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Home › Conditions › Substance-Related Disorders

Substance-Related Disorders

Subtypes of Substance-Related Disorders

Substance Use Disorder 21 Drug use disorders 1

25 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Substance-Related Disorders

55 trials tracked for Substance-Related Disorders: 9 in phase 3 or 4 and 4 with published results. The most-cited published study has 75 citations.

55Trials tracked
9Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 4 Phase 3 5 Phase 2 3 Phase 1 5 Other / NA 38
  1. Phase 4 Relapse Prevention With Varenicline Completed · 75 cited
  2. Phase 4 Smoking Cessation Treatment for Methadone Maintenance Patients Completed · 75 cited
  3. Phase 3 Non-Invasive Vagal Nerve Stimulation in Opioid Use Disorders Completed · 28 cited
  4. Phase 4 Buprenorphine to Improve HIV Care Engagement and Outcomes Completed · 22 cited
  5. Phase 4 Interactions Between Drug Effects and Environments II Completed
  6. Phase 3 Rapid HIV Testing and Counseling in Drug Abuse Treatment Completed
Show 44 more trials
  1. Phase 3 Treating Violence-Prone Substance Use Disorder Patients Completed
  2. Phase 3 Prescription Opioid Addiction Treatment Study (POATS) Completed
  3. Phase 3 Voucher-Based Incentives in a Prevention Setting Completed
  4. Phase 2 Combined Treatment for Alcohol-Dependent Individuals With PTSD Completed
  5. Phase 2 Prescription Opioid Effects in Abusers Versus Non-Abusers Completed
  6. Phase 2 Interactive Motivational Media for Perinatal Drug Abuse - 3 Completed
  7. Phase 1 Pilot Clinical Trial of Computer-based Motivational Intervention - 1 Completed
  8. Phase 1 Neural Mechanisms of Cannabinoid-impaired Decision-Making in Emerging Adults Completed
  9. Phase 1 The Women's Recovery Group Study: Stage I Trial Completed
  10. Phase 1 Alcohol, Behavior, and Brain Imaging Completed
  11. Phase 1 Middle School to High School Transition Project: Depression and Substance Abuse Prevention Completed
  12. N/A MISSION-Vet HUD-VASH Implementation Study Completed
  13. N/A Working With HIV Clinics to Adopt Addiction Treatments Using Implementation Facilitation Completed
  14. N/A Abuse Liability of Reduced Nicotine Content Cigarettes Within a Complex Tobacco Marketplace Completed
  15. N/A We The Village Family Support Study Completed
  16. N/A A Brief Community Linkage Intervention for Dually Diagnosed Individuals Completed
  17. N/A Community Health Worker Training to Reduce Depression and Substance Use Stigma in TB/HIV Care in South Africa Completed
  18. N/A Mindfulness Meditation for the Treatment of Women With Comorbid PTSD and SUD Completed
  19. N/A Women's Treatment and Early Recovery Completed
  20. N/A Treatment Engagement With Technology-assisted Treatment Completed
  21. N/A Group Motivational Interviewing (GMI) For Homeless Veterans In VA Services Completed
  22. N/A Preventing Impaired Driving Among Adolescents Completed
  23. N/A Screening to Augment Referral to Treatment- Project START Completed
  24. N/A Incentives to Decrease Opioid Use - Pilot Completed
  25. N/A A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity Completed
  26. N/A Intervention for Veterans With Depression, Substance Disorder, and Trauma Completed
  27. N/A Preventing Addiction Related Suicide (PARS) Completed
  28. N/A Family Engagement, Cross-System Linkage to Substance Use Treatment for Juvenile Probationers -- Phase 3 Completed
  29. N/A Preventing Violence Among Veterans in Substance Use Disorder Treatment Completed
  30. N/A Testing a Brief Substance Misuse Preventative Intervention for Parents/Guardians of 5th-7th Grade Students Completed
  31. N/A A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity Pilot Completed
  32. N/A SET-Recovery/Healthy Home Completed
  33. N/A Palonosetron and Hydroxyzine to Reduce Opioid Withdrawal Completed
  34. N/A Functional Magnetic Resonance Imaging of Opioid Withdrawal in Healthy Human Volunteers Completed
  35. N/A Encouraging Judicious Prescribing of Opioids in Los Angeles County Completed
  36. N/A Behavioral Insights to Encourage Judicious Prescribing of Opioids Completed
  37. N/A Development of a Patient Centered Mental Health Intervention for Recent Veterans Completed
  38. N/A First Episode Schizophrenia and Cannabis-Related Disorder Study Completed
  39. N/A Multisite RCT of STEP-Home: A Transdiagnostic Skill-based Community Reintegration Workshop Completed
  40. N/A Skills Based Counseling for Adherence and Depression in HIV+ Methadone Patients - 1 Completed
  41. N/A Screening and Brief Advice to Reduce Teen Substance Use Completed
  42. N/A Optimizing Behavioral Health Homes for Adults With Serious Mental Illness Completed
  43. N/A Scalable Digital Delivery of Evidence-based Training for Professionals to Maximize Treatment Rates of OUD in Families Completed
  44. N/A Data-driven Identification for Substance Misuse Completed

Showing the 50 most-cited and recently-updated of 55 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Substance-Related Disorders: what the trials found

Varenicline was evaluated for smoking cessation; results showed no significant difference in biochemically verified abstinence (p=0.24) or severe global psychiatric symptoms (p=0.15) 3. Clinical data noted a mean of 9.1 to 37 days for attempts to quit lasting at least 24 hours 3, with reported times to relapse of 9.1 and 16.4 days 4.

Behavioral and pharmacological interventions include Buprenorphine/naloxone 5, stimulant or sedative administration 6, and Oxygen (15-O) Water 7. Other established protocols include Interpersonal Violence Prevention Intervention 9, Voucher-Based Reinforcement Therapy 10, Standard Medical Management of Prescription Opiate Abuse 11, and Brief computer-delivered interventions [14, 19].

Public health interventions for high-risk behaviors included on-site HIV rapid testing and brief counseling; this resulted in significantly higher rates of self-reported receipt of results (p<0.001) and a significant reduction in the sharing of needles used in drug use (p=0.044) 8.

Recent results — preliminary, needs further review

  • Mindfulness Meditation was associated with significantly higher treatment completion rates, fewer days of any drug use, and lower scores for psychological symptoms (all p<0.05) 2.
  • webCHAT showed no significant differences in outcomes related to alcohol/cannabis use, driving under the influence, or riding with an impaired driver 1.
  • Processing clinical notes in EHR data during routine care showed no significant difference in the proportion of patients with a universal screen positive who received SBIRT (p=0.20) 20.
  • Other recent interventions include commercially available cigarettes 21 and the Preventing Addiction Related Suicide (PARS) program 22.

For the clinician treating this condition

  • Mindfulness Meditation is associated with improved treatment completion and reduced drug use days compared to standard approaches.
  • Varenicline shows no significant impact on biochemical abstinence or psychiatric symptom severity in the studied populations.
  • On-site rapid testing combined with brief counseling significantly reduces needle-sharing behaviors among drug users.

AI synthesis of 14 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Study Buddy Intervention Fails to Improve Retention in Rural PWUD Longitudinal Research
Anesthesiology & Pain Medicine RCT
Study Buddy Intervention Fails to Improve Retention in Rural PWUD Longitudinal Research Study buddy approach did not improve retention in rural drug use research
A randomized controlled trial of 739 rural people who use drugs (PWUD) in the US found that adding a participant-referred 'study buddy' inte…
Asking rural people who use drugs to recruit a 'study buddy' did not improve their chances of staying in long-term health research compared …
Apr 2, 2026