Observational analysis of a multi-channel blood biomarker framework for Alzheimer's amyloid detection
Can a simple blood test spot Alzheimer's brain changes as well as a brain scan?
This observational analysis from the ADNI cohort evaluates a Virtual Spectral Decomposition (VSD) framework using plasma biomarkers to detec…
A new blood test combining four markers spots Alzheimer's brain changes with 90% accuracy, outperforming single-marker tests without needing…
Review of UK Biobank data identifies plasma protein mediators in cardiometabolic disease progression.
New Blood Test Clues Could Predict Diabetes Complications Years Earlier
This observational review analyzes UK Biobank data from 53,030 participants to evaluate plasma proteins as mediators in secondary disease de…
A new blood test spots specific proteins that warn of heart, kidney, and brain problems years before they happen in people with diabetes or …
Genome-wide association study identifies inverse association between HSV-1 DNA and Alzheimer's disease risk.
Alzheimer’s Brains Have Less Herpes Virus DNA Than Expected
This observational genome-wide association study examined HSV-1 DNA presence in persons with Alzheimer's disease and controls. Researchers f…
A new look at brain data suggests the herpes virus might not be the cause of Alzheimer’s after all.
Systematic review summarizes complement system alterations in Alzheimer's disease pathogenesis and therapeutic potential
Could a hidden immune response be driving Alzheimer's disease?
This systematic review evaluates the role of complement system alterations in Alzheimer's disease. Authors synthesize evidence linking dysre…
A hidden immune system error called the complement system may drive excessive brain connection loss and inflammation in Alzheimer's disease.
Posdinemab shows linear pharmacokinetics and predicted tau reduction in Phase 1 AD study
New Alzheimer's Drug Could Silence Brain's Toxic Tangles
This Phase 1 mechanistic population pharmacokinetic-pharmacodynamic model evaluated posdinemab in 69 healthy adults and participants with Al…
A new Alzheimer's drug could silence toxic brain tangles before memory loss worsens, offering hope for millions of families facing early-sta…
Review of bilingualism effects on naming performance in Catalan-Spanish speakers with cognitive impairment
Why Knowing Two Languages Changes the Story
This narrative review synthesizes observational evidence on bilingualism and naming performance in Catalan-Spanish bilinguals with Alzheimer…
Active bilinguals with early memory loss made more naming errors than those who only knew one language well, showing that fluency matters fo…
APOE epsilon4 allele frequencies vary widely across Indian populations with implications for dementia risk assessment.
A Single Gene Could Change How India Screens for Alzheimer's
This observational study analyzed APOE epsilon4 allele frequencies in 9,524 individuals from the GenomeIndia dataset representing diverse In…
Alzheimer's risk in India varies wildly by region, with some tribal groups facing much higher genetic danger than others, demanding new scre…
Mini-review synthesizes dementia risk and cognitive trajectories in individuals with schizophrenia.
Do people with schizophrenia face a higher risk of dementia, and what does that mean for their care?
This mini-review examines the relationship between schizophrenia and dementia, covering Alzheimer's disease, vascular dementia, and other fo…
People with schizophrenia face a two- to threefold higher risk of dementia, but it's not a direct path to Alzheimer's—brain development, agi…
Plasma biomarker models show high discrimination but NPV decline in cross-cohort Alzheimer's validation
Can a blood test predict Alzheimer's in new patients? The answer depends on where the test was developed.
A cohort study in ADNI and A4 cohorts (n=885 and n=822) found that machine learning models using plasma biomarkers achieved ROC AUCs of 0.91…
A promising Alzheimer's blood test loses its accuracy when used on a different patient group, raising concerns about false reassurance in re…
VeraBIND Tau assay predicts tau-PET positivity in older adults with high sensitivity and specificity.
A Blood Test That Sees Alzheimer's Before Memory Slips
This observational study evaluated the VeraBIND Tau assay against plasma pTau217 in 145 older adults, including cognitively unimpaired and i…
A new blood test detects active Alzheimer's tau protein years before memory slips, offering a simple flu-style draw to spot the disease in p…
Systematic review hypothesizes vitamin D3 and A combination may mitigate neurodegeneration
Could Two Common Vitamins Slow Alzheimer's and Parkinson's?
A systematic review proposes a hypothesis that combined vitamin D3 and vitamin A therapy may mitigate neurodegeneration in Alzheimer's and P…
A new theory suggests taking vitamins D and A together could protect brain cells by activating a unique switch to fight Alzheimer's and Park…
SILA algorithm estimates tau positivity onset from PET imaging in Alzheimer's disease cohorts
A New Brain Scan Tool Can Predict Alzheimer's 20 Years Before Symptoms
A cohort study of 673 participants from ADNI and WISC applied the SILA algorithm to longitudinal tau PET imaging. The algorithm estimated ta…
A new brain scan tool can pinpoint when toxic proteins start building up in the brain, predicting Alzheimer's 20 years before symptoms appea…