YAP and TAZ Overexpression Predicts Worse Survival in Oral Squamous Cell Carcinoma
Hippo Pathway Markers Linked to Oral Cancer Survival Rates
This meta-analysis of 17 studies examined the prognostic value of Hippo pathway effectors YAP and TAZ in oral squamous cell carcinoma. Poole…
New data suggests that specific proteins in the Hippo pathway may help predict survival outcomes for patients with oral squamous cell carcin…
Oral HPV reshapes mucosal microbial composition in a sex and population dependent manner
Oral and genital health linked to specific bacteria and HPV
This mini-review synthesizes evidence regarding the interaction between HPV infection and mucosal microbiota in oral, anorectal, and penile …
New research shows how specific bacteria and the HPV virus interact in the mouth and genital areas to influence cancer risk.
SMMI framework provides a conceptual model for risk stratification in high-risk oral potentially malignant disorders
New Framework Helps Identify Risk of Oral Cancer Development
This evidence-ranked conceptual review proposes the spatial-microbial-metabolic-immune (SMMI) framework to study malignant transformation ri…
A new conceptual framework looks at how microbes and the immune system might help doctors better identify high risk for oral cancer developm…
Distinct microbial taxa and functional pathways are associated with oral squamous cell carcinoma
Specific Bacteria Linked to Oral Squamous Cell Carcinoma
This meta-analysis identifies specific microbial taxa and functional pathways associated with oral squamous cell carcinoma. The findings hig…
Researchers identified specific types of bacteria and genetic pathways that are more common in people with oral squamous cell carcinoma.
Submental Artery Island Flap Shows 16% Pooled Locoregional Recurrence in Oral Cavity Reconstruction
Submental artery island flap is a safe option for oral cancer
This meta-analysis pooled data on the submental artery island flap (SAIF) for oral cavity defects after oral squamous cell carcinoma resecti…
A specific surgical technique called the submental artery island flap shows a low recurrence rate for patients with oral cavity defects.
Impact of Perineural Invasion on Survival Outcomes in Oral Squamous Cell Carcinoma
Perineural invasion linked to poorer outcomes in oral squamous cell carcinoma
A meta-analysis of 23,580 patients confirms that perineural invasion is a potent independent predictor of poor survival and high recurrence …
A large review of over 23,000 patients shows that cancer cells spreading along nerves are linked to higher recurrence and lower survival rat…
AI-based MRI shows 0.82 AUC for detecting cervical lymph node metastases in oral squamous cell carcinoma
AI tools help detect lymph node spread in oral cancer
This meta-analysis of 548 patients evaluates AI-based MRI for detecting cervical lymph node metastases in oral squamous cell carcinoma. The …
Artificial intelligence may help doctors better identify if oral cancer has spread to lymph nodes before surgery.
Higher preoperative neutrophil-to-lymphocyte ratio predicts poorer survival in oral squamous cell carcinoma patients
High white blood cell ratios predict survival in oral cancer
This meta-analysis of 30 studies indicates that a higher preoperative neutrophil-to-lymphocyte ratio (NLR) is significantly associated with …
A high ratio of neutrophils to lymphocytes before surgery can help doctors predict survival outcomes for patients with oral squamous cell ca…
Deep Learning algorithms demonstrate potential for diagnosing oral potentially malignant disorders and squamous cell carcinoma
Artificial Intelligence Shows Potential for Detecting Oral Cancer
This meta-analysis evaluated the diagnostic accuracy of deep learning models using white light digital photographs to identify oral malignan…
New research shows that deep learning tools can help identify oral cancer and precancerous conditions using simple digital photos.
Ninjin’yoeito attenuates postoperative Prognostic Nutritional Index decline in patients with oral squamous cell carcinoma
Ninjin’yoeito may help patients with oral squamous cell carcinoma
This single-arm clinical trial evaluated the impact of Ninjin’yoeito on nutritional status in patients with oral squamous cell carcinoma und…
A small study suggests that Ninjin’yoeito could help maintain nutritional health in patients undergoing surgery for oral cancer.
Circulating miRNAs show high diagnostic accuracy for oral squamous cell carcinoma with AUC of approximately 0.90
Saliva and blood tests may help identify oral cancer
This systematic review and meta-analysis evaluated the diagnostic accuracy of circulating microRNAs in blood and saliva for oral squamous ce…
New data suggests that specific molecules in saliva and blood could help doctors more accurately identify patients with oral squamous cell c…
Hyperspectral imaging shows strong diagnostic performance for oral cancer detection in scoping review
Hyperspectral imaging shows promise for detecting oral cancer
This scoping review of 15 studies found that hyperspectral imaging (HSI) demonstrates strong diagnostic performance for detecting and charac…
A new review finds hyperspectral imaging can spot oral cancer with high accuracy, offering a non-contact alternative for margin assessment.
Research across Head and Neck Cancer
Related studies from across the Head and Neck Cancer family.
Post-operative ctDNA linked to worse survival in HPV-negative HNSCC, but estimate unstable
ctDNA levels may signal cancer return in head and neck cancer
This meta-analysis examined post-operative ctDNA as a prognostic marker in HPV-negative head and neck squamous cell carcinoma. Detectable ct…
Detecting traces of cancer DNA in the blood after surgery may help identify patients at higher risk of cancer returning.
Cisplatin Chemoradiotherapy for Elderly Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck
New trial tests chemotherapy for elderly patients with head cancer
This trial protocol describes a study evaluating the use of weekly cisplatin in elderly patients with locally advanced squamous cell carcino…
A new trial aims to see if adding a specific chemotherapy drug helps elderly patients with advanced head and neck cancer.
Retropharyngeal lymph node involvement in oropharyngeal squamous cell carcinoma occurs in 11% to 16% of patients
Retropharyngeal lymph node involvement impacts staging for throat cancer
This meta-analysis of 8,887 patients with oropharyngeal squamous cell carcinoma (OPSCC) identified a pooled prevalence of retropharyngeal ly…
New data shows that certain lymph nodes in the throat area are more likely to spread cancer in specific types of throat cancer cases.
Response-adapted surgery after neoadjuvant immune checkpoint inhibitors improves pathologic complete response in mucosal HNSCC
Response-Adapted Surgery May Help Preserve Organs in Head Cancer
This meta-analysis of patients with resectable mucosal head and neck squamous cell carcinoma (HNSCC) found that response-adapted surgery (RA…
A new approach to surgery after immunotherapy may help patients with head and neck cancer keep more of their natural tissue and function.
Smoking history linked to worse survival in HPV-positive oropharyngeal cancer after TORS
Smoking History Linked to Worse Survival in Throat Cancer
In HPV-associated oropharyngeal cancer treated with transoral robotic surgery, smoking history was tied to worse overall survival, though re…
A history of smoking is linked to a higher risk of death for patients with certain types of throat cancer treated with robotic surgery.
Evaluating Dose Escalation to 60 Gy in Locally Advanced Esophageal Squamous Cell Carcinoma
Trial shows higher radiation dose does not improve cancer survival
A Phase 3 trial compares 60 Gy versus 50 Gy of radiotherapy with concurrent chemotherapy for patients with unresectable esophageal squamous …
A large trial shows that increasing radiation doses for advanced esophageal cancer does not improve survival but may increase side effects.
Weekly Cisplatin Regimen Shows Noninferiority to Standard Dosing in Head and Neck Cancer
Weekly cisplatin treatment shows promise for head and neck cancer
A randomized trial confirms that weekly cisplatin dosing achieves noninferiority in overall survival for high-risk squamous cell carcinoma p…
A new trial shows that giving chemotherapy weekly instead of every three weeks may offer a comparable survival rate for head and neck cancer…
Plant extracts like curcumin and resveratrol may inhibit HNSCC growth via specific signaling pathways
Plant extracts may slow growth of head and neck cancer
This systematic review examines the effects of plant extracts, including resveratrol, curcumin, quercetin, and anthocyanins, on head and nec…
Certain plant compounds like curcumin and resveratrol show promise in stopping cancer cell growth and resisting chemotherapy in lab studies.
Cetuximab-based regimens achieve 47% objective response rate in HNSCC after immune checkpoint inhibitor failure
Cetuximab shows activity for head and neck cancer patients
This meta-analysis evaluates cetuximab-based regimens for patients with recurrent or metastatic head and neck squamous cell carcinoma follow…
New data shows cetuximab-based treatments provide meaningful results for head and neck cancer patients after other treatments fail.
Immune cell-based therapy shows no significant benefits for tumor response or survival in HNSCC trials
Immune cell therapy shows limited promise for head and neck cancer
This meta-analysis of 30 trials involving 953 patients evaluated immune cell-based therapy (ICT) for head and neck squamous cell carcinoma. …
New data on immune cell-based therapies for head and neck cancer shows mixed results and a need for more rigorous testing.
Perioperative and postoperative immunotherapy timing determines clinical outcomes in locally advanced head and neck squamous cell carcinoma
Timing of immunotherapy affects outcomes for head and neck cancer
This narrative review examines the impact of immunotherapy sequencing on patients with locally advanced head and neck squamous cell carcinom…
The timing of immunotherapy treatment significantly changes how well it controls local and distant spread in head and neck cancer.
HPV16 constitutes 92.5% of single infections in oropharyngeal squamous cell carcinoma cases
HPV16 Remains the Most Common Type in Throat Cancer
This meta-analysis of 183 studies involving 17,443 patients identifies HPV16 as the predominant genotype in oropharyngeal squamous cell carc…
A large global study of over 17,000 cases shows that HPV16 is the primary driver of most HPV-related throat cancers.
Questions about Oral Squamous Cell Carcinoma
Are there new treatments that target cell death to help oral squamous cell carcinoma?
Yes, new treatments targeting cell death pathways like ferroptosis, cuproptosis, and autophagy are being studied for oral squamous cell carcinoma, with some showing promise in early research.
Full answer →Can bacteria in my mouth change as my oral squamous cell carcinoma gets worse?
Yes, research shows that the oral microbiome, including bacteria like Veillonella, shifts as OSCC progresses, with different patterns in early vs. advanced stages.
Full answer →Does a specific blood test score predict my survival time after oral squamous cell carcinoma?
Yes, blood test scores like COP-MPV, mGPS, NLR, and PLR are linked to survival in OSCC, but they are not precise enough to predict individual survival time.
Full answer →All Oral Squamous Cell Carcinoma Articles
- YAP and TAZ Overexpression Predicts Worse Survival in Oral Squamous Cell Carcinoma
- Oral HPV reshapes mucosal microbial composition in a sex and population dependent manner
- SMMI framework provides a conceptual model for risk stratification in high-risk oral potentially malignant disorders
- Distinct microbial taxa and functional pathways are associated with oral squamous cell carcinoma
- Submental Artery Island Flap Shows 16% Pooled Locoregional Recurrence in Oral Cavity Reconstruction
- Impact of Perineural Invasion on Survival Outcomes in Oral Squamous Cell Carcinoma
- AI-based MRI shows 0.82 AUC for detecting cervical lymph node metastases in oral squamous cell carcinoma
- Higher preoperative neutrophil-to-lymphocyte ratio predicts poorer survival in oral squamous cell carcinoma patients
- Deep Learning algorithms demonstrate potential for diagnosing oral potentially malignant disorders and squamous cell carcinoma
- Ninjin’yoeito attenuates postoperative Prognostic Nutritional Index decline in patients with oral squamous cell carcinoma
- Circulating miRNAs show high diagnostic accuracy for oral squamous cell carcinoma with AUC of approximately 0.90
- Hyperspectral imaging shows strong diagnostic performance for oral cancer detection in scoping review
- Oral diseases stem from disrupted host-microbiome-immune balance, narrative review argues
- Molecular markers may improve risk assessment in oral potentially malignant disorders
- Narrative review explores mitochondrial-targeted therapeutics for oral squamous cell carcinoma
- Meta-analysis finds BCI_net prognostic for overall survival in oral squamous cell carcinoma
- Narrative review explores Veillonella's dynamic role in oral squamous cell carcinoma
- Meta-analysis finds frozen section reliable for tumor-free margins in OSCC
- Narrative review discusses targeting ferroptosis and cuproptosis in oral squamous cell carcinoma
- Iron and oxidative stress biomarkers linked to oral cancer recurrence after surgery
- Personalized swallowing rehab improves outcomes after oral cancer surgery
- High NSUN3 expression linked to poor survival in oral squamous cell carcinoma
- Classification framework shows 79% to 98% performance for oral squamous cell carcinoma on histopathological images
- Review links oral microbiome dysbiosis to malignant transformation in oral lichen planus
- Systematic review finds serum biomarkers show variable diagnostic accuracy for oral cancer detection