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Home › Conditions › Mood Disorders

Mood Disorders

Subtypes of Mood Disorders

Affective disorders 1

13 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Mood Disorders

37 trials tracked for Mood Disorders: 10 in phase 3 or 4 and 4 with published results. The most-cited published study has 20 citations.

37Trials tracked
10Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 4 Phase 3 6 Phase 2 6 Other / NA 21
  1. Phase 3 A Study of Flexible-dose Brexpiprazole as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder, the Delphinus Trial Completed · 20 cited
  2. Phase 4 Stress & Premenstrual Symptoms Study Completed · 17 cited
  3. Phase 3 Safety and Tolerability of Oral OPC-34712 as Adjunctive Therapy in Adults With Major Depressive Disorder (the Orion Trial) Completed · 13 cited
  4. Phase 3 Study of the Safety and Efficacy of Fixed-dose Brexpiprazole (OPC-34712) as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder With and Without Anxious Distress Completed · 7 cited
  5. Phase 4 Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation Completed
  6. Phase 4 A Clinical Trial Via Telepsychiatry of Treatments for the Management of Emotional Dysregulation in Youth Completed
Show 31 more trials
  1. Phase 4 Effects of Epigallocatechin Gallate (EGCG) in Healthy, Young Adults Completed
  2. Phase 3 Study of the Safety and Efficacy of Fixed Dose OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder (the Pyxis Trial) Completed
  3. Phase 3 Study of the Safety and Efficacy of Two Fixed Doses of OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder (the Polaris Trial) Completed
  4. Phase 3 An Open-Label Trial Measuring Satisfaction And Convenience Of Two Formulations Of Lamotrigine In Subjects With A Mood Disorder Completed
  5. Phase 2 A Clinical Trial of Intravenous (IV) Ganaxolone in Women With Postpartum Depression Completed
  6. Phase 2 Comparison of the Analgesic Effects of Dronabinol and Smoked Marijuana in Daily Marijuana Smokers Completed
  7. Phase 2 A Clinical Trial of Oral Ganaxolone in Women With Postpartum Depression Completed
  8. Phase 2 The Effects of Cannabidiol on the Driving Ability of Healthy Adults Completed
  9. Phase 2 Technology Enhanced Family Treatment Completed
  10. Phase 2 Rapid Antidepressant Effects of Ketamine in Major Depression Completed
  11. N/A SimpleC Wellness Platform With Social Robot Interaction Completed
  12. N/A Hostile Interpretation Bias Training to Treat Irritability Completed
  13. N/A Evaluating the Role of Expectations in Response to Caffeine Consumption: An RCT Completed
  14. N/A Brain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART) Completed
  15. N/A Polyunsaturated Fatty Acids (PUFA) Status and Cognitive Function in Healthy Young Adults Completed
  16. N/A Online Yoga for Individuals With Mood Disorders Completed
  17. N/A Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms Completed
  18. N/A One-Day Acceptance and Commitment Training Intervention in Primary Care Patients Completed
  19. N/A The Effects of Cranial Electrotherapy Stimulation (CES) on Brain Function, Brain Chemistry and Mood Completed
  20. N/A VITAL-DEP: Depression Endpoint Prevention in the VITamin D and OmegA-3 TriaL Completed
  21. N/A Managing Cancer and Living Meaningfully Completed
  22. N/A The Impact of the COVID-19 (SARS-CoV-2 Disease) on Psychopathology Completed
  23. N/A Investigational Test of a New Sleep Supplement Completed
  24. N/A Mobile-enhanced Group CBT for Adolescents at Risk Severe Mood Disorders Completed
  25. N/A Efficacy of Sleep Interventions for Posttraumatic Stress Disorder (PTSD) Completed
  26. N/A Evaluating the Effects of Omega-3 Fatty Acids on Heart Disease and Behavior Completed
  27. N/A Reproductive Life Planning for Women With Mental Illness Completed
  28. N/A Transcranial Direct Current Stimulation Therapy for Bipolar Depression Completed
  29. N/A The Emotional, Physical and Cognitive Benefits of Purposeful Green Space Activities on Seniors Completed
  30. N/A Differential Effects of Clomiphene Citrate in Women Undergoing Superovulation Completed
  31. N/A Optimizing Cognitive Remediation Completed

Showing the 37 most-cited and recently-updated of 37 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Meta-analysis finds small habenula volume reductions in mood disorders do not survive correction
Psychiatry Meta-analysis
Meta-analysis finds small habenula volume reductions in mood disorders do not survive correction Brain region volume differences in mood disorders may not be significant after statistical correction
A meta-analysis of 15 samples (1,230-1,236 participants) found small but significant reductions in left and right habenula volume in mood di…
Initial signs of smaller brain regions in mood disorders vanished after rigorous statistical checks, showing early findings often don't hold…
Apr 3, 2026

Questions about Mood Disorders

Does adding high-frequency rTMS and exercise reduce negative emotions in methamphetamine use disorder?

Yes, a 2024 trial found that adding high-frequency rTMS to exercise significantly reduced depression, anxiety, and craving in methamphetamine use disorder compared to exercise alone.

Full answer →