Specialized palliative care intervention enrollment patterns in a glioblastoma randomized controlled trial sub-analysis
Glioblastoma trial reveals why patients skip or delay visits
This sub-analysis of the Early Palliative Care for Patients with Glioblastoma (EPCOG) trial examined enrollment and retention among 556 scre…
Many glioblastoma patients skip or delay study visits due to illness or lack of interest, a new trial analysis finds.
LP-184 Alone and With Spironolactone in Recurrent Glioblastoma: Phase 1a Results
New drug combo may help brain cancer patients who have run out of options
This Phase 1a trial in 63 patients (16 with glioblastoma) found LP-184 was well tolerated but with more transaminitis and thrombocytopenia i…
A new drug combination could help brain cancer patients by making their current medicine work much harder inside the tumor.
Meta-analysis of TKI combinations in glioblastoma shows improved PFS and ORR with mixed safety signals.
New Hope for Glioblastoma Patients Emerges
This meta-analysis evaluated combination treatments incorporating tyrosine kinase inhibitors (TKIs) versus TKI-free control regimens in 1,43…
Imagine getting the hardest diagnosis a person can hear: a fast-growing brain tumor with few good treatment options.
GSC-associated gene signature predicts survival in adult and pediatric high-grade glioma patients.
New Brain Tumor Test Predicts Survival More Accurately
This cohort study evaluated a GSC-associated gene signature involving the FAM86B1/FAM86B2 axis in adult and pediatric high-grade glioma pati…
A new model uses specific genes to predict how long patients might live with aggressive brain tumors.
Unsupervised clustering of glioma RNAseq data shows diagnostic and prognostic potential
AI-powered analysis reveals hidden brain tumor subtypes with survival links
This unsupervised clustering analysis of public TCGA glioma RNAseq data (n=692) found high diagnostic concordance and prognostic separation.…
A new AI method sorted brain tumors into groups that matched clinical diagnoses 91% of the time and uncovered subtypes tied to survival.
ERS-related DNA methylation profiles stratify glioblastoma patients into four subtypes with 92.4% prediction accuracy.
New AI Tool Could Help Doctors Choose Better Brain Tumor Treatments
This cohort analysis of a TCGA glioblastoma population integrated ERS-related DNA methylation profiles with non-negative matrix factorizatio…
Scientists used AI to find hidden patterns in brain tumors that could lead to better treatment plans.
Narrative review on ferroptosis-targeting strategies for glioblastoma modulation
New Brain Tumor Strategy Targets Iron to Boost Immune Attack
This narrative review synthesizes mechanisms and strategies for targeting ferroptosis in glioblastoma. It highlights potential to enhance an…
This new approach uses the tumor's own iron problem to help the body's immune system destroy cancer cells more effectively.
Systematic review evaluates Treg depletion and reprogramming strategies for glioblastoma in adults.
A New Tactic to Outsmart the Brain’s Most Aggressive Cancer
This systematic review examined interventions targeting regulatory T cells in adults with glioblastoma. Specific main results and numerical …
Researchers are designing new weapons that could help a patient’s own immune system finally attack a deadly brain tumor.
Phase 1/2 trial shows RT + bevacizumab + olaptesed pegol extends PFS and OS in unmethylated GBM
New Drug Combo Slows Brain Cancer Growth
A Phase 1/2 expansion arm in six patients with newly-diagnosed, unmethylated GBM found that adding bevacizumab to radiotherapy and olaptesed…
Adding a second drug to stop blood vessel growth gives patients with brain cancer more time before the disease returns.
DOC1021 vaccine with SOC showed favorable 12-month OS in newly-diagnosed glioblastoma patients.
A New Brain Cancer Vaccine Shows Promise Where Other Treatments Fail
This Phase I clinical study evaluated DOC1021 (dubodencel) integrated with standard of care (SOC) in newly-diagnosed and recurrent glioblast…
A new type of personalized vaccine, added to standard treatment, was safe and linked to significantly longer survival for patients with a no…
Multi-omics integration identifies candidate genes and cell-type-specific effects in glioma.
Could genetic clues finally pinpoint the right cells to target in deadly brain tumors?
This computational analysis integrated GWAS, bulk tissue, and single-cell multi-omics data to investigate glioma. The study prioritized 11 h…
A new analysis of genetic maps shows deadly brain tumors drive growth by increasing communication between support cells and nerve cells.
PARPi combinations show no significant clinical improvement in adult patients with glioblastoma.
PARPi drugs show limited benefit for glioblastoma due to brain barriers
This systematic review evaluated poly-ADP-ribose polymerase inhibitors (PARPi) combined with standard therapy for adult patients with gliobl…
A systematic review examined PARP inhibitors used with standard treatments for adult glioblastoma patients. The analysis found that these dr…