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Home › Medications › propofol

propofol

20 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of propofol

89 trials tracked of propofol: 49 in phase 3 or 4 and 12 with published results. The most-cited published study has 280 citations.

89Trials tracked
49Phase 3 & 4
0Recruiting
12With published results
Phase distribution
Phase 4 36 Phase 3 13 Phase 2 5 Phase 1 2 Other / NA 33
  1. Phase 3 The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure Completed · 280 cited
  2. Phase 4 The Effect of Different Sedation Regimes on Cognitive Function in Lower Gastrointestinal System Endoscopy Completed · 169 cited
  3. Phase 4 UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study Completed · 63 cited
  4. Phase 3 Sugammadex After Continuous Infusion of Rocuronium During Sevoflurane and Propofol Anesthesia (P05949; MK-8616-028) Completed · 54 cited
  5. Phase 4 Total Intravenous Anesthesia in Sinus Surgery Completed · 47 cited
  6. Phase 4 Propofol vs. Midazolam-based Balanced Propofol for Nonanesthesiologist Moderate Sedation in Colonoscopy Completed · 43 cited
Show 44 more trials
  1. Phase 4 Ketamine and Propofol for Upper Endoscopy Completed · 29 cited
  2. Phase 4 Cognitive Functions After TIVA With Dexmedetomidine Completed · 26 cited
  3. Phase 3 Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU1) Completed · 6 cited
  4. Phase 3 Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU2) Completed · 5 cited
  5. Phase 4 Comparison of Bolus Dosing of Methohexital and Propofol in Elective Direct Current Cardioversion Completed · 4 cited
  6. Phase 4 Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy Completed · 2 cited
  7. Phase 4 The Effects of General Anesthetics on Upper Airway Collapsibility in Healthy Subjects Completed
  8. Phase 4 Propofol Versus Alfentanil Versus Nitrous Oxide for Moderate Procedural Sedation Completed
  9. Phase 4 Dexmedetomidine Versus Propofol in Vitreoretinal Surgery Completed
  10. Phase 4 Patient Satisfaction With Propofol for Out Patient Colonoscopy Completed
  11. Phase 4 The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI) Completed
  12. Phase 4 Moderate Versus Deep Procedural Sedation With Propofol in the Emergency Department Completed
  13. Phase 4 Propofol and Dexmedetomidine Versus a Propofol Only Regimen for Sedation During Colonoscopy Completed
  14. Phase 4 Propofol in Emergence Agitation Completed
  15. Phase 4 Dexmedetomidine and Propofol for Pediatric MRI Sedation Completed
  16. Phase 4 Study of Sedative Medications in Patients With Severe Infection and Respiratory Failure Completed
  17. Phase 4 Neuroimaging of Anesthetic Modulation of Human Consciousness Completed
  18. Phase 4 Recovery Profile Comparison Between Remifentanil-propofol or Desflurane Anesthesia Monitored With Bispectral Index. Completed
  19. Phase 4 Opioid-Free Shoulder Arthroplasty Completed
  20. Phase 4 Propofol for Pediatric Tracheal Intubation With Deep Anesthesia During Sevoflurane Induction Completed
  21. Phase 4 Safety and Efficacy of Dexmedetomidine (DEX) for Sedation of Subjects ≥1 Month to <17 Years Undergoing MRI Scans Completed
  22. Phase 4 Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain Completed
  23. Phase 4 Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea Completed
  24. Phase 4 Desflurane or Propofol Anesthesia in Elderly Obese Patients Undergoing Total Knee Replacement Completed
  25. Phase 4 Efficacy of Propofol or Midazolam Compare to Placebo for Preoperative Medication Completed
  26. Phase 4 Propofol Administered by Gastroenterologists by Target Controlled Infusion Pump During Endoscopy Completed
  27. Phase 4 Propofol Versus Ketamine for Moderate Procedural Sedation in the Emergency Department (ED) Completed
  28. Phase 4 Dexmedetomidine vs Propofol TIVA (Total Intravenous Anesthesia) and Interscalene Block Completed
  29. Phase 4 Propofol Versus Sevoflurane Recovery After Gynecological Surgery Completed
  30. Phase 4 Regimen of Alfentanil in Propofol Sedative Fibro-bronchoscopy Completed
  31. Phase 4 Efficacy and Safety Profiles of Combination Sedation Propofol With Midazolam and Meperidine. Completed
  32. Phase 4 Stress During Deep Sedation With Propofol With and Without Alfentanil Completed
  33. Phase 4 Randomized Clinical Trial of Propofol, 1:1 and 4:1 Combination of Propofol and Ketamine for Procedural Sedation Completed
  34. Phase 4 Effects of General Anesthesia and Spinal-Morphine Anesthesia on Recovery and Comfort After Benign Abdominal Hysterectomy Completed
  35. Phase 3 Low-dose Propofol for Pediatric Migraine Completed
  36. Phase 3 Propofol in Obese Children Completed
  37. Phase 3 Evaluate Use of Caudal Nerve Blocks in Adult Penile Prosthesis Completed
  38. Phase 3 Efficacy and Safety of HSK3486 Compared to Propofol in Induction of General Anesthesia in Adults Having Elective Surgery Completed
  39. Phase 3 Efficacy and Safety of HSK3486 Compared to Propofol for Adults Undergoing Elective Surgery With General Anesthesia Completed
  40. Phase 3 Safety and Efficacy of HSK3486 Compared to Propofol for Induction of General Anesthesia in Adults With Elective Surgery Completed
  41. Phase 3 Use of a Modified Propofol Emulsion in Adults Completed
  42. Phase 3 Xenon Compared to Sevoflurane and Total Intravenous Anaesthesia for Coronary Artery Bypass Graft Surgery Completed
  43. Phase 3 Evaluate the Use of Paravertebral Block in Reconstructive Breast Surgery Completed
  44. Phase 2 Analgesic Effect of IV Acetaminophen in Tonsillectomies Completed

Showing the 50 most-cited and recently-updated of 89 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Narrative review on remimazolam reversal with flumazenil versus propofol sedation
Rheumatology Meta-analysis
Narrative review on remimazolam reversal with flumazenil versus propofol sedation New Sedation Reversal Method Cuts Recovery Time by 4 Minutes
This narrative review synthesizes evidence on flumazenil reversal of remimazolam-induced sedation compared to propofol-based sedation.
A new sedation reversal method helps patients wake up four minutes faster after procedures while reducing breathing and blood pressure issue…
Frontiers Apr 20, 2026
Preoperative femoral nerve block reduces rebound pain after knee arthroplasty versus postoperative block
Rheumatology RCT
Preoperative femoral nerve block reduces rebound pain after knee arthroplasty versus postoperative block Give Nerve Block Before Surgery To Stop Pain
In an RCT of 186 patients undergoing total knee arthroplasty, preoperative femoral nerve block with ropivacaine reduced rebound pain inciden…
Getting a pain-numbing shot before knee surgery cuts rebound pain in half, helps patients sleep better, and reduces the need for strong pain…
Frontiers Apr 10, 2026
Pilot RCT assesses feasibility of comparing propofol vs. sevoflurane anesthesia for stroke thrombectomy
Neurology RCT
Pilot RCT assesses feasibility of comparing propofol vs. sevoflurane anesthesia for stroke thrombectomy Pilot study tests feasibility of comparing anesthesia types for stroke surgery
A pilot RCT enrolled 93 patients undergoing endovascular thrombectomy for acute ischemic stroke to assess the feasibility of comparing propo…
A pilot study testing two anesthesia types for stroke surgery found the research process worked well without showing differences in patient …
Apr 9, 2026
Regional anesthesia with propofol sedation versus general anesthesia in unilateral total knee arthroplasty patients
Rheumatology Cohort
Regional anesthesia with propofol sedation versus general anesthesia in unilateral total knee arthroplasty patients Numb Legs, Faster Walks: New Knee Surgery Data
This retrospective cohort study evaluated 250 patients undergoing unilateral total knee arthroplasty to compare regional anesthesia with mon…
New knee surgery data shows regional anesthesia leads to faster walking and fewer readmissions without increasing dangerous blood clot risk.
Frontiers Apr 9, 2026
Outpatient IV sedation for dental care in special needs patients shows 3.3% minor complication rate
Dermatology Cohort
Outpatient IV sedation for dental care in special needs patients shows 3.3% minor complication rate Study describes use of IV sedation for dental care in patients with special needs
A retrospective cohort study of 212 special health care needs patients (mean age 11.1 years) undergoing outpatient IV sedation for dental pr…
Over 2,200 dental procedures were safely performed on children with autism and Down syndrome using IV sedation at a Venezuelan clinic, with …
Frontiers Apr 8, 2026
Literature review associates TIVA and regional anesthesia with better immune preservation in cancer surgery
Rheumatology Cohort
Literature review associates TIVA and regional anesthesia with better immune preservation in cancer surgery Anesthesia choices during cancer surgery may affect immune function and recurrence risk
A literature review synthesizing clinical trials, cohort studies, and meta-analyses suggests total intravenous anesthesia with propofol and …
Choosing anesthesia with propofol and regional blocks may help preserve immune cells that fight cancer, while high-dose opioids can reduce t…
Frontiers Apr 7, 2026
Remimazolam infusion associated with easier mask ventilation than propofol during anaesthesia induction
Emergency Medicine RCT
Remimazolam infusion associated with easier mask ventilation than propofol during anaesthesia induction Small study finds remimazolam may ease mask ventilation during anesthesia induction
In a randomised trial of 76 adults undergoing elective surgery, continuous remimazolam infusion was associated with less mask ventilation di…
Patients given remimazolam had easier breathing through a mask and more stable blood pressure during surgery induction compared to propofol.
Apr 2, 2026
Remimazolam noninferior to propofol for ICU sedation in postoperative cancer patients
Drug Pipeline
Remimazolam noninferior to propofol for ICU sedation in postoperative cancer patients A new sedative for cancer surgery patients may cause fewer dangerous drops in blood pressure
A single-center noninferiority RCT of 80 postoperative cancer patients requiring mechanical ventilation found remimazolam achieved comparabl…
A new sedative for cancer surgery patients causes fewer dangerous drops in blood pressure and breathing slowdowns compared to the standard d…
Frontiers Mar 31, 2026