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Pregnancy complications

Subtypes of Pregnancy complications

Gestational Diabetes Mellitus 37 Adverse birth outcomes 1 Ectopic pregnancy 1 Fetal Alcohol Spectrum Disorders 1 Fetal Death 0 Pregnancy Complications, Infectious 0

44 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for pregnancy complications

19 trials tracked for pregnancy complications: 6 in phase 3 or 4 and 3 with published results. The most-cited published study has 119 citations.

19Trials tracked
6Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 4 Phase 3 2 Phase 2 3 Other / NA 10
  1. Phase 3 High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention Completed · 119 cited
  2. Phase 3 Furosemide vs. Placebo for Severe Antepartum Hypertension Completed · 8 cited
  3. Phase 4 Carbetocin Myocardium Trial 2014 Part 2 Completed · 7 cited
  4. Phase 4 Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial Completed
  5. Phase 4 Optimal Blood Pressure Treatment Thresholds Postpartum Completed
  6. Phase 4 Intravenous Versus Oral Iron in Late Pregnancy: Results of Treatment Completed
Show 13 more trials
  1. Phase 2 A Clinical Trial of Intravenous (IV) Ganaxolone in Women With Postpartum Depression Completed
  2. Phase 2 A Clinical Trial of Oral Ganaxolone in Women With Postpartum Depression Completed
  3. Phase 2 Progesterone for the Management of Preterm, Premature Rupture of the Membranes: A Randomized Controlled Trial. Completed
  4. N/A An Evaluation of the Team Birth Project Completed
  5. N/A Use of a Novel Computerized Decision Aid for Prenatal Aneuploidy Screening Completed
  6. N/A Continuous Glucose Monitoring in Pregnant Women Undergoing Betamethasone Therapy Completed
  7. N/A Sedentary Behavior Reduction in Pregnancy Intervention Study Completed
  8. N/A Metformin Versus Insulin in Pregnant Women With Type 2 Diabetes Completed
  9. N/A Validating a New Method to Assess Estimated Blood Loss in the Obstetric Population Completed
  10. N/A Comparative Effectiveness of Treatment Options for Genital Herpes Infection to Reduce Adverse Pregnancy Outcomes Completed
  11. N/A Low Plasma Mannose Binding Lectin (p-MBL) Level is a Risk Factor for Recurrent Pregnancy Loss (RPL) Completed
  12. N/A Acute Exercise Effects in Obese Pregnancy Completed
  13. N/A Health and Wellbeing of Pregnant and Post-Partum Women During the COVID-19 Pandemic Completed

Showing the 19 most-cited and recently-updated of 19 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Pregnancy complications: what the trials found

New evidence regarding pregnancy management includes the use of Mifepristone, which was associated with delivery within 12 hours in 5 cases and within 24 hours in 13 cases 2. Additionally, a feasibility study confirmed that 61 participants were eligible, enrolled, and retained under usual care protocols 1.

Clinical evaluations of uterine tone using Oxytocin showed scores of 7 and 8 3, while the administration of Ferli-6® was also documented in clinical settings 4. Regarding nutritional interventions, a large-scale study found that Folic Acid 4 mg did not significantly impact the incidence of preeclampsia (p=0.37), spontaneous abortion (p=0.37), or placenta abruption (p=0.21) 5.

Pharmacological management for blood pressure in pregnancy included Furosemide, which resulted in systolic and diastolic blood pressures of 139/84 and 154/87 at 2 hours post-administration 6. For postpartum mental health, Ganaxolone was evaluated; it showed reductions in both HAMD17 scores (ranging from -11.0 to -14.3) and EPDS scores (ranging from -1.9 to -8.8) 7, with a separate trial confirming significant reductions in EPDS scores 8.

Recent results — preliminary, needs further review

  • 17-Hydroxyprogesterone Caproate was evaluated for neonatal outcomes, but results for respiratory distress syndrome (p=0.31) and intraventricular hemorrhage (p=>0.99) were not statistically significant 9.
  • Sedentary behavior reduction showed statistically significant improvements in standing time and steps per day (p=<0.05) 11.
  • Resistance exercise was associated with a statistically significant increase in endothelial function (p=<0.05) 13.

For the clinician treating this condition

  • Mifepristone is utilized for induction, with documented delivery outcomes within 12 and 24 hours 2.
  • Folic Acid at 4 mg did not show a statistically significant effect on preeclampsia or placental complications in a large cohort 5.
  • Ganaxolone demonstrated measurable reductions in depression scales (HAMD17 and EPDS) in clinical trials [7, 8].

AI synthesis of 11 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Questions about pregnancy complications

Do socioeconomic factors impact the risk of pregnancy complications?

Social and environmental conditions can impact pregnancy outcomes by influencing biological pathways, such as those involving placental health.

Full answer →

All pregnancy complications Articles