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Home › Conditions › Atherosclerosis

Atherosclerosis

Subtypes of Atherosclerosis

Peripheral Artery Disease 3 Chronic Limb-Threatening Ischemia 1

36 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Atherosclerosis

80 trials tracked for Atherosclerosis: 31 in phase 3 or 4 and 12 with published results. The most-cited published study has 421 citations.

80Trials tracked
31Phase 3 & 4
0Recruiting
12With published results
Phase distribution
Phase 4 13 Phase 3 18 Phase 2 19 Phase 1 1 Other / NA 29
  1. Phase 3 Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) as Add-on to Ezetimibe Therapy in Patients With Elevated LDL-C (CLEAR Tranquility) Completed · 421 cited
  2. Phase 3 Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events) Completed · 359 cited
  3. Phase 4 Reducing Total Cardiovascular Risk in an Urban Community Completed · 192 cited
  4. Phase 4 Testosterone Replacement in Older Men and Atherosclerosis Progression Completed · 170 cited
  5. Phase 4 Evaluate Carotid Artery Plaque Composition by Magnetic Resonance Imaging in People Receiving Cholesterol Medication Completed · 129 cited
  6. Phase 3 The Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy Trial Completed · 122 cited
Show 44 more trials
  1. Phase 3 RANGER™ Paclitaxel Coated Balloon vs Standard Balloon Angioplasty Completed · 80 cited
  2. Phase 3 A phase3 Study Measuring the Effect of Rosuvastatin 20 mg on Carotid Intima-Media Thickness in Chinese Subjects With Subclinical Atherosclerosis Completed · 38 cited
  3. Phase 3 Inflammation and Vascular Function in Atherosclerosis Completed · 36 cited
  4. Phase 4 Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression Completed · 32 cited
  5. Phase 4 Effects of Sitagliptin on Endothelial Function in Type 2 Diabetes on Background Metformin Therapy Completed · 30 cited
  6. Phase 4 Mineralocorticoid Receptor Antagonism Clinical Evaluation in Atherosclerosis Trial Completed · 15 cited
  7. Phase 4 Pharmacogenomics of Antiplatelet Response Completed
  8. Phase 4 Rivaroxaban Versus Warfarin in the Evaluation of Progression of Coronary Calcium Completed
  9. Phase 4 Trial of Cilostazol in Symptomatic Intracranial Arterial Stenosis II Completed
  10. Phase 4 Aspirin Dose and Atherosclerosis in Patients With Metabolic Syndrome Completed
  11. Phase 4 Evaluation of The Effects of Nebivolol in Comparison to Atenolol on Wall Shear Stress and Rupture Prone Coronary Plaques Completed
  12. Phase 4 Effect of Molsidomine on the Endothelial (Internal Layer of Blood Vessels) Dysfunction in Patients With Angina Pectoris Completed
  13. Phase 4 Aspirin Dose and Atherosclerosis in Patients With Heart Disease Completed
  14. Phase 3 Intensive Glycemic Control and Skeletal Health Study Completed
  15. Phase 3 PROMUS Element Japan Small Vessel Trial Completed
  16. Phase 3 Rosiglitazone Versus a Sulfonylurea On Progression Of Atherosclerosis In Patients With Heart Disease And Type 2 Diabetes Completed
  17. Phase 3 Benefits of Medical Therapy Plus Stenting for Renal Atherosclerotic Lesions Completed
  18. Phase 3 A Clinical Trial Comparing Cangrelor to Clopidogrel Standard Therapy in Subjects Who Require Percutaneous Coronary Intervention (PCI) (CHAMPION PHOENIX) Completed
  19. Phase 3 A Prospective, Multi-center Trial to Assess an Everolimus-Eluting Coronary Stent System (PROMUS Element™) Completed
  20. Phase 3 Trial to Assess the Ocular Safety of Vorapaxar (SCH 530348) in Participants With Atherosclerosis (Study P05183) Completed
  21. Phase 3 Action to Control Cardiovascular Risk in Diabetes (ACCORD) Completed
  22. Phase 3 12-week Open-label, Phase IIIb Comparing Efficacy and Safety of Rosuvastatin (CRESTOR™) in Combination With Ezetimibe Completed
  23. Phase 3 Trial to Assess the Effects of Vorapaxar (SCH 530348; MK-5348) in Preventing Heart Attack and Stroke in Patients With Atherosclerosis (TRA 2°P - TIMI 50) (P04737) Completed
  24. Phase 3 High-Density Lipoprotein (HDL) Cholesterol Increased Plaque Stabilization in the Elderly Completed
  25. Phase 3 Salsalate Therapy to Reduce Insulin Resistance and Cardiovascular Risk Completed
  26. Phase 2 Revacept in Symptomatic Carotid Stenosis Completed
  27. Phase 2 Stroke Minimization Through Additive Anti-atherosclerotic Agents in Routine Treatment Completed
  28. Phase 2 ELITE: Early Versus Late Intervention Trial With Estradiol Completed
  29. Phase 2 Vitamin D to Improve Endothelial Function in SLE Completed
  30. Phase 2 Integrated Biomarker And Imaging Study - 2 Completed
  31. Phase 2 Trial of Clopidogrel After Surgery for Coronary Artery Disease (CASCADE Trial) Completed
  32. Phase 2 Rilonacept to Improve Artery Function in Patients With Atherosclerosis Completed
  33. Phase 2 Women's Isoflavone Soy Health (WISH) Trial Completed
  34. Phase 2 Trial to Assess the Safety and Effects of Vorapaxar in Japanese Subjects With Acute Coronary Syndrome (P04772; MK-5348-016) Completed
  35. Phase 2 A Study to Evaluate the Effects of 3 Months Dosing With GW856553, as Assessed FDG-PET/CT Imaging Completed
  36. Phase 2 LEVANT I, The Lutonix Paclitaxel-Coated Balloon for the Prevention of Femoropopliteal Restenosis Completed
  37. Phase 2 Safety & Effectiveness on Vascular Structure and Function of ACZ885 in Atherosclerosis and Either T2DM or IGT Patients Completed
  38. Phase 2 Multiple Ascending Doses of MEDI6012 in Subjects With Stable Atherosclerotic Cardiovascular Disease Completed
  39. Phase 2 Effect of Valsartan on Carotid Artery Disease Completed
  40. Phase 2 Study Effect of VIA-2291 on Atherosclerotic Vascular Inflammation in Patients Undergoing Elective Carotid Endarterectomy Completed
  41. Phase 2 Pentoxifylline and Combination Antiretroviral Therapy to Improve Blood Vessel Function in HIV-Infected People Completed
  42. Phase 2 A Phase II Clinical Study of SB-480848 in Dyslipidemic Patients Completed
  43. Phase 2 Evaluate SLN360 in Participants With Elevated Lipoprotein(a) at High Risk of Atherosclerotic Cardiovascular Disease Events Completed
  44. Phase 2 Evaluating the Effectiveness of Pentoxifylline at Improving Blood Vessel Function in HIV-infected People Not Receiving Antiretroviral Medications Completed

Showing the 50 most-cited and recently-updated of 80 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Narrative review explores metformin and trimetazidine in cardiovascular conditions
Cardiology Sys. Review
Narrative review explores metformin and trimetazidine in cardiovascular conditions The Hidden Cell Death Process Quietly Driving Heart Disease
This narrative review examines the roles of metformin and trimetazidine in cardiovascular diseases, atherosclerosis, vascular calcification,…
A specific type of cell death driven by iron and fat damage plays a key role in multiple heart conditions, including heart failure and ather…
Frontiers Apr 18, 2026
IL-17A inhibition improves skin lesions and early atherosclerosis markers in psoriasis vulgaris patients
Cardiology Cohort
IL-17A inhibition improves skin lesions and early atherosclerosis markers in psoriasis vulgaris patients Psoriasis Is Linked to Heart Disease — and One Drug May Help Both
This retrospective cohort and prospective intervention study evaluated IL-17A inhibitors for psoriasis vulgaris and associated cardiovascula…
Psoriasis and heart disease share deep biological roots, and a specific drug may improve both conditions at once.
Frontiers Apr 18, 2026
Narrative review conceptualizes CVD as systemic immune–metabolic–inflammatory disease
Oncology Sys. Review
Narrative review conceptualizes CVD as systemic immune–metabolic–inflammatory disease Review suggests immune and metabolic factors drive cardiovascular disease progression
This narrative review synthesizes evidence on cardiovascular disease as a systemic immune–metabolic–inflammatory condition.
Immune and metabolic factors actively drive heart disease progression, offering new ways to assess risk and tailor prevention strategies.
Frontiers Apr 17, 2026
Meta-analysis finds 7% incidence of suspected carotid atheromas on dental panoramic radiographs
Radiology & Imaging Meta-analysis
Meta-analysis finds 7% incidence of suspected carotid atheromas on dental panoramic radiographs Dental X-rays May Show Calcified Artery Plaque in Some Patients
This systematic review and meta-analysis of 34 cross-sectional studies in dental practice synthesizes evidence on calcified carotid artery a…
About 7% of dental X-rays show signs of artery plaque, meaning routine scans might reveal hidden heart risks that need medical attention.
Apr 15, 2026
Mini-review examines coronary artery calcium scoring for risk stratification and plaque progression
Radiology & Imaging Sys. Review
Mini-review examines coronary artery calcium scoring for risk stratification and plaque progression CAC scoring helps identify high-risk patients and may slow plaque growth in coronary artery disease
This mini-review synthesizes evidence on coronary artery calcium scoring for coronary artery disease risk assessment.
CAC scoring identifies high-risk patients and may slow plaque growth in coronary artery disease, offering a robust way to measure heart risk…
Frontiers Apr 15, 2026
Review of quercetin in metabolic diseases shows promise but lacks clinical validation
Diabetes & Endocrinology RCT
Review of quercetin in metabolic diseases shows promise but lacks clinical validation Review suggests quercetin may have multiple beneficial effects on metabolic conditions
This review evaluates quercetin for conditions including diabetes, obesity, and gout.
A natural compound found in fruits and vegetables shows promise for managing type 2 diabetes, obesity, and fatty liver disease, though human…
Frontiers Apr 13, 2026
Systematic review examines lipid-immune crosstalk and dyslipidemia in rheumatoid arthritis patients
Allergy & Immunology Sys. Review
Systematic review examines lipid-immune crosstalk and dyslipidemia in rheumatoid arthritis patients The Hidden Link Between Arthritis Pain and Your Heart Health
This systematic review evaluated epidemiological evidence, clinical management strategies, and pathophysiological mechanisms regarding lipid…
Abnormal cholesterol is a direct driver of rheumatoid arthritis, explaining why people with RA face such a high risk of heart attack and str…
Frontiers Apr 13, 2026
CHIP mutations increase cardiovascular risk and mortality in older adults independent of traditional factors
Cardiology Cohort
CHIP mutations increase cardiovascular risk and mortality in older adults independent of traditional factors Your Aging Blood Cells May Be Quietly Attacking Your Heart
This review synthesizes evidence regarding clonal hematopoiesis of indeterminate potential (CHIP) in individuals older than 70 years.
Aging blood cell mutations called CHIP quietly raise heart attack risk by fueling inflammation, affecting over 10% of adults over 70.
Frontiers Apr 13, 2026
Pre-eclampsia history associated with increased subclinical atherosclerosis markers in meta-analysis
Radiology & Imaging Meta-analysis
Pre-eclampsia history associated with increased subclinical atherosclerosis markers in meta-analysis Early Warning Signs: Pre-eclampsia Linked to Heart Risk
A meta-analysis of 35 case-control studies including 20,235 women found that a history of pre-eclampsia was associated with increased caroti…
Heart trouble signs appear during pregnancy and stay for years, meaning waiting to check a woman's heart health after delivery might be too …
Apr 12, 2026
Systematic review identifies shared immune mechanisms and therapeutic targets across cardiovascular inflammatory diseases
Rheumatology Sys. Review
Systematic review identifies shared immune mechanisms and therapeutic targets across cardiovascular inflammatory diseases Could one immune problem be driving three different heart conditions?
A systematic review examined shared immunological mechanisms across atherosclerosis, myocarditis, and vasculitis.
Three different heart diseases might share one immune trigger, suggesting new ways to treat plaque buildup, heart muscle inflammation, and b…
Frontiers Apr 8, 2026
Reduced anti-CXCR3 antibodies associated with systemic autoimmunity and atherosclerosis in cohort study
Rheumatology Cohort
Reduced anti-CXCR3 antibodies associated with systemic autoimmunity and atherosclerosis in cohort study Study finds link between specific antibody levels and heart disease risk in autoimmune conditions
An observational cohort study of patients with rheumatoid arthritis, Sjogren disease, and controls found reduced anti-CXCR3 antibody levels …
Low levels of a specific antibody in early arthritis and joint pain are linked to higher heart disease risk and poorer medication responses.
medRxiv Apr 4, 2026
GLP-1RAs associated with improved walking distance in diabetes with PAD, but limb event evidence uncertain
Nutrition & Obesity Medicine Meta-analysis
GLP-1RAs associated with improved walking distance in diabetes with PAD, but limb event evidence uncertain GLP-1 drugs linked to better walking distance in diabetes patients with leg artery disease
A meta-analysis of 7 studies (107,092 adults with type 2 diabetes and PAD) found GLP-1RAs were associated with improved walking distance in …
GLP-1 diabetes drugs linked to better walking distance in people with leg artery disease, based on analysis of seven studies involving over …
Apr 2, 2026

Questions about Atherosclerosis

Are TNF pathway proteins linked to my atherosclerosis risk?

Yes, higher levels of TNF pathway proteins in your blood are linked to increased atherosclerosis and stroke risk, independent of other risk factors.

Full answer →
Does having high HDL cholesterol lower my atherosclerosis risk?

High HDL cholesterol is linked to lower carotid plaque risk in some studies, but raising HDL with drugs has not consistently reduced cardiovascular events, so the relationship is complex.

Full answer →
Can macrophage signatures help predict my atherosclerosis risk?

Yes, macrophage signatures are emerging as tools to predict atherosclerosis risk, but they are not yet ready for routine clinical use.

Full answer →
How do soil contaminants and low nutrients affect my atherosclerosis risk?

Soil contaminants increase atherosclerosis risk by promoting oxidative stress and inflammation, while low nutrients reduce your body's defenses against artery damage.

Full answer →