Systematic review and meta-analysis of oxidative stress biomarkers in older adults with T2DM or Parkinson's disease
Parkinson’s and Diabetes Linked by Hidden Body Damage
This systematic review and meta-analysis evaluated oxidative stress biomarkers in serum, plasma, or leukocytes from 7,521 human subjects age…
Two common diseases may fuel each other through invisible cell damage, making care harder for millions living with both Parkinson's and type…
Literature review synthesizes Schisandra chinensis effects on gut microbiota and metabolic pathways across multiple conditions
This Ancient Berry May Quiet Inflammation From Your Gut to Your Brain
This literature review examines the potential of Schisandra chinensis regarding gut health and metabolic regulation.
An ancient berry used for centuries may rebalance gut bacteria to calm inflammation linked to digestive issues, liver disease, diabetes, and…
SBSPON gene variant rs2291219 linked to higher T2DM risk in Northwest Indian population
A Hidden Gene May Be Quietly Raising Your Type 2 Diabetes Risk
A case-control candidate gene association study in a Northwest Indian population found SBSPON gene expression was significantly higher in in…
A hidden gene linked to higher type 2 diabetes risk may also be shortening the protective caps on DNA inside immune cells, signaling faster …
Systematic review and meta-analysis of Mendelian randomization studies examining T2DM and cancer associations
Diabetes Linked to Two Specific Cancers
This systematic review and meta-analysis of Mendelian randomization studies evaluated the association between type 2 diabetes mellitus and s…
Type 2 diabetes raises the risk of pancreatic and endometrial cancers, according to a new analysis of genetic studies.
Bioinformatics study identifies shared immune genes and potential drugs for PCOS and T2DM
Could existing drugs treat shared genes in PCOS and type 2 diabetes?
A preclinical bioinformatics and experimental validation study analyzed GEO datasets from patients with PCOS and T2DM, identifying 239 commo…
A study identified 239 genes linked to both PCOS and type 2 diabetes, with 40 existing drugs like maraviroc potentially targeting them for n…
Multidisciplinary management in T2DM patients yielded a 29.24% remission rate in a single-arm observational study
Nearly 1 in 3 Reversed Type 2 Diabetes in Special Clinic
This single-arm observational study evaluated 171 patients with Type 2 Diabetes Mellitus receiving remission-oriented treatment at a special…
A special diabetes clinic helped nearly one in three patients reach remission, meaning they no longer needed diabetes pills after six months…
GLP-1RA use shows sex-specific pancreatitis and hypotension risks in T2D second-line therapy study
Diabetes drugs work differently in women than men
A retrospective cohort study of 5.15 million adults with type 2 diabetes compared second-line therapies.
Diabetes drugs work differently for women than men, revealing distinct safety and effectiveness outcomes in a massive study of 5 million adu…
Circulating spexin levels are significantly lower in patients with type 2 diabetes mellitus compared to controls
The Hormone That Goes Missing When Diabetes Arrives
This systematic review and meta-analysis evaluated circulating spexin levels in 1,122 patients with type 2 diabetes mellitus and 681 control…
A little-known hormone called spexin shows up in much smaller amounts in people with type 2 diabetes, hinting at a possible link scientists …
Meta-analysis identifies risk factors for diabetic kidney disease in Asian patients with type 2 diabetes
High Blood Pressure Is A Major Kidney Killer For Asian Diabetics
A meta-analysis of 24 studies including 12,047 Asian patients with type 2 diabetes found that SBP, hypertension, HbA1c, WHR, FBG, UA, Cr, ag…
High blood pressure is a top kidney killer for Asian diabetics, making blood pressure control just as critical as managing sugar levels to p…
Single-dose fultagliptin benzoate pharmacokinetics and safety in patients with mild to moderate renal insufficiency versus healthy volunteers
A New Diabetes Pill That Stays Longer When Kidneys Slow
This Phase I, non-randomized, open-label, parallel-control trial evaluated the pharmacokinetics, pharmacodynamics, and safety of a single or…
A new diabetes pill builds up in the body when kidneys slow, meaning some patients with mild or moderate kidney issues may need half the usu…
MTHFR C677T polymorphism linked to elevated risk of schizophrenia and type 2 diabetes comorbidity in Han Chinese patients
Gene variation linked to higher risk of schizophrenia and diabetes in Chinese patients
This observational cohort study examined Han Chinese patients with comorbid schizophrenia and type 2 diabetes mellitus alongside healthy con…
A specific gene variation linked to schizophrenia and diabetes may serve as a susceptibility factor for these conditions appearing together …
Protocol compares Mediterranean and low-carb diets for diabetes remission in Lebanese adults
Two Diets Go Head-to-Head for Type 2 Diabetes Remission
This randomized controlled trial protocol will compare a low-calorie Mediterranean-style diet to a low-calorie, low-carbohydrate diet for di…
A trial in Lebanon will test if a low-calorie Mediterranean or low-carb diet can put type 2 diabetes into remission, focusing on real-world …
Research across Type 2 Diabetes
Related studies from across the Type 2 Diabetes family.
Once-weekly basal insulin improves HbA1c by 0.09% and time in range over daily regimens
Weekly insulin offers easier management for people with type 2 diabetes
This meta-analysis of 14 randomized controlled trials involving 8,487 subjects found that once-weekly basal insulin analogs provide superior…
A new review of clinical trials shows weekly insulin can manage blood sugar as well as daily shots while reducing the number of injections.
Resveratrol supplementation significantly reduces LDL-C but lacks consistent impact on glycemic indices in type 2 diabetes
Resveratrol fails to improve blood sugar in type 2 diabetes
This umbrella review and meta-analysis of 10 meta-analyses evaluated resveratrol for managing type 2 diabetes. While a significant reduction…
Resveratrol supplements did not lower blood sugar or improve cholesterol in type 2 diabetes, except for a small drop in LDL cholesterol.
SGLT2 inhibitors associated with lower all-cause mortality in heart transplant recipients with type 2 diabetes
SGLT2 inhibitors associated with lower mortality in heart transplant patients
This meta-analysis examined the impact of SGLT2 inhibitor use on outcomes for heart transplant recipients with type 2 diabetes. The authors …
New analysis suggests SGLT2 inhibitors may lower death rates for heart transplant recipients with type 2 diabetes without increasing UTI ris…
Single-incision sleeve plus bypass shows short-term safety and metabolic improvement in 3 patients with obesity and T2DM
SILSG-JJB Procedure Shows Promise for Weight Loss and Diabetes
This case report and review describes 3 female patients with severe obesity and type 2 diabetes who underwent single-incision laparoscopic s…
A new surgical approach may help people with severe obesity and Type 2 Diabetes achieve weight loss and better blood sugar levels.
Transcriptomic analysis identifies 337 high-confidence genes associated with Type 2 Diabetes in human pancreatic islets
Meta-analysis reveals 337 genes linked to type 2 diabetes in islets
This meta-analysis of transcriptomic data from human pancreatic islets identified 337 high-confidence T2D-associated genes. The study also d…
A meta-analysis of human pancreatic islets identified 337 high-confidence genes tied to type 2 diabetes, and a 10-gene panel perfectly disti…
Semaglutide reduces risk of kidney decline or death in type 2 diabetes and CKD
Semaglutide lowers kidney and heart risks in type 2 diabetes patients
This randomized controlled trial enrolled 3,533 participants with type 2 diabetes and chronic kidney disease. Once-weekly subcutaneous semag…
A large trial shows once-weekly semaglutide reduces kidney failure and death risks in people with type 2 diabetes and chronic kidney disease…
GLP-1 receptor agonists may reduce cognitive decline in type 2 diabetes patients with dementia
GLP-1 drugs may slow cognitive decline in type 2 diabetes
A systematic review of systematic reviews and meta-analyses found that GLP-1 receptor agonists are associated with reduced overall cognitive…
A review of reviews suggests GLP-1 drugs like Ozempic may help protect memory and thinking in people with type 2 diabetes.
Evolocumab reduces cardiovascular events in diabetes without known atherosclerosis
Evolocumab cuts heart events in high-risk diabetes patients
This prespecified subgroup analysis of a phase 3 RCT evaluated evolocumab added to statin therapy in 3655 high-risk patients with type 2 dia…
Adding evolocumab to statins reduced heart attacks and strokes by about 30% in high-risk diabetes patients without known heart disease.
Insulin degludec/liraglutide ranks highest for HbA1c reduction with SUCRA value of 89.4%
Comparing Combination Diabetes Drugs for Blood Sugar Control
This network meta-analysis evaluated 12,815 patients with type 2 diabetes to compare fixed-ratio combination products and their individual c…
A review of 12,815 patients found that insulin degludec/liraglutide may be best for lowering blood sugar, but has more side effects than oth…
scFv-based biologics show potential for immunomodulation in type 1 and type 2 diabetes
Review explores scFv biologics for Type 1 and Type 2 diabetes care
This narrative review explores the potential of single-chain variable fragment (scFv)-based biologics for treating type 1 and type 2 diabete…
This review looks at scFv-based biologics for diabetes. It discusses how these treatments might help with immune control and blood sugar bal…
Long-term voglibose use likely caused leukopenia in a 71-year-old man with type 2 diabetes
Switching diabetes drugs reversed low white blood cell counts in a 71-year-old man
This case report describes a 71-year-old male with well-controlled type 2 diabetes who developed leukopenia after long-term voglibose use. W…
A 71-year-old man with type 2 diabetes saw his white blood cell count rise after switching from voglibose to acarbose, suggesting the first …
Metabolic subtypes identify Japanese adults with prediabetes at highest or lowest T2D risk
Japanese adults with prediabetes benefit most from lifestyle changes in one specific metabolic group
This randomized controlled trial enrolled 295 Japanese adults with impaired glucose tolerance in the Japanese Diabetes Prevention Program. P…
A study of 295 Japanese adults found that lifestyle changes work best for those with a specific metabolic pattern. This group had the lowest…
Questions about Type 2 Diabetes Mellitus
Does a higher nutritional risk index lower osteoporosis risk in women with Type 2 Diabetes?
Yes, a higher Geriatric Nutritional Risk Index (GNRI) is linked to lower osteoporosis risk in women with type 2 diabetes, based on multiple studies.
Full answer →Which glucose-lowering therapies work best for heart failure and Type 2 Diabetes?
SGLT-2 inhibitors (like empagliflozin, dapagliflozin) are the most effective glucose-lowering therapies for heart failure in type 2 diabetes, reducing hospitalizations and cardiovascular death.
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