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Home › Conditions › Atherosclerosis

Atherosclerosis

Subtypes of Atherosclerosis

Peripheral Artery Disease 3 Chronic Limb-Threatening Ischemia 1

36 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Atherosclerosis

80 trials tracked for Atherosclerosis: 31 in phase 3 or 4 and 12 with published results. The most-cited published study has 421 citations.

80Trials tracked
31Phase 3 & 4
0Recruiting
12With published results
Phase distribution
Phase 4 13 Phase 3 18 Phase 2 19 Phase 1 1 Other / NA 29
  1. Phase 3 Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) as Add-on to Ezetimibe Therapy in Patients With Elevated LDL-C (CLEAR Tranquility) Completed · 421 cited
  2. Phase 3 Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events) Completed · 359 cited
  3. Phase 4 Reducing Total Cardiovascular Risk in an Urban Community Completed · 192 cited
  4. Phase 4 Testosterone Replacement in Older Men and Atherosclerosis Progression Completed · 170 cited
  5. Phase 4 Evaluate Carotid Artery Plaque Composition by Magnetic Resonance Imaging in People Receiving Cholesterol Medication Completed · 129 cited
  6. Phase 3 The Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy Trial Completed · 122 cited
Show 44 more trials
  1. Phase 3 RANGER™ Paclitaxel Coated Balloon vs Standard Balloon Angioplasty Completed · 80 cited
  2. Phase 3 A phase3 Study Measuring the Effect of Rosuvastatin 20 mg on Carotid Intima-Media Thickness in Chinese Subjects With Subclinical Atherosclerosis Completed · 38 cited
  3. Phase 3 Inflammation and Vascular Function in Atherosclerosis Completed · 36 cited
  4. Phase 4 Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression Completed · 32 cited
  5. Phase 4 Effects of Sitagliptin on Endothelial Function in Type 2 Diabetes on Background Metformin Therapy Completed · 30 cited
  6. Phase 4 Mineralocorticoid Receptor Antagonism Clinical Evaluation in Atherosclerosis Trial Completed · 15 cited
  7. Phase 4 Pharmacogenomics of Antiplatelet Response Completed
  8. Phase 4 Rivaroxaban Versus Warfarin in the Evaluation of Progression of Coronary Calcium Completed
  9. Phase 4 Trial of Cilostazol in Symptomatic Intracranial Arterial Stenosis II Completed
  10. Phase 4 Aspirin Dose and Atherosclerosis in Patients With Metabolic Syndrome Completed
  11. Phase 4 Evaluation of The Effects of Nebivolol in Comparison to Atenolol on Wall Shear Stress and Rupture Prone Coronary Plaques Completed
  12. Phase 4 Effect of Molsidomine on the Endothelial (Internal Layer of Blood Vessels) Dysfunction in Patients With Angina Pectoris Completed
  13. Phase 4 Aspirin Dose and Atherosclerosis in Patients With Heart Disease Completed
  14. Phase 3 Intensive Glycemic Control and Skeletal Health Study Completed
  15. Phase 3 PROMUS Element Japan Small Vessel Trial Completed
  16. Phase 3 Rosiglitazone Versus a Sulfonylurea On Progression Of Atherosclerosis In Patients With Heart Disease And Type 2 Diabetes Completed
  17. Phase 3 Benefits of Medical Therapy Plus Stenting for Renal Atherosclerotic Lesions Completed
  18. Phase 3 A Clinical Trial Comparing Cangrelor to Clopidogrel Standard Therapy in Subjects Who Require Percutaneous Coronary Intervention (PCI) (CHAMPION PHOENIX) Completed
  19. Phase 3 A Prospective, Multi-center Trial to Assess an Everolimus-Eluting Coronary Stent System (PROMUS Element™) Completed
  20. Phase 3 Trial to Assess the Ocular Safety of Vorapaxar (SCH 530348) in Participants With Atherosclerosis (Study P05183) Completed
  21. Phase 3 Action to Control Cardiovascular Risk in Diabetes (ACCORD) Completed
  22. Phase 3 12-week Open-label, Phase IIIb Comparing Efficacy and Safety of Rosuvastatin (CRESTOR™) in Combination With Ezetimibe Completed
  23. Phase 3 Trial to Assess the Effects of Vorapaxar (SCH 530348; MK-5348) in Preventing Heart Attack and Stroke in Patients With Atherosclerosis (TRA 2°P - TIMI 50) (P04737) Completed
  24. Phase 3 High-Density Lipoprotein (HDL) Cholesterol Increased Plaque Stabilization in the Elderly Completed
  25. Phase 3 Salsalate Therapy to Reduce Insulin Resistance and Cardiovascular Risk Completed
  26. Phase 2 Revacept in Symptomatic Carotid Stenosis Completed
  27. Phase 2 Stroke Minimization Through Additive Anti-atherosclerotic Agents in Routine Treatment Completed
  28. Phase 2 ELITE: Early Versus Late Intervention Trial With Estradiol Completed
  29. Phase 2 Vitamin D to Improve Endothelial Function in SLE Completed
  30. Phase 2 Integrated Biomarker And Imaging Study - 2 Completed
  31. Phase 2 Trial of Clopidogrel After Surgery for Coronary Artery Disease (CASCADE Trial) Completed
  32. Phase 2 Rilonacept to Improve Artery Function in Patients With Atherosclerosis Completed
  33. Phase 2 Women's Isoflavone Soy Health (WISH) Trial Completed
  34. Phase 2 Trial to Assess the Safety and Effects of Vorapaxar in Japanese Subjects With Acute Coronary Syndrome (P04772; MK-5348-016) Completed
  35. Phase 2 A Study to Evaluate the Effects of 3 Months Dosing With GW856553, as Assessed FDG-PET/CT Imaging Completed
  36. Phase 2 LEVANT I, The Lutonix Paclitaxel-Coated Balloon for the Prevention of Femoropopliteal Restenosis Completed
  37. Phase 2 Safety & Effectiveness on Vascular Structure and Function of ACZ885 in Atherosclerosis and Either T2DM or IGT Patients Completed
  38. Phase 2 Multiple Ascending Doses of MEDI6012 in Subjects With Stable Atherosclerotic Cardiovascular Disease Completed
  39. Phase 2 Effect of Valsartan on Carotid Artery Disease Completed
  40. Phase 2 Study Effect of VIA-2291 on Atherosclerotic Vascular Inflammation in Patients Undergoing Elective Carotid Endarterectomy Completed
  41. Phase 2 Pentoxifylline and Combination Antiretroviral Therapy to Improve Blood Vessel Function in HIV-Infected People Completed
  42. Phase 2 A Phase II Clinical Study of SB-480848 in Dyslipidemic Patients Completed
  43. Phase 2 Evaluate SLN360 in Participants With Elevated Lipoprotein(a) at High Risk of Atherosclerotic Cardiovascular Disease Events Completed
  44. Phase 2 Evaluating the Effectiveness of Pentoxifylline at Improving Blood Vessel Function in HIV-infected People Not Receiving Antiretroviral Medications Completed

Showing the 50 most-cited and recently-updated of 80 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Narrative review links soil contaminants and micronutrient depletion to hypertension, atherosclerosis, and neurodegenerative processes
Cardiology Sys. Review
Narrative review links soil contaminants and micronutrient depletion to hypertension, atherosclerosis, and neurodegenerative processes The Hidden Link Between Dirty Soil and Your Heart and Brain
This narrative review synthesizes a plausible pathophysiologic framework linking soil contaminants and depleted essential micronutrients to …
The soil your food grows in may be quietly damaging your heart and brain, and experts say we have been overlooking this danger for too long.
Frontiers May 7, 2026
Meta-analysis links TNF pathway proteins to ischemic stroke risk and recurrence
Cardiology Meta-analysis
Meta-analysis links TNF pathway proteins to ischemic stroke risk and recurrence Higher TNF proteins linked to increased stroke risk in large study
This meta-analysis of observational cohorts synthesizes evidence that circulating TNF pathway proteins are associated with incident and recu…
People with more TNF proteins in their blood had a higher chance of having a stroke. This was seen in two large groups of adults.
medRxiv May 5, 2026
Sex differences in outcomes after stroke in NVAF with ASCVD: a post hoc analysis
Cardiology RCT
Sex differences in outcomes after stroke in NVAF with ASCVD: a post hoc analysis Women and Men With AFib and Clogged Arteries Share Same Stroke Risk
This post hoc analysis of an RCT included 222 patients with recent ischemic stroke or TIA, NVAF, and ASCVD. No significant sex differences w…
Women and men with AFib and clogged arteries face similar risks for stroke, heart attack, and bleeding over two years.
May 2, 2026
CHIP mutations linked to higher lymph node metabolic activity in people with treated HIV
Cardiology Cohort
CHIP mutations linked to higher lymph node metabolic activity in people with treated HIV CHIP Mutations Linked to Lymph Nodes Not Arteries in HIV Patients
This cohort study of 230 people with HIV ages 31-74 years found that clonal hematopoiesis of indeterminate potential (CHIP) was not associat…
New research shows HIV patients with specific gene changes have active lymph nodes but not thicker arteries yet.
medRxiv Apr 30, 2026
Review discusses translational potential of macrophage-state signatures for atherosclerosis risk stratification and therapeutic targeting
Allergy & Immunology Sys. Review
Review discusses translational potential of macrophage-state signatures for atherosclerosis risk stratification and therapeutic targeting Macrophage states in plaque may help predict heart attack risk
This narrative review explores the translational potential of macrophage-state signatures for risk stratification, molecular imaging, and th…
A review suggests that understanding different immune cell states in artery plaque could improve how doctors assess heart disease risk and g…
Frontiers Apr 29, 2026
Retrospective cohort examines pre-amputation vascular workup phenotypes in chronic limb-threatening ischemia patients
Cardiology Cohort
Retrospective cohort examines pre-amputation vascular workup phenotypes in chronic limb-threatening ischemia patients One in Six Amputations Happen Without Key Imaging
This retrospective cohort study analyzed 10,666 Medicare fee-for-service beneficiaries with chronic limb-threatening ischemia undergoing maj…
Many patients lose limbs without ever getting the scans that could save them, especially those with dementia or limited mobility, a new anal…
medRxiv Apr 28, 2026
Female sex and high HDL-c linked to lower carotid plaque risk in a Chinese cohort
Cardiology Cohort
Female sex and high HDL-c linked to lower carotid plaque risk in a Chinese cohort New Tool Predicts Hidden Heart Risk Early
This retrospective cohort study of 12,391 individuals in Xinjiang, China, found that female sex and HDL-c >1.55 mmol/L were associated with …
A new scoring system can predict hidden artery plaque years before heart problems strike—especially in people over 45 or who smoke.
Frontiers Apr 25, 2026
Review of estrogen decline, diet, and microbial therapeutics for atherosclerosis in perimenopausal women
Cardiology Sys. Review
Review of estrogen decline, diet, and microbial therapeutics for atherosclerosis in perimenopausal women Perimenopause Changes Your Heart Risk in Unexpected Ways
This narrative review examines the potential role of declining estrogen levels, dietary modification, microbial therapeutics, and precision …
Many women worry about heart health as they approach menopause.
Frontiers Apr 24, 2026
Narrative review on dyslipidemia and erectile dysfunction pathophysiology
Diabetes & Endocrinology Sys. Review
Narrative review on dyslipidemia and erectile dysfunction pathophysiology High Cholesterol May Damage Sexual Function Directly
This narrative review synthesizes evidence on dyslipidemia and erectile dysfunction.
High blood fats may directly harm sexual function beyond just heart risks.
Frontiers Apr 23, 2026
Narrative review discusses screening and prevention in rheumatic and musculoskeletal disease populations
Cardiology Sys. Review
Narrative review discusses screening and prevention in rheumatic and musculoskeletal disease populations Joint Pain May Signal Hidden Risk in Your Legs
This narrative review examines patients with rheumatic and musculoskeletal diseases (RMDs), including rheumatoid arthritis and systemic lupu…
Inflammation from autoimmune conditions can silently damage blood vessels in your legs.
Frontiers Apr 23, 2026
Narrative mini-review discusses mechanisms driving coronary atherosclerosis in patients with systemic lupus erythematosus
Allergy & Immunology Sys. Review
Narrative mini-review discusses mechanisms driving coronary atherosclerosis in patients with systemic lupus erythematosus Why Lupus Can Speed Up Heart Disease, Even in Young People
This narrative mini-review synthesizes mechanistic insights regarding the link between systemic lupus erythematosus and coronary atheroscler…
Understanding how lupus harms blood vessels could help prevent heart attacks in people who don’t look high-risk.
Frontiers Apr 22, 2026
Review Examines IL-32 Role in Cardiovascular Diseases and Atherosclerosis
Allergy & Immunology Sys. Review
Review Examines IL-32 Role in Cardiovascular Diseases and Atherosclerosis New Blood Test Could Predict Heart Disease Risk Years Earlier
This review evaluates the role of IL-32 across cardiovascular diseases, atherosclerosis, myocardial infarction, and heart failure.
This research could change how doctors spot heart disease risk, giving patients more time to prevent it.
Frontiers Apr 22, 2026

Questions about Atherosclerosis

Are TNF pathway proteins linked to my atherosclerosis risk?

Yes, higher levels of TNF pathway proteins in your blood are linked to increased atherosclerosis and stroke risk, independent of other risk factors.

Full answer →
Does having high HDL cholesterol lower my atherosclerosis risk?

High HDL cholesterol is linked to lower carotid plaque risk in some studies, but raising HDL with drugs has not consistently reduced cardiovascular events, so the relationship is complex.

Full answer →
Can macrophage signatures help predict my atherosclerosis risk?

Yes, macrophage signatures are emerging as tools to predict atherosclerosis risk, but they are not yet ready for routine clinical use.

Full answer →
How do soil contaminants and low nutrients affect my atherosclerosis risk?

Soil contaminants increase atherosclerosis risk by promoting oxidative stress and inflammation, while low nutrients reduce your body's defenses against artery damage.

Full answer →