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Home › Conditions › Pregnancy

Pregnancy

Subtypes of Pregnancy

Twin Pregnancy 2 Adolescent pregnancy 0

18 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Pregnancy

125 trials tracked for Pregnancy: 22 in phase 3 or 4 and 11 with published results. The most-cited published study has 824 citations.

125Trials tracked
22Phase 3 & 4
0Recruiting
11With published results
Phase distribution
Phase 4 7 Phase 3 15 Phase 2 3 Phase 1 3 Other / NA 97
  1. Phase 3 Antenatal Late Preterm Steroids (ALPS): A Randomized Placebo-Controlled Trial Completed · 824 cited
  2. Phase 3 Thyroid Therapy for Mild Thyroid Deficiency in Pregnancy Completed · 470 cited
  3. Phase 3 Maternal Antiviral Prophylaxis to Prevent Perinatal Transmission of Hepatitis B Virus in Thailand Completed · 284 cited
  4. Phase 3 Safety and Pharmacokinetics of Dolutegravir in Pregnant HIV Mothers and Their Neonates: A Pilot Study Completed · 113 cited
  5. Phase 3 Vitamin D Status of Pregnant Women and Their Children in Eau Claire, South Carolina Completed · 104 cited
  6. Phase 3 Kansas University DHA Outcome Study (KUDOS) Follow-Up Completed · 62 cited
Show 44 more trials
  1. Phase 4 Sexual Absorption of Vaginal Progesterone Completed · 40 cited
  2. Phase 3 Induction With Misoprostol: Oral Mucosa Versus Vaginal Epithelium (IMPROVE) Completed · 35 cited
  3. Phase 3 A Single-arm, Open-label, Study to Assess the Pharmacokinetics of Darunavir and Ritonavir, Darunavir and Cobicistat, Etravirine, and Rilpivirine in HIV-1 Infected Pregnant Women Completed · 28 cited
  4. Phase 4 Effects of Bupivacaine Induced Motor Blockade During the Second Stage of Labor Completed · 16 cited
  5. Phase 3 Effect of Dexamethasone on Labor Induction Completed
  6. Phase 4 Outcomes of Neuraxial Anesthetic Technique on the Trial of Labor After Cesarean (TOLAC) Completed
  7. Phase 4 Safety and Immunogenicity of Simultaneous Tdap and IIV in Pregnant Women Completed
  8. Phase 4 Increased Cefazolin During Cesarean Delivery in Obese Population Completed
  9. Phase 4 Transverse Abdominis Plane (TAP) Block After Cesarean Delivery Completed
  10. Phase 4 Gastric Volumes by US in Term Parturients Undergoing CS With and Without Metoclopramide Completed
  11. Phase 3 Pregnancy in Polycystic Ovary Syndrome II Completed
  12. Phase 3 Study of the Safety and Contraceptive Efficacy of C31G Compared to Conceptrol® Completed
  13. Phase 3 DHA Supplementation and Pregnancy Outcome Completed
  14. Phase 3 RCT Comparing Methadone and Buprenorphine in Pregnant Women Completed
  15. Phase 3 Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation Completed
  16. Phase 3 Effects of Docosahexaenoic Acid (DHA) on Fetal Cardiac Outcomes Completed
  17. Phase 2 Study of Pharmacology of 17-OHPC in Pregnancy Completed
  18. Phase 2 Effectiveness of Metformin Compared to Insulin in Pregnant Women With Mild Preexisting or Early Gestational Diabetes Completed
  19. Phase 2 Intravaneous Iron(1000 mg Low Molecular Weight Iron Dextran Over 60 Minutes) for Pregnant Women Completed
  20. Phase 1 Electrode-based Sensor for Non-invasive Fetal Heart Rate and EMG Monitoring With Improved Reliability Completed
  21. Phase 1 Comparing Anti-XA Levels in Post-Cesarean Patients Undergoing Enoxaparin Thromboprophylaxis Completed
  22. Phase 1 Study to Evaluate Suppression of Ovulation and Pharmacokinetics of Medroxyprogesterone Acetate Following Administration of TV-46046 in Women With Ovulatory Cycle Completed
  23. N/A Does Maternal Fever During Labor Analgesia Has Any Relationship With Maternal Ventilation? Completed
  24. N/A Local Anesthesia and Pain Perception During an Amniocentesis Completed
  25. N/A Phone-Based Postpartum Continuing Care for Smoking Cessation Completed
  26. N/A Effects of Oral Probiotic Supplementation on Group B Strep (GBS) Rectovaginal Colonization in Pregnancy Completed
  27. N/A The Effect of Protease Inhibitors on the Pharmacokinetics of Oral Norethindrone Contraception Completed
  28. N/A A Prenatal Bonding Intervention for Pregnant Women With Depression Completed
  29. N/A Copper T380 IUD Versus Oral Levonorgestrel for Emergency Contraception vs. Plan B for Emergency Contraception Completed
  30. N/A Comparison of Staples Versus Prolene Suture for Skin Closure at Cesarean Delivery Completed
  31. N/A Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05714 (Care Program)(P05715) Completed
  32. N/A EnBrace HR for Depression Treatment and Prevention in Women Trying to Conceive and Early Pregnancy Completed
  33. N/A Mobile App for Prenatal Care to Reduce Visits and Improve Satisfaction Study Completed
  34. N/A Comparison of SureCALL® Labor Monitor® and Tocodynamometer Measurement in Preterm and Term Pregnant Women Completed
  35. N/A Organization of Teratology Information Services (OTIS) Autoimmune Diseases in Pregnancy Project Completed
  36. N/A Computer-delivered Screening & Brief Intervention for Marijuana Use in Pregnancy Completed
  37. N/A Shared Decision Making for Prescription Opioids After Cesarean Delivery Completed
  38. N/A Foley Bulb With Oral Misoprostol for Induction of Labor Completed
  39. N/A Sleep Disruption in New Mothers: An Intervention Trial Completed
  40. N/A Clearblue Advanced Fertility Monitor Consumer One Cycle at Home Study Completed
  41. N/A Neuropathic Pain in Pregnancy Completed
  42. N/A Fetal Neurobehavior in Non-methadone Maintained Women in Substance Abuse Treatment Completed
  43. N/A Evaluating HITSystem 2.1 to Improve Viral Suppression in Kenya Completed
  44. N/A Immune Responses to the Flu Shot During Pregnancy Completed

Showing the 50 most-cited and recently-updated of 125 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Pregnancy: what the trials found

Pharmacological management of pregnancy and neonatal outcomes includes several established interventions. Betamethasone significantly improved neonatal composite outcomes (p=0.02) and reduced the number of neonates with severe respiratory complications (p<0.001) and those requiring immediate resuscitation after birth (p=0.003) 9. Levothyroxine administration in women with subclinical hypothyroidism or hypothyroxinemia during the first half of pregnancy did not significantly impact children's intellectual function at 5 years, the week of gestation at delivery, or the rate of preterm delivery 10.

Management of labor and pain involves various modalities. Epidural bupivacaine plus fentanyl showed no significant difference in the duration of the second stage of labor or the number of newborns with low APGAR scores at 1 or 5 minutes 3. Epidural anesthesia was associated with successful analgesia (VAS) and favorable neonatal APGAR scores 8. Dexamethasone did not significantly impact Bishop scores or the latent phase of labor 17. For gastric management, metoclopramide resulted in a significant reduction in gastric volume (p=0.001) during procedures involving intrathecal anesthesia 4.

Specific treatments for maternal and fetal health include tenofovir disoproxil fumarate, which showed 0% to 3% infection rates of Hepatitis B in infants at 6 months 11, and dolutegravir, which demonstrated a cord-to-maternal plasma ratio of 1.21 12. Supplementation with DHA was evaluated for cognitive function (no significant difference reported) 14 and neonatal behavioral scores 22. Clomiphene citrate was associated with a statistically significant increase in live births (p=0.007) 21.

Recent results — preliminary, needs further review

  • [] A fetal monitoring device is currently under investigation.

For the clinician treating this condition

  • Betamethasone is effective in improving neonatal respiratory outcomes and reducing the need for immediate resuscitation 9.
  • Levothyroxine does not appear to affect neurodevelopmental outcomes or delivery timing in women with subclinical hypothyroidism during early pregnancy 10.
  • Epidural bupivacaine plus fentanyl provides analgesia without significantly altering the duration of the second stage of labor or neonatal APGAR scores 3.

AI synthesis of 11 cited trials, updated Jun 24, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Report describes alcohol and substance co-use among pregnant females in the United States
OB/GYN & Women's Health
Report describes alcohol and substance co-use among pregnant females in the United States Report examines alcohol and substance use patterns among pregnant people in the US
An observational report describes alcohol and substance co-use among pregnant females aged 12-44 years in the United States.
A new report looks at how often pregnant people in the US use alcohol and other substances together, aiming to clarify current trends.
CDC Apr 4, 2026
Observational report finds inconsistencies and disparities in alcohol screening for pregnant persons
OB/GYN & Women's Health
Observational report finds inconsistencies and disparities in alcohol screening for pregnant persons Report finds inconsistencies in alcohol screening for pregnant people across U.S. regions
An observational report from 24 U.S. jurisdictions found inconsistencies and disparities in alcohol screening and brief intervention among p…
A new report reveals inconsistent alcohol screening and counseling for pregnant people across 24 U.S. states and territories.
CDC Apr 4, 2026
Observational report examines smoking behaviors among women before, during, and after pregnancy
OB/GYN & Women's Health
Observational report examines smoking behaviors among women before, during, and after pregnancy Report examines smoking patterns in women before, during, and after pregnancy
An observational report describes cigarette smoking behaviors among pregnant women during the perinatal period in the United States.
A new report details smoking habits in women before, during, and after pregnancy, but its findings have not yet been released.
CDC Apr 4, 2026
Field report notes increase in parvovirus B19 infections among pregnant persons in Minnesota
OB/GYN & Women's Health
Field report notes increase in parvovirus B19 infections among pregnant persons in Minnesota Are more pregnant people in Minnesota getting parvovirus B19 infections?
A field report from Minnesota describes an increase in human parvovirus B19 infections among pregnant persons.
Minnesota health officials report more pregnant people are getting infected with parvovirus B19, a common virus that can cause serious anemi…
CDC Apr 4, 2026
Birth and infant outcomes assessed in over 5,000 U.S. pregnancies with SARS-CoV-2 infection
OB/GYN & Women's Health
Birth and infant outcomes assessed in over 5,000 U.S. pregnancies with SARS-CoV-2 infection Study examines birth outcomes for over 5,000 pregnant women with COVID-19 in the U.S
An observational study of approximately 5,252 women with laboratory-confirmed SARS-CoV-2 infection during pregnancy in 16 U.S.
Data from over 5,000 U.S. pregnancies with COVID-19 shows what happened to babies, but specific health outcomes and risks remain unreported …
CDC Apr 4, 2026
Cervical pessary versus progesterone for preterm birth prevention in twin pregnancy with short cervix
Pediatrics RCT
Cervical pessary versus progesterone for preterm birth prevention in twin pregnancy with short cervix For twin pregnancies with a short cervix, does a cervical pessary help prevent early birth?
A small, single-center RCT in 34 individuals with twin pregnancy and cervical length ≤38 mm compared cervical pessary to vaginal progesteron…
For twin pregnancies with a short cervix, a new study found that daily vaginal progesterone led to fewer complications and less early birth …
Apr 3, 2026

Questions about Pregnancy

Can psychosocial interventions help pregnant women who smoke stop smoking?

Yes, psychosocial interventions like counseling and incentives help pregnant women quit smoking, with moderate-quality evidence from large reviews.

Full answer →