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Home › Conditions › Substance-Related Disorders

Substance-Related Disorders

Subtypes of Substance-Related Disorders

Substance Use Disorder 19 Drug use disorders 1

23 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Substance-Related Disorders

55 trials tracked for Substance-Related Disorders: 9 in phase 3 or 4 and 4 with published results. The most-cited published study has 72 citations.

55Trials tracked
9Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 4 Phase 3 5 Phase 2 3 Phase 1 5 Other / NA 38
  1. Phase 4 Relapse Prevention With Varenicline Completed · 72 cited
  2. Phase 4 Smoking Cessation Treatment for Methadone Maintenance Patients Completed · 72 cited
  3. Phase 3 Non-Invasive Vagal Nerve Stimulation in Opioid Use Disorders Completed · 27 cited
  4. Phase 4 Buprenorphine to Improve HIV Care Engagement and Outcomes Completed · 20 cited
  5. Phase 4 Interactions Between Drug Effects and Environments II Completed
  6. Phase 3 Rapid HIV Testing and Counseling in Drug Abuse Treatment Completed
Show 44 more trials
  1. Phase 3 Treating Violence-Prone Substance Use Disorder Patients Completed
  2. Phase 3 Prescription Opioid Addiction Treatment Study (POATS) Completed
  3. Phase 3 Voucher-Based Incentives in a Prevention Setting Completed
  4. Phase 2 Combined Treatment for Alcohol-Dependent Individuals With PTSD Completed
  5. Phase 2 Prescription Opioid Effects in Abusers Versus Non-Abusers Completed
  6. Phase 2 Interactive Motivational Media for Perinatal Drug Abuse - 3 Completed
  7. Phase 1 Pilot Clinical Trial of Computer-based Motivational Intervention - 1 Completed
  8. Phase 1 Neural Mechanisms of Cannabinoid-impaired Decision-Making in Emerging Adults Completed
  9. Phase 1 The Women's Recovery Group Study: Stage I Trial Completed
  10. Phase 1 Alcohol, Behavior, and Brain Imaging Completed
  11. Phase 1 Middle School to High School Transition Project: Depression and Substance Abuse Prevention Completed
  12. N/A MISSION-Vet HUD-VASH Implementation Study Completed
  13. N/A Working With HIV Clinics to Adopt Addiction Treatments Using Implementation Facilitation Completed
  14. N/A Abuse Liability of Reduced Nicotine Content Cigarettes Within a Complex Tobacco Marketplace Completed
  15. N/A We The Village Family Support Study Completed
  16. N/A A Brief Community Linkage Intervention for Dually Diagnosed Individuals Completed
  17. N/A Community Health Worker Training to Reduce Depression and Substance Use Stigma in TB/HIV Care in South Africa Completed
  18. N/A Mindfulness Meditation for the Treatment of Women With Comorbid PTSD and SUD Completed
  19. N/A Women's Treatment and Early Recovery Completed
  20. N/A Treatment Engagement With Technology-assisted Treatment Completed
  21. N/A Group Motivational Interviewing (GMI) For Homeless Veterans In VA Services Completed
  22. N/A Preventing Impaired Driving Among Adolescents Completed
  23. N/A Screening to Augment Referral to Treatment- Project START Completed
  24. N/A Incentives to Decrease Opioid Use - Pilot Completed
  25. N/A A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity Completed
  26. N/A Intervention for Veterans With Depression, Substance Disorder, and Trauma Completed
  27. N/A Preventing Addiction Related Suicide (PARS) Completed
  28. N/A Family Engagement, Cross-System Linkage to Substance Use Treatment for Juvenile Probationers -- Phase 3 Completed
  29. N/A Preventing Violence Among Veterans in Substance Use Disorder Treatment Completed
  30. N/A Testing a Brief Substance Misuse Preventative Intervention for Parents/Guardians of 5th-7th Grade Students Completed
  31. N/A A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity Pilot Completed
  32. N/A SET-Recovery/Healthy Home Completed
  33. N/A Palonosetron and Hydroxyzine to Reduce Opioid Withdrawal Completed
  34. N/A Functional Magnetic Resonance Imaging of Opioid Withdrawal in Healthy Human Volunteers Completed
  35. N/A Encouraging Judicious Prescribing of Opioids in Los Angeles County Completed
  36. N/A Behavioral Insights to Encourage Judicious Prescribing of Opioids Completed
  37. N/A Development of a Patient Centered Mental Health Intervention for Recent Veterans Completed
  38. N/A First Episode Schizophrenia and Cannabis-Related Disorder Study Completed
  39. N/A Multisite RCT of STEP-Home: A Transdiagnostic Skill-based Community Reintegration Workshop Completed
  40. N/A Skills Based Counseling for Adherence and Depression in HIV+ Methadone Patients - 1 Completed
  41. N/A Screening and Brief Advice to Reduce Teen Substance Use Completed
  42. N/A Optimizing Behavioral Health Homes for Adults With Serious Mental Illness Completed
  43. N/A Scalable Digital Delivery of Evidence-based Training for Professionals to Maximize Treatment Rates of OUD in Families Completed
  44. N/A Data-driven Identification for Substance Misuse Completed

Showing the 50 most-cited and recently-updated of 55 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Cannabis-involved ED visits increased among US youth during COVID-19 pandemic
Infectious Disease
Cannabis-involved ED visits increased among US youth during COVID-19 pandemic Cannabis-related emergency visits rose among young people during COVID-19 pandemic
A US report found cannabis-involved emergency department visits were higher among persons under 25 during the COVID-19 pandemic period compa…
Emergency visits for cannabis use among young people rose during the COVID-19 pandemic compared to before.
CDC Apr 5, 2026
Report describes alcohol and substance co-use among pregnant females in the United States
OB/GYN & Women's Health
Report describes alcohol and substance co-use among pregnant females in the United States Report examines alcohol and substance use patterns among pregnant people in the US
An observational report describes alcohol and substance co-use among pregnant females aged 12-44 years in the United States.
A new report looks at how often pregnant people in the US use alcohol and other substances together, aiming to clarify current trends.
CDC Apr 4, 2026
Planned trial compares injectable antipsychotics to usual care for psychosis with stimulant use
Psychiatry Phase III
Planned trial compares injectable antipsychotics to usual care for psychosis with stimulant use Hong Kong trial planned to test antipsychotic injections for substance use with psychosis
A trial record describes a planned phase 2/3 study of 165 individuals in Hong Kong with substance use disorders and psychosis.
Hong Kong researchers plan a trial to test long-acting antipsychotic injections for people with substance use disorders and psychosis.
CT.gov Apr 3, 2026
COVID-19 pandemic linked to adverse mental health in US adults with disabilities
Psychiatry
COVID-19 pandemic linked to adverse mental health in US adults with disabilities Report examines mental health and substance use among disabled adults during pandemic
An observational report describes adverse mental health symptoms or substance use among US adults with disabilities during the COVID-19 pand…
A report highlights adverse mental health symptoms and substance use among adults with disabilities during the COVID-19 pandemic.
CDC Apr 3, 2026
Health center visit rates studied in US adults with mental health or substance use disorders
Psychiatry
Health center visit rates studied in US adults with mental health or substance use disorders How often do adults with mental health or substance use disorders visit health centers?
An observational study examined health center visit rates among US adults with mental health disorders, substance use disorders, or both.
We don't yet know how frequently adults with mental health or substance use disorders visit health centers.
CDC Apr 3, 2026
Psychological interventions show minimal symptom benefit, no substance use effect in schizophrenia with SUD
Psychiatry Meta-analysis
Psychological interventions show minimal symptom benefit, no substance use effect in schizophrenia with SUD Do current talk therapies help people with schizophrenia who also use substances?
A meta-analysis of 35 RCTs (3,831 participants) found psychological interventions for adults with schizophrenia and substance use disorders …
Nearly half of people with schizophrenia also use substances, yet current talk therapies show almost no benefit for reducing drug or alcohol…
Apr 3, 2026
Observational report examines racial and ethnic disparities in mental health during COVID-19 pandemic
Psychiatry
Observational report examines racial and ethnic disparities in mental health during COVID-19 pandemic Did the pandemic hit some communities harder with stress and substance use?
An observational report describes racial and ethnic disparities in stress, worry, mental health conditions, and substance use among U.S.
A new report shows stress, worry, and substance use during the pandemic hit some racial and ethnic groups in the United States harder than o…
CDC Apr 3, 2026
Field report describes overdose deaths involving eutylone, a psychoactive bath salt, in the United States
Psychiatry
Field report describes overdose deaths involving eutylone, a psychoactive bath salt, in the United States What happens when people overdose on the bath salt drug eutylone?
A field report describes overdose deaths involving eutylone, a psychoactive bath salt, in the United States.
A new report confirms that eutylone, a dangerous synthetic stimulant often sold as bath salts, is causing fatal overdoses in the United Stat…
CDC Apr 3, 2026
School racism experiences associated with mental health, suicide risk, and substance use in US high school students
Psychiatry
School racism experiences associated with mental health, suicide risk, and substance use in US high school students Report finds links between school racism and student mental health, substance use
An observational report found associations between experiencing racism in school and poor mental health, substance use, and suicide risk amo…
A new report links racism in schools to worse mental health, substance use, and suicide risk among high school students from all backgrounds…
CDC Apr 3, 2026
School-based resilience interventions reduce adolescent tobacco, alcohol, and illicit substance use
Pediatrics Meta-analysis
School-based resilience interventions reduce adolescent tobacco, alcohol, and illicit substance use School resilience programs linked to lower substance use in students
A meta-analysis of school-based studies in students aged 6-18 years found resilience interventions were associated with reduced substance us…
School resilience programs that teach coping skills are linked to lower tobacco, alcohol, and drug use among students aged 6 to 18.
Apr 2, 2026
Study Buddy Intervention Fails to Improve Retention in Rural PWUD Longitudinal Research
Anesthesiology & Pain Medicine RCT
Study Buddy Intervention Fails to Improve Retention in Rural PWUD Longitudinal Research Study buddy approach did not improve retention in rural drug use research
A randomized controlled trial of 739 rural people who use drugs (PWUD) in the US found that adding a participant-referred 'study buddy' inte…
Asking rural people who use drugs to recruit a 'study buddy' did not improve their chances of staying in long-term health research compared …
Apr 2, 2026