Bioinformatics study identifies shared immune genes and potential drugs for PCOS and T2DM
Could existing drugs treat shared genes in PCOS and type 2 diabetes?
A preclinical bioinformatics and experimental validation study analyzed GEO datasets from patients with PCOS and T2DM, identifying 239 commo…
A study identified 239 genes linked to both PCOS and type 2 diabetes, with 40 existing drugs like maraviroc potentially targeting them for n…
Cross-Sectional Analysis of Protective Foot Sensation and Complications in 387 Type 2 Diabetes Patients
Smoking and kidney disease link to worse diabetes nerve damage in feet
This retrospective cross-sectional study evaluated 387 patients with Type 2 diabetes and Diabetic Peripheral Neuropathy at University Hospit…
Smoking and severe kidney disease greatly increase the risk of losing protective feeling in the feet, leading to dangerous complications for…
Multidisciplinary management in T2DM patients yielded a 29.24% remission rate in a single-arm observational study
Nearly 1 in 3 Reversed Type 2 Diabetes in Special Clinic
This single-arm observational study evaluated 171 patients with Type 2 Diabetes Mellitus receiving remission-oriented treatment at a special…
A special diabetes clinic helped nearly one in three patients reach remission, meaning they no longer needed diabetes pills after six months…
Tirzepatide shows greater lean body mass loss than semaglutide in first-episode GLP-1RA users with type 2 diabetes
One Weight-Loss Drug Trims More Muscle Than the Other — Here's Why
An observational study of 670,422 first-episode GLP-1RA users with type 2 diabetes found tirzepatide was associated with greater relative le…
Losing weight with a popular injection drug is not all equal — one drug may chip away at your muscle more than the other, which matters grea…
Mini-review links insulin to worse COVID-19 outcomes in type 2 diabetes patients
Diabetes Meds Do Not Stop COVID-19
A mini-review of observational studies in patients with type 2 diabetes mellitus found that insulin was linked to worse COVID-19 outcomes, w…
Recent research proves that common diabetes pills do not protect you from getting sick or dying from a virus infection.
GLP-1RA use shows sex-specific pancreatitis and hypotension risks in T2D second-line therapy study
Diabetes drugs work differently in women than men
A retrospective cohort study of 5.15 million adults with type 2 diabetes compared second-line therapies.
Diabetes drugs work differently for women than men, revealing distinct safety and effectiveness outcomes in a massive study of 5 million adu…
Preprint paired analysis suggests VSG may improve metabolic and renal markers in youth with T2D and obesity
Surgery Stops Kidney Damage in Obese Teens With Diabetes
This preprint paired analysis examined vertical sleeve gastrectomy (VSG) in youth with type 2 diabetes and obesity over 12 months.
This new study shows that weight-loss surgery can actually heal early signs of kidney stress in teenagers by turning off harmful chemical si…
Meta-analysis finds high prevalence of adverse outcomes in African women with hyperglycaemia in pregnancy
High Sugar in Pregnancy Risks C-Section in Africa
A systematic review and meta-analysis of 9,742 women with hyperglycaemia in pregnancy in Africa found high prevalence rates of caesarean sec…
High blood sugar during pregnancy in Africa significantly raises the risk of needing a C-section, threatening both mother and baby.
Orforglipron shows superior HbA1c reduction versus oral semaglutide in adults with type 2 diabetes on metformin
A New Diabetes Pill Takes On Ozempic's Oral Cousin
A phase 3 RCT of 1698 adults with type 2 diabetes inadequately controlled on metformin found that once-daily oral orforglipron (12 mg or 36 …
A new once-daily diabetes pill called orforglipron lowered blood sugar better than oral semaglutide in a major head-to-head trial, but at th…
Single aerobic exercise bout shows mixed effects on glucose and neuronal insulin signaling in obesity
A Single Workout That Talks to Your Brain
A small RCT in 15 sedentary adults with obesity found a single bout of aerobic exercise at 70% VO₂max showed a trend toward lower glucose AU…
One workout session raised insulin signals in brain particles, offering a clue to how exercise may protect against Alzheimer's over time.
Circulating spexin levels are significantly lower in patients with type 2 diabetes mellitus compared to controls
The Hormone That Goes Missing When Diabetes Arrives
This systematic review and meta-analysis evaluated circulating spexin levels in 1,122 patients with type 2 diabetes mellitus and 681 control…
A little-known hormone called spexin shows up in much smaller amounts in people with type 2 diabetes, hinting at a possible link scientists …
Meta-analysis identifies risk factors for diabetic kidney disease in Asian patients with type 2 diabetes
High Blood Pressure Is A Major Kidney Killer For Asian Diabetics
A meta-analysis of 24 studies including 12,047 Asian patients with type 2 diabetes found that SBP, hypertension, HbA1c, WHR, FBG, UA, Cr, ag…
High blood pressure is a top kidney killer for Asian diabetics, making blood pressure control just as critical as managing sugar levels to p…
Research across Diabetes
Related studies from across the Diabetes family.
A 6 dimension and 42 item system provides early risk assessment for high-risk diabetic feet
Experts Develop New Risk Assessment System for Diabetic Feet
This expert consultation and guideline describes the development of an early risk assessment system for high-risk diabetic feet. The consens…
A new assessment system identifies risk factors like nerve damage and circulation to help manage and prevent complications in patients with …
Evaluating the Impact of Digital Health Interventions on Chronic Disease Self-Care Outcomes
Digital health tools show mixed results for managing chronic diseases
Digital tools show promise for heart failure monitoring but lack consistent evidence for improving medication adherence or general diabetes …
New data shows that while digital tools like apps can help heart failure patients monitor their health, they may not improve medication habi…
Pharmacist-led telepharmacy may improve medication adherence and reduce blood pressure in patients with NCDs
Pharmacist Led Telepharmacy May Improve Medication Adherence For Chronic Illness
This systematic review analyzed 21 trials involving 5440 participants to evaluate pharmacist-led telepharmacy for managing non-communicable …
Remote pharmacist services through phone or video may help patients with high blood pressure and diabetes stick to their daily medication pl…
Pancreatic cancer involves multilayered mechanisms from environment to immune escape
Review reveals complex causes of pancreatic cancer
This narrative review synthesizes the multilayered mechanisms of pancreatic cancer, including environmental exposure, genetic susceptibility…
Pancreatic cancer arises from a mix of genetics, lifestyle, and inflammation, review finds.
Individualized six-phase antithrombotic strategy leads to left ventricular thrombus resolution and neurological recovery
New strategy helps manage heart blood clots after heart attack
This case report describes an individualized six-phase antithrombotic strategy for a 27-year-old male with myocardial infarction, stroke, hy…
A tailored six-phase treatment plan helped a young man recover fully from a stroke and heart attack while successfully clearing dangerous bl…
High prevalence of microvascular and macrovascular complications among adult Ugandans with diabetes
High rates of diabetes complications found in adult Ugandans
This meta-analysis examined the prevalence of various diabetic complications, including neuropathy and retinopathy, in a large cohort of adu…
More than half of Ugandan adults with diabetes suffer from nerve damage, highlighting a critical need for earlier screening and better care.
Immunometabolic dysregulation drives hyperalgesia and hypoesthesia in diabetic peripheral neuropathy
New research explores how inflammation drives nerve damage in diabetes
This narrative review explores the pathophysiology of diabetic peripheral neuropathy, focusing on how hyperglycemia, lipotoxicity, and intes…
Chronic high blood sugar causes more than just high glucose; it triggers a cycle of inflammation and immune stress that damages nerves.
Chronic hyperglycemia causes multi-level nerve damage across the peripheral, autonomic, and central nervous systems
Understanding how high blood sugar damages the entire nervous system in diabetes
This narrative review synthesizes how chronic hyperglycemia impacts the entire neuroaxis in patients with diabetes. It details metabolic and…
High blood sugar can damage nerves throughout the whole body. This affects your senses, movement, and internal organs.
Pancreatic tissue engineering faces vascularization hurdle in type 1 diabetes therapy
New tissue engineering methods aim to improve pancreatic transplants
This narrative review examines pancreatic tissue engineering for type 1 diabetes, highlighting insufficient vascularization as the dominant …
Current pancreas transplants are limited by a shortage of donors and the need for lifelong drugs. New engineering techniques may offer a dif…
CAR technology for autoimmune disorders, infectious diseases, fibrotic lesions, inflammatory bowel disease, and type 1 diabetes is reviewed
Chimeric antigen receptor technology may help treat autoimmune disorders and other conditions
This narrative review discusses the application of chimeric antigen receptor (CAR) technology across autoimmune disorders, infectious diseas…
A narrative review suggests chimeric antigen receptor technology could be useful for treating autoimmune disorders, infectious diseases, and…
HIV linked to lower odds of post-TB lung disease; undernutrition raises risk
Undernutrition and HIV may lower or raise lung damage risk after tuberculosis in low-income nations
This systematic review and meta-analysis of 41 studies in LMICs found that HIV was associated with reduced odds of spirometry-defined post-t…
New analysis of data from low-income countries shows mixed results on how HIV, diabetes, and poor nutrition affect lung health after tubercu…
scFv-based biologics show potential for immunomodulation in type 1 and type 2 diabetes
Review explores scFv biologics for Type 1 and Type 2 diabetes care
This narrative review explores the potential of single-chain variable fragment (scFv)-based biologics for treating type 1 and type 2 diabete…
This review looks at scFv-based biologics for diabetes. It discusses how these treatments might help with immune control and blood sugar bal…
Questions about Type 2 Diabetes
What common genes link Polycystic Ovary Syndrome and type 2 diabetes according to recent studies?
Recent studies link PCOS and type 2 diabetes through shared genetic variants, notably the insulin gene VNTR and epigenetic changes in metabolism-related genes.
Full answer →What are the standard treatment options available for someone with Type 2 Diabetes?
Standard treatment for type 2 diabetes includes lifestyle changes (diet, exercise), metformin, other medications like GLP-1 agonists (e.g., semaglutide, tirzepatide), and sometimes insulin, along with monitoring blood sugar and managing cardiovascular risk.
Full answer →What are the best lifestyle changes to manage Type 2 Diabetes effectively?
A Mediterranean diet, regular physical activity, weight loss, and digital health tools can effectively manage type 2 diabetes, with medication support as needed.
Full answer →