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Home › Conditions › pregnancy complications

Pregnancy complications

Subtypes of Pregnancy complications

Gestational Diabetes Mellitus 32 Adverse birth outcomes 1 Ectopic pregnancy 1 Fetal Alcohol Spectrum Disorders 1 Fetal Death 0 Pregnancy Complications, Infectious 0

38 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for pregnancy complications

19 trials tracked for pregnancy complications: 6 in phase 3 or 4 and 3 with published results. The most-cited published study has 119 citations.

19Trials tracked
6Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 4 Phase 3 2 Phase 2 3 Other / NA 10
  1. Phase 3 High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention Completed · 119 cited
  2. Phase 3 Furosemide vs. Placebo for Severe Antepartum Hypertension Completed · 8 cited
  3. Phase 4 Carbetocin Myocardium Trial 2014 Part 2 Completed · 7 cited
  4. Phase 4 Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial Completed
  5. Phase 4 Optimal Blood Pressure Treatment Thresholds Postpartum Completed
  6. Phase 4 Intravenous Versus Oral Iron in Late Pregnancy: Results of Treatment Completed
Show 13 more trials
  1. Phase 2 A Clinical Trial of Intravenous (IV) Ganaxolone in Women With Postpartum Depression Completed
  2. Phase 2 A Clinical Trial of Oral Ganaxolone in Women With Postpartum Depression Completed
  3. Phase 2 Progesterone for the Management of Preterm, Premature Rupture of the Membranes: A Randomized Controlled Trial. Completed
  4. N/A An Evaluation of the Team Birth Project Completed
  5. N/A Use of a Novel Computerized Decision Aid for Prenatal Aneuploidy Screening Completed
  6. N/A Continuous Glucose Monitoring in Pregnant Women Undergoing Betamethasone Therapy Completed
  7. N/A Sedentary Behavior Reduction in Pregnancy Intervention Study Completed
  8. N/A Metformin Versus Insulin in Pregnant Women With Type 2 Diabetes Completed
  9. N/A Validating a New Method to Assess Estimated Blood Loss in the Obstetric Population Completed
  10. N/A Comparative Effectiveness of Treatment Options for Genital Herpes Infection to Reduce Adverse Pregnancy Outcomes Completed
  11. N/A Low Plasma Mannose Binding Lectin (p-MBL) Level is a Risk Factor for Recurrent Pregnancy Loss (RPL) Completed
  12. N/A Acute Exercise Effects in Obese Pregnancy Completed
  13. N/A Health and Wellbeing of Pregnant and Post-Partum Women During the COVID-19 Pandemic Completed

Showing the 19 most-cited and recently-updated of 19 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Pregnancy complications: what the trials found

New evidence regarding pregnancy management includes the use of Mifepristone, which was associated with delivery within 12 hours in 5 cases and within 24 hours in 13 cases 2. Additionally, a feasibility study confirmed that 61 participants were eligible, enrolled, and retained under usual care protocols 1.

Clinical evaluations of uterine tone using Oxytocin showed scores of 7 and 8 3, while the administration of Ferli-6® was also documented in clinical settings 4. Regarding nutritional interventions, a large-scale study found that Folic Acid 4 mg did not significantly impact the incidence of preeclampsia (p=0.37), spontaneous abortion (p=0.37), or placenta abruption (p=0.21) 5.

Pharmacological management for blood pressure in pregnancy included Furosemide, which resulted in systolic and diastolic blood pressures of 139/84 and 154/87 at 2 hours post-administration 6. For postpartum mental health, Ganaxolone was evaluated; it showed reductions in both HAMD17 scores (ranging from -11.0 to -14.3) and EPDS scores (ranging from -1.9 to -8.8) 7, with a separate trial confirming significant reductions in EPDS scores 8.

Recent results — preliminary, needs further review

  • 17-Hydroxyprogesterone Caproate was evaluated for neonatal outcomes, but results for respiratory distress syndrome (p=0.31) and intraventricular hemorrhage (p=>0.99) were not statistically significant 9.
  • Sedentary behavior reduction showed statistically significant improvements in standing time and steps per day (p=<0.05) 11.
  • Resistance exercise was associated with a statistically significant increase in endothelial function (p=<0.05) 13.

For the clinician treating this condition

  • Mifepristone is utilized for induction, with documented delivery outcomes within 12 and 24 hours 2.
  • Folic Acid at 4 mg did not show a statistically significant effect on preeclampsia or placental complications in a large cohort 5.
  • Ganaxolone demonstrated measurable reductions in depression scales (HAMD17 and EPDS) in clinical trials [7, 8].

AI synthesis of 11 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Survey finds 11.5% of US pregnant women report drinking, 3.9% binge drinking in past month
OB/GYN & Women's Health
Survey finds 11.5% of US pregnant women report drinking, 3.9% binge drinking in past month Survey finds some pregnant women in the US report drinking alcohol or binge drinking
An observational survey of pregnant women aged 18-44 in the US found 11.5% reported current alcohol consumption and 3.9% reported binge drin…
A recent survey shows 11.5% of pregnant women in the US reported drinking alcohol and 3.9% reported binge drinking in the past 30 days.
CDC Apr 4, 2026
Tight glycemic targets in GDM reduce LGA births and cesarean rates but increase insulin use
Diabetes & Endocrinology RCT
Tight glycemic targets in GDM reduce LGA births and cesarean rates but increase insulin use Can stricter blood sugar targets during pregnancy lead to healthier births?
A single-center, open-label RCT of 650 women with GDM found tight glycemic targets (fasting <5.1 mmol/L, postprandial <7.0 mmol/L) reduced L…
Stricter blood sugar targets for pregnant women with diabetes lower risks of large babies and C-sections but require more insulin therapy.
Apr 3, 2026