Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Conditions › Spinal Cord Injury

Spinal Cord Injury

21 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Spinal Cord Injury

99 trials tracked for Spinal Cord Injury: 18 in phase 3 or 4 and 3 with published results. The most-cited published study has 42 citations.

99Trials tracked
18Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 6 Phase 3 12 Phase 2 21 Phase 1 6 Other / NA 54
  1. Phase 3 Resistance Training and Testosterone After Spinal Cord Injury Completed · 42 cited
  2. Phase 3 Blood Pressure, Cerebral Blood Flow and Cognition in Spinal Cord Injury Completed · 18 cited
  3. Phase 3 Treatment of Post-SCI Hypotension Completed · 7 cited
  4. Phase 4 Bowel Care and Cardiovascular Function After Spinal Cord Injury Completed
  5. Phase 4 tSCI Contrast Enhanced Ultrasound Study Completed
  6. Phase 4 Effect of Parathyroid Hormone (PTH) and Weight-Bearing on Bone in Spinal Cord Injury (SCI) Completed
Show 44 more trials
  1. Phase 4 Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury. Completed
  2. Phase 4 Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia Completed
  3. Phase 4 Efficacy and Safety of Standard Oral Colonoscopic Preparations With or Without Neostigmine Compared to Pulse-Irrigation Colonic Lavage Completed
  4. Phase 3 Fenofibrate Treatment in SCI Completed
  5. Phase 3 Zoledronic Acid in Acute Spinal Cord Injury Completed
  6. Phase 3 Effects of Electrical Stimulation and Vitamin D Supplementation on Bone Health Following Spinal Cord Injury. Completed
  7. Phase 3 Testosterone Replacement Therapy in Chronic Spinal Cord Injury Completed
  8. Phase 3 Prevention of Low Blood Pressure in Persons With Tetraplegia Completed
  9. Phase 3 Safety and Efficacy of Oral Fampridine-SR for the Treatment of Spasticity Resulting From Spinal Cord Injury Completed
  10. Phase 3 Use of an Oral Beta-2 Agonist in Persons With Spinal Cord Injury Completed
  11. Phase 3 Enhancing Indoor, Community, and Advanced Wheelchair Skills in Spinal Cord Injury (SCI) Completed
  12. Phase 3 Safety and Efficacy of Oral Fampridine-Sustained Release (SR) for the Treatment of Spasticity Resulting From Spinal Cord Injury Completed
  13. Phase 2 Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of SUN13837 Injection in Adult Subjects With Acute Spinal Cord Injury (ASCI) Completed
  14. Phase 2 Development of an Ergonomic Wheelchair Pushrim Completed
  15. Phase 2 Effect of Teriparatide, Vibration and the Combination on Bone Mass and Bone Architecture in Chronic Spinal Cord Injury Completed
  16. Phase 2 Safety and Efficacy of L-NAME and Midodrine to Increase MAP Completed
  17. Phase 2 12 Month Extension Study of the Effect of Teriparatide on Bone in People With Chronic Spinal Cord Injury (SCI) Completed
  18. Phase 2 Effects of Vaporized Marijuana on Neuropathic Pain Completed
  19. Phase 2 Prevention of Bone Loss After Acute SCI by Zoledronic Acid Completed
  20. Phase 2 Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan Dose Response Clinical Trial Completed
  21. Phase 2 Role of Enhancing Serotonin Receptors Activity for Sleep Apnea Treatment in Patients With SCI Completed
  22. Phase 2 Effect of Alendronate on Bone in People With Chronic Spinal Cord Injury (SCI) Previously Treated With Teriparatide Completed
  23. Phase 2 P300 Brain Computer Interface Keyboard to Operate Assistive Technology Completed
  24. Phase 2 The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury Completed
  25. Phase 2 Testosterone and Long Pulse Stimulation After SCI Completed
  26. Phase 2 Neuromodulation Techniques After SCI Completed
  27. Phase 2 Efficacy and Safety of Lithium Carbonate in the Treatment of Chronic Spinal Cord Injuries Completed
  28. Phase 2 A Dose Response Trial Using 5 and 10 Mg of Midodrine Hydrochloride Completed
  29. Phase 2 Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan/Lidocaine Combination Clinical Trial Completed
  30. Phase 2 Lokomat Versus Strength Training in Chronic Incomplete Spinal Cord Injury Completed
  31. Phase 2 Multifaceted Treatment of Catheter-related Urinary Tract Infection Completed
  32. Phase 2 Functional Electrical Stimulation (FES) Driven Stepping in Individuals With Spinal Cord Injury Completed
  33. Phase 2 Enhancement of Pressure Healing With Pulsatile Lavage Completed
  34. Phase 1 Colonizing Neurogenic Bladders With Benign Flora Completed
  35. Phase 1 Evaluation of a Tongue Operated Assistive Technology for Individuals With Severe Paralysis Completed
  36. Phase 1 High Frequency SARS for Neurogenic Bladder and Bowel Emptying Completed
  37. Phase 1 Safety Study of Local Administration of Autologous Bone Marrow Stromal Cells in Chronic Paraplegia Completed
  38. Phase 1 Subarachnoid Administrations of Adults Autologous Mesenchymal Stromal Cells in SCI Completed
  39. Phase 1 Two Devices for Reflex Voiding Following Spinal Cord Injury Completed
  40. N/A Exoskeletal-assisted Walking to Improve Mobility, Bowel Function and Cardio-Metabolic Profiles in Persons With SCI Completed
  41. N/A Restoring Walking With a Powered Exoskeleton After Spinal Cord Injury Completed
  42. N/A A Neuroprosthesis for Prolonged Standing After SCI Using Multi-Contact Peripheral Nerve Electrodes Completed
  43. N/A The Effects Upon the Bladder of Transcutaneous Tibial Nerve Stimulation in Acute Traumatic Spinal Cord Injury Completed
  44. N/A Powered Exoskeletons in Persons With SCI Completed

Showing the 50 most-cited and recently-updated of 99 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Systematic review and meta-analysis of Danshen for spinal cord injury in animal models
Drug Pipeline Meta-analysis
Systematic review and meta-analysis of Danshen for spinal cord injury in animal models This Common Herb May Help Spinal Cord Injuries Heal Faster
This systematic review and meta-analysis of 35 randomized controlled trials in animal models of spinal cord injury found that Danshen extrac…
A common Chinese herb may help spinal cord injuries heal faster by reducing swelling and protecting nerve cells, but human studies are still…
Frontiers Apr 20, 2026
Narrative review discusses exosomes for spinal cord injury without reported outcomes or safety data
Rheumatology Sys. Review
Narrative review discusses exosomes for spinal cord injury without reported outcomes or safety data Could exosomes help heal spinal cord injuries, but this review offers only ideas, not proof
This narrative review examines the potential of exosomes derived from various cell sources for treating spinal cord injury.
Exosomes might one day help repair broken spinal cord connections, but this review only gathers existing ideas without testing them on real …
Frontiers Apr 20, 2026
Canadian policies for spinal cord injury supplies vary widely, often relying on means-testing rather than medical need
Primary Care & Family Medicine Sys. Review
Canadian policies for spinal cord injury supplies vary widely, often relying on means-testing rather than medical need Over 80,000 Canadians with spinal cord injuries face funding gaps that limit their daily independence and safety
This systematic review examined health care delivery for over 80,000 Canadians with spinal cord injury across provincial and federal levels.
Over 80,000 Canadians with spinal cord injuries face funding gaps that limit their daily independence and safety.
Frontiers Apr 13, 2026
Pilot RCT finds Cognitive Multisensory Rehabilitation may improve sensorimotor function in spinal cord injury
Physical Medicine & Rehab RCT
Pilot RCT finds Cognitive Multisensory Rehabilitation may improve sensorimotor function in spinal cord injury A New Kind of Therapy Rewires the Brain to Ease Spinal Cord Pain
A pilot RCT of 16 adults with spinal cord injury compared Cognitive Multisensory Rehabilitation (CMR) to adaptive fitness.
Early research suggests a therapy focused on rebuilding the brain's map of the body can offer lasting relief where medications often fail.
medRxiv Apr 13, 2026
Narrative review examines autonomic modulation strategies for spinal cord injury recovery
Neurology Sys. Review
Narrative review examines autonomic modulation strategies for spinal cord injury recovery Fixing the Body's Wiring for Spinal Cord Recovery
A narrative review synthesizing emerging evidence (2020–2025) examines autonomic modulation strategies for spinal cord injury.
High stress blocks spinal cord healing by stopping the brain from rewiring, so calming the body is just as important as physical therapy for…
Frontiers Apr 10, 2026
Plastic changes in brainstem reticular formation may be involved in spasticity onset across stroke and spinal cord injury
Neurology Sys. Review
Plastic changes in brainstem reticular formation may be involved in spasticity onset across stroke and spinal cord injury Could brainstem plastic changes trigger spasticity in stroke and spinal cord injury patients?
This systematic review examined pathophysiological similarities in spasticity among humans, primates, and rodents.
Spasticity after stroke or spinal cord injury may stem from plastic changes in the brainstem, though evidence remains limited and controvers…
Frontiers Apr 9, 2026
First-in-human case study of BCI-spinal stimulation shows hand function gains in chronic tetraplegia
Physical Medicine & Rehab
First-in-human case study of BCI-spinal stimulation shows hand function gains in chronic tetraplegia Can a brain-spine connection help someone with paralysis move their hand again?
A first-in-human case study in one individual with chronic, motor-complete cervical spinal cord injury tested a brain-computer interface pai…
A brain-spine connection helped a person with severe paralysis regain hand function, with improvements lasting even after therapy ended.
medRxiv Apr 8, 2026
Spinal cord injury linked to altered cortical excitability response to repeated tDCS
Neurology
Spinal cord injury linked to altered cortical excitability response to repeated tDCS Could a brain's 'reset button' work differently after spinal cord injury?
A crossover study in 20 adults with thoracic or below spinal cord injury and 20 healthy controls found greater corticomotor excitability fac…
After spinal cord injury, the brain's 'reset button' may weaken, leading to greater excitability and potentially explaining persistent sympt…
medRxiv Apr 5, 2026
Hypnotic cognitive therapy reduces pain intensity in adults with spinal cord injury
Anesthesiology & Pain Medicine RCT
Hypnotic cognitive therapy reduces pain intensity in adults with spinal cord injury Remote hypnosis therapy shows modest pain relief for adults with spinal cord injury
A randomized controlled trial in 127 community-residing adults with spinal cord injury and chronic pain found that 6 weeks of remote hypnoti…
Remote hypnosis therapy offered by phone or video call helped adults with spinal cord injury manage chronic pain and reduced depression symp…
Apr 3, 2026

Questions about Spinal Cord Injury

Do Canadian policies for spinal cord injury supplies rely on means-testing rather than medical need?

Yes, Canadian policies for spinal cord injury supplies often use means-testing (income-based eligibility) rather than medical need, leading to wide inequities across provinces.

Full answer →
Are exosomes currently a safe or effective treatment for spinal cord injury based on reviews?

No, exosomes are not yet a safe or effective treatment for spinal cord injury in humans; evidence is limited to animal studies and early preclinical research.

Full answer →
What did studies find about Danshen extract for spinal cord injury in animal models?

Studies in animal models found that Danshen extract significantly improves motor function, reduces inflammation, oxidative stress, apoptosis, and spinal cord edema after spinal cord injury.

Full answer →
Can repetitive transcranial magnetic stimulation reduce neuropathic pain for spinal cord injury patients?

Yes, repetitive transcranial magnetic stimulation (rTMS) can reduce neuropathic pain in spinal cord injury patients, based on multiple studies including meta-analyses and randomized trials.

Full answer →