Digital memory assessment and plasma pTau217 identify preclinical Alzheimer's disease participants at elevated risk for progression.
Two simple tests may help find early Alzheimer's risk faster
This analysis of data from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) Study evaluated cognitively unimpaired, amylo…
Two simple tests can spot older adults at high risk for Alzheimer's decline, helping doctors find the right patients faster for new treatmen…
Plasma p-tau217 shows no correlation with age or comorbidity in adolescents
A key Alzheimer's marker doesn't change with age in teens, study finds
A cohort study of 41 adolescents found plasma p-tau217 did not correlate with age or BMI z-score and showed no differences by comorbidity or…
A new blood test for Alzheimer's shows wildly different results depending on whether blood is drawn from a vein or a finger prick in teens.
Normative modeling of brain structure in healthy individuals elucidates cortical atrophy patterns in Alzheimer's disease
Researchers create detailed brain growth charts using over 78,000 healthy brain scans
A modeling study using over 78,000 healthy brain scans generated lifespan cortical thickness growth charts and revealed three principal thic…
New brain growth charts built from 78,000 healthy scans reveal exactly how the cortex changes from youth to old age and how Alzheimer's diff…
Methodological analysis questions predictive value of plasma p-tau217 disease clocks for Alzheimer's onset
Study questions how well a blood test predicts Alzheimer's disease symptom timing
A methodological analysis of ADNI data from individuals who progressed to symptomatic Alzheimer's disease found that baseline age alone expl…
A new analysis suggests Alzheimer's blood test models may overstate their accuracy because they rely mostly on age rather than actual biomar…
Observational study derives six-stage amyloid-tau PET model for Alzheimer's disease progression
Researchers propose new six-stage model for tracking Alzheimer's brain changes
An observational analysis of 3,293 individuals from 8 neuroimaging studies derived a data-driven, six-stage model of amyloid and tau patholo…
A new six-stage model tracks how Alzheimer's proteins spread through the brain, revealing that people with similar brain patterns can experi…
Qualitative study identifies systemic barriers and caregiver burden in Latino dementia care navigation
What happens when dementia care systems fail Latino families?
A qualitative study of 23 Latino care partners of individuals with Alzheimer's disease and related dementias identified two meta-themes: a m…
Latino dementia caregivers become exhausted navigators when healthcare systems fail to match their language and cultural needs.
Bilingualism associated with different gray matter patterns in Alzheimer's variants but comparable cognition
Study finds different brain volume patterns in bilingual versus monolingual Alzheimer's patients
An observational study of 224 participants with amnestic AD or logopenic variant PPA found bilinguals showed different gray matter volume pa…
Bilingual Alzheimer's patients show different brain volume patterns than monolinguals, yet both groups scored similarly on cognitive tests.
Active bilingualism associated with delayed symptom onset in Alzheimer's disease clinical stages
Can speaking two languages actively delay Alzheimer's symptoms?
A retrospective observational study of patients with amnestic MCI, amnestic dementia, and biomarker-confirmed AD found active bilingualism w…
Actively speaking two languages is linked to a delay of over two years in the first signs of memory problems for people with mild cognitive …
Hormone therapy shows no significant effect on Alzheimer's biomarker changes in postmenopausal women
Does hormone therapy affect Alzheimer's risk? A long-term study finds no clear link.
A randomized trial in postmenopausal women from the Women's Health Initiative Memory Study found no significant differences in rates of chan…
A 15-year study of postmenopausal women found that hormone therapy neither increases nor decreases Alzheimer's-related brain markers over th…
Body weight variability associated with increased dementia risk in meta-analysis of cohort studies
Large weight fluctuations linked to higher dementia risk in research review
A systematic review and meta-analysis of 16 cohort studies found that highest levels of body weight fluctuation were associated with increas…
Large swings in body weight are linked to a higher risk of dementia, including Alzheimer's and vascular types, but not general cognitive dec…
Meta-analysis finds distinct fMRI activation patterns in MCI and Alzheimer's disease during cognitive tasks
What happens in the brain when memory starts to slip? A new analysis maps the changes.
A coordinate-based meta-analysis of 90 task-based fMRI studies (N=2824) found spatial convergence of aberrant brain activation in patients w…
When memory fades, brain scans show activity shifting to sound and hearing areas in Alzheimer's, while mild impairment affects spatial and s…
Meta-analysis finds Icariin improves cognition in Alzheimer's animal models at 68 mg/kg dose
Icariin compound shows promise for improving memory in Alzheimer's animal studies
A systematic review and meta-analysis of 31 preclinical studies in Alzheimer's disease animal models found Icariin treatment significantly i…
A natural compound called Icariin improved memory and thinking in animal models of Alzheimer's disease by protecting brain cells from damage…