided PCI using zotarolimus drug-eluting stents with coronary artery bypass grafting…
Patients with complex heart disease treated with stents had lower costs and better quality of life than those who had surgery after five yea…
FFR-guided complete revascularization reduces unplanned revascularization in MI patients with multivessel CAD
Complete Heart Repair May Stop Future Emergencies
A meta-analysis of 3,054 patients with myocardial infarction and multivessel coronary artery disease found that FFR-guided complete revascul…
Fixing all blocked heart arteries during surgery may stop future emergencies and unplanned procedures for patients with heart attacks.
Ticagrelor Not Noninferior to Prasugrel in Diabetes Patients With Multivessel CAD After PCI
New study shows ticagrelor did not beat prasugrel for heart attack prevention in diabetics
This randomized clinical trial of 1,800 patients with diabetes and multivessel coronary artery disease undergoing PCI compared ticagrelor pl…
For diabetics with heart stents, a new study found ticagrelor offered no clear advantage over prasugrel in preventing death, heart attacks, …
iFR-guided CABG improves mid-term graft patency versus angiography alone in multivessel disease
Can a simple test during heart surgery help grafts stay open longer?
A single-blinded RCT in patients with multivessel disease and intermediate stenoses found iFR-guided CABG significantly improved LIMA-to-LAD…
A simple pressure test during heart surgery keeps new blood vessel grafts open longer, with 80.5% staying clear versus 56.8% with standard i…
Research across Myocardial ischemia
Related studies from across the Myocardial ischemia family.
IVUS-guided PCI did not significantly reduce target-vessel failure compared to angiography-guided PCI
Trial shows IVUS guidance does not reduce risk for heart patients
This randomized controlled trial of 2020 patients undergoing complex PCI found that IVUS-guided PCI with stent-optimization criteria resulte…
New data suggests that using special ultrasound imaging during complex heart procedures may not lower the risk of major complications.
IVUS-guided PCI shows no significant difference over angiography-guided PCI for primary outcomes
Trial shows ultrasound imaging adds no benefit for heart surgery
This randomized controlled trial of 806 patients with unprotected left main coronary artery disease found that IVUS-guided PCI did not signi…
A large trial found that using ultrasound guidance during certain heart procedures did not improve safety or outcomes compared to standard m…
Pre-transplant coronary artery disease increases all-cause mortality and post-transplant cardiovascular events in kidney recipients
Pre-existing heart disease increases risks for kidney transplant patients
This meta-analysis of 112,416 kidney transplant recipients found that pre-existing coronary artery disease (CAD) is associated with signific…
Patients with pre-existing coronary artery disease face significantly higher risks of death and graft failure after receiving a kidney trans…
High-intensity interval aerobic exercise improves brachial FMD in coronary artery disease and heart failure
High intensity interval training improves blood flow in heart patients
This network meta-analysis of 6,818 adults with coronary artery disease or chronic heart failure found that high-intensity interval aerobic …
Specific types of intense exercise may improve blood vessel function for people living with heart failure or coronary artery disease.
Higher pan-immune-inflammation value linked to worse outcomes after PCI for ACS
High inflammation scores predict worse heart outcomes in patients with acute coronary syndrome
This systematic review and meta-analysis of 18,715 adults with acute coronary syndrome undergoing PCI found that higher pan-immune-inflammat…
A new analysis shows higher inflammation markers predict death and heart failure in adults with acute coronary syndrome undergoing heart pro…
Colchicine reduces major adverse cardiovascular events in coronary artery disease without increasing serious adverse events
Low-dose colchicine reduces heart attack risk for coronary artery disease patients
This systematic review and meta-analysis evaluated colchicine in patients with coronary artery disease and acute coronary syndromes. The ana…
A large analysis shows low-dose colchicine lowers major heart events for coronary artery disease patients without increasing serious risks, …
Sirolimus and paclitaxel-coated balloons show similar outcomes for coronary in-stent restenosis
Sirolimus and paclitaxel balloons show similar results for heart disease
This GRADE-assessed systematic review and meta-analysis of 3,633 participants with coronary artery disease found no notable variations betwe…
Two drug-coated balloons for coronary artery disease work about equally well, a new analysis finds.
Polymer-free and biodegradable-polymer drug-eluting stents show comparable outcomes in PCI
New review shows polymer-free stents work like biodegradable ones for heart patients
A meta-analysis compared polymer-free drug-eluting stents (PF-DES) with biodegradable-polymer drug-eluting stents (BP-DES) in patients under…
A large study of over 11,000 patients found that polymer-free stents are just as safe as older biodegradable ones. Doctors saw no major diff…
Complete revascularization shows high probability of benefit for NSTEMI patients with multivessel disease
Complete revascularization shows high probability of benefit for NSTEMI patients with multivessel disease
This Bayesian re-analysis of a randomized trial evaluated complete versus culprit-only revascularization in patients with non-ST-elevation m…
A Bayesian re-analysis suggests complete revascularization offers a high probability of clinically meaningful benefit compared to treating o…
Breast arterial calcification on mammography predicts higher cardiovascular event risk in women
Calcium on mammograms signals higher heart risk for women
This systematic review and meta-analysis evaluated breast arterial calcification (BAC) in women across approximately 25,000 participants in …
Calcium seen on mammograms links to higher heart attack risk in women. This large review found a strong connection between breast arterial c…
Mini review examines sudden cardiac death risks in marathon runners across different age groups
Marathon running links to higher heart risk in older men and full-distance participants
This mini review synthesizes evidence on sudden cardiac death (SCD) and coronary artery disease in marathon runners. The authors note that r…
A review of marathon runners shows heart risks vary by age, sex, and race distance, with most events happening near the finish.
Serum resistin levels rise progressively with worsening severity of coronary heart disease and acute myocardial infarction in this meta-analysis
High blood resistin levels linked to heart disease severity in large analysis
A network meta-analysis of 9,169 subjects reveals that serum resistin levels increase stepwise as coronary heart disease severity worsens. W…
A large network meta-analysis found that higher serum resistin levels are linked to worse coronary heart disease and acute heart attacks.
Questions about Multivessel Coronary Artery Disease
Does using FFR guidance reduce the need for repeat heart surgery in multivessel CAD patients?
Using FFR guidance to decide on stenting reduces the need for repeat heart surgery in patients with multivessel coronary artery disease.
Full answer →