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ST-Segment Elevation Myocardial Infarction

Part of Myocardial ischemia

13 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for ST-Segment Elevation Myocardial Infarction

5 trials tracked for ST-Segment Elevation Myocardial Infarction: 4 in phase 3 or 4 and 2 with published results. The most-cited published study has 153 citations.

5Trials tracked
4Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 4 Phase 2 1
  1. Phase 4 Platelet Inhibition With Cangrelor and Crushed Ticagrelor in STEMI Completed · 153 cited
  2. Phase 4 The Effect of IV Cangrelor and Oral Ticagrelor Study Completed · 46 cited
  3. Phase 4 Influence of Morphine on Pharmacokinetics and Pharmacodynamics of Ticagrelor in Patients With Acute Myocardial Infarction Completed
  4. Phase 4 Distal Protection Device in ST-elevation Myocardial Infarction (STEMI) Completed
  5. Phase 2 Sonothrombolysis in Patients With STEMI Completed

Showing the 5 most-cited and recently-updated of 5 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

ST-Segment Elevation Myocardial Infarction: what the trials found

Cangrelor has been evaluated in Phase 4 trials for the management of ST-segment Elevation Myocardial Infarction, demonstrating a significant reduction in platelet reactivity as measured by VerifyNow PRU (63 vs. 214; p<0.001) [1, 2].

Morphine administration was assessed in Phase 4 trials, showing specific impacts on platelet aggregation and P2Y12 reaction units, while a majority of patients (57%) exhibited high platelet reactivity following a ticagrelor loading dose 3.

Additionally, the use of distal protection and thrombus aspiration via the GuardWire Plus system was evaluated in Phase 4 trials for this condition 4.

Recent results — preliminary, needs further review

  • Definity (Lipid Microspheres) Intravenous Suspension showed a high rate of ST-segment resolution (>50%) at 30 minutes post-PCI in a small Phase 2 study, with associated measurements in Wall Motion Score Index and Microvascular Perfusion Score Index 5.

For the clinician treating this condition

  • Cangrelor is associated with significantly lower platelet reactivity compared to standard measures in STEMI patients 1.
  • Morphine use and ticagrelor loading doses are associated with specific measurable changes in platelet aggregation and reaction units 3.
  • Mechanical interventions such as distal protection and thrombus aspiration (GuardWire Plus) have been evaluated in Phase 4 clinical settings 4.

AI synthesis of 4 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Myocardial ischemia

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Questions about ST-Segment Elevation Myocardial Infarction

Are many current STEMI treatment guidelines based on strong scientific evidence?

No, many current STEMI treatment guidelines are based on moderate or low-quality evidence, with only a small fraction supported by high-level studies.

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Can a CT scan show hidden lung water that predicts bad outcomes in STEMI?

Yes, a CT scan can detect hidden lung water (extravascular lung water) in STEMI patients, and this finding is linked to a higher risk of in-hospital major adverse cardiovascular events.

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How accurate is the new model for predicting heart failure after STEMI surgery?

A new model predicts acute heart failure after STEMI PCI with 82.4% accuracy, 74% sensitivity, and 86.8% specificity, outperforming older scores.

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Does the timing of my heart surgery affect how well blood flows in STEMI?

Yes, timing matters: longer delays from symptom onset to PCI are linked to worse blood flow and outcomes in STEMI.

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Can taking nicorandil during heart surgery improve blood flow for STEMI patients?

Yes, a 2024 trial found that giving intracoronary nicorandil during primary PCI improves blood flow (TIMI grade) and reduces microvascular resistance in STEMI patients.

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See all 5 questions about ST-Segment Elevation Myocardial Infarction →