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Home › Conditions › peripheral neuropathy

Peripheral neuropathy

Subtypes of Peripheral neuropathy

Neurofibromatosis Type 1 7 Carpal Tunnel Syndrome 2 Hand-Arm Vibration Syndrome 1 Hereditary Spastic Paraplegia 1 Miller Fisher syndrome 1 Neuralgic amyotrophy 1 Parsonage-Turner syndrome 1

19 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for peripheral neuropathy

41 trials tracked for peripheral neuropathy: 11 in phase 3 or 4 and 2 with published results. The most-cited published study has 1016 citations.

41Trials tracked
11Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 3 11 Phase 2 12 Other / NA 18
  1. Phase 3 Duloxetine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer Completed · 1,016 cited
  2. Phase 3 Targeting Inflammation With Salsalate in Type 1 Diabetes Neuropathy Completed · 12 cited
  3. Phase 3 Randomized Placebo-Controlled Trial of Glutamine for Breast Cancer Patients With Peripheral Neuropathy Completed
  4. Phase 3 Open Label Safety And Efficacy Study Of Pregabalin In Subjects With Nerve Pain Asociated With Human Immunodeficiency Virus (HIV) Neuropathy Completed
  5. Phase 3 A Study of Sativex® for Relief of Peripheral Neuropathic Pain Associated With Allodynia. Completed
  6. Phase 3 A Study of Sativex® for Pain Relief of Peripheral Neuropathic Pain, Associated With Allodynia Completed
Show 35 more trials
  1. Phase 3 Topical Amitriptyline and Ketamine Cream in Treating Peripheral Neuropathy Caused by Chemotherapy in Cancer Patients Completed
  2. Phase 3 Study of Pregabalin Versus Placebo in the Treatment of Nerve Pain Associated With HIV Neuropathy Completed
  3. Phase 3 A Study to Compare the Safety and Tolerability of Sativex® in Patients With Neuropathic Pain. Completed
  4. Phase 3 A Study to Determine the Maintenance of Effect After Long-term Treatment of Sativex® in Subjects With Neuropathic Pain Completed
  5. Phase 3 Glutamic Acid in Reducing Nerve Damage Caused by Vincristine in Young Patients With Cancer Completed
  6. Phase 2 Alpha-lipoic Acid in Patients at Risk for Paclitaxel Induced Neuropathy Completed
  7. Phase 2 Glutamine in Treating Neuropathy Caused by Vincristine in Young Patients With Lymphoma, Leukemia, or Solid Tumors Completed
  8. Phase 2 SERENDEM : MD1003 in Patients Suffering From Demyelinating Neuropathies, an Open Label Pilot Study Completed
  9. Phase 2 Minocycline Hydrochloride in Reducing Chemotherapy-Induced Peripheral Neuropathy and Acute Pain in Patients With Breast Cancer Undergoing Treatment With Paclitaxel Completed
  10. Phase 2 Effects of Vaporized Marijuana on Neuropathic Pain Completed
  11. Phase 2 Acupuncture for Chemo-Induced Peripheral Neuropathy Completed
  12. Phase 2 Micro-mobile Foot Compression and Diabetic Foot Completed
  13. Phase 2 MC5-A Scrambler Therapy in Reducing Peripheral Neuropathy Caused by Chemotherapy Completed
  14. Phase 2 Pregabalin in Preventing Acute Pain Syndrome in Patients Receiving Paclitaxel Completed
  15. Phase 2 Pilot Study to Determine Effects of Salsalate in Type 1 Diabetes and Painful Peripheral Neuropathy Completed
  16. Phase 2 Electrical Stimulation Therapy Using the MC5-A Scrambler in Reducing Peripheral Neuropathy Caused by Chemotherapy Completed
  17. Phase 2 Safety and Efficacy Study of ADL5859 in Participants With Neuropathic Pain Associated With Diabetic Peripheral Neuropathy Completed
  18. N/A Voxx Human Performance Technology Socks for Chemotherapy-Induced Peripheral Neuropathy Completed
  19. N/A Electrical Stimulation to Accelerate Wound Healing Completed
  20. N/A Investigating Mechanisms Underlying Spinal Cord Stimulation Efficacy Using Virtual Reality and Full Body Illusion Completed
  21. N/A OPEN Study: Pain Management Treatment Needs Interviews Completed
  22. N/A Reversing Diabetic Peripheral Neuropathy Through Exercise Completed
  23. N/A A Wearable "Balance Booster" - Stepping Closer to the Market Completed
  24. N/A Lidocaine for Diabetic Peripheral Neuropathy Completed
  25. N/A Botulinum Toxin Effects on Plantar Ulcer Recurrence Completed
  26. N/A Ultrasound in Detecting Taxane-Induced Neuropathy in Patients With Breast Cancer Completed
  27. N/A Evaluation of an Exercise Intervention for Vincristine Induced Peripheral Neuropathy in Pediatric Cancer Patients Completed
  28. N/A Electrical Stimulation Pain Therapy in Treating Chronic Pain and Numbness Caused By Chemotherapy in Patients With Cancer Completed
  29. N/A Lower Extremity Splinting to Manage Pain and Sleep Disturbances Associated With HIV/AIDS Related Peripheral Neuropathy Completed
  30. N/A Peak Plantar Pressures While Wearing a Carbon Fiber Off Loading Orthoses Completed
  31. N/A MC5-A Scrambler Therapy or TENS Therapy in Treating Patients With Chemotherapy-Induced Peripheral Neuropathy Completed
  32. N/A BlueWind Medical Reprieve System for the Treatment of PNP Completed
  33. N/A Effects of Light Emitting Diode Irradiation on the Conduction Parameters of the Superficial Radial Nerve Completed
  34. N/A Venlafaxine in Preventing Chronic Oxaliplatin-Induced Neuropathy In Patients Receiving Combination Chemotherapy Completed
  35. N/A Clinical Efficacy and Human Factors Validation Testing of the Erchonia EVRL for Providing Temporary Relief of Diabetic Peripheral Neuropathy Foot Pain Completed

Showing the 41 most-cited and recently-updated of 41 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Biological and clinical factors associated with peripheral neuropathy in rheumatoid arthritis cohort
Neurology Cohort
Biological and clinical factors associated with peripheral neuropathy in rheumatoid arthritis cohort RA Nerve Damage Linked to This Common Marker
This retro-prospective cross-sectional study evaluated 63 patients with rheumatoid arthritis to assess biological and clinical factors linke…
You wake up with tingling in your hands. It feels like pins and needles.
Frontiers Apr 21, 2026
Retrospective cohort describes Parsonage-Turner syndrome presentation and recovery in 42 patients
Neurology Cohort
Retrospective cohort describes Parsonage-Turner syndrome presentation and recovery in 42 patients The Shoulder Pain Many Doctors Miss for Weeks
A retrospective cohort of 42 patients with Parsonage-Turner syndrome at a Chinese hand surgery center found an average annual incidence of 4…
A rare nerve disorder often starts with severe shoulder pain, yet diagnosis takes two months on average, delaying treatment and recovery.
Frontiers Apr 14, 2026
Losartan reduces incidence and delays onset of paclitaxel-induced peripheral neuropathy in women with early-stage breast cancer
Oncology RCT
Losartan reduces incidence and delays onset of paclitaxel-induced peripheral neuropathy in women with early-stage breast cancer Losartan may reduce nerve pain from breast cancer chemotherapy in small trial
This single-center, open-label randomized controlled trial enrolled 89 women with early-stage breast cancer scheduled for weekly paclitaxel.
A common blood pressure drug called losartan significantly reduced nerve pain and improved quality of life for women receiving breast cancer…
Apr 9, 2026
Sweden saw a five-fold increase in vibration check-ups among exposed workers between 2016 and 2022
Nephrology Meta-analysis
Sweden saw a five-fold increase in vibration check-ups among exposed workers between 2016 and 2022 Why do workers with hand-arm vibration fears skip mandatory medical checks?
This mixed-methods meta-analysis examined medical check-up for vibrations (MCV) participation among vibration-exposed workers in Sweden.
Workers skip mandatory hand-vibration check-ups because employers don't offer them and they fear a diagnosis will hurt their careers.
Frontiers Apr 6, 2026
SPG4 frequency is 33.3% in Central Chinese HSP families with 7 novel SPAST variants identified
Genetics & Precision Medicine Cohort
SPG4 frequency is 33.3% in Central Chinese HSP families with 7 novel SPAST variants identified Genetic study finds SPAST variants in one-third of Chinese families with hereditary spastic paraplegia
An observational cohort study of 63 unrelated hereditary spastic paraplegia (HSP) families from Central China found SPAST variants in 33.3% …
Genetic testing found SPAST gene changes in one-third of Chinese families with hereditary spastic paraplegia, including seven new variants a…
Frontiers Apr 3, 2026
Mobile App with Contingency Management Improves Pain Outcomes in Adults with NF1
Anesthesiology & Pain Medicine RCT
Mobile App with Contingency Management Improves Pain Outcomes in Adults with NF1 Can a phone app help adults with NF1 manage their chronic pain?
A randomized trial in 108 adults with Neurofibromatosis Type 1 and chronic pain found that the iCanCope mobile app plus contingency manageme…
Adults with NF1 who used a phone app with rewards reported less pain interference and greater confidence in managing their chronic pain comp…
Apr 2, 2026
Case report describes multimodal treatment and single-cell sequencing in NF1 patient with Malignant Triton Tumor
Oncology
Case report describes multimodal treatment and single-cell sequencing in NF1 patient with Malignant Triton Tumor What happens when a rare cancer returns? One young woman's story offers a clue
A case report describes a 23-year-old woman with neurofibromatosis type 1 and Malignant Triton Tumor.
A 23-year-old woman with a rare chest tumor found disease stabilization after surgery failed, using a mix of chemotherapy, targeted therapy,…
Frontiers Apr 1, 2026

Questions about peripheral neuropathy

Can surgery for insulinoma reverse chronic hypoglycemia-induced peripheral neuropathy?

Surgery for insulinoma reliably cures the hypoglycemia, but a case report shows nerve damage from chronic low blood sugar may only partly improve, not fully reverse [4].

Full answer →