Meta-analysis suggests high BMI causally increases vascular-related dementia risk via blood pressure mediation
Higher body weight linked to increased risk of vascular dementia
This Mendelian randomization meta-analysis evaluates the causal link between high body mass index and vascular-related dementia. The analysi…
A large genetic study shows that a higher body mass index (BMI) raises the risk of vascular-related dementia. High blood pressure plays a ke…
AI-assisted PET radiomics improves Alzheimer's diagnosis over conventional methods in meta-analysis
AI helps PET scans spot early Alzheimer’s with new precision
A systematic review of 5,765 patients shows AI radiomics significantly boosts diagnostic accuracy for Alzheimer's versus mild cognitive impa…
AI-powered PET scans may better distinguish early Alzheimer’s from mild memory loss, but results for healthy people are less clear.
Review highlights microglia-targeted therapies as emerging Alzheimer's strategy beyond amyloid
New Alzheimer's treatment targets brain inflammation instead of plaques
This narrative review synthesizes evidence on microglia-targeted therapeutic strategies for Alzheimer's disease, including TREM2 agonism, CD…
Forget the plaque-clearing drugs. The real action in Alzheimer's research is now inside your brain's own immune cells, and scientists say ta…
Review of nanoparticle systems for Alzheimer's disease brain delivery challenges
Tiny Particles Could Finally Deliver Alzheimer’s Drugs to the Brain
This narrative review synthesizes evidence on nanoparticle-based drug delivery for Alzheimer's disease. It highlights nose-to-brain and rece…
A new wave of microscopic drug carriers could solve Alzheimer’s biggest treatment problem: getting medicine past the brain’s natural securit…
Narrative review of Alzheimer's disease without reported intervention or outcomes
New research shows how fixing fats could slow brain inflammation in Alzheimer's
This narrative review addresses Alzheimer's disease but does not report specific interventions, populations, or outcomes. The authors note t…
Doctors now see that changing how the body handles fats might help stop the brain inflammation that causes Alzheimer's disease.
Systematic review of AI applications for protein misfolding diseases
AI Reveals Hidden Link Between Brain Proteins and Immune Attacks
This is a systematic review of artificial intelligence applications for neurodegenerative diseases involving protein misfolding. The authors…
• AI shows misfolded proteins trick the brain's immune system into attack mode • Helps adults with Alzheimer's and kids with rare brain diso…
Exercise interventions significantly improve subjective sleep quality in patients with Alzheimer's disease based on meta-analysis findings
Exercise Improves Sleep Quality in Alzheimer's Patients Study Finds
A systematic review of 893 patients found that exercise programs significantly enhanced subjective sleep quality, though objective measures …
Exercise may help Alzheimer's patients sleep better, especially those with severe insomnia, though objective data is still unclear.
Systematic review and meta-analysis of dual-task walking in adults with dementia shows slower speed and shorter steps versus controls
New Walking Tests Reveal Hidden Dementia Signs Before Memory Fails
This systematic review and meta-analysis evaluates instrumented dual-task paradigms versus single-task conditions in adults with clinically …
• Movement changes during thinking tasks signal early dementia • Helps people worried about memory loss get earlier answers • Still needs te…
Financial compensation during recruitment did not improve consent rates for Alzheimer's disease study participants in this trial
Offering money to join Alzheimer's research may backfire
This randomized trial found that offering potential financial compensation during recruitment actually lowered consent rates compared to a c…
New research suggests that mentioning payment during recruitment may actually reduce enrollment in Alzheimer's studies.
Meta-analysis identifies new genetic loci for Alzheimer disease across diverse veteran populations
New Alzheimer’s Genes Found in Veterans Study Unlock Fresh Treatment Paths
This meta-analysis of genetic data from the VA Million Veterans Program evaluated Alzheimer disease and related dementias in European, Hispa…
A massive study of US Veterans uncovered 26 new gene regions tied to dementia, pointing to fresh targets for future treatments.
FDA Approves Rexulti (brexpiprazole) for Agitation in Alzheimer's Dementia
FDA approves Rexulti to treat agitation in Alzheimer's patients
FDA approved Rexulti (brexpiprazole) for treatment of agitation associated with dementia due to Alzheimer's disease. It is not indicated for…
The FDA approved Rexulti (brexpiprazole) to treat agitation in people with Alzheimer's disease. This is a new option for managing this chall…
FDA Approves Auvelity (dextromethorphan/bupropion) for Major Depressive Disorder and Agitation in Alzheimer's
FDA approves new drug Auvelity for depression and Alzheimer's agitation.
The FDA approved Auvelity (dextromethorphan/bupropion) for major depressive disorder (MDD) and agitation associated with dementia due to Alz…
The FDA approved Auvelity for major depressive disorder and agitation in Alzheimer's disease. It combines two medicines into one pill. This …
Questions about Alzheimer's Disease
Is there a genetic link between kidney function and Alzheimer Disease for my family?
Current research finds no overall genetic link between kidney function and Alzheimer disease, though some shared biological pathways may exist.
Full answer →Does having brain reserve protect me from Alzheimer Disease symptoms if I am inactive?
Research shows that having more brain reserve, such as from higher education, can help maintain cognitive function even when Alzheimer's disease pathology is present, even in people who are physically inactive.
Full answer →Are there new genetic markers for Alzheimer disease found in veteran populations?
Yes, a meta-analysis of the VA Million Veterans Program identified 17 new genetic loci in European, 4 in African, and 3 in Hispanic veteran populations for Alzheimer's disease.
Full answer →Do genetic tests find new risk factors for Alzheimer's in veteran populations?
Yes, genetic tests can find new risk factors for Alzheimer's in veteran populations, as shown by a meta-analysis including the VA Million Veterans Program that identified 17 new genetic loci in European ancestry veterans.
Full answer →What is the new FDA-approved medication for agitation in Alzheimer's disease?
The FDA has approved Auvelity (dextromethorphan/bupropion) for treating agitation in Alzheimer's disease, making it the first medication specifically approved for this indication.
Full answer →Can exercise programs really improve sleep quality for people with Alzheimer's disease?
Yes, exercise programs can improve subjective sleep quality in people with Alzheimer's disease, based on a meta-analysis of 12 randomized trials showing a significant reduction in PSQI scores.
Full answer →