Narrative review explores ferroptosis-immune crosstalk in CNS diseases as therapeutic target
New hope for brain diseases by targeting a deadly cell death cycle
This narrative review synthesizes evidence on the interplay between ferroptosis and immune responses in CNS disorders including Alzheimer's,…
Scientists found a way to stop a deadly cell death cycle that makes brain diseases worse, offering new hope for patients with Alzheimer's an…
Meta-analysis shows MRI volumetric differences in Parkinson's disease with mild cognitive impairment versus cognitively normal patients
New scan signs reveal early brain changes in Parkinson's dementia risk
This systematic review and meta-analysis evaluates gray matter volume alterations across six subcortical regions in patients with Parkinson'…
A new scan pattern shows specific brain shrinkage in Parkinson's patients who are starting to forget things, helping doctors catch dementia …
Review of P-BANN framework for Parkinson disease proteomics data analysis
New tool helps map proteins in Parkinson disease
This methodological review synthesizes the application of the P-BANN framework, a biologically annotated neural network model, to proteomics…
A new method finds specific protein groups linked to disease pathways in Parkinson disease, offering a fresh way to study the condition.
Soft robotic exoskeleton training improved gait speed and stride length in people with Parkinson disease over four weeks
Soft robotic suits helped people with Parkinson disease walk faster and move better
This randomized controlled pilot study enrolled 56 people with Parkinson disease.
A pilot study found that adding soft robotic exoskeleton training to standard rehab improved walking speed, stride length, and balance in pe…
Review of LLM-generated synthetic Parkinson's patients for in silico trials
AI creates synthetic patients to help Parkinson's trials work better
This review synthesizes a methodological proof-of-concept on generating synthetic Parkinson's disease patients using a large language model.
New AI technology creates virtual patients to help test Parkinson's drugs without breaking privacy rules during clinical research.
Psychomotor retardation in depression linked to increased Parkinson's risk
Slowed movement in depression signals higher Parkinson disease risk
A retrospective cohort study of 6327 individuals with depression found that those with psychomotor retardation had a 43% higher risk of deve…
Depression with slowed movement links to future Parkinson risk, suggesting physical signs may warn of brain changes years before diagnosis.
Narrative review highlights association between abnormal bilirubin and Parkinson's disease motor outcomes
Bilirubin’s Hidden Role in Slowing Parkinson’s Progress
This narrative review examines the relationship between abnormal bilirubin levels and Parkinson's disease in patients.
A common substance in your blood—usually linked to jaundice—might actually shield the brain in Parkinson’s disease, changing how doctors cou…
Review of iRBD biomarker-positive participants shows higher rates of cognitive and autonomic symptoms compared to healthy controls
Sleep disorder signals hidden brain changes before official Parkinson's diagnosis
This observational review analyzes data from 197 iRBD participants with positive CSF neuronal alpha-synuclein seed amplification assay and 1…
People with this specific sleep disorder show clear signs of brain changes that happen before doctors officially diagnose Parkinson's diseas…
Cross-sectional review links illness perceptions to quality of life variance in Parkinson disease patients
Parkinson’s patients’ mindset affects quality of life more than symptoms
This cross-sectional study reviews data from 58 people with idiopathic Parkinson disease across multiple centers.
Many Parkinson’s patients suffer more from how they think about their illness than from their physical symptoms, a new look at daily life re…
Auditory targeted memory reactivation during NREM sleep nap shows no effect on motor retention
Sleep sounds changed brain waves but did not fix motor memory in Parkinson's
This study investigated the effects of auditory targeted memory reactivation (TMR) during a 2-hour NREM sleep nap on motor sequence learning…
New sleep sounds changed brain waves but did not improve movement memory in Parkinson's patients, showing a gap between brain activity and r…
Narrative review proposes connectomic-guided psychosurgery framework for treatment-refractory patients
Researchers report framework for psychosurgery in treatment-refractory cases
This narrative critical review synthesizes contemporary psychosurgery options for treatment-refractory psychiatric disorders.
A new framework proposes connectomic-guided psychosurgery for treatment-refractory OCD, depression, and related disorders, based on symptom …
CSF SAA status associates with levodopa responsiveness and motor progression in Parkinson's disease patients
Parkinson’s test predicts levodopa response and motor decline speed
This observational cohort study analyzed 223 sporadic Parkinson's disease participants from the PPMI cohort initiating levodopa.
Test reveals Parkinson’s patients with alpha-synuclein seeds respond better to levodopa and decline slower than those without the seeds.