Low OT-NLR predicts superior survival in recurrent/metastatic HNSCC treated with cetuximab plus nivolumab
A Simple Blood Ratio May Predict Cancer Drug Success
This Phase II clinical trial evaluated patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) receiving combine…
A low white blood cell ratio found in blood tests predicts better survival and treatment response for advanced head and neck cancer patients…
Breg-related gene signature predicts survival and immune landscape in head and neck squamous cell carcinoma
Your Immune System Holds a Hidden Clue to Head and Neck Cancer Survival
This cohort study analyzed patients with head and neck squamous cell carcinoma (HNSCC) using bioinformatics data from TCGA and GEO databases…
A new eight-gene test predicts head and neck cancer survival better than standard measures, helping doctors identify which patients might be…
Regional motif diversity score in cfDNA predicts pembrolizumab response in head and neck cancer
Can a DNA pattern predict who will heal from head and neck cancer immunotherapy?
A phase II trial in 68 patients with locally advanced, resectable HNSCC found that a regional motif diversity score (rMDS) in cell-free DNA …
A new DNA pattern in blood can reliably predict which head and neck cancer patients will respond to immunotherapy and live longer without th…
Research across Head and Neck Cancer
Related studies from across the Head and Neck Cancer family.
Advanced experimental models and computational tools provide dynamic frameworks for understanding oral disease progression
New Research Tools Help Map Complex Oral Diseases
This mini-review examines the integration of advanced experimental models, such as organ-on-chip systems and patient-derived organoids, with…
Advanced modeling and AI tools are helping researchers better understand the molecular causes behind conditions like gum disease and oral ca…
Microbial metabolites may promote or suppress cancer progression through inflammation, DNA damage, or immune modulation
Microbial metabolites may drive cancer growth or stop it through inflammation and DNA damage
This narrative review examines the role of microbial metabolites in carcinogenesis and cancer progression across multiple malignancies. The …
Microbial metabolites can promote cancer growth via inflammation or suppress it through immune changes, but we need more proof before using …
Molecular markers may improve risk assessment in oral potentially malignant disorders
Molecular tools may improve risk assessment for oral lesions
This narrative review examines the limitations of conventional histopathological grading for oral potentially malignant disorders (OPMDs) an…
A review suggests molecular methods could better assess risk for oral potentially malignant disorders where standard grading is unreliable.
Aspiration pneumonia affects 74.8% of head and neck cancer patients after chemoradiotherapy
Aspiration pneumonia strikes most head and neck cancer patients after chemoradiation
This supplementary analysis of a phase II/III trial in Japan found that 74.8% of 151 patients with resected high-risk head and neck cancer d…
Three in four head and neck cancer patients develop aspiration pneumonia after chemoradiation. Severe swallowing problems and reconstruction…
Radiotherapy and chemotherapy show no clear link to obstructive sleep apnea in head and neck cancer patients
Radiation for head and neck cancer may raise sleep apnea risk
This scoping review with exploratory meta-analysis of 13 studies found no significant association between radiotherapy or chemotherapy and i…
A review of 13 studies suggests a possible link between radiation for head and neck cancer and mild sleep apnea, but the evidence is too wea…
Robot-assisted oesophagectomy shows non-inferior survival in oesophageal squamous cell carcinoma
Robot-assisted surgery may improve survival for oesophageal cancer patients
A randomised trial compared robot-assisted versus thoracoscopic oesophagectomy for resectable oesophageal squamous cell carcinoma. The autho…
A large trial found robot-assisted oesophagectomy linked to higher five-year survival than thoracoscopic surgery for oesophageal squamous ce…
Scoping review of AI for head and neck cancer risk stratification
AI techniques show promise for staging head and neck cancer
This scoping review synthesized 44 studies on AI techniques for risk stratification in head and neck cancer. The authors found moderate to h…
A review of 44 studies suggests artificial intelligence could help predict cancer spread in head and neck cases, though more testing is need…
Narrative review covers diagnostic and treatment strategies for metastatic head and neck cancer with no identifiable primary tumor
Doctors use many tools to treat head and neck cancer when the main tumor is hidden
This narrative review addresses diagnostic and treatment strategies for metastatic cases of head and neck cancer with no identifiable primar…
When head and neck cancer spreads but the original spot is missing, doctors use many tools. Imaging, special tests, and surgery help find th…
Evidence mapping review on nutritional prehabilitation for head and neck cancer patients
Nutritional prehabilitation improves outcomes for head and neck cancer patients
This evidence mapping review synthesized 6 systematic evaluations, 13 randomized controlled trials, and 4 observational studies on pretreatm…
Nutritional prehabilitation helps patients with head and neck cancer by improving their nutritional status and quality of life while reducin…
Systematic review and meta-analysis of ML with cfDNA for cancer detection across stages
Simple blood test spots early cancer without scary scans
This systematic review and meta-analysis of 109 articles synthesized diagnostic performance of machine learning with circulating cell-free D…
• AI analyzes blood fragments to catch hidden cancers early • Helps people avoid painful biopsies and late diagnoses • Still in labs not rea…
Meta-analysis finds sex-based differences in ICI survival benefit for advanced gastroesophageal cancer
Immunotherapy Works Differently for Men and Women with Stomach Cancer
This meta-analysis of 15 RCTs examined immune-checkpoint inhibition for advanced gastroesophageal cancer. It found a significant overall sur…
Men with esophageal cancer gain a clear survival edge from immunotherapy, while women do not, but both sexes benefit similarly in stomach ca…
Narrative review explores mitochondrial-targeted therapeutics for oral squamous cell carcinoma
New drug strategy targets mouth cancer's hidden power source
This narrative review discusses the potential of mitochondrial-targeted therapeutics in oral squamous cell carcinoma (OSCC). The authors syn…
Targeting the cell's power source could help overcome stubborn mouth cancer resistance.
Questions about Head and Neck Squamous Cell Carcinoma
What is the objective response rate for becotatug vedotin in recurrent head and neck cancer?
Becotatug vedotin showed a 20.9% objective response rate in recurrent or metastatic head and neck squamous cell carcinoma after prior therapy.
Full answer →Does reducing radiotherapy doses lower toxicity in head and neck squamous cell carcinoma?
Yes, reducing radiotherapy doses through margin reduction, adaptive planning, or proton therapy can lower acute and late toxicity in head and neck squamous cell carcinoma, though clinical benefits may be modest in unselected patients.
Full answer →What are the risks of HPV-associated head and neck squamous cell carcinoma?
HPV-associated head and neck squamous cell carcinoma risks include persistent HPV infection (especially HPV16), distinct metabolic changes, and epigenetic dysregulation, but these tumors often have a better prognosis than HPV-negative cancers.
Full answer →How do therapeutic cancer vaccines work for head and neck squamous cell carcinoma?
Therapeutic cancer vaccines train the immune system to recognize and attack HNSCC cells by targeting tumor-specific antigens, but achieving durable responses remains challenging.
Full answer →