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Home › Conditions › Osteoporosis

Osteoporosis

Subtypes of Osteoporosis

Postmenopausal Osteoporosis 1

37 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Osteoporosis

164 trials tracked for Osteoporosis: 75 in phase 3 or 4 and 13 with published results. The most-cited published study has 343 citations.

164Trials tracked
75Phase 3 & 4
0Recruiting
13With published results
Phase distribution
Phase 4 30 Phase 3 45 Phase 2 37 Phase 1 10 Other / NA 42
  1. Phase 3 Extension Study to Evaluate the Long Term Safety and Efficacy of Denosumab in the Treatment of Osteoporosis Completed · 343 cited
  2. Phase 3 Using Soy Estrogens to Prevent Bone Loss and Other Menopausal Symptoms Completed · 179 cited
  3. Phase 3 Study to Evaluate Efficacy of Odanacatib (MK-0822) on Bone Mineral Density (BMD) and Bone Micro-architecture and Overall Safety in Postmenopausal Women (MK-0822-031) Completed · 122 cited
  4. Phase 4 Treatment With Zoledronic Acid Subsequent to Denosumab in Osteoporosis Completed · 104 cited
  5. Phase 3 Denosumab for Prevention of Osteoporosis in Renal Transplant Recipients Completed · 103 cited
  6. Phase 4 Bone Histomorphometry in Postmenopausal Men and Women With Osteoarthritis Undergoing Total Hip Replacement Completed · 47 cited
Show 44 more trials
  1. Phase 3 Study to Evaluate the Safety and Efficacy of BA058 (Abaloparatide) for Prevention of Fracture in Postmenopausal Women Completed · 47 cited
  2. Phase 3 Early Effects of Abaloparatide on Tissue-Based Indices of Bone Formation and Resorption Completed · 40 cited
  3. Phase 3 An Efficacy and Safety Trial of Intravenous Zoledronic Acid Twice Yearly in Osteoporotic Children Treated With Glucocorticoids Completed · 40 cited
  4. Phase 3 A Study to Assess Safety and Efficacy of Odanacatib (MK-0822) in Men With Osteoporosis (MK-0822-053) Completed · 21 cited
  5. Phase 4 Efficacy and Safety of Brand Versus Generic Alendronate for Osteoporosis Treatment Completed · 12 cited
  6. Phase 4 Bone Health in Aging HIV Infected Women Completed · 8 cited
  7. Phase 3 Safety and Efficacy of Abaloparatide-SC in Men With Osteoporosis (ATOM) Completed
  8. Phase 4 Bisphosphonate Therapy for Osteogenesis Imperfecta Completed
  9. Phase 4 A Study That Will Compare the Effect of Two Drugs on Participants With Low Bone Mass and a Recent Hip Fracture Completed
  10. Phase 4 Effectiveness of DiscontinuinG bisphosphonatEs Study: R21 Pilot Study Completed
  11. Phase 4 Fracture (FX) Improvement With Teriparatide: FiX-IT Study Completed
  12. Phase 4 Effect of Zoledronic Acid on Femoral Bone Loss Following Total Hip Arthroplasty Completed
  13. Phase 4 Efficacy and Safety Study of Risedronate, Cholecalciferol Combination Tablet in Patients With Osteoporosis Completed
  14. Phase 4 Effect of Atorvastatin on Bone-vascular Axis Completed
  15. Phase 4 Preventing Osteoporosis Using Denosumab Completed
  16. Phase 4 Denosumab (DMAB) Discontinuation And Switching In Glucocorticoid-Induced Osteoporosis (GIOP): A Pilot Study Completed
  17. Phase 4 Effect of Bisphosphonate on Bone Loss in Postmenopausal Women With Breast Cancer Initiating Aromatase Inhibitor Therapy Completed
  18. Phase 4 Effects of Teriparatide or Denosumab on Bone in Postmenopausal Women With Osteoporosis Completed
  19. Phase 4 Effect of Parathyroid Hormone (PTH) and Weight-Bearing on Bone in Spinal Cord Injury (SCI) Completed
  20. Phase 4 Do Aromatase Inhibitors (AIs) Decrease Intestinal Calcium Absorption? Completed
  21. Phase 4 A Study of Teriparatide in Japanese Osteoporosis Patients Completed
  22. Phase 4 Effect of Full Length Parathyroid Hormone, PTH(1-84) or Strontium Ranelate on Bone Markers in Postmenopausal Women With Primary Osteoporosis (FP-006-IM) Completed
  23. Phase 4 Risedronate and Parathyroid Hormone to Reverse Osteoporosis Caused by Chronic Steroid Use Completed
  24. Phase 4 Does Treatment of Hypovitaminosis D Increase Calcium Absorption? Completed
  25. Phase 4 Switch From Tenofovir to Raltegravir for Low Bone Mineral Density Completed
  26. Phase 4 Enhancing Osteoporosis Therapy: Can We Open the Anabolic Window? Completed
  27. Phase 4 Alendronate Prevents Microarchitectural Deterioration of Trabecular Bone in Early Postmenopausal Women Completed
  28. Phase 4 Effects of Zoledronic Acid and Raloxifene on Bone Turnover Markers in Postmenopausal Women With Low Bone Mineral Density Completed
  29. Phase 4 Acetaminophen or Fluvastatin Compared to Placebo on the Transient Post-Dose Symptoms (PDS) Following an Intravenous (i.v.) Infusion of a Single Dose of Zoledronic Acid 5mg, in Post-menopausal Women With Low Bone Mass Completed
  30. Phase 4 Evaluation of the Effects of Teriparatide on Skeleton Images in Postmenopausal Women With Osteoporosis Completed
  31. Phase 4 Does Omeprazole Decrease Intestinal Calcium Absorption? Completed
  32. Phase 4 Antiepileptic Drugs and Osteoporotic Prevention Trial Completed
  33. Phase 4 The Effect of Protein on Calcium Absorption and Gastric Acid Production Completed
  34. Phase 3 Evaluation of New or Worsening Lens Opacifications in Men With Non-metastatic Prostate Cancer Receiving Denosumab for Bone Loss Completed
  35. Phase 3 Zoledronate in Preventing Osteoporosis and Bone Fractures in Patients With Locally Advanced Nonmetastatic Prostate Cancer Undergoing Radiation Therapy and Hormone Therapy Completed
  36. Phase 3 Forteo for the Treatment of Unexplained Osteoporosis in Premenopausal Women Completed
  37. Phase 3 1 Year Open-label Extension to CZOL446H2337 Safety and Efficacy Trial of Zoledronic Acid Twice Yearly in Osteoporotic Children Treated With Glucocorticoids Completed
  38. Phase 3 A Study to Test the Efficacy, Safety and Tolerability of Romosozumab Treatment in Postmenopausal Chinese Women With Osteoporosis Completed
  39. Phase 3 Study Evaluating Bazedoxifene/Conjugated Estrogens Combinations In Postmenopausal Women Completed
  40. Phase 3 A Study for Patients With Osteoporosis Completed
  41. Phase 3 Vertebroplasty for the Treatment of Fractures Due to Osteoporosis Completed
  42. Phase 3 Denosumab Adherence Preference Satisfaction Study Completed
  43. Phase 3 Study of MK-217A/Alendronate Sodium 70-mg/Vitamin D3 5600 IU Combination Tablet (MK-0217A-329) Completed
  44. Phase 3 Study Evaluating The Effects Of Bazedoxifene/Conjugated Estrogens On Endometrial Safety And Postmenopausal Osteoporosis Completed

Showing the 50 most-cited and recently-updated of 164 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
VBQ and Hounsfield Units Predict Subsequent Fractures After Vertebral Augmentation
Orthopedics & Sports Medicine Meta-analysis
VBQ and Hounsfield Units Predict Subsequent Fractures After Vertebral Augmentation Vertebral Bone Quality Scores Predict Fracture Risk After Vertebral Augmentation
This meta-analysis of 7364 patients found that higher VBQ scores and lower HU values are significantly associated with subsequent fractures …
A large analysis of 7,364 patients shows Vertebral Bone Quality scores better predict future fractures after vertebral augmentation than sta…
May 1, 2026
Romosozumab improves shear bone strength in postmenopausal women with osteoporosis in BCT substudies
Drug Pipeline RCT
Romosozumab improves shear bone strength in postmenopausal women with osteoporosis in BCT substudies Romosozumab May Help Spinal Fusion Surgery Last Longer
This retrospective secondary analysis of phase 2 and 3 randomized trial data evaluated romosozumab in postmenopausal women with low bone den…
A bone drug may make spinal fusion surgery more secure for women with weak bones, new virtual tests suggest.
May 1, 2026
Systematic Review and Meta-Analysis Links α-Klotho to Frailty and Bone Health in Aging
Nephrology Meta-analysis
Systematic Review and Meta-Analysis Links α-Klotho to Frailty and Bone Health in Aging Higher Alpha-Klotho Levels Mean Less Frailty And Better Bones
This systematic review and meta-analysis of 109 studies found that higher circulating α-Klotho levels were associated with lower odds of fra…
New research shows that higher Alpha-Klotho levels protect against frailty and bone loss, offering hope for better aging outcomes.
Apr 30, 2026
Narrative review examines coronary risk and vascular effects of bisphosphonates, denosumab, and romosozumab in osteoporosis
Diabetes & Endocrinology Sys. Review
Narrative review examines coronary risk and vascular effects of bisphosphonates, denosumab, and romosozumab in osteoporosis Osteoporosis drugs show no clear heart risk or benefit
This narrative review evaluates the cardiovascular safety profile of anti-osteoporosis therapies including bisphosphonates, denosumab, and r…
Common osteoporosis drugs don't have a clear effect on heart health, but one newer drug still raises safety questions.
Frontiers Apr 29, 2026
Nomogram Predicts Osteoporosis Risk in Rheumatoid Arthritis Patients
Rheumatology Cohort
Nomogram Predicts Osteoporosis Risk in Rheumatoid Arthritis Patients New tool predicts osteoporosis risk in rheumatoid arthritis patients
A single-center retrospective study of 349 RA patients developed a nomogram predicting osteoporosis risk.
A new prediction model identified osteoporosis in 37.8% of rheumatoid arthritis patients, using factors like sex and body mass.
Frontiers Apr 29, 2026
Machine learning radiomics on MRI sequences predicts osteoporosis and abnormal bone density in retrospective cohort
Diabetes & Endocrinology Cohort
Machine learning radiomics on MRI sequences predicts osteoporosis and abnormal bone density in retrospective cohort MRI scans can predict bone weakness better than standard tests for some conditions
This retrospective cohort study analyzed 320 MR scans from 160 patients with mean age 61.27 ± 12.72 years.
New analysis shows specific MRI sequences predict abnormal bone density and osteoporosis with high accuracy in patients over 60.
Frontiers Apr 29, 2026
Narrative review explores gut metabolites postbiotics obesity fatty liver and bone loss associations
Orthopedics & Sports Medicine Sys. Review
Narrative review explores gut metabolites postbiotics obesity fatty liver and bone loss associations Your Gut Microbes May Be Secretly Stealing Your Bone Strength
This narrative review examines the relationship between gut metabolites, postbiotics, and conditions including obesity, fatty liver, and bon…
A leaky gut can block calcium and vitamin D from reaching your bones, raising fracture risk.
Frontiers Apr 28, 2026
Narrative review links gut dysbiosis and immune changes to osteoporosis mechanisms in postmenopausal women and older adults
Orthopedics & Sports Medicine Sys. Review
Narrative review links gut dysbiosis and immune changes to osteoporosis mechanisms in postmenopausal women and older adults Your Gut Holds the Key to Strong Bones
This narrative review synthesizes current evidence on the interactions between the gut microbiota and osteoporosis pathogenesis in postmenop…
Many people think strong bones come only from milk and exercise.
Frontiers Apr 23, 2026
Meta-analysis of preclinical studies supports kaempferol for osteoporosis
ENT (Otolaryngology) Meta-analysis
Meta-analysis of preclinical studies supports kaempferol for osteoporosis Nature's Shield for Weakening Bones
This systematic review and meta-analysis of 12 randomized controlled trials in osteoporotic animal models found that kaempferol significantl…
A natural compound found in plants may help stop bone loss, offering a new hope for osteoporosis patients.
Frontiers Apr 23, 2026
L1 Cortical Bone Quantitative CT Parameters Show Association With Osteoporosis in 169 Patient Cohort
Rheumatology Cohort
L1 Cortical Bone Quantitative CT Parameters Show Association With Osteoporosis in 169 Patient Cohort Spine CT Scans May Predict Osteoporosis Risk Without Extra Tests
This retrospective cohort study evaluated L1 cortical bone quantitative CT parameters in 169 participants undergoing chest-abdominal or lumb…
A new study finds that routine spine CT scans can reveal osteoporosis risk by measuring cortical bone, potentially reducing the need for ext…
Frontiers Apr 23, 2026
Higher Geriatric Nutritional Risk Index linked to lower osteoporosis risk in diabetic women
Diabetes & Endocrinology Cohort
Higher Geriatric Nutritional Risk Index linked to lower osteoporosis risk in diabetic women Better nutrition linked to lower osteoporosis risk in women with diabetes
This retrospective observational cohort study of 324 postmenopausal women with type 2 diabetes found that a higher Geriatric Nutritional Ris…
A simple nutrition score may help spot osteoporosis risk in women with type 2 diabetes, new hospital data suggests.
Frontiers Apr 22, 2026
Review examines current endocrine causes of secondary osteoporosis and clinical management approaches
Diabetes & Endocrinology Sys. Review
Review examines current endocrine causes of secondary osteoporosis and clinical management approaches Why Normal Hormones Can Still Break Bones
This review synthesizes evidence on endocrine-related secondary osteoporosis across conditions like hypercortisolism and male hypogonadism.
You might think strong bones only come from aging women or older men.
Frontiers Apr 21, 2026

Questions about Osteoporosis

Can MRI scans and machine learning predict osteoporosis and abnormal bone density?

Yes, MRI scans combined with machine learning can predict osteoporosis and abnormal bone density with high accuracy, often matching or exceeding CT-based methods.

Full answer →
Can VBQ scores and Hounsfield Units predict fractures after vertebral augmentation?

Yes, both VBQ scores and Hounsfield Units can predict fractures after vertebral augmentation, with VBQ showing slightly better sensitivity.

Full answer →
Does romosozumab improve bone strength in postmenopausal women with osteoporosis?

Yes, romosozumab improves bone strength in postmenopausal women with osteoporosis, as shown by increases in shear bone strength, volumetric BMD, and trabecular bone score in clinical trials.

Full answer →