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Oncology
Cohort
Deep learning segmentation with CT elasticity features predicts right recurrent laryngeal nerve metastasis in esophageal cancer.
AI Can Spot Hidden Cancer Spread in the Neck Before Surgery
This retrospective cohort study of 415 patients with esophageal squamous cell carcinoma evaluated a deep learning-based segmentation model w…
This research could help surgeons avoid damaging a vital nerve during esophageal cancer surgery, making operations safer and more precise.
Frontiers
Apr 24, 2026
Oncology
RCT
Neoadjuvant Chemoimmunotherapy Alters Tumor Microenvironment in Esophageal Cancer
Combination therapy may help overcome resistance in esophageal cancer.
This Phase 3 RCT in 55 patients with locally advanced esophageal squamous cell carcinoma compared neoadjuvant chemotherapy alone versus comb…
A small trial suggests combination therapy might help overcome resistance in esophageal cancer by targeting specific immune cells.
Apr 23, 2026
Allergy & Immunology
Cohort
Timing of surgery after neoadjuvant chemoimmunotherapy impacts survival in operable esophageal squamous cell carcinoma
Shrink Faster, Live Longer: Timing Saves Lives in Esophageal Cancer
This multicenter retrospective cohort study evaluated 163 patients with operable esophageal squamous cell carcinoma receiving neoadjuvant ch…
Faster tumor shrinkage and surgery within six weeks of treatment predict longer survival for esophageal cancer patients receiving new therap…
Frontiers
Apr 14, 2026
Oncology
Meta-analysis
PD-1 inhibitors + chemo improve OS, PFS, ORR in first-line advanced ESCC; benefit limited in PD-L1 CPS <1
Who benefits most from new esophageal cancer treatment? Most patients do, except one group.
A meta-analysis of 8 RCTs (n=4702) found first-line PD-1 inhibitors plus chemotherapy significantly improved OS (HR=0.68, 95% CI: 0.63-0.74;…
For most advanced esophageal cancer patients, adding immunotherapy to chemotherapy extends life and shrinks tumors, but those with low PD-L1…
NEJM
Mar 30, 2026