Lorcaserin reduces weight and fat mass, alters lipidomics in 48 adults with obesity over 6 months
Small study finds lorcaserin reduces weight and fat in adults with obesity
A 6-month randomized controlled trial in 48 adults with obesity found lorcaserin (10 mg twice daily) reduced total body weight, total body f…
Adults with obesity taking lorcaserin lost more total weight and abdominal fat than those taking a placebo pill over six months.
Tirzepatide improves patient-reported physical function in adults with overweight or obesity
Tirzepatide may improve physical function for adults with overweight or obesity
A meta-analysis of 4,531 participants found that once-weekly tirzepatide 10 or 15 mg significantly improved physical function scores compare…
Adults with overweight or obesity taking tirzepatide reported better physical function scores on two questionnaires compared to those taking…
Network meta-analysis compares exercise types for insulin resistance in youth with overweight or obesity
Which exercise works best for insulin resistance in kids with extra weight?
A network meta-analysis of 63 RCTs involving 3,286 children and adolescents with overweight or obesity compared exercise modalities.
For kids with extra weight, short bursts of intense exercise best lower insulin levels, while mixing cardio and weights works best for dropp…
Myosteatosis and visceral obesity show small associations with minor postoperative complications after colorectal surgery
Can a routine CT scan predict who struggles to heal after colon surgery?
A prospective RCT substudy of 219 adults undergoing elective colorectal surgery found that myosteatosis and visceral obesity had small but s…
A routine CT scan can spot low muscle quality and high belly fat, which are linked to minor complications after colon surgery.
Phase 1 trial of once-weekly eloralintide shows weight reduction in obesity over 12 weeks
Can a new weekly injection help people lose weight? Early results show promise
A Phase 1 randomised controlled trial in 100 participants with obesity or overweight found that once-weekly subcutaneous eloralintide result…
A new weekly shot helped people with obesity lose between 2.6% and 11.3% of their body weight in early safety testing, though larger studies…
Bariatric surgery associated with lower cardiovascular risks than GLP-1RA therapy in adults with obesity
Study finds bariatric surgery linked to lower heart risks than GLP-1 drugs in adults with obesity
A meta-analysis of observational studies including 39,569 adults with obesity found bariatric surgery was associated with lower risks of mor…
Adults with obesity who had bariatric surgery faced lower risks of death and heart failure than those taking GLP-1 drugs like Wegovy.
GLP-1RA use associated with lower obesity-related cancer risk in meta-analysis of adults with T2DM/obesity
Large review finds link between GLP-1 drugs and lower obesity-related cancer risk
A systematic review and meta-analysis of 3,960,974 adults with type 2 diabetes and/or obesity found GLP-1RA use was associated with a signif…
A large review of studies involving nearly 4 million adults with type 2 diabetes or obesity found that using GLP-1 receptor agonists was ass…
Sarcopenic obesity prevalence is 28% in adults with advanced knee OA and severe obesity
Sarcopenic obesity found in 28% of adults with severe knee osteoarthritis and obesity
A cross-sectional baseline analysis of a pilot RCT (n=50) found sarcopenic obesity prevalence was 28% among adults with advanced knee OA and…
Nearly one-third of adults with severe knee arthritis and obesity have low muscle mass, leading to worse walking distance, function, and qua…
Systematic review maps gut microbiome–epigenetic crosstalk in obesity and type 2 diabetes
What's happening in your gut that might affect your weight and blood sugar?
A systematic review and bibliometric analysis of over 1,100 documents identified three major epigenetic domains involved in gut microbiome c…
Gut bacteria changes linked to obesity and type 2 diabetes may influence genetic switches, with research in this area growing nearly 28% ann…
Mediterranean lifestyle intervention reduces BMI, fat mass in preschool girls at risk of obesity
Could a Mediterranean lifestyle help preschool girls at risk of obesity? A new study suggests it might
In a 12-month RCT of 206 preschoolers at risk of obesity, a Mediterranean lifestyle intervention (diet, physical activity) significantly red…
A Mediterranean lifestyle improved body fat and BMI for preschool girls at risk of obesity, but the same healthy habits did not help boys in…
Feasibility RCT Evaluates Group-Based Weight Management Program for Severe Obesity
Can group support help people with severe obesity lose weight effectively?
A feasibility RCT assessed the PROGROUP intervention for severe obesity, revising its logic model to improve delivery and context assumption…
Group support programs for severe obesity can help people lose weight and keep it off by building strong community identity and habits.
CFT Improves Depression and Emotional Eating in Severe Obesity: RCT Results
Can Kindness to Yourself Help Tackle Obesity and Depression?
In a single-centre RCT with 91 participants, group-based Compassion Focused Therapy (CFT) significantly improved self-compassion, mood, and …
A 10-session therapy teaching self-compassion helped people with severe obesity feel less shame, eat healthier, and improve their mood for m…
Questions about Obesity
Are there rising trends in severe obesity prevalence among children and adolescents in the US?
Data from the US National Health and Nutrition Examination Survey shows that severe obesity in children and adolescents aged 2 to 19 years more than doubled between 1999 and 2018.
Full answer →Does a group-based weight management program work for people with severe obesity?
Group-based programs like PROGROUP and Compassion Focused Therapy show promise for people with severe obesity by improving psychological outcomes and helping deliver complex interventions.
Full answer →How does a low-fat diet affect muscle mass in adults with obesity?
A low-fat diet leads to modest muscle loss in adults with obesity, but combining it with resistance exercise can help preserve muscle.
Full answer →Do women with obesity lose more weight on GLP-1 drugs than men?
Yes, research shows women with obesity tend to lose more weight on GLP-1 drugs than men, though the difference is modest and varies by individual factors.
Full answer →Do digital lifestyle interventions help adults with obesity lose weight?
Yes, stand-alone digital lifestyle interventions help adults with obesity lose weight and improve diet quality, though results vary by program design and engagement.
Full answer →What factors influence eating behaviors in adults with obesity?
Eating behaviors in adults with obesity are influenced by psycho-emotional factors (stress, impulsivity), socio-environmental stressors (work, relationships), and maladaptive patterns like rapid eating and irregular meal timing.
Full answer →Is tirzepatide as effective as sleeve gastrectomy for obesity?
A 2024 network meta-analysis found tirzepatide and sleeve gastrectomy produce equivalent weight loss (about 21% total body weight), but individual results vary and surgery offers durable long-term outcomes.
Full answer →