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Insulin Resistance

Subtypes of Insulin Resistance

Metabolic Syndrome 45

55 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Insulin Resistance

100 trials tracked for Insulin Resistance: 25 in phase 3 or 4 and 5 with published results. The most-cited published study has 97 citations.

100Trials tracked

25Phase 3 & 4

0Recruiting

5With published results

Phase distribution

Phase 4 16 Phase 3 9 Phase 2 27 Phase 1 3 Other / NA 45

Phase 4 Relationship Between Insulin Resistance and Statin Induced Type 2 Diabetes, and Integrative Personal Omics Profiling Completed · 97 cited
Phase 4 Pioglitazone as a Treatment for Lipid and Glucose Abnormalities In Patients With Schizophrenia Completed · 53 cited
Phase 4 The Health Influences of Puberty (HIP) Study Completed · 45 cited
Phase 3 A Trial of Tadalafil and Glycemic Traits Completed · 38 cited
Phase 4 Pioglitazone in Patients With Mood Disorders Completed · 35 cited
Phase 4 Contribution of Pancreatic αcells Function to Blood Glucose Regulation in Chinese Type 2 Diabetics- the Effect of Sitagliptin on Glucagon Secretion, Insulin Secretion and Insulin Resistance in Chinese Type 2 Diabetics Completed

Show 44 more trials

Phase 4 Endogenous Opioid Activity and Affective State in Insulin Resistant Women Completed
Phase 4 Ziprasidone for Improving Insulin Sensitivity in People With Schizophrenia Who Are at Risk for Diabetes Completed
Phase 4 Effect of Dexmedetomidine on Postoperative Glucose and Insulin Levels. Completed
Phase 4 Treatment of Insomnia and Glucose Metabolism Completed
Phase 4 Effect of Vitamin D Supplementation on Muscle Mass and Function Completed
Phase 4 Metformin in Insulin Resistant Left Ventricular (LV) Dysfunction (TAYSIDE Trial) Completed
Phase 4 U-500R Insulin In Type 2 Diabetes With Severe Insulin Resistance Via Omnipod Completed
Phase 4 Pioglitazone for the Treatment of Bipolar Disorder and Comorbid Metabolic Syndrome or Insulin Resistance Completed
Phase 4 Mechanisms Underlying Metabolic Syndrome in Obesity Completed
Phase 4 Oral Contraceptives in the Metabolic Syndrome Completed
Phase 4 Effectiveness of Aripiprazole for Improving Side Effects of Clozapine in the Treatment of People With Schizophrenia Completed
Phase 3 Trial of Leptin Replacement Therapy in Patients With Lipodystrophy Completed
Phase 3 ENAC Blockade and Arterial Stiffness Completed
Phase 3 ARREST PAD (Peripheral Arterial Disease) Completed
Phase 3 Omega-3 Fatty Acids and Insulin Sensitivity Completed
Phase 3 Hydroxychloroquine to Improve Insulin Sensitivity in Rheumatoid Arthritis Completed
Phase 3 Dipeptidyl Peptidase-4 Inhibition and Immune Function in HIV Completed
Phase 3 Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes Completed
Phase 3 Salsalate Therapy to Reduce Insulin Resistance and Cardiovascular Risk Completed
Phase 2 Thyroid Hormone to Induce Non-Insulin Mediated Glucose Disposal in People With Insulin Receptor Mutations Completed
Phase 2 PK/PD Study of U-500 Regular Insulin Completed
Phase 2 Effect of Vitamin D Repletion on Insulin Resistance and Systemic Inflammation Completed
Phase 2 CD36 in Nutrient Delivery and Its Dysfunction Completed
Phase 2 Role of Growth Hormone Antagonism in Modulating Insulin Sensitivity in Subjects With Pre-diabetes Completed
Phase 2 Metformin Effect on Brain Function in Insulin Resistant Elderly People Completed
Phase 2 Safety and Efficacy of Salsalate to Treat Endothelial Dysfunction in HIV-infected Adults Completed
Phase 2 Stool Transplantation for Treatment of Insulin Resistance in Morbidly Obese Patients Completed
Phase 2 Comparison of Aliskiren and Amlodipine on Insulin Resistance and Endothelial Dysfunction in Patients With Hypertension and Metabolic Syndrome Completed
Phase 2 Metformin to Augment Low Milk Supply (MALMS) Study Completed
Phase 2 Effects of Testosterone Gel on Carbohydrate and Lipid Metabolism In Elderly Obese Men Completed
Phase 2 Anti-Inflammatory Small Drug Adjunctive Therapy for Type 2 Diabetes Completed
Phase 2 Effects of Acipimox on Mitochondrial Function in Obesity Completed
Phase 2 T-IR- Study to Understand the Effects of Testosterone and Estrogen on the Body's Response to the Hormone Insulin Completed
Phase 2 Study Testing Benefits of Ursolic Acid (UA) as a Countermeasure To Myopenia and Insulin Resistance in Chronic Spinal Cord Injury (SCI) Completed
Phase 2 Pioglitazone to Treat Fatty Liver in People With HIV Infection Completed
Phase 2 Growth Hormone and/or Rosiglitazone for HIV-Associated Increased Abdominal Fat and Insulin Resistance Completed
Phase 2 Effect of Salicylate on Glucose Metabolism in Insulin Resistance States Completed
Phase 2 eIMPACT-DM Pilot Trial: Depression Treatment to Reduce Diabetes Risk Completed
Phase 2 Insulin Resistance and Testosterone in Women Completed
Phase 2 Correction of Vitamin D Levels and Its Effect on Insulin Resistance and Weight Gain in Obese Youth Completed
Phase 2 Blood Lipopolysaccharide (LPS) Rifaximin Study Completed
Phase 2 Effect of Rosiglitazone on the Vascular Biology of Human Fat Tissue Completed
Phase 2 Effect of Resveratrol on Age-related Insulin Resistance and Inflammation in Humans Completed
Phase 2 Effect of Insulin Sensitizer Therapy on Atherothrombotic and Inflammatory Profiles Associated With Insulin Resistance Completed

Showing the 50 most-cited and recently-updated of 100 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

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Questions about Insulin Resistance

What genetic factors linked to fat distribution cause my insulin resistance?

Genetic variants linked to fat distribution, such as those affecting subcutaneous vs. visceral fat storage, can drive insulin resistance by promoting inflammation and impairing adipose function.

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Will taking low-dose amiloride reduce my blood pressure and help insulin resistance?

Yes, low-dose amiloride (5 mg daily) can reduce blood pressure and may improve insulin resistance in adults with obesity and metabolic syndrome, based on a 24-week trial.

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How do adipose tissue macrophages affect my obesity and insulin resistance?

Adipose tissue macrophages (ATMs) promote obesity-related inflammation and insulin resistance by shifting to a pro-inflammatory state, driven by metabolic changes like increased glycolysis and mitophagy.

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Does exposure to microgravity change fat distribution and worsen my insulin resistance?

Yes, exposure to microgravity changes fat distribution by increasing visceral fat and promoting inflammation, which worsens insulin resistance.

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Can acupoint catgut embedding help treat my abdominal obesity and insulin resistance?

Early evidence suggests acupoint catgut embedding may reduce waist circumference and improve insulin resistance in abdominal obesity, but larger, high-quality trials are needed to confirm its effectiveness.

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See all 5 questions about Insulin Resistance →