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Obesity

132 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Obesity

833 trials tracked for Obesity: 164 in phase 3 or 4 and 73 with published results. The most-cited published study has 6045 citations.

833Trials tracked
164Phase 3 & 4
0Recruiting
73With published results
Phase distribution
Phase 4 76 Phase 3 88 Phase 2 98 Phase 1 32 Other / NA 539
  1. Phase 4 The Effect of GLP-1 Agonists Versus OCs on Reproductive Disorders and Cardiovascular Risks in Overweight PCOS Completed · 6,045 cited
  2. Phase 3 Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity Completed · 4,362 cited
  3. Phase 4 Comparing a Virtual vs. Face to Face Weight Management Program Using Phentermine for Patients With Overweight or Obesity Completed · 1,813 cited
  4. Phase 3 Research Study to Investigate How Well Semaglutide Works in People Living With Heart Failure and Obesity Completed · 1,386 cited
  5. Phase 3 STEP 6: Research Study Investigating How Well Semaglutide Works in People Living With Overweight or Obesity Completed · 1,279 cited
  6. Phase 3 Research Study Investigating How Well Semaglutide Works in People With Type 2 Diabetes Suffering From Overweight or Obesity Completed · 1,262 cited
Show 44 more trials
  1. Phase 3 Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity Completed · 1,214 cited
  2. Phase 3 Research Study to Look at How Well Semaglutide is at Lowering Weight When Taken Together With an Intensive Lifestyle Program Completed · 989 cited
  3. Phase 3 Research Study to Investigate How Well Semaglutide Works Compared to Liraglutide in People Living With Overweight or Obesity Completed · 861 cited
  4. Phase 3 Two-year Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity Completed · 764 cited
  5. Phase 3 A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Who Have Obesity or Are Overweight Completed · 664 cited
  6. Phase 3 Effect of Liraglutide for Weight Management in Pubertal Adolescent Subjects With Obesity Completed · 658 cited
  7. Phase 3 Obstructive Sleep Apnea Master Protocol GPIF: A Study of Tirzepatide (LY3298176) in Participants With Obstructive Sleep Apnea Completed · 628 cited
  8. Phase 3 A Research Study on How Well Semaglutide Works in Adolescents With Overweight or Obesity Completed · 618 cited
  9. Phase 3 A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities Completed · 399 cited
  10. Phase 3 Research Study to Investigate How Well Semaglutide Tablets Taken Once Daily Work in People Who Are Overweight or Living With Obesity (OASIS 1) Completed · 371 cited
  11. Phase 3 Research Study Looking at How Well Semaglutide Works in People Suffering From Obesity and Knee Osteoarthritis Completed · 309 cited
  12. Phase 4 A Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors Completed · 263 cited
  13. Phase 4 Effect of Liraglutide on Epicardial Fat in Subjects With Type 2 Diabetes Completed · 242 cited
  14. Phase 4 Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy Completed · 236 cited
  15. Phase 3 Effect and Safety of Liraglutide 3.0 mg as an Adjunct to Intensive Behaviour Therapy for Obesity in a Non-specialist Setting Completed · 190 cited
  16. Phase 3 Individualized Obesity Pharmacotherapy Completed · 187 cited
  17. Phase 3 Effect and Safety of Liraglutide 3.0 mg in Subjects With Overweight or Obesity and Type 2 Diabetes Mellitus Treated With Basal Insulin Completed · 179 cited
  18. Phase 4 The Effect of Exenatide on Weight and Hunger in Obese, Healthy Women Completed · 154 cited
  19. Phase 3 Research Study Looking at How Well Semaglutide Works in People Living With Obesity and Prediabetes Completed · 140 cited
  20. Phase 4 Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial Completed · 139 cited
  21. Phase 3 A Study of Tirzepatide (LY3298176) in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF) and Obesity: The SUMMIT Trial Completed · 135 cited
  22. Phase 4 Lifestyle Modification and Liraglutide Completed · 112 cited
  23. Phase 3 Research Study of How Well Semaglutide Works in People Living With Overweight or Obesity. Completed · 111 cited
  24. Phase 3 A Study of Tirzepatide (LY3298176) in Chinese Participants Without Type 2 Diabetes Who Have Obesity or Overweight (SURMOUNT-CN) Completed · 104 cited
  25. Phase 3 EQW, DAPA, EQW/DAPA, DAPA/MET ER and PHEN/TPM ER in Obese Women With PolycysticOvary Syndrome (PCOS) Completed · 92 cited
  26. Phase 3 Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Acute Treatment Completed · 87 cited
  27. Phase 3 Liver and Fat Regulation in Overweight Adolescent Girls Completed · 85 cited
  28. Phase 4 Effect of Exenatide in Obese Patients With Accelerated Gastric Emptying Completed · 76 cited
  29. Phase 4 Adding Liraglutide to High Dose Insulin: Breaking the Cycle Completed · 73 cited
  30. Phase 3 Effect of Liraglutide for Weight Management in Paediatric Subjects With Prader-Willi Syndrome Completed · 68 cited
  31. Phase 3 Research Study Looking at How Well Semaglutide Tablets Taken Once Daily Work in People Who Have a Body Weight Above the Healthy Range Completed · 60 cited
  32. Phase 3 A Research Study to See How Semaglutide Helps People With Excess Weight, Lose Weight (STEP UP) Completed · 49 cited
  33. Phase 4 The Health Influences of Puberty (HIP) Study Completed · 45 cited
  34. Phase 3 A Trial of Tadalafil and Glycemic Traits Completed · 38 cited
  35. Phase 3 Calorie Restriction and Changes in Body Composition, Disease, Function, and Quality of Life in Older Adults Completed · 38 cited
  36. Phase 3 The Effects of Exenatide (Byetta ) on Energy Expenditure and Weight Loss in Nondiabetic Obese Subjects Completed · 38 cited
  37. Phase 4 Aromatase Inhibitors and Weight Loss in Severely Obese Hypogonadal Male Veterans (Pilot) Completed · 37 cited
  38. Phase 4 Examination of the Anti-inflammatory and Insulin Sensitizing Properties of Doxycycline in Humans Completed · 35 cited
  39. Phase 3 Obesity and Asthma: Nutrigenetic Response to Omega-3 Fatty Acids Completed · 33 cited
  40. Phase 4 Pharmacokinetics Of Tigecycline In Morbidly Obese Subjects Completed · 31 cited
  41. Phase 3 A Study of Tirzepatide (LY3298176) in Participants With Obesity Disease Completed · 30 cited
  42. Phase 4 Fish Oils and Adipose Inflammation Reduction Completed · 28 cited
  43. Phase 4 Real World Effectiveness of Combining an Employer-based Weight Management Program With Medication for Chronic Weight Management in Employees With Obesity Completed · 28 cited
  44. Phase 3 A Research Study to See How Semaglutide Helps People With Excess Weight and Type 2 Diabetes Lose Weight Completed · 25 cited

Showing the 50 most-cited and recently-updated of 833 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Questions about Obesity

Are there rising trends in severe obesity prevalence among children and adolescents in the US?

Data from the US National Health and Nutrition Examination Survey shows that severe obesity in children and adolescents aged 2 to 19 years more than doubled between 1999 and 2018.

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Does a group-based weight management program work for people with severe obesity?

Group-based programs like PROGROUP and Compassion Focused Therapy show promise for people with severe obesity by improving psychological outcomes and helping deliver complex interventions.

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How does a low-fat diet affect muscle mass in adults with obesity?

A low-fat diet leads to modest muscle loss in adults with obesity, but combining it with resistance exercise can help preserve muscle.

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Do women with obesity lose more weight on GLP-1 drugs than men?

Yes, research shows women with obesity tend to lose more weight on GLP-1 drugs than men, though the difference is modest and varies by individual factors.

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Do digital lifestyle interventions help adults with obesity lose weight?

Yes, stand-alone digital lifestyle interventions help adults with obesity lose weight and improve diet quality, though results vary by program design and engagement.

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What factors influence eating behaviors in adults with obesity?

Eating behaviors in adults with obesity are influenced by psycho-emotional factors (stress, impulsivity), socio-environmental stressors (work, relationships), and maladaptive patterns like rapid eating and irregular meal timing.

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Is tirzepatide as effective as sleeve gastrectomy for obesity?

A 2024 network meta-analysis found tirzepatide and sleeve gastrectomy produce equivalent weight loss (about 21% total body weight), but individual results vary and surgery offers durable long-term outcomes.

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See all 7 questions about Obesity →