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Home › Conditions › Vitamin D deficiency

Vitamin D deficiency

Part of Malnutrition

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Vitamin D deficiency

69 trials tracked for Vitamin D deficiency: 25 in phase 3 or 4 and 8 with published results. The most-cited published study has 843 citations.

69Trials tracked
25Phase 3 & 4
0Recruiting
8With published results
Phase distribution
Phase 4 12 Phase 3 13 Phase 2 12 Phase 1 2 Other / NA 30
  1. Phase 3 Evaluation of Vitamin D Requirements During Pregnancy Completed · 843 cited
  2. Phase 3 Vitamin D to Improve Outcomes by Leveraging Early Treatment Completed · 301 cited
  3. Phase 4 The Effects of Vitamin D on Angiogenic Factors in Women With Polycystic Ovary Syndrome Completed · 114 cited
  4. Phase 3 Vitamin D Status of Pregnant Women and Their Children in Eau Claire, South Carolina Completed · 103 cited
  5. Phase 3 Establishing the Vitamin D Requirements During Lactation Completed · 67 cited
  6. Phase 4 Treatment Study of Vitamin D Deficiency in Adolescents Completed · 24 cited
Show 44 more trials
  1. Phase 3 Hypovitaminosis D in Neurocritical Patients Completed · 21 cited
  2. Phase 4 Vitamin D and Coronary Calcification Study Completed · 12 cited
  3. Phase 4 Vitamin D Repletion in Primary Hyperparathyroidism Completed
  4. Phase 4 Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS Completed
  5. Phase 4 Can Vitamin D Reduce Heart Muscle Damage After Bypass Surgery? Completed
  6. Phase 4 Vitamin Deficiency in Immigrants, a Treatment Study Completed
  7. Phase 4 Efficacy of Vitamin D2 to Treat Chronic Kidney Disease Mineral and Bone Disorder Completed
  8. Phase 4 Does Treatment of Hypovitaminosis D Increase Calcium Absorption? Completed
  9. Phase 4 Treatment of Vitamin D Insufficiency Completed
  10. Phase 4 Effect of Omega-3 Fatty Acid on Vitamin D Activation Completed
  11. Phase 4 Vitamin D Repletion in Stone Formers With Hypercalciuria Completed
  12. Phase 3 Safety and Efficacy of CTAP101 to Treat Secondary Hyperparathyroidism in Stage 3 or 4 CKD and Vitamin D Insufficiency Completed
  13. Phase 3 Safety and Efficacy of CTAP101 to Treat Secondary Hyperparathyroidism in Stage 3 or 4 CKD and Vitamin D Insufficiency Completed
  14. Phase 3 Extension Study of CTAP101-CL-3001 or CTAP101-CL-3002 Completed
  15. Phase 3 Improving the Understanding of the Response to Vitamin D Supplementation Completed
  16. Phase 3 Vitamin D in Vulnerable Adults (VIVA-VA) Completed
  17. Phase 3 Effect of Vitamin D Treatment in Primary Hyperparathyroidism Completed
  18. Phase 3 Safety of Vitamin D Supplementation in Older Persons Completed
  19. Phase 3 Controlled Trial of Prenatal Vitamin D3 Supplementation to Prevent Vitamin D Deficiency in Mothers and Their Infants Completed
  20. Phase 2 Vitamin D Supplementation in RNA-seq Profiles of Single-core Prostate Samples, Among Veterans Completed
  21. Phase 2 Prevention of Vitamin D Deficiency Following Pediatric CHD Surgery: a Phase II Dose Evaluation Randomized Controlled Trial Comparing Usual Care With a High Dose Pre-operative Supplementation Regimen Based on the Institute of Medicine Daily Upper Tolerable Intake Level Completed
  22. Phase 2 Study of Vitamin D and Effect on Heart Disease and Insulin Resistance Completed
  23. Phase 2 Safety, Efficacy, and Feasibility of High-dose Cholecalciferol in Pediatric Patients With Cystic Fibrosis Completed
  24. Phase 2 Daily Vitamin D for Sickle-cell Respiratory Complications Completed
  25. Phase 2 Effect of Vitamin D3 Supplementation in Pregnancy on Risk of Pre-eclampsia Completed
  26. Phase 2 Blue Sky Study: Impact of Milk and Vitamin D for Child Growth and Health Completed
  27. Phase 2 Topical Delivery of Vitamin D3 as Vitamin D Supplementation Completed
  28. Phase 2 Vitamin D for Sickle-cell Respiratory Complications Completed
  29. Phase 2 Correction of Vitamin D Levels and Its Effect on Insulin Resistance and Weight Gain in Obese Youth Completed
  30. Phase 2 Blood Pressure in Blacks and Calcium (BBC) and Vitamin D Study Completed
  31. Phase 2 Nutrition and Body Composition in Acute Lymphoblastic Leukemia Completed
  32. Phase 1 Human Pharmacology Trial of Calcium-vitamin D3 Tablet in Healthy Participants Completed
  33. Phase 1 Effect of Vitamin D Supplementation on Endothelial Function in Obese Adolescents Completed
  34. N/A Cholecalciferol in Newly Diagnosed Non-Hodgkin Lymphoma or Chronic Lymphocytic Leukemia With Vitamin D Deficiency Completed
  35. N/A Vitamin D Supplementation in Kidney Disease Completed
  36. N/A Vitamin D Supplementation in Psychiatric Illnesses Completed
  37. N/A Vitamin D and Vascular Health in Children Completed
  38. N/A Incidence of HANA Conditions in HIV-infected Individuals Completed
  39. N/A Treatment of Vitamin D Deficiency in Intestinal Rehabilitation Clinic Patients With a Portable Ultraviolet B Lamp Completed
  40. N/A Effect of Vitamin D3 on Vascular Function Completed
  41. N/A Cholecalciferol (Vitamin D3) Therapy in Chronic Kidney Disease (CKD) Subjects Completed
  42. N/A Vitamin D in HIV-Infected Patients on HAART Completed
  43. N/A hCAP18 Levels and Vitamin D Deficiency in Healthy Subjects Completed
  44. N/A Vitamin D Replacement After Kidney Transplant Completed

Showing the 50 most-cited and recently-updated of 69 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Routine vitamin D testing in Saudi Arabia shows nearly half of patients have deficiency levels
Drug Pipeline Cohort
Routine vitamin D testing in Saudi Arabia shows nearly half of patients have deficiency levels Half of patients tested for vitamin D levels were found to be deficient
This retrospective cross-sectional analysis evaluated serum 25-hydroxyvitamin D concentrations in 14,369 patients at a Saudi hospital.
A large analysis of routine tests shows nearly half of patients had low vitamin D, highlighting a widespread need for better public health m…
Frontiers Apr 29, 2026
Pre-diagnostic vitamin D deficiency linked to higher thyroid cancer risk in a large retrospective cohort
Nutrition & Obesity Medicine Cohort
Pre-diagnostic vitamin D deficiency linked to higher thyroid cancer risk in a large retrospective cohort Could low vitamin D before diagnosis raise your risk of developing thyroid cancer?
This retrospective propensity score–matched cohort study analyzed adults aged ≥ 18 y with serum 25-hydroxyvitamin D measurements within the …
Low vitamin D levels before a thyroid cancer diagnosis are linked to a higher risk of developing the disease over ten years, according to ne…
Frontiers Apr 21, 2026
Vitamin D deficiency associated with depression in adolescents and young adults, stronger in females
Psychiatry Meta-analysis
Vitamin D deficiency associated with depression in adolescents and young adults, stronger in females Vitamin D deficiency linked to depression in adolescents and young adults, especially females
A systematic review and meta-analysis of 27,956 adolescents and young adults found vitamin D deficiency (<50 nmol/L) was associated with dep…
Young people with low vitamin D levels are twice as likely to have depression, a link that is especially strong in females.
medRxiv Apr 4, 2026
Vitamin D3 supplementation improved exercise tolerance in deficient male COPD patients in small RCT
Pulmonology & Critical Care RCT
Vitamin D3 supplementation improved exercise tolerance in deficient male COPD patients in small RCT Vitamin D supplements linked to better walking ability in men with COPD and low vitamin D
A 26-week double-blind RCT in 40 vitamin D3-deficient male COPD patients found that oral vitamin D3 supplementation (80,000 IU/week then adj…
Men with COPD and low vitamin D levels walked farther and felt less breathless after taking supplements for six months.
Apr 2, 2026

Research across Malnutrition

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Plasma choline and betaine discriminate low vs adequate choline intake in controlled feeding study
Radiology & Imaging RCT
Plasma choline and betaine discriminate low vs adequate choline intake in controlled feeding study Can a simple blood test tell if you're getting enough choline?
A double-blind randomized crossover controlled feeding study in healthy adults found plasma choline and betaine concentrations strongly disc…
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Apr 6, 2026

Questions about Vitamin D deficiency

Why are the effects of Vitamin D deficiency on depression stronger in females?

Research shows that low Vitamin D levels are linked to a higher risk of depression in women compared to men, with studies finding stronger associations specifically in female populations.

Full answer →