Hyperspectral imaging shows strong diagnostic performance for oral cancer detection in scoping review
Hyperspectral imaging shows promise for detecting oral cancer
This scoping review of 15 studies found that hyperspectral imaging (HSI) demonstrates strong diagnostic performance for detecting and charac…
A new review finds hyperspectral imaging can spot oral cancer with high accuracy, offering a non-contact alternative for margin assessment.
Oral diseases stem from disrupted host-microbiome-immune balance, narrative review argues
New research explores how oral bacteria drive gum disease
This narrative review argues that periodontitis, dental caries, and oral squamous cell carcinoma should be understood as disorders of host-m…
Oral health depends on a delicate balance between your immune system, tissue barriers, and the trillions of microbes living in your mouth.
Molecular markers may improve risk assessment in oral potentially malignant disorders
Molecular tools may improve risk assessment for oral lesions
This narrative review examines the limitations of conventional histopathological grading for oral potentially malignant disorders (OPMDs) an…
A review suggests molecular methods could better assess risk for oral potentially malignant disorders where standard grading is unreliable.
Narrative review explores mitochondrial-targeted therapeutics for oral squamous cell carcinoma
New drug strategy targets mouth cancer's hidden power source
This narrative review discusses the potential of mitochondrial-targeted therapeutics in oral squamous cell carcinoma (OSCC). The authors syn…
Targeting the cell's power source could help overcome stubborn mouth cancer resistance.
Meta-analysis finds BCI_net prognostic for overall survival in oral squamous cell carcinoma
A new cancer test reads tumor cell chats to predict survival
This meta-analysis of 2 cohorts (TCGA-HNSC n=519, GSE65858 n=270) found that the BCI_net directional composite was independently associated …
Your cancer cells may be chatting with each other, and a new test that listens to those conversations could predict how aggressive the disea…
Narrative review explores Veillonella's dynamic role in oral squamous cell carcinoma
Oral bacteria shift early in cancer and vanish as tumors grow
This narrative review examines the role of Veillonella species in oral squamous cell carcinoma (OSCC). The authors report a dynamic, stage-d…
A specific mouth bacteria appears early in cancer development but disappears as tumors grow larger, suggesting it helps start the problem ra…
Meta-analysis finds frozen section reliable for tumor-free margins in OSCC
Surgeons rely on frozen sections to ensure clean cuts for oral cancer patients
This systematic review and meta-analysis of 19 studies (9 with complete data) assessed frozen section analysis for detecting tumor-free marg…
A new review confirms that frozen section analysis is a highly reliable way for surgeons to check if oral cancer has been fully removed duri…
Narrative review discusses targeting ferroptosis and cuproptosis in oral squamous cell carcinoma
New ideas target cell death pathways for oral cancer
This narrative review explores the potential of targeting ferroptosis and cuproptosis in patients with oral squamous cell carcinoma.
A review explores fresh ways to fight oral cancer by targeting specific cell death pathways. This approach offers new hope for patients with…
Iron and oxidative stress biomarkers linked to oral cancer recurrence after surgery
Iron levels and oxidative stress linked to cancer return in oral squamous cell carcinoma patients
This retrospective cohort study of 240 patients with oral squamous cell carcinoma who underwent radical surgery found that 36.7% experienced…
Among 240 oral cancer patients, high iron and oxidative stress markers were more common in those whose cancer came back after surgery.
Personalized swallowing rehab improves outcomes after oral cancer surgery
New Swallowing Therapy Helps Oral Cancer Patients Eat and Speak More Easily
This randomized controlled trial in 300 patients with oral squamous cell carcinoma found that a personalized swallowing rehabilitation progr…
Personalized swallowing therapy helps oral cancer patients recover faster, eat more naturally, and avoid dangerous complications like pneumo…
High NSUN3 expression linked to poor survival in oral squamous cell carcinoma
High NSUN3 protein makes oral cancer spread faster
This cohort study of 60 oral squamous cell carcinoma patients found that upregulated NSUN3 expression is an independent risk factor for poor…
Imagine waking up with a sore in your mouth that won't heal.
Review links oral microbiome dysbiosis to malignant transformation in oral lichen planus
Bacteria That Turn Harmful Mouth Sores Into Cancer
This narrative review synthesizes evidence regarding oral microbiome dysbiosis as a potential driver of malignant transformation in oral lic…
Changing the bad bacteria in your mouth could stop a painful sore from becoming cancer.
Research across Head and Neck Cancer
Related studies from across the Head and Neck Cancer family.
Lenvatinib plus pembrolizumab did not improve overall survival compared to standard of care
Trial shows lenvatinib and pembrolizumab do not improve survival
This Phase 2 randomized trial evaluated lenvatinib and pembrolizumab in 374 adults with recurrent or metastatic head and neck squamous cell …
A Phase 2 trial found that a combination of lenvatinib and pembrolizumab did not improve overall survival for patients with advanced head an…
High tumor mutational burden correlates with improved objective response rate in HNSCC patients
High tumor mutation burden predicts better results in head cancer
This meta-analysis of 1472 patients with head and neck squamous cell carcinoma (HNSCC) found that high tumor mutational burden (TMB) is asso…
A high number of mutations in a tumor may help doctors predict which patients will respond best to immunotherapy.
Combination Therapies Improve Progression Free Survival in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Combination therapies show promise for advanced head and neck cancer
This meta-analysis evaluated combination therapies involving targeted agents or immunotherapy with chemotherapy for patients with recurrent …
Combining immunotherapy or targeted drugs with chemotherapy may help patients with advanced head and neck cancer live longer without the dis…
Camrelizumab and apatinib show higher response rates and survival in treatment-naive patients with ESCC
Treatment Naive Patients Show Better Survival with Camrelizumab and Apatinib
This meta-analysis evaluates the efficacy of camrelizumab plus apatinib for advanced or metastatic esophageal squamous cell carcinoma. The a…
Patients with advanced esophageal cancer who have not had prior treatment may see better survival rates when using a combination of camreliz…
Sintilimab may trigger autoimmune GFAP astrocytopathy in esophageal squamous cell carcinoma patients
New cancer treatment may cause rare brain inflammation in patients
This case report and literature review describes a patient with advanced esophageal squamous cell carcinoma who developed autoimmune GFAP as…
A new type of immunotherapy for esophageal cancer can trigger a rare brain condition, requiring doctors to watch for early signs of neurolog…
HPV shows strong association with oropharyngeal SCC while other oncogenic viruses show limited evidence
Viruses linked to oral and throat cancers in new review
This systematic review examines the role of various oncogenic viruses in oral and oropharyngeal squamous cell carcinomas. It identifies a co…
A strong link between HPV and throat cancer is confirmed, while other viruses show less clear evidence of causing cancer.
Neoadjuvant chemoimmunotherapy improves pathological response and surgical rates in resectable esophageal squamous cell carcinoma
Immune therapy shows promise for esophageal squamous cell carcinoma
This meta-analysis of randomized controlled trials involving 1070 patients found that neoadjuvant chemoimmunotherapy (NIC) significantly imp…
Adding immune checkpoint inhibitors to chemotherapy before surgery significantly improves tumor response rates in patients with esophageal c…
Early recognition of femoral metastasis in HNSCC is essential to facilitate timely palliative intervention
New data reveals management of head and neck cancer spread
This systematic review characterizes clinical features and management outcomes for patients with head and neck squamous cell carcinoma (HNSC…
Identifying how head and neck cancer spreads to the femur can help doctors provide better care and improve quality of life for patients.
Pretreatment CPS and HPV status correlate with pathological response in neoadjuvant immunotherapy for LAHNSCC
Certain markers may predict how well immunotherapy treats head cancer
This meta-analysis of 26 studies involving 980 patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC) found that hig…
New data suggests that specific biological markers can help doctors predict how well a patient's tumor will respond to immunotherapy.
High PTTG1 expression correlates with poorer survival and advanced disease in various solid tumors
High levels of PTTG1 protein linked to worse cancer outcomes
This meta-analysis of 22 studies from 21 articles analyzed the prognostic value of PTTG1 expression across multiple solid tumors. High PTTG1…
A review of 22 studies shows that high levels of the PTTG1 protein are linked to shorter survival times in several types of solid tumors.
HOX gene dysregulation influences cellular processes but currently lacks utility as reliable HNSCC biomarkers
HOX genes play complex roles in head and neck cancer
This mini-review examines the role of HOX genes in head and neck squamous cell carcinoma (HNSCC). The authors conclude that while these gene…
New research highlights how HOX genes drive tumor growth and survival in head and neck cancers, though their use as clinical tools is still …
Local brain therapies associated with reduced mortality in HNSCC patients with brain metastasis
Local brain treatments linked to modest survival gains in rare head and neck cancer cases
This retrospective cohort analysis evaluated 201 patients with head and neck squamous cell carcinoma and brain metastasis from three tertiar…
Local brain treatments linked to lower death risk for rare head and neck cancer patients who develop brain metastases, though most still die…
Questions about Oral Squamous Cell Carcinoma
Are there new treatments that target cell death to help oral squamous cell carcinoma?
Yes, new treatments targeting cell death pathways like ferroptosis, cuproptosis, and autophagy are being studied for oral squamous cell carcinoma, with some showing promise in early research.
Full answer →Can bacteria in my mouth change as my oral squamous cell carcinoma gets worse?
Yes, research shows that the oral microbiome, including bacteria like Veillonella, shifts as OSCC progresses, with different patterns in early vs. advanced stages.
Full answer →Does a specific blood test score predict my survival time after oral squamous cell carcinoma?
Yes, blood test scores like COP-MPV, mGPS, NLR, and PLR are linked to survival in OSCC, but they are not precise enough to predict individual survival time.
Full answer →All Oral Squamous Cell Carcinoma Articles
- Hyperspectral imaging shows strong diagnostic performance for oral cancer detection in scoping review
- Oral diseases stem from disrupted host-microbiome-immune balance, narrative review argues
- Molecular markers may improve risk assessment in oral potentially malignant disorders
- Narrative review explores mitochondrial-targeted therapeutics for oral squamous cell carcinoma
- Meta-analysis finds BCI_net prognostic for overall survival in oral squamous cell carcinoma
- Narrative review explores Veillonella's dynamic role in oral squamous cell carcinoma
- Meta-analysis finds frozen section reliable for tumor-free margins in OSCC
- Narrative review discusses targeting ferroptosis and cuproptosis in oral squamous cell carcinoma
- Iron and oxidative stress biomarkers linked to oral cancer recurrence after surgery
- Personalized swallowing rehab improves outcomes after oral cancer surgery
- High NSUN3 expression linked to poor survival in oral squamous cell carcinoma
- Classification framework shows 79% to 98% performance for oral squamous cell carcinoma on histopathological images
- Review links oral microbiome dysbiosis to malignant transformation in oral lichen planus
- Systematic review finds serum biomarkers show variable diagnostic accuracy for oral cancer detection