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Pregnancy complications

Subtypes of Pregnancy complications

Gestational Diabetes Mellitus 32 Adverse birth outcomes 1 Ectopic pregnancy 1 Fetal Alcohol Spectrum Disorders 1 Fetal Death 0 Pregnancy Complications, Infectious 0

38 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for pregnancy complications

19 trials tracked for pregnancy complications: 6 in phase 3 or 4 and 3 with published results. The most-cited published study has 119 citations.

19Trials tracked

6Phase 3 & 4

0Recruiting

3With published results

Phase distribution

Phase 4 4 Phase 3 2 Phase 2 3 Other / NA 10

Phase 3 High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention Completed · 119 cited
Phase 3 Furosemide vs. Placebo for Severe Antepartum Hypertension Completed · 8 cited
Phase 4 Carbetocin Myocardium Trial 2014 Part 2 Completed · 7 cited
Phase 4 Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial Completed
Phase 4 Optimal Blood Pressure Treatment Thresholds Postpartum Completed
Phase 4 Intravenous Versus Oral Iron in Late Pregnancy: Results of Treatment Completed

Show 13 more trials

Phase 2 A Clinical Trial of Intravenous (IV) Ganaxolone in Women With Postpartum Depression Completed
Phase 2 A Clinical Trial of Oral Ganaxolone in Women With Postpartum Depression Completed
Phase 2 Progesterone for the Management of Preterm, Premature Rupture of the Membranes: A Randomized Controlled Trial. Completed
N/A An Evaluation of the Team Birth Project Completed
N/A Use of a Novel Computerized Decision Aid for Prenatal Aneuploidy Screening Completed
N/A Continuous Glucose Monitoring in Pregnant Women Undergoing Betamethasone Therapy Completed
N/A Sedentary Behavior Reduction in Pregnancy Intervention Study Completed
N/A Metformin Versus Insulin in Pregnant Women With Type 2 Diabetes Completed
N/A Validating a New Method to Assess Estimated Blood Loss in the Obstetric Population Completed
N/A Comparative Effectiveness of Treatment Options for Genital Herpes Infection to Reduce Adverse Pregnancy Outcomes Completed
N/A Low Plasma Mannose Binding Lectin (p-MBL) Level is a Risk Factor for Recurrent Pregnancy Loss (RPL) Completed
N/A Acute Exercise Effects in Obese Pregnancy Completed
N/A Health and Wellbeing of Pregnant and Post-Partum Women During the COVID-19 Pandemic Completed

Showing the 19 most-cited and recently-updated of 19 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Pregnancy complications: what the trials found

New evidence regarding pregnancy management includes the use of Mifepristone, which was associated with delivery within 12 hours in 5 cases and within 24 hours in 13 cases ². Additionally, a feasibility study confirmed that 61 participants were eligible, enrolled, and retained under usual care protocols ¹.

Clinical evaluations of uterine tone using Oxytocin showed scores of 7 and 8 ³, while the administration of Ferli-6® was also documented in clinical settings ⁴. Regarding nutritional interventions, a large-scale study found that Folic Acid 4 mg did not significantly impact the incidence of preeclampsia (p=0.37), spontaneous abortion (p=0.37), or placenta abruption (p=0.21) ⁵.

Pharmacological management for blood pressure in pregnancy included Furosemide, which resulted in systolic and diastolic blood pressures of 139/84 and 154/87 at 2 hours post-administration ⁶. For postpartum mental health, Ganaxolone was evaluated; it showed reductions in both HAMD17 scores (ranging from -11.0 to -14.3) and EPDS scores (ranging from -1.9 to -8.8) ⁷, with a separate trial confirming significant reductions in EPDS scores ⁸.

Recent results — preliminary, needs further review

17-Hydroxyprogesterone Caproate was evaluated for neonatal outcomes, but results for respiratory distress syndrome (p=0.31) and intraventricular hemorrhage (p=>0.99) were not statistically significant ⁹.
Sedentary behavior reduction showed statistically significant improvements in standing time and steps per day (p=<0.05) ¹¹.
Resistance exercise was associated with a statistically significant increase in endothelial function (p=<0.05) ¹³.

For the clinician treating this condition

Mifepristone is utilized for induction, with documented delivery outcomes within 12 and 24 hours ².
Folic Acid at 4 mg did not show a statistically significant effect on preeclampsia or placental complications in a large cohort ⁵.
Ganaxolone demonstrated measurable reductions in depression scales (HAMD17 and EPDS) in clinical trials [7, 8].

AI synthesis of 11 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

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