Population study links PALB2 variants to increased cancer risk and mortality in two large cohorts
Large study finds PALB2 gene variant linked to higher cancer risk and mortality
A case-control study of over 636,000 adults from UK Biobank and Geisinger MyCode cohorts found heterozygous PALB2 pathogenic/likely pathogen…
A common gene variant called PALB2 is linked to higher odds of breast, pancreatic, and other cancers plus reduced survival compared to peopl…
Phase Ib trial: Mam-A DNA vaccine plus endocrine therapy induces T cells in ER+ breast cancer
Can a breast cancer vaccine help the immune system target tumors?
A phase Ib clinical trial in 21 patients with estrogen receptor-positive breast cancer prior to surgery found that adding Mammaglobin-A DNA …
A breast cancer vaccine triggered specific immune cells to attack tumors in early trial patients, showing promising biological activity befo…
Observational genomic study of over 500 Indian breast tumors identifies novel mutations and subtypes
Study maps genetic landscape of breast cancer tumors from over 500 patients in India
An observational study analyzed whole-genome and transcriptome data from over 500 treatment-naive breast tumors in India. It identified nove…
A genetic map of breast cancer in over 500 Indian patients reveals new mutations that help tumors evade the immune system and predict recurr…
Meta-analysis finds BMI affects pCR rates in breast cancer patients receiving neoadjuvant chemotherapy
Body weight may affect breast cancer treatment response, large analysis suggests
A systematic review and meta-analysis of 15,235 breast cancer patients undergoing neoadjuvant chemotherapy found that overweight or obese pa…
Overweight or obese women with breast cancer are less likely to achieve a complete response to chemotherapy before surgery, a large analysis…
NAUTILUS RCT reports 11.2% ALN metastasis rate in SLNB arm for cT1-2/N0 breast cancer
Study details baseline characteristics in breast cancer trial testing lymph node biopsy omission
This randomized controlled trial of 1,734 cT1-2/N0 breast cancer patients reports baseline characteristics and axillary lymph node status. I…
Patients with early-stage breast cancer and small tumors might skip a painful arm surgery if their cancer hasn't spread, based on new trial …
Single-fraction stereotactic partial breast irradiation shows promising early control in early-stage breast cancer
Can a single radiation dose protect women after breast cancer surgery?
A prospective single-institution phase 2 trial of 148 patients with early-stage breast cancer after breast-conserving surgery found single-f…
A single radiation dose for breast cancer recovery showed low recurrence and mild side effects in early results from a new treatment approac…
Aerobic exercise correlates with BDNF methylation changes and cognitive improvements in breast cancer survivors
Exercise linked to brain function changes in women with breast cancer
This RCT substudy of 117 women with early-stage breast cancer found that six months of aerobic exercise correlated with methylation changes …
Aerobic exercise in women with breast cancer changed brain health molecules linked to better attention and mental flexibility after six mont…
Observational study finds association between social determinants and mammography use in US women
What keeps women from getting mammograms? New study points to life circumstances.
An observational study of women in the United States described an association between social determinants of health/health-related social ne…
Stable housing and reliable transportation are key to getting mammograms, as a new study links these life circumstances to cancer screening …
Risk-stratified breast cancer screening shows high acceptance of de-escalation in low-risk women
Study tests personalized breast cancer screening schedules based on risk
A randomized trial in 1,801 women aged 50-67 tested a risk-stratified screening program using the CanRisk model. After 292 days, only 3.8% o…
Women at low breast cancer risk were comfortable waiting up to four years for their next mammogram instead of the standard two-year schedule…
Cryoablation shows 3.64% 5-year recurrence in selected early-stage breast cancer patients
Cryoablation shows low recurrence rate in early-stage breast cancer after six years
A prospective phase 2 multicenter study of 83 women aged ≥50 with stage I, HR+, HER2-, node-negative invasive ductal carcinoma found a 5-yea…
Cryoablation kept early-stage breast cancer from returning in 97.6% of women over six years, with no serious side effects reported in this s…
Breast asymmetry analysis from mammograms shows association with short-term breast cancer risk
Can a mammogram's hidden patterns predict short-term breast cancer risk?
A matched case-control study in women with mammograms near diagnosis found that bilateral breast asymmetry measures were associated with bre…
Hidden patterns in raw mammogram images linked to breast cancer risk fade when pictures are processed for doctors to review.
Qualitative study finds cautiously positive attitudes toward AI in breast cancer screening in Serbia
Radiologists and women in Serbia show cautious openness to AI in breast cancer screening
A qualitative cohort study of radiologists and screening-aged women in Serbia found cautiously positive attitudes toward AI use in breast ca…
Serbian radiologists and women support using AI in breast cancer screening, but they remain cautious until safety and effectiveness are prov…