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Home › Conditions › Substance-Related Disorders

Substance-Related Disorders

Subtypes of Substance-Related Disorders

Substance Use Disorder 19 Drug use disorders 1

23 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Substance-Related Disorders

55 trials tracked for Substance-Related Disorders: 9 in phase 3 or 4 and 4 with published results. The most-cited published study has 72 citations.

55Trials tracked
9Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 4 Phase 3 5 Phase 2 3 Phase 1 5 Other / NA 38
  1. Phase 4 Relapse Prevention With Varenicline Completed · 72 cited
  2. Phase 4 Smoking Cessation Treatment for Methadone Maintenance Patients Completed · 72 cited
  3. Phase 3 Non-Invasive Vagal Nerve Stimulation in Opioid Use Disorders Completed · 27 cited
  4. Phase 4 Buprenorphine to Improve HIV Care Engagement and Outcomes Completed · 20 cited
  5. Phase 4 Interactions Between Drug Effects and Environments II Completed
  6. Phase 3 Rapid HIV Testing and Counseling in Drug Abuse Treatment Completed
Show 44 more trials
  1. Phase 3 Treating Violence-Prone Substance Use Disorder Patients Completed
  2. Phase 3 Prescription Opioid Addiction Treatment Study (POATS) Completed
  3. Phase 3 Voucher-Based Incentives in a Prevention Setting Completed
  4. Phase 2 Combined Treatment for Alcohol-Dependent Individuals With PTSD Completed
  5. Phase 2 Prescription Opioid Effects in Abusers Versus Non-Abusers Completed
  6. Phase 2 Interactive Motivational Media for Perinatal Drug Abuse - 3 Completed
  7. Phase 1 Pilot Clinical Trial of Computer-based Motivational Intervention - 1 Completed
  8. Phase 1 Neural Mechanisms of Cannabinoid-impaired Decision-Making in Emerging Adults Completed
  9. Phase 1 The Women's Recovery Group Study: Stage I Trial Completed
  10. Phase 1 Alcohol, Behavior, and Brain Imaging Completed
  11. Phase 1 Middle School to High School Transition Project: Depression and Substance Abuse Prevention Completed
  12. N/A MISSION-Vet HUD-VASH Implementation Study Completed
  13. N/A Working With HIV Clinics to Adopt Addiction Treatments Using Implementation Facilitation Completed
  14. N/A Abuse Liability of Reduced Nicotine Content Cigarettes Within a Complex Tobacco Marketplace Completed
  15. N/A We The Village Family Support Study Completed
  16. N/A A Brief Community Linkage Intervention for Dually Diagnosed Individuals Completed
  17. N/A Community Health Worker Training to Reduce Depression and Substance Use Stigma in TB/HIV Care in South Africa Completed
  18. N/A Mindfulness Meditation for the Treatment of Women With Comorbid PTSD and SUD Completed
  19. N/A Women's Treatment and Early Recovery Completed
  20. N/A Treatment Engagement With Technology-assisted Treatment Completed
  21. N/A Group Motivational Interviewing (GMI) For Homeless Veterans In VA Services Completed
  22. N/A Preventing Impaired Driving Among Adolescents Completed
  23. N/A Screening to Augment Referral to Treatment- Project START Completed
  24. N/A Incentives to Decrease Opioid Use - Pilot Completed
  25. N/A A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity Completed
  26. N/A Intervention for Veterans With Depression, Substance Disorder, and Trauma Completed
  27. N/A Preventing Addiction Related Suicide (PARS) Completed
  28. N/A Family Engagement, Cross-System Linkage to Substance Use Treatment for Juvenile Probationers -- Phase 3 Completed
  29. N/A Preventing Violence Among Veterans in Substance Use Disorder Treatment Completed
  30. N/A Testing a Brief Substance Misuse Preventative Intervention for Parents/Guardians of 5th-7th Grade Students Completed
  31. N/A A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity Pilot Completed
  32. N/A SET-Recovery/Healthy Home Completed
  33. N/A Palonosetron and Hydroxyzine to Reduce Opioid Withdrawal Completed
  34. N/A Functional Magnetic Resonance Imaging of Opioid Withdrawal in Healthy Human Volunteers Completed
  35. N/A Encouraging Judicious Prescribing of Opioids in Los Angeles County Completed
  36. N/A Behavioral Insights to Encourage Judicious Prescribing of Opioids Completed
  37. N/A Development of a Patient Centered Mental Health Intervention for Recent Veterans Completed
  38. N/A First Episode Schizophrenia and Cannabis-Related Disorder Study Completed
  39. N/A Multisite RCT of STEP-Home: A Transdiagnostic Skill-based Community Reintegration Workshop Completed
  40. N/A Skills Based Counseling for Adherence and Depression in HIV+ Methadone Patients - 1 Completed
  41. N/A Screening and Brief Advice to Reduce Teen Substance Use Completed
  42. N/A Optimizing Behavioral Health Homes for Adults With Serious Mental Illness Completed
  43. N/A Scalable Digital Delivery of Evidence-based Training for Professionals to Maximize Treatment Rates of OUD in Families Completed
  44. N/A Data-driven Identification for Substance Misuse Completed

Showing the 50 most-cited and recently-updated of 55 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Social exclusion and cultural barriers hinder substance use service access for immigrants in Europe
Primary Care & Family Medicine Sys. Review
Social exclusion and cultural barriers hinder substance use service access for immigrants in Europe Social exclusion blocks immigrants from addiction care in Europe
This systematic scoping review identifies significant barriers to substance use services for immigrants in Europe, including language challe…
Language, stigma, and discrimination keep immigrants in Europe from getting help for substance use, a new review finds.
Frontiers Jun 10, 2026
Plant-derived compounds show potential for substance use disorders, depression, anxiety
Drug Pipeline Sys. Review
Plant-derived compounds show potential for substance use disorders, depression, anxiety Plant extracts may help with depression and anxiety, but more research is needed
This narrative review examines plant-derived metabolites and essential oils from Hypericum perforatum, Rhodiola rosea, and Withania somnifer…
A review suggests plant-derived compounds like St. John's Wort and Rhodiola might help with mood disorders, though effects need further vali…
Frontiers Jun 2, 2026
Modified strategies for integrating mental health into NCD care in India
Primary Care & Family Medicine Guideline
Modified strategies for integrating mental health into NCD care in India India’s Mental Health Care Gets a New Blueprint for Action
Nine implementation strategies were modified to integrate mental and substance use disorder screening into NCD care in India, showing feasib…
India is testing a smarter way to treat mental health conditions inside regular diabetes and heart disease clinics, and early results show i…
Frontiers May 13, 2026
Mini review notes elevated substance use in sexual minority women compared to heterosexual women
Psychiatry Sys. Review
Mini review notes elevated substance use in sexual minority women compared to heterosexual women Substance use is higher among sexual minority women than heterosexual women
This narrative mini review examines substance use patterns in sexual minority women (SMW) versus heterosexual women. The authors synthesize …
A review shows substance use is more common among sexual minority women. Bisexual women face the highest risk. This review highlights the ne…
Frontiers May 7, 2026
Semaglutide linked to lower neuropsychiatric event risk vs other diabetes drugs in observational study
Diabetes & Endocrinology Cohort
Semaglutide linked to lower neuropsychiatric event risk vs other diabetes drugs in observational study Semaglutide linked to lower neuropsychiatric risk than other diabetes drugs
This observational cohort study analyzed 63,215 patients with baseline neuropsychiatric conditions across a large US federated data platform…
A large observational study suggests semaglutide may be associated with a lower risk of neuropsychiatric conditions compared to other common…
medRxiv Apr 24, 2026
Scoping review of mental health in sub-Saharan African university students during COVID-19
Primary Care & Family Medicine Sys. Review
Scoping review of mental health in sub-Saharan African university students during COVID-19 Mental health crisis among African university students revealed
This systematic scoping review synthesized evidence on mental health among university students in sub-Saharan Africa during the COVID-19 pan…
Depression, anxiety, and suicidality are common among university students in sub-Saharan Africa, but help-seeking is rare. A new review maps…
Frontiers Apr 23, 2026
Systematic review of mobile health just-in-time adaptive interventions for youth mental health and substance use
Pediatrics Meta-analysis
Systematic review of mobile health just-in-time adaptive interventions for youth mental health and substance use Smartphone Alerts That Learn Your Teen’s Habits May Boost Mental Health
This systematic review synthesized 61 mobile health just-in-time adaptive interventions for adolescents and young adults.
This could change how mental health care works for young people — before crises happen.
medRxiv Apr 23, 2026
Global Burden of Disease 2023 data show rising drug use disorder burden in the US and India through 2040
Drug Pipeline Cohort
Global Burden of Disease 2023 data show rising drug use disorder burden in the US and India through 2040 Drug Use Patterns Are Splitting in Three Major Countries—And What Comes Next Could Affect Millions
This review analyzed Global Burden of Disease 2023 data for drug use disorders in China, India, and the United States.
While China's drug use rates are falling, the US faces a sharp rise through 2040, leaving India with mixed trends as opioid disorders drive …
Frontiers Apr 19, 2026
HIV outbreak reported among persons who inject drugs in Kanawha County, West Virginia
Infectious Disease
HIV outbreak reported among persons who inject drugs in Kanawha County, West Virginia HIV outbreak reported among people who inject drugs in West Virginia county
A descriptive outbreak investigation report documented an HIV outbreak among persons who inject drugs in Kanawha County, West Virginia, duri…
Health officials report an HIV outbreak among people who inject drugs in Kanawha County, West Virginia, during the pandemic.
CDC Apr 6, 2026
Analysis examines synthetic opioid and stimulant co-involved overdose deaths by occupations and industries
Infectious Disease
Analysis examines synthetic opioid and stimulant co-involved overdose deaths by occupations and industries Analysis looks at overdose deaths involving both opioids and stimulants across different jobs
An observational report analyzed synthetic opioid and stimulant co-involved overdose deaths across occupations and industries in the United …
A new analysis examines how different jobs and industries might connect to overdose deaths involving both synthetic opioids and stimulants.
CDC Apr 5, 2026
Survey examines substance use patterns among U.S. high school students before and during COVID-19
Infectious Disease
Survey examines substance use patterns among U.S. high school students before and during COVID-19 Survey examines substance use patterns among U.S. high school students during the pandemic
An observational survey report examined substance use patterns among U.S.
A survey looked at how substance use patterns among U.S. high school students may have changed during the COVID-19 pandemic compared to befo…
CDC Apr 5, 2026
Pennsylvania report examines controlled substance prescribing patterns before fatal overdoses
Infectious Disease
Pennsylvania report examines controlled substance prescribing patterns before fatal overdoses What prescriptions did people have before dying from an overdose in Pennsylvania?
An observational report from Pennsylvania analyzed controlled substance prescribing patterns preceding fatal overdoses involving opioids, st…
A new Pennsylvania report maps the controlled substance prescriptions people received before dying from an overdose involving opioids or sti…
CDC Apr 5, 2026

All Substance-Related Disorders Articles