Preclinical deep learning model for diabetic retinopathy screening in low-resource settings
AI Model Spots Diabetic Eye Disease from Smartphone Photos
This preclinical study evaluates an imbalance-aware optimal transport learning approach for diabetic retinopathy detection from smartphone i…
A new AI approach detects diabetic retinopathy from smartphone images with 89% sensitivity, offering hope for low-resource screening.
Meta-analysis links diabetic retinopathy with anxiety and depression in over 383,000 patients
Diabetes Eye Disease and Depression Feed Each Other — and Doctors Are Just Catching On
This meta-analysis synthesizes observational data from 383,195 patients with diabetic retinopathy and/or diabetes mellitus to evaluate the a…
Diabetic eye disease and depression trap patients in a two-way cycle where each condition significantly raises the risk of the other.
Three-parameter online nomogram predicts diabetic retinopathy risk in community-dwelling type 2 diabetes patients
Three Numbers Could Tell Your Doctor If Your Eyes Are at Risk
This retrospective cohort study evaluated a three-parameter online nomogram using diabetes duration, HbA1c, and high BMI (≥24 kg/m²) to pred…
A free, web-based calculator using only your diabetes duration, blood sugar control, and BMI could help doctors spot who needs an urgent eye…
Cross-sectional review of diabetic retinopathy prevalence and risk factors in 384 Somaliland patients
Half of Diabetic Patients at This Hospital Had Eye Damage — and Didn't Know It
This observational, descriptive cross-sectional review examines diabetic retinopathy (DR) prevalence and associated risk factors among 384 p…
Half of diabetic patients at a Somaliland hospital had serious eye damage without knowing it, proving regular screenings are vital for preve…
Post hoc analysis compares brolucizumab and aflibercept for diabetic macular edema
A New Eye Injection Works Even If You've Had Treatment Before
A post hoc analysis of a randomized trial in 517 participants with diabetic macular edema compared intravitreal brolucizumab to aflibercept …
People with diabetic eye disease who have already tried other injections may still get meaningful vision improvement from brolucizumab.
Subretinal saline injection added to vitrectomy for diabetic macular edema with hard exudates
Does a simple salt solution injection help eyes with diabetic swelling?
A randomized trial in 56 patients with diabetic macular edema and hard exudates compared vitrectomy with subretinal balanced salt solution i…
A simple salt solution injection under the retina helped patients with diabetic eye swelling see better and reduced fluid buildup within sev…
FDA Approves Eylea HD (aflibercept) for nAMD, DME, Diabetic Retinopathy, and Macular Edema Following RVO
FDA approves a new, higher-dose version of the eye medicine Eylea
The FDA has approved Eylea HD, a VEGF inhibitor, for the treatment of neovascular age-related macular degeneration, diabetic macular edema, …
FDA approves higher-dose Eylea to treat four eye conditions that damage the retina and threaten vision, potentially reducing how often patie…
CA-1 levels elevated in aqueous humor of DME patients compared to controls in cross-sectional study
Study finds elevated protein levels in eye fluid of patients with diabetic macular edema
A retrospective cross-sectional study of 74 DME patients and 30 controls found carbonic anhydrase-1 (CA-1) levels in aqueous humor were mark…
Patients with diabetic macular edema have eye fluid protein levels about 10 times higher than those without the condition.
Research across Diabetes
Related studies from across the Diabetes family.
Immunometabolic dysregulation drives hyperalgesia and hypoesthesia in diabetic peripheral neuropathy
New research explores how inflammation drives nerve damage in diabetes
This narrative review explores the pathophysiology of diabetic peripheral neuropathy, focusing on how hyperglycemia, lipotoxicity, and intes…
Chronic high blood sugar causes more than just high glucose; it triggers a cycle of inflammation and immune stress that damages nerves.
Chronic hyperglycemia causes multi-level nerve damage across the peripheral, autonomic, and central nervous systems
Understanding how high blood sugar damages the entire nervous system in diabetes
This narrative review synthesizes how chronic hyperglycemia impacts the entire neuroaxis in patients with diabetes. It details metabolic and…
High blood sugar can damage nerves throughout the whole body. This affects your senses, movement, and internal organs.
Local antibiotic delivery systems increase healing rates in diabetic foot osteomyelitis compared with control groups in this meta-analysis
Local Antibiotics May Boost Healing in Diabetic Foot Infections
This systematic review and meta-analysis evaluated local antibiotic delivery systems versus control groups for patients with diabetic foot o…
A new analysis suggests local antibiotic delivery may improve healing for diabetic foot bone infections, but more research is needed.
Antibiotic cement achieves 85.2% healing rate in diabetic foot osteomyelitis meta-analysis
Antibiotic cement may help heal diabetic foot infections without major surgery
A systematic review and meta-analysis of 82 patients with diabetic foot osteomyelitis found a weighted healing rate of 85.2% with antibiotic…
A meta-analysis suggests antibiotic-impregnated cement can heal diabetic foot osteomyelitis in most patients, though some still need surgery…
SGLT2 inhibitor use associated with increased diabetic ketoacidosis risk, especially with elevated HbA1c
New review shows SGLT2 drugs raise DKA risk when blood sugar is high
This meta-analysis of observational and randomized trials found SGLT2 inhibitor use is associated with an increased risk of diabetic ketoaci…
A big review of many studies found that medicines for diabetes called SGLT2 inhibitors can increase the chance of a serious condition called…
Perioperative anti-VEGF injections improve vision and reduce bleeding in proliferative diabetic retinopathy
Anti-VEGF injections before eye surgery improve vision and reduce bleeding in diabetic retinopathy
This network meta-analysis evaluated the timing of perioperative anti-VEGF injections for proliferative diabetic retinopathy. Results indica…
A network meta-analysis of 2,646 eyes found that perioperative anti-VEGF injections improved vision and reduced bleeding in patients with pr…
Exosomes show promise as biomarkers and therapeutic vectors in diabetic complications
Review suggests exosomes may help target multiple diabetes complications
This narrative review explores the role of exosomes in diabetic kidney disease, retinopathy, and peripheral neuropathy. It highlights their …
A narrative review suggests exosomes might inform strategies to target multiple diabetes complications together, though clinical standardiza…
Scoping review maps burden of diabetic emergencies in African healthcare settings
Diabetic emergencies in Africa show wide variation in rates and outcomes
This scoping review synthesizes data from 25 studies regarding diabetic emergencies in Africa. The authors report wide variation in reported…
A review of 25 studies finds diabetic emergencies in Africa vary widely, with high death rates and long hospital stays.
Review of 16 cases shows 25% mortality for pulmonary mucormycosis in DKA patients treated with amphotericin B
Treatment for rare lung infection kills one in four patients with diabetic ketoacidosis
This case report and literature review synthesizes data from 16 patients with diabetic ketoacidosis complicated by invasive pulmonary mucorm…
A review of 16 patients found that one in four died from this rare lung infection. Early diagnosis and surgery are key.
Narrative review of salvianolic acids for kidney disease pharmacokinetics and anti-fibrotic activity
Salvianolic Acids Show Potential for Kidney Disease Treatment
This narrative review synthesizes evidence on salvianolic acids A, B, and C for kidney conditions. It focuses on pharmacokinetic parameters,…
A review suggests salvianolic acids may help kidney conditions, though low absorption and fast metabolism limit current use.
Review of immune checkpoint inhibitor-associated diabetes mellitus in two patients
Diabetes Danger Lingers Months After Cancer Treatment Ends
This narrative review and case report describes two patients with immune checkpoint inhibitor-associated diabetes mellitus. The authors synt…
• Some patients develop dangerous diabetes long after stopping immunotherapy • Helps cancer survivors using newer immune-boosting drugs • St…
Pregabalin 300 or 600 mg/day significantly reduces pain in painful diabetic peripheral neuropathy versus placebo
Higher doses of pregabalin helped reduce pain scores for people with painful diabetic nerve problems compared to placebo
This randomized controlled trial enrolled 729 patients with painful diabetic peripheral neuropathy. Pregabalin doses of 300 mg/day and 600 m…
A study found that taking 300 or 600 mg of pregabalin daily lowered pain scores better than a fake pill. Lower doses did not work as well fo…
Questions about Diabetic Macular Edema
How does brolucizumab compare to aflibercept for treating diabetic macular edema over time?
Brolucizumab and aflibercept both improve vision in diabetic macular edema, but brolucizumab may allow longer intervals between injections while carrying a higher risk of intraocular inflammation.
Full answer →Are aflibercept biosimilars as safe and effective as the original drug for diabetic macular edema?
Yes, aflibercept biosimilars are as safe and effective as the original drug for diabetic macular edema, based on a systematic review and meta-analysis.
Full answer →Does taking aflibercept every 8 weeks keep vision gains in diabetic macular edema?
Yes, taking aflibercept every 8 weeks maintains vision gains in diabetic macular edema, as shown in a 96-week trial where the 2 mg every 8 weeks regimen kept visual improvements comparable to extended dosing of 8 mg.
Full answer →Is the new drug Pavblu approved for treating diabetic macular edema?
Yes, Pavblu (aflibercept) is FDA-approved for treating diabetic macular edema (DME).
Full answer →Can suprachoroidal injections help improve vision in diabetic macular edema?
Yes, early studies show suprachoroidal injections of triamcinolone can improve vision and reduce swelling in diabetic macular edema, but more research is needed.
Full answer →