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Home › Conditions › Acute Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome

Subtypes of Acute Respiratory Distress Syndrome

Acute Lung Injury 4 Hyaline membrane disease 1 Neonatal respiratory distress syndrome 1 Preterm Infant Respiratory Distress 0

24 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Acute Respiratory Distress Syndrome

67 trials tracked for Acute Respiratory Distress Syndrome: 12 in phase 3 or 4 and 10 with published results. The most-cited published study has 1406 citations.

67Trials tracked
12Phase 3 & 4
0Recruiting
10With published results
Phase distribution
Phase 4 1 Phase 3 11 Phase 2 23 Phase 1 3 Other / NA 29
  1. Phase 3 Post-exposure Prophylaxis / Preemptive Therapy for SARS-Coronavirus-2 Completed · 1,406 cited
  2. Phase 3 Reevaluation Of Systemic Early Neuromuscular Blockade Completed · 876 cited
  3. Phase 3 Antenatal Late Preterm Steroids (ALPS): A Randomized Placebo-Controlled Trial Completed · 813 cited
  4. Phase 3 Vitamin D to Improve Outcomes by Leveraging Early Treatment Completed · 301 cited
  5. Phase 3 Pre-exposure Prophylaxis for SARS-Coronavirus-2 Completed · 128 cited
  6. Phase 3 Comparison of Aerosol Delivery of Infasurf to Usual Care in Spontaneously Breathing RDS Patients Completed · 91 cited
Show 44 more trials
  1. Phase 3 Dornase Alfa for ARDS in Patients With Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Completed · 75 cited
  2. Phase 3 Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure Completed · 27 cited
  3. Phase 3 A Multi-center Trial to Determine if Curosurf® Reduces the Duration of Mechanical Ventilation in Very Preterm Infants Completed · 19 cited
  4. Phase 3 A Study to Test Whether Different Doses of Alteplase Help People With Severe Breathing Problems Because of COVID-19 Completed · 3 cited
  5. Phase 4 Premedication for Non-Emergency Endotracheal Intubation In the NICU Completed
  6. Phase 3 Nitric Oxide Administration for Acute Respiratory Distress Syndrome Completed
  7. Phase 2 Trial to Assess the Safety and Tolerability of Lucinactant for Inhalation in Premature Neonates Completed
  8. Phase 2 Clinical Trial to Evaluate CERC-002 in Adults With COVID-19 Pneumonia and Acute Lung Injury Completed
  9. Phase 2 Fibrinolytic Therapy to Treat ARDS in the Setting of COVID-19 Infection Completed
  10. Phase 2 Multiple Dosing of Mesenchymal Stromal Cells in Patients With ARDS (COVID-19) Completed
  11. Phase 2 Extracorporeal Membrane Oxygenation (ECMO) in Non-intubated Patients With Acute Respiratory Distress Syndrome (ARDS) Completed
  12. Phase 2 Losartan for Patients With COVID-19 Requiring Hospitalization Completed
  13. Phase 2 LIPS-B: Lung Injury Prevention Study With Budesonide and Beta Completed
  14. Phase 2 Tenecteplase in Patients With COVID-19 Completed
  15. Phase 2 LSALT Peptide vs. Placebo to Prevent ARDS and Acute Kidney Injury in Patients Infected With SARS-CoV-2 (COVID-19) Completed
  16. Phase 2 Efficacy and Safety of Itolizumab in COVID-19 Complications Completed
  17. Phase 2 The Safety and Efficacy of Lucinactant for Inhalation in Premature Neonates 26 to 32 Weeks Gestational Age Completed
  18. Phase 2 Safety, Tolerability and Preliminary Efficacy of FP-1201 in ALI and ARDS. Phase I/II Completed
  19. Phase 2 Double-blind, Randomized, Controlled Clinical Trial to Assess Efficacy of MSC in Patients With COVID-19 ARDS Completed
  20. Phase 2 A Study of APL-9 in Adults With Mild to Moderate ARDS Due to COVID-19 Completed
  21. Phase 2 Losartan for Patients With COVID-19 Not Requiring Hospitalization Completed
  22. Phase 2 Use of UC-MSCs for COVID-19 Patients Completed
  23. Phase 2 Vadadustat for the Prevention and Treatment of Acute Respiratory Distress Syndrome (ARDS) in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) Completed
  24. Phase 2 Mesenchymal Stromal Cells for the Treatment of SARS-CoV-2 Induced Acute Respiratory Failure (COVID-19 Disease) Completed
  25. Phase 2 LIPS-A: Lung Injury Prevention Study With Aspirin Completed
  26. Phase 2 Ganciclovir/Valganciclovir for Prevention of CMV Reactivation in Acute Injury of the Lung and Respiratory Failure Completed
  27. Phase 2 A Phase II Randomized Trial of Fish Oil in Patients With Acute Lung Injury (ALI) Completed
  28. Phase 2 Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery Completed
  29. Phase 2 Extracellular Vesicle Infusion Treatment for COVID-19 Associated ARDS Completed
  30. Phase 1 Effects of TNX-832 (Sunol cH36) in Subjects With Acute Lung Injury/Acute Respiratory Distress Syndrome Completed
  31. Phase 1 Defibrotide Therapy for SARS-CoV2 (COVID-19) Acute Respiratory Distress Syndrome (ARDS) Completed
  32. Phase 1 Human Mesenchymal Stem Cells For Acute Respiratory Distress Syndrome Completed
  33. N/A Restore Resilience in Critically Ill Children Completed
  34. N/A A Study Promoting Critical Illness Recovery in the Elderly Completed
  35. N/A Ventilator-induced Lung Injury Vortex in Patients With SARS-CoV-2 Completed
  36. N/A Comparative Effectiveness Study of Bubble CPAP Devices in the NICU Completed
  37. N/A Prehospital Telemedicine Feasibility/Acceptability Pilot Completed
  38. N/A Early PP With HFNC Versus HFNC in COVID-19 Induced Moderate to Severe ARDS Completed
  39. N/A The Role of Circulating Soluble CD74 in Acute Lung Injury Completed
  40. N/A A Comparison of Methods of Discontinuing Nasal CPAP in Premature Infants <30 Weeks Gestation Completed
  41. N/A Retrospective Review of Mechanically Ventilated Patients Using a Continuous Data Collection System. Completed
  42. N/A ED Lung Protective Ventilation to Reduce Complications Completed
  43. N/A Implementation of Nudges to Promote Utilization of Low Tidal Volume Ventilation (INPUT) Study Completed
  44. N/A Trial of Non Invasive Ventilation for Respiratoy Distress Syndrome Completed

Showing the 50 most-cited and recently-updated of 67 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
LISA and ENSURE show similar need for ventilation in preterm neonates with respiratory distress syndrome
Pediatrics RCT
LISA and ENSURE show similar need for ventilation in preterm neonates with respiratory distress syndrome Two Ways To Save Tiny Lungs Work Equally Well
An open-label, single-center RCT in 118 preterm neonates requiring surfactant therapy found no difference in need for invasive mechanical ve…
When a preemie's lungs fail, how doctors deliver the life-saving medicine may matter less than how carefully they follow the plan.
Apr 16, 2026
Umbilical cord-derived mesenchymal stromal cells for severe COVID-19 ARDS show qualitative improvement and tolerability
Pulmonology & Critical Care RCT
Umbilical cord-derived mesenchymal stromal cells for severe COVID-19 ARDS show qualitative improvement and tolerability Fresh Cells Help Severe Lungs Recover
This randomized controlled trial summary included 37 patients with severe COVID-19 acute respiratory distress syndrome receiving freshly cul…
Freshly cultured cells from umbilical cords helped patients with severe COVID-19 lung damage recover faster and feel better for months.
Apr 16, 2026
LSTM-based model showed improved ventilator triggering metrics compared to Auto-Trak in a small trial
Pulmonology & Critical Care
LSTM-based model showed improved ventilator triggering metrics compared to Auto-Trak in a small trial Smarter Ventilators May Finally Breathe in Sync With You
This clinical trial evaluated an LSTM-based model versus an Auto-Trak model for ventilator triggering control in 10 volunteers and 5 patient…
A new AI-powered breathing machine controller may reduce the dangerous mismatch between a ventilator's rhythm and a patient's own breathing …
medRxiv Apr 16, 2026
Systematic review examines miRNA-mediated neutrophil regulation for acute lung injury, asthma, fibrosis, and lung cancer
Allergy & Immunology Sys. Review
Systematic review examines miRNA-mediated neutrophil regulation for acute lung injury, asthma, fibrosis, and lung cancer Tiny Molecules in Your Blood May Control Lung Inflammation
This systematic review evaluated miRNA-mediated regulation of neutrophil dynamics as a potential therapeutic strategy for acute lung injury,…
Tiny molecules in your blood act as a switch that controls the immune cells causing lung damage in asthma, fibrosis, and cancer.
Frontiers Apr 14, 2026
AI applications in acute care showed potential but face significant implementation challenges
Emergency Medicine Cohort
AI applications in acute care showed potential but face significant implementation challenges AI Is Quietly Changing How ERs Save Lives. Here’s How
This narrative review examined artificial intelligence (AI) applications in patients within emergency departments and intensive care units.
Artificial intelligence is moving into emergency rooms to help doctors spot life-threatening problems faster, but it’s not ready to run the …
Frontiers Apr 11, 2026
Prolonged prone positioning shows oxygenation benefit but inconclusive mortality effect in COVID-19 ARDS
Pulmonology & Critical Care Meta-analysis
Prolonged prone positioning shows oxygenation benefit but inconclusive mortality effect in COVID-19 ARDS Longer prone positioning may improve oxygen levels in COVID-19 ARDS patients
A meta-analysis of 996 COVID-19 patients with moderate-to-severe ARDS compared prolonged (>24 h/session) to standard (≤24 h/session) prone p…
Prolonged prone positioning for severe lung failure showed a trend toward lower death rates but increased pressure injury risks in COVID-19 …
Apr 7, 2026
Extended prone positioning associated with lower mortality but more pressure injuries in COVID-19 ARDS
Pulmonology & Critical Care Meta-analysis
Extended prone positioning associated with lower mortality but more pressure injuries in COVID-19 ARDS Could longer time spent face-down help more COVID-19 patients on ventilators survive?
A meta-analysis of 2412 adults with moderate-to-severe COVID-19 ARDS found extended prone positioning (≥24 h) was associated with reduced mo…
Keeping COVID-19 patients face-down longer than 24 hours lowers death risk but increases pressure sores, with no change to ventilator time.
Apr 6, 2026
Outbreak report summarizes patterns and characteristics of vaping-associated lung injury cases
Infectious Disease
Outbreak report summarizes patterns and characteristics of vaping-associated lung injury cases What did we learn from the vaping lung injury outbreak?
An observational outbreak report summarized patterns and characteristics of lung injury cases associated with e-cigarette use across multipl…
A 2019 wave of serious lung injuries swept across the United States, and all the cases had one thing in common: the people affected had used…
CDC Apr 6, 2026
Antenatal dexamethasone reduces respiratory support need in late preterm infants in Vietnamese RCT
Pulmonology & Critical Care RCT
Antenatal dexamethasone reduces respiratory support need in late preterm infants in Vietnamese RCT Can a steroid shot before late preterm birth help babies breathe easier?
A randomized controlled trial of 294 pregnant women at risk of late preterm delivery in Vietnam found antenatal dexamethasone reduced infant…
Giving mothers a steroid shot before late preterm birth cut the need for breathing support in babies by nearly 10%, reducing hospital stays …
Apr 2, 2026
Extracellular histones drive thrombo-inflammation in sepsis, stroke, and ARDS, review finds
Neurology Sys. Review
Extracellular histones drive thrombo-inflammation in sepsis, stroke, and ARDS, review finds Could tiny proteins released during cell death be making blood clots worse?
A systematic review synthesizes evidence on extracellular histones as damage-associated molecular patterns (DAMPs) in thrombo-inflammatory c…
Tiny proteins released when cells die may trigger dangerous blood clots and inflammation in severe illnesses like sepsis and stroke, offerin…
Frontiers Apr 2, 2026
NHFOV non-inferior to CPAP for primary respiratory support in preterm neonates ≥30 weeks with RDS
Pediatrics RCT
NHFOV non-inferior to CPAP for primary respiratory support in preterm neonates ≥30 weeks with RDS For premature babies with breathing trouble, is a newer breathing support method as safe as the standard one?
In an RCT of 142 preterm neonates ≥30 weeks with RDS, NHFOV was non-inferior to CPAP for treatment failure (RD 0.00, 90% CI -0.06 to +0.06) …
A newer breathing method for premature babies is just as safe as the standard one, while helping infants spend significantly less time on su…
Mar 30, 2026
Hyper-oncotic Albumin Reduces Mortality in ARDS Compared to Crystalloid
Pulmonology & Critical Care Meta-analysis
Hyper-oncotic Albumin Reduces Mortality in ARDS Compared to Crystalloid Could hyper-oncotic albumin save lives in patients with severe lung issues?
Meta-analysis shows hyper-oncotic albumin reduces mortality in ARDS (OR=0.61, CI 0.43-0.85) vs. crystalloid. RCTs show no benefit.
Patients with severe lung issues had lower death rates when given hyper-oncotic albumin instead of standard fluids, though results varied by…
Mar 28, 2026

Questions about Acute Respiratory Distress Syndrome

Is prone positioning recommended for adults with moderate-to-severe COVID-19 ARDS?

Yes, prone positioning is recommended for adults with moderate-to-severe COVID-19 ARDS, especially when receiving mechanical ventilation, as it improves oxygenation and may reduce mortality.

Full answer →
Can artificial intelligence help treat patients in the intensive care unit?

Yes, AI shows promise in ICU care for tasks like ARDS subphenotyping, ventilator synchrony, and imaging analysis, but real-world use remains limited by data quality and implementation challenges.

Full answer →
Can nasal high-flow oxygen replace CPAP for primary respiratory support in babies with respiratory distress syndrome?

Nasal high-flow oxygen cannot replace CPAP for primary respiratory support in babies with respiratory distress syndrome because clinical trials show it leads to significantly higher treatment failure rates compared to CPAP.

Full answer →
Are LISA and ENSURE treatments equally good for preterm babies with respiratory distress syndrome?

Research shows that LISA and ENSURE are equally good at reducing the need for mechanical ventilation in preterm babies with respiratory distress syndrome.

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What are the mortality effects of prone positioning for COVID-19 Acute Respiratory Distress Syndrome?

Prone positioning for COVID-19 ARDS improves oxygenation and may reduce mortality, especially with extended sessions (>24 h), but increases pressure injury risk.

Full answer →
Does prolonged prone positioning improve oxygenation for Acute Respiratory Distress Syndrome?

Yes, prolonged prone positioning (≥24 hours) improves oxygenation in ARDS, but its effect on mortality is uncertain and it increases pressure injury risk.

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Can lung ultrasound accurately diagnose Acute Respiratory Distress Syndrome?

Yes, lung ultrasound is a reliable, non-invasive tool for diagnosing ARDS, with high specificity (87%) and good sensitivity (75%) according to a large meta-analysis.

Full answer →
See all 7 questions about Acute Respiratory Distress Syndrome →