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Home › Conditions › Infertility

Infertility

Subtypes of Infertility

Male Infertility 5 Diminished ovarian reserve 3 Asthenozoospermia 2

34 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Infertility

84 trials tracked for Infertility: 51 in phase 3 or 4 and 16 with published results. The most-cited published study has 540 citations.

84Trials tracked
51Phase 3 & 4
0Recruiting
16With published results
Phase distribution
Phase 4 27 Phase 3 24 Phase 2 6 Phase 1 2 Other / NA 25
  1. Phase 3 S0230 Goserelin in Preventing Ovarian Failure in Women Receiving Chemotherapy for Breast Cancer Completed · 540 cited
  2. Phase 3 Evidence-based Stimulation Trial With Human rFSH in Europe and Rest of World 1 Completed · 285 cited
  3. Phase 4 Safety and Efficacy of Pre-defined, Fixed Dose of Gonal-f Pen Based on Subject Baseline Characteristics in Subjects Undergoing in Vitro Fertilization (IVF) Completed · 120 cited
  4. Phase 4 Combined Letrozole and Clomid in Women With Infertility and PCOS Completed · 96 cited
  5. Phase 3 Phase 3 Study to Evaluate the Efficacy and Safety of Pergoveris® in Assisted Reproductive Technology (ESPART) Completed · 92 cited
  6. Phase 3 Efficacy and Safety of FE 999049 in Controlled Ovarian Stimulation in Japanese Women Completed · 69 cited
Show 44 more trials
  1. Phase 4 Effect of hCG on Receptivity of the Human Endometrium Completed · 65 cited
  2. Phase 4 MENOPUR® in a Gonadotropin-Releasing Hormone (GnRH) Antagonist Cycle With Single-Blastocyst Transfer in a High Responder Subject Population Completed · 50 cited
  3. Phase 4 Sonographic Hysterosalpingography: Oil vs Water Based Media (SHOW Trial) Completed · 47 cited
  4. Phase 4 Sexual Absorption of Vaginal Progesterone Completed · 40 cited
  5. Phase 3 Evidence-based Stimulation Trial With Human rFSH in Europe and Rest of World 2 Completed · 20 cited
  6. Phase 4 Endometrial Markers and Response of Endometriosis Patients to Prolonged GnRH Agonist Prior to IVF Completed · 19 cited
  7. Phase 4 Follicular Steroid Genesis in Controlled Ovarian Stimulation Completed · 10 cited
  8. Phase 3 Administration of Follicle-stimulating Hormone (FSH) and Low Dose Human Chorionic Gonadotropin (hCG) for Oocyte Maturity While Decreasing hCG Exposure in In Vitro Fertilization (IVF) Cycles Completed · 7 cited
  9. Phase 3 Recombinant FSH Investigation in the Treatment of Infertility With Assisted Reproductive Technology (ART) (RITA-1) Completed · 1 cited
  10. Phase 3 A Trial to Compare the Ovarian Response of REKOVELLE and GONAL-F in Conventional Dosing in Women Undergoing Controlled Ovarian Stimulation Completed
  11. Phase 4 Maximal Stimulation and Delayed Fertilization for Diminished Ovarian Reserve: a Randomized Pilot Study Completed
  12. Phase 4 A Non-inferiority Trial on Pain Relief During Oocyte Retrieval Completed
  13. Phase 4 FSH in GnRH-AntagoniST Controlled Ovarian Hyperstimulation Cycles (FAST) Completed
  14. Phase 4 RCT of Fixed vs Titrated Letrozole in Breast Cancer Patient Undergoing IVF Completed
  15. Phase 4 Ovulation Trigger With hCG Compared to GnRH Agonist in Patients With Repeated IVF Failures Completed
  16. Phase 4 Menopur Mixed Protocol Completed
  17. Phase 4 Predictive Factors for Ovarian Stimulation Using a Fixed Daily Dose of 200 IU Recombinant FSH (Study 142003)(P05696) Completed
  18. Phase 4 Menopur® Versus Follistim® in Polycystic Ovarian Syndrome (PCOS) Completed
  19. Phase 4 Use of High Cost Monitoring During Letrozole Ovulation Induction Completed
  20. Phase 4 Study to Examine Effect of Recombinant Luteinizing Hormone (r-Lh) and Recombinant Human Chorionic Gonadotropin (r-hCG) for Ovarian Stimulation in Assisted Reproduction Techniques (ART) Completed
  21. Phase 4 Progesterone Serum Levels in Subfertile Female Patients Undergoing in Vitro Fertilisation (IVF) Completed
  22. Phase 4 The Evaluation of Recombinant LH Supplementation in Patients With Suboptimal Response to Recombinant FSH Undergoing ICSI Completed
  23. Phase 4 CONSORT Randomized Controlled Trial in Assisted Reproductive Technology Completed
  24. Phase 4 MENOPUR® Versus FOLLISTIM® Completed
  25. Phase 4 The Influence of Adjuvant Medical Treatment of Peritoneal Endometriosis on the Outcome of IVF. A Prospective Randomized Analysis. Completed
  26. Phase 4 A Study of the Efficacy and Safety of Highly Purified Menotrophin Versus Recombinant Follitropin Alfa Completed
  27. Phase 4 Trial Comparing hCG Triggering Versus hCG Associated With GnRH Agonist Completed
  28. Phase 4 Comparison of Crinone 8% Intravaginal Gel and IM Progesterone Supplementation for In Vitro Fertilization (IVF) Completed
  29. Phase 4 Concomitant Administration of FSH With HCG Improves Oocyte Maturation and Quality Double -Blinded Randomized Trial Completed
  30. Phase 3 Multi-centre Study to Compare Efficacy and Safety of AFOLIA and Gonal-f in Women for Assisted Reproductive Treatment Completed
  31. Phase 3 Phase III Study Comparing Efficacy and Safety of AFOLIA vs Gonal-f® RFF in Women (35 to 42) Undergoing IVF Completed
  32. Phase 3 Convenience and Safety of Assisted Reproductive Technology Procedures Using a Gonal-F Filled by Mass (Fbm) Liquid Formulation Applied by Pen for Ovulation Induction and In-vitro Fertilization Completed
  33. Phase 3 A Randomised Trial Using Highly Purified Human Chorionic Gonadotropin (HP-hCG) and Recombinant Human Chorionic Gonadotropin (rhCG) in Women Undergoing Controlled Ovarian Stimulation Completed
  34. Phase 3 Comparison of MENOPUR Liquid and Powder in Women Undergoing Assisted Reproductive Technology (ART) Completed
  35. Phase 3 Efficacy and Tolerability of Human FSH Versus Recombinant FSH (Follitropin Alpha) in ICSI. Completed
  36. Phase 3 Frozen-thawed Embryo Transfer (FTET) Cycle Follow-up Protocol (P06031) Completed
  37. Phase 3 MENOPUR in Gonadotrophin-releasing Hormone (GnRH) Antagonist Cycles With Single Embryo Transfer Completed
  38. Phase 3 Efficacy Study of Granulocyte-macrophage Colony Stimulating Factor (GM-CSF) for Use in Human IVF Completed
  39. Phase 3 A Prospective Study to Evaluate the Addition of Subcutaneous Recombinant Human-Luteinizing Hormone With Recombinant Human-Follicle Stimulating Hormone on Follicular Development in Women Undergoing Ovarian Stimulation for Assisted Reproductive Technologies Completed
  40. Phase 3 SJ-0021 (Gonalef®) Versus Purified Pituitary Gonadotropin (Fertinorm-P®) for Ovulation Induction in Japanese Infertile Women Completed
  41. Phase 3 Safety and Efficacy Study in in Vitro Fertilisation (IVF) Patients Completed
  42. Phase 3 To Investigate Efficacy and Safety of a Single Injection of Org 36286 for Ovarian Stimulation Using Daily Recombinant FSH as Reference (Ensure)(P05690/MK-8962-001) Completed
  43. Phase 3 Does Endometrial Injury Improve Intrauterine Insemination Outcome? Completed
  44. Phase 3 Comparative Study Between Minidose Long Protocol and Microdose Flare Protocol in Controlled Ovarian Hyperstimulation Completed

Showing the 50 most-cited and recently-updated of 84 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Narrative review links ultra-processed food to obesity and multiple metabolic conditions
Nutrition & Obesity Medicine Sys. Review
Narrative review links ultra-processed food to obesity and multiple metabolic conditions Is Ultra-Processed Food Driving Obesity And Infertility
This narrative review examines the association between ultra-processed food (UPF) consumption and adverse health outcomes.
Ultra-processed foods might hurt your health by causing weight gain or by acting directly on your body without weight gain at all.
Frontiers Apr 29, 2026
Vaginal and semen microbiota parameters in 475 infertile couples undergoing IVF
Infectious Disease Cohort
Vaginal and semen microbiota parameters in 475 infertile couples undergoing IVF Microbes in semen and vaginal fluid do not match up for IVF success
This retrospective cohort study evaluated baseline clinical, biochemical, and microbiological parameters in 475 infertile couples undergoing…
New data shows that the germs living in a woman and man do not match up, which could change how doctors predict IVF success rates for patien…
Frontiers Apr 29, 2026
Systematic review and meta-analysis of Zishen Yutai Pill for IVF-ET outcomes
Drug Pipeline Meta-analysis
Systematic review and meta-analysis of Zishen Yutai Pill for IVF-ET outcomes Zishen Pill Boosts IVF Success Rates
This systematic review and meta-analysis of 5,660 participants undergoing IVF-ET found that Zishen Yutai Pill was associated with significan…
Imagine waiting months for a pregnancy test.
Frontiers Apr 24, 2026
Dydrogesterone vs micronized progesterone for ongoing pregnancy in frozen embryo transfer
Drug Pipeline RCT
Dydrogesterone vs micronized progesterone for ongoing pregnancy in frozen embryo transfer New Fertility Drug Option May Be Easier to Use, But Is It as Effective?
This pilot randomized controlled trial compared dydrogesterone to micronized vaginal progesterone in 150 women undergoing artificial cycle f…
For many women trying to get pregnant through IVF, the final step can feel uncomfortable.
Frontiers Apr 24, 2026
Narrative review of TCM active ingredients for asthenozoospermia notes current knowledge gaps and limitations
OB/GYN & Women's Health Sys. Review
Narrative review of TCM active ingredients for asthenozoospermia notes current knowledge gaps and limitations Natural Herbs May Help Fix Sperm Movement Issues
This narrative review examines Traditional Chinese Medicine (TCM) active ingredients, including flavonoids, polysaccharides, saponins, and p…
A new analysis suggests specific plant ingredients could improve sperm quality where standard treatments often fall short.
Frontiers Apr 23, 2026
Systematic review and meta-analysis on LH-active gonadotropins for ovarian stimulation in infertility
Diabetes & Endocrinology Meta-analysis
Systematic review and meta-analysis on LH-active gonadotropins for ovarian stimulation in infertility Adding LH-active hormone to fertility treatment doesn't boost live births
This meta-analysis of 56 RCTs with 14,034 women found little to no difference in live birth or ongoing pregnancy when adding LH-active gonad…
For women using fertility drugs, adding LH doesn't improve live birth or pregnancy odds, but it may slightly lower egg yield without raising…
Frontiers Apr 22, 2026
Systematic review of antioxidant and anti-inflammatory strategies for male infertility and immune-mediated testicular disorders
OB/GYN & Women's Health Sys. Review
Systematic review of antioxidant and anti-inflammatory strategies for male infertility and immune-mediated testicular disorders Sperm Health Tied to Immune System in New Way
This systematic review synthesizes evidence on targeted antioxidant and anti-inflammatory interventions for male infertility and related imm…
John and Maria tried for years to have a baby.
Frontiers Apr 22, 2026
Early follicular androgen levels correlate with oocyte yield in ovarian stimulation cycles
OB/GYN & Women's Health Cohort
Early follicular androgen levels correlate with oocyte yield in ovarian stimulation cycles Early androgen levels may help predict ovarian response during fertility treatment
This retrospective cohort study of 299 stimulation cycles in women undergoing controlled ovarian hyperstimulation found that early follicula…
Higher early androgen levels are linked to better oocyte yield in women undergoing ovarian stimulation, but the connection is not yet proven…
Frontiers Apr 22, 2026
Sperm DNA fragmentation and mitochondrial potential predict IVF outcomes in asthenozoospermia
Diabetes & Endocrinology Cohort
Sperm DNA fragmentation and mitochondrial potential predict IVF outcomes in asthenozoospermia Sperm DNA Test Could Boost Your IVF Success Chances
This retrospective cohort study assessed 320 asthenozoospermic men and 100 controls undergoing IVF.
Checking sperm DNA and energy levels gives a clearer picture of IVF success than standard sperm counts alone.
Frontiers Apr 22, 2026
Endometrial ultrasound parameters predict pregnancy after frozen embryo transfer in infertile patients
Diabetes & Endocrinology Cohort
Endometrial ultrasound parameters predict pregnancy after frozen embryo transfer in infertile patients Ultrasound features may help predict pregnancy after frozen embryo transfer
This cohort study developed a prediction model using endometrial ultrasound parameters in 218 infertile patients undergoing frozen-thawed em…
A new model uses routine ultrasound features to estimate pregnancy chances after frozen embryo transfer, offering personalized guidance for …
Frontiers Apr 22, 2026
L-ergothioneine may improve ovarian reserve markers and symptoms in women with diminished ovarian reserve
Diabetes & Endocrinology Cohort
L-ergothioneine may improve ovarian reserve markers and symptoms in women with diminished ovarian reserve A Mushroom Compound That Nudged Ovaries Back to Life
A small, single-center, open-label, self-controlled trial in 36 women with diminished ovarian reserve found that oral L-ergothioneine (120 m…
Forty women with early ovarian decline saw real improvements in key hormones and better sleep after taking an antioxidant found in mushrooms…
medRxiv Apr 14, 2026
Longer frozen embryo storage linked to lower live birth rates in retrospective cohort study
Diabetes & Endocrinology Cohort
Longer frozen embryo storage linked to lower live birth rates in retrospective cohort study Does an Embryo's Time in the Freezer Matter?
A retrospective cohort study of 4205 infertile patients undergoing frozen-thawed embryo transfer found that storage duration beyond 3 months…
A large new study suggests embryos frozen for more than six months may lead to fewer successful pregnancies, raising questions for patients …
Frontiers Apr 14, 2026

Questions about Infertility

Can ultra-processed food consumption linked to obesity affect metabolic conditions in people with infertility?

Yes, ultra-processed food consumption is linked to obesity and can worsen metabolic conditions in people with infertility by increasing oxidative stress and inflammation.

Full answer →
Does taking Zishen Yutai Pill improve outcomes for patients undergoing IVF-ET for infertility?

Yes, a meta-analysis of 18 RCTs found Zishen Yutai Pill significantly improves clinical pregnancy and live birth rates in women undergoing IVF-ET.

Full answer →
How does having a higher body mass index affect oxidative stress during IVF for infertility?

Higher BMI increases oxidative stress during IVF by reducing antioxidant defenses and increasing lipid peroxidation, which may impair egg quality and treatment success.

Full answer →