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Psychiatry
Racial discrimination linked to negative symptoms in schizophrenia via defeatist beliefs
Why Some Patients Can't Shake the "I'll Fail" Mindset
An observational study of 208 Black and White individuals with schizophrenia-spectrum disorder found that Black participants had greater neg…
For Black Americans with schizophrenia, the stress of racism may fuel low motivation and withdrawal that standard medication rarely touches.
medRxiv
Apr 16, 2026
Psychiatry
RCT
Aripiprazole linked to less insight improvement than dopamine antagonists in schizophrenia trial
Can reducing symptoms help people with schizophrenia gain insight into their illness?
A 6-week RCT of 144 schizophrenia spectrum disorder patients found symptom reduction was associated with improved clinical insight. Patients…
Reducing symptoms helps people with schizophrenia gain insight into their illness, but early improvement in hallucinations and delusions mat…
Apr 7, 2026
Psychiatry
Cohort
Danish cohort study identifies ten clinically distinct schizophrenia subgroups with genetic associations
What if schizophrenia isn't one illness, but ten different ones?
An observational cohort study of 22,092 individuals in the Danish iPSYCH registry identified ten clinically distinct schizophrenia spectrum …
Ten different conditions exist within schizophrenia, each with unique symptoms and genetic patterns found in over 22,000 Danish patients.
medRxiv
Apr 5, 2026
Psychiatry
Cohort
Gray matter volume deviations in schizophrenia linked to symptom severity and cognitive function
Can brain volume patterns help us understand schizophrenia symptoms?
An observational cohort study of 379 schizophrenia spectrum disorder patients and 149 healthy controls found that more negative gray matter …
A scattered pattern of less brain tissue linked to focusing on important details predicts how severe schizophrenia symptoms are.
medRxiv
Apr 4, 2026