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Home › Conditions › pregnancy complications

Pregnancy complications

Subtypes of Pregnancy complications

Gestational Diabetes Mellitus 32 Adverse birth outcomes 1 Ectopic pregnancy 1 Fetal Alcohol Spectrum Disorders 1 Fetal Death 0 Pregnancy Complications, Infectious 0

38 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for pregnancy complications

19 trials tracked for pregnancy complications: 6 in phase 3 or 4 and 3 with published results. The most-cited published study has 119 citations.

19Trials tracked
6Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 4 Phase 3 2 Phase 2 3 Other / NA 10
  1. Phase 3 High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention Completed · 119 cited
  2. Phase 3 Furosemide vs. Placebo for Severe Antepartum Hypertension Completed · 8 cited
  3. Phase 4 Carbetocin Myocardium Trial 2014 Part 2 Completed · 7 cited
  4. Phase 4 Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial Completed
  5. Phase 4 Optimal Blood Pressure Treatment Thresholds Postpartum Completed
  6. Phase 4 Intravenous Versus Oral Iron in Late Pregnancy: Results of Treatment Completed
Show 13 more trials
  1. Phase 2 A Clinical Trial of Intravenous (IV) Ganaxolone in Women With Postpartum Depression Completed
  2. Phase 2 A Clinical Trial of Oral Ganaxolone in Women With Postpartum Depression Completed
  3. Phase 2 Progesterone for the Management of Preterm, Premature Rupture of the Membranes: A Randomized Controlled Trial. Completed
  4. N/A An Evaluation of the Team Birth Project Completed
  5. N/A Use of a Novel Computerized Decision Aid for Prenatal Aneuploidy Screening Completed
  6. N/A Continuous Glucose Monitoring in Pregnant Women Undergoing Betamethasone Therapy Completed
  7. N/A Sedentary Behavior Reduction in Pregnancy Intervention Study Completed
  8. N/A Metformin Versus Insulin in Pregnant Women With Type 2 Diabetes Completed
  9. N/A Validating a New Method to Assess Estimated Blood Loss in the Obstetric Population Completed
  10. N/A Comparative Effectiveness of Treatment Options for Genital Herpes Infection to Reduce Adverse Pregnancy Outcomes Completed
  11. N/A Low Plasma Mannose Binding Lectin (p-MBL) Level is a Risk Factor for Recurrent Pregnancy Loss (RPL) Completed
  12. N/A Acute Exercise Effects in Obese Pregnancy Completed
  13. N/A Health and Wellbeing of Pregnant and Post-Partum Women During the COVID-19 Pandemic Completed

Showing the 19 most-cited and recently-updated of 19 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Pregnancy complications: what the trials found

New evidence regarding pregnancy management includes the use of Mifepristone, which was associated with delivery within 12 hours in 5 cases and within 24 hours in 13 cases 2. Additionally, a feasibility study confirmed that 61 participants were eligible, enrolled, and retained under usual care protocols 1.

Clinical evaluations of uterine tone using Oxytocin showed scores of 7 and 8 3, while the administration of Ferli-6® was also documented in clinical settings 4. Regarding nutritional interventions, a large-scale study found that Folic Acid 4 mg did not significantly impact the incidence of preeclampsia (p=0.37), spontaneous abortion (p=0.37), or placenta abruption (p=0.21) 5.

Pharmacological management for blood pressure in pregnancy included Furosemide, which resulted in systolic and diastolic blood pressures of 139/84 and 154/87 at 2 hours post-administration 6. For postpartum mental health, Ganaxolone was evaluated; it showed reductions in both HAMD17 scores (ranging from -11.0 to -14.3) and EPDS scores (ranging from -1.9 to -8.8) 7, with a separate trial confirming significant reductions in EPDS scores 8.

Recent results — preliminary, needs further review

  • 17-Hydroxyprogesterone Caproate was evaluated for neonatal outcomes, but results for respiratory distress syndrome (p=0.31) and intraventricular hemorrhage (p=>0.99) were not statistically significant 9.
  • Sedentary behavior reduction showed statistically significant improvements in standing time and steps per day (p=<0.05) 11.
  • Resistance exercise was associated with a statistically significant increase in endothelial function (p=<0.05) 13.

For the clinician treating this condition

  • Mifepristone is utilized for induction, with documented delivery outcomes within 12 and 24 hours 2.
  • Folic Acid at 4 mg did not show a statistically significant effect on preeclampsia or placental complications in a large cohort 5.
  • Ganaxolone demonstrated measurable reductions in depression scales (HAMD17 and EPDS) in clinical trials [7, 8].

AI synthesis of 11 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Early pregnancy serum uric acid levels associated with gestational diabetes risk in cohort study
Nutrition & Obesity Medicine Cohort
Early pregnancy serum uric acid levels associated with gestational diabetes risk in cohort study High Uric Acid Before 20 Weeks Signals Diabetes Risk
This cohort study of 44,609 singleton pregnant women at three medical centers found a nonlinear association between serum uric acid levels b…
High uric acid before 20 weeks of pregnancy signals a higher risk for gestational diabetes, helping doctors spot trouble early.
Frontiers Apr 17, 2026
Systematic review examines placental biology and social context in Black and African American women with pregnancy complications
OB/GYN & Women's Health Sys. Review
Systematic review examines placental biology and social context in Black and African American women with pregnancy complications The Organ That Records Stress, Racism, and Poverty — Before Birth
This systematic review investigates factors including placental biology, genetic variation, and socioeconomic exposures among Black and Afri…
The placenta records stress, racism, and poverty before birth, shaping higher complication rates for Black women through biology shaped by t…
Frontiers Apr 16, 2026
Early pregnancy FT4 levels show non-linear association with gestational diabetes mellitus risk in 40,682 women
Diabetes & Endocrinology Cohort
Early pregnancy FT4 levels show non-linear association with gestational diabetes mellitus risk in 40,682 women Low-Normal Thyroid Hormones Raise Diabetes Risk
This retrospective cohort study of 40,682 pregnant women evaluated early pregnancy thyroid hormones (FT4, TSH) against normal function range…
Even thyroid numbers that look "normal" on a lab report might actually signal a higher chance of developing gestational diabetes.
Frontiers Apr 16, 2026
First-trimester serum retinol quintiles and pregnancy outcomes in a Chinese prospective cohort
Diabetes & Endocrinology Cohort
First-trimester serum retinol quintiles and pregnancy outcomes in a Chinese prospective cohort High Vitamin A Might Lower Diabetes Risk But Raise C-Section Odds
A prospective cohort of 1,077 singleton pregnancies in China examined first-trimester serum retinol by quintile.
High vitamin A levels early in pregnancy lower diabetes and low birth weight risks but increase the chance of a C-section.
Frontiers Apr 15, 2026
Meta-analysis finds high prevalence of adverse outcomes in African women with hyperglycaemia in pregnancy
Diabetes & Endocrinology Meta-analysis
Meta-analysis finds high prevalence of adverse outcomes in African women with hyperglycaemia in pregnancy High Sugar in Pregnancy Risks C-Section in Africa
A systematic review and meta-analysis of 9,742 women with hyperglycaemia in pregnancy in Africa found high prevalence rates of caesarean sec…
High blood sugar during pregnancy in Africa significantly raises the risk of needing a C-section, threatening both mother and baby.
Apr 14, 2026
Self-reported racial discrimination associated with postpartum depression and low birth weight in pregnant women
OB/GYN & Women's Health Meta-analysis
Self-reported racial discrimination associated with postpartum depression and low birth weight in pregnant women Discrimination Linked to Baby's Low Weight and Mom's Mood
This systematic review and meta-analysis of 1,473,417 participants assessed associations between self-reported interpersonal racial discrimi…
Experiencing racism during pregnancy is a serious health risk that doctors must address to keep moms and babies safe.
Frontiers Apr 14, 2026
Prospective cohort study links dietary intake, gut microbiome, and plasma metabolome differences in Chinese pregnant women with gestational diabetes mellitus
OB/GYN & Women's Health Cohort
Prospective cohort study links dietary intake, gut microbiome, and plasma metabolome differences in Chinese pregnant women with gestational diabetes mellitus Diet Changes Gut Bacteria That Affect Blood Sugar
This prospective cohort study examined 173 patients with gestational diabetes mellitus (GDM) and 47 healthy pregnant controls in China.
Eating certain foods changes your gut bugs, which then changes the chemicals in your blood that control insulin.
Frontiers Apr 14, 2026
Lower early pregnancy Lp(a) levels associated with higher gestational diabetes risk in retrospective cohort
Diabetes & Endocrinology Cohort
Lower early pregnancy Lp(a) levels associated with higher gestational diabetes risk in retrospective cohort A Simple Blood Test in Early Pregnancy May Flag Diabetes Risk
A retrospective cohort study of 14,527 pregnant women found that lower serum Lp(a) levels within the first 20 weeks of gestation were associ…
Low levels of a cholesterol-linked protein in early pregnancy are linked to a higher risk of developing gestational diabetes later on.
Frontiers Apr 14, 2026
Early pregnancy biomarkers associated with gestational diabetes risk in AMA nulliparous women
Diabetes & Endocrinology Cohort
Early pregnancy biomarkers associated with gestational diabetes risk in AMA nulliparous women Early Pregnancy Clues That Flag Diabetes Risk After 35
A retrospective single-center cohort study of 354 advanced maternal age nulliparous women found urinary glucose positivity, elevated fasting…
For women choosing pregnancy later in life, there may now be early signals your OB can watch for — long before the standard glucose test.
Frontiers Apr 13, 2026
Systematic review links neutrophil extracellular trap dysregulation to pregnancy complications
Diabetes & Endocrinology Sys. Review
Systematic review links neutrophil extracellular trap dysregulation to pregnancy complications Web of White Blood Cells Linked to Pregnancy Risks
A systematic review of emerging evidence indicates that dysregulation of neutrophil extracellular trap (NET) formation and clearance is stro…
A sticky web of white blood cells meant to fight germs can instead trigger serious pregnancy risks like preeclampsia and preterm birth when …
Frontiers Apr 12, 2026
Systematic review finds 54.8% of Indian women with reproductive morbidities seek treatment
OB/GYN & Women's Health Meta-analysis
Systematic review finds 54.8% of Indian women with reproductive morbidities seek treatment Half of Indian women ignore reproductive pain
This systematic review and meta-analysis examined health-seeking behavior for reproductive morbidities among Indian women.
Ignoring common reproductive problems like pelvic pain or irregular periods leads to worse health outcomes for millions of women in India.
Frontiers Apr 11, 2026
Patient-led insulin titration in GDM linked to faster glycemic control and lower macrosomia risk in small RCT
Diabetes & Endocrinology RCT
Patient-led insulin titration in GDM linked to faster glycemic control and lower macrosomia risk in small RCT Could letting pregnant women adjust their own insulin lead to healthier babies?
A single-center, nonblinded RCT of 56 individuals with GDM requiring insulin found patient-led titration achieved target fasting glucose fas…
Pregnant women who adjusted their own insulin doses reached target blood sugar faster and had babies far less likely to be born very large t…
Apr 8, 2026