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Home › Conditions › Frailty

Frailty

21 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Frailty

30 trials tracked for Frailty: 1 in phase 3 or 4 and 1 with published results. The most-cited published study has 75 citations.

30Trials tracked
1Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 3 1 Phase 2 6 Other / NA 23
  1. Phase 3 Starting a Testosterone and Exercise Program After Hip Injury Completed · 75 cited
  2. Phase 2 Metformin for Preventing Frailty in High-risk Older Adults Completed
  3. Phase 2 Nitrites, Skeletal Muscle Mitochondrial Bioenergetics, and Physical Activity in Old Age Completed
  4. Phase 2 Reducing Frailty for Older Cancer Survivors Using Supplements Completed
  5. Phase 2 Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease Completed
  6. Phase 2 AllogeneiC Human Mesenchymal Stem Cells (hMSC) in Patients With Aging FRAilTy Via IntravenoUS Delivery Completed
Show 24 more trials
  1. Phase 2 Ghrelin in Healthy and Frail Older Women Completed
  2. N/A Effect of Behavioral Lifestyle Intervention on Frailty in Older Adults With Diabetes Completed
  3. N/A LIFT Intervention in Liver Transplant Candidates Completed
  4. N/A The Impact of a Home-Based Walking Exercise Program on Heart Failure Completed
  5. N/A Implementing CAPABLE in PSH Completed
  6. N/A Strength on Wheels: A Meal Delivery and Exercise Intervention for Homebound Older Adults Completed
  7. N/A Synergizing Home Health Rehabilitation Therapy Completed
  8. N/A MoveStrong at Home: A Feasibility Study of a Model for Remote Delivery of Functional Strength and Balance Training Combined With Nutrition Education for Older Pre-frail Adults. Completed
  9. N/A Prehabilitation of Veterans With Exercise and Nutrition Completed
  10. N/A Multi-Component Prehabilitation for Major Elective Surgery Completed
  11. N/A Pilot Mobile for Dementia and Frailty Completed
  12. N/A Frail2Fit Study: Online Nutrition and Exercise Support for Older Adults With Frailty Completed
  13. N/A Pilot Testing a Home-Based Rehabilitation Intervention Designed to Improve Outcomes of Frail Veterans Following Cardiothoracic Surgery Completed
  14. N/A Education for Prevention and Treatment of Frailty Completed
  15. N/A Stand if You Can: A Standing Intervention in Long Term Care Completed
  16. N/A Supporting Habit Formation to Attenuate Prefrailty in Elders: Pilot Study Completed
  17. N/A Effects of Tai Chi on Frailty in Elderly Adults Completed
  18. N/A Pilot of Cognitive Stimulation Therapy for Pre-frail Stroke Survivors Completed
  19. N/A Connect-Home Clinical Trial Completed
  20. N/A The BRAINFOOD Trial to Prevent Recurrent Hepatic Encephalopathy. Completed
  21. N/A Piloting Prehabilitation Before Abdominal Surgery Completed
  22. N/A FrAilty Care and wEll-funcTion in Community Dwelling Older Adults Completed
  23. N/A Depression and Pain Perseverance Through Empowered Recovery Intervention Completed
  24. N/A Mobile Health Intervention to Support Healthful Diet Completed

Showing the 30 most-cited and recently-updated of 30 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Frailty: what the trials found

Pharmacological interventions for frailty, specifically Testosterone, did not result in statistically significant changes in Six Minute Walk Distance (p=0.853), Total Lean Body Mass (p=0.336), or Appendicular Lean Body Mass (p=0.934) 4.

The use of mobile applications for dietary intervention showed no significant change in adherence to the Mediterranean Diet (aMed) score 18. Additionally, mobile apps were associated with specific changes in Mediterranean Diet (MED) adherence scores, HOMA-IR scores, and Mediterranean Diet Knowledge scores at 3 months 22.

Recent results — preliminary, needs further review

  • The FRAGSALUD health intervention program showed a change of 2.3 vs 1.4 in Fried Frailty Criteria at 6 months, and 2.5 vs 1.4 at 12 months 13.
  • An ADL-enhanced program resulted in Motor Skills Scores ranging from 1.1 to 1.5 3.
  • Newer interventions include the 'Liver FrailTy' (LIFT) intervention 1, a home-based walking program 2, and supervised aerobic/resistance training with nutritional support 14.

For the clinician treating this condition

  • Testosterone administration does not demonstrate significant improvements in gait distance or lean body mass in frailty populations 4.
  • Mobile applications for Mediterranean Diet education and adherence show measurable but specific impacts on knowledge and adherence scores [18, 22].

AI synthesis of 8 cited trials, updated Jun 26, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Frailty shows strong positive association with depression in older adults with coronary heart disease
Primary Care & Family Medicine Meta-analysis
Frailty shows strong positive association with depression in older adults with coronary heart disease The Hidden Link That Makes Heart Recovery Harder for Older Adults
This systematic review and meta-analysis evaluated 2,628 older adults with coronary heart disease to assess the link between frailty and dep…
In older heart patients, frailty and depression form a dangerous cycle where each condition makes the other much more likely to develop.
Frontiers Apr 13, 2026
Multimodal sensor-based framework detects frailty in retired adults aged 65+ in primary care
Geriatrics & Aging Cohort
Multimodal sensor-based framework detects frailty in retired adults aged 65+ in primary care New Sensor Tool Catches Frailty Early in Primary Care
This prospective cohort study enrolled 145 retired adults aged 65 years or older in primary care in southern Réunion Island.
A simple sensor tool combined with basic questions can spot early signs of frailty in older adults before they become dangerous.
Frontiers Apr 11, 2026
Exercise reduces complications and improves function in frail elderly cancer patients on chemotherapy
Geriatrics & Aging Meta-analysis
Exercise reduces complications and improves function in frail elderly cancer patients on chemotherapy Exercise helps frail elderly cancer patients undergoing chemotherapy avoid complications
A meta-analysis of 1,655 frail elderly cancer patients undergoing chemotherapy found exercise interventions significantly reduced complicati…
For frail elderly cancer patients on chemotherapy, exercise cuts complication risks by 60% while boosting energy and walking distance.
Apr 8, 2026
Exercise training improves multiple outcomes in frail older adults with heart failure
Geriatrics & Aging Meta-analysis
Exercise training improves multiple outcomes in frail older adults with heart failure Can exercise help frail older adults with heart failure feel better and move more freely?
A systematic review of randomized controlled trials in frail adults aged ≥60 years with heart failure found that exercise training significa…
Exercise training for frail older adults with heart failure improved symptoms, mobility, mood, and blood markers in studies across Japan and…
Frontiers Apr 8, 2026
Qualitative study finds older adults support development of food-based frailty supplement
Nutrition & Obesity Medicine
Qualitative study finds older adults support development of food-based frailty supplement Older adults express interest in a biscuit-based food supplement for frailty
A qualitative interview study of 30 UK adults aged 50-89 found strong perceived need for a food-based frailty supplement, with preference fo…
Older adults want a tasty biscuit supplement to help with frailty, prioritizing taste, convenience, and affordable options to fit into their…
medRxiv Apr 8, 2026
Older adults with fewer than 20 teeth have 3.6 times higher odds of frailty in meta-analysis
Geriatrics & Aging Meta-analysis
Older adults with fewer than 20 teeth have 3.6 times higher odds of frailty in meta-analysis Older adults with fewer than 20 teeth have higher odds of frailty, study finds
A systematic review and meta-analysis of 11 observational studies including 18,472 adults aged 60+ found that having fewer than 20 remaining…
Older adults with fewer than 20 teeth have 3.6 times higher odds of frailty, a condition that reduces strength and energy, according to a ne…
Apr 7, 2026
Exercise training improves physical performance and handgrip strength in frail nursing home residents
Geriatrics & Aging
Exercise training improves physical performance and handgrip strength in frail nursing home residents Can exercise help nursing home residents stay stronger and more independent?
A 12-month pragmatic controlled trial in 95 frail nursing home residents found that twice-weekly resistance and aerobic exercise significant…
For older adults in nursing homes, staying physically strong is key to maintaining independence.
Apr 4, 2026
Observational study links frailty index and neuroimaging markers to dementia risk in UK Biobank cohort
Geriatrics & Aging
Observational study links frailty index and neuroimaging markers to dementia risk in UK Biobank cohort Could a simple frailty score combined with brain scans help predict dementia risk?
An observational study of 63,509 dementia-free UK Biobank participants found that a higher frailty index was associated with adverse neuroim…
A new score combining overall health and brain scan details can predict dementia risk and death in older adults with strong accuracy.
medRxiv Apr 4, 2026
Meta-analysis links higher ultra-processed food intake to increased frailty risk in older adults
Nutrition & Obesity Medicine Meta-analysis
Meta-analysis links higher ultra-processed food intake to increased frailty risk in older adults Study links ultra-processed foods to higher frailty risk in older adults
A systematic review and meta-analysis of 105,327 older adults found higher consumption of ultra-processed foods was associated with a 43% in…
Older adults who eat more ultra-processed foods face a 43% higher risk of frailty compared to those who consume less of these industrial foo…
medRxiv Apr 3, 2026

Questions about Frailty

Can sensors detect frailty in retired adults aged 65 and older?

Yes, sensors can detect frailty in retired adults aged 65+ by measuring gait, balance, grip strength, and other physiological signals, with studies showing high accuracy.

Full answer →
Is prediabetes linked to a higher chance of developing frailty?

Yes, prediabetes is linked to a higher chance of developing frailty in adults aged 50 and older, according to a large pooled analysis of longitudinal studies.

Full answer →
Can higher alpha-Klotho levels help lower the risk of frailty?

Yes, higher alpha-Klotho levels are linked to lower frailty risk, with a meta-analysis showing 39% lower odds of frailty per unit increase.

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Does frailty make adults with cancer more likely to feel depressed?

Yes, frailty significantly increases the likelihood of depression in adults with cancer, with frail patients having nearly six times higher odds of depressive symptoms.

Full answer →