Procalcitonin-guided care in sepsis shows no difference in early antibiotic initiation but lower 28-day mortality
A simple test in emergency rooms may lower death rates for sepsis patients
This phase 3 randomised controlled trial in 7667 patients with suspected sepsis across 20 English and Welsh emergency departments compared p…
A new test used to guide treatment for sepsis in emergency rooms lowered death rates without changing how quickly antibiotics were given.
Meta-analysis shows association between adequate antimicrobial therapy and reduced hospital length of stay
Right Antibiotic Choice Cuts Hospital Stay by Nearly Two Weeks
This meta-analysis of 4158 adult hospitalised patients examines the relationship between adequate empirical antibiotic therapy and clinical …
Choosing the right antibiotic from the start can cut a hospital stay by nearly two weeks for adults with serious infections.
Narrative review on multi-omic technologies for pediatric sepsis biomarker discovery
Multi-omic technologies may transform pediatric sepsis care from empiric treatment to precision medicine
This narrative review synthesizes evidence on multi-omic technologies and computational biology for pediatric sepsis biomarker discovery.
A review suggests multi-omic technologies could shift pediatric sepsis care from empiric treatment to precision medicine.
Narrative review of Shenfu Injection for sepsis-induced gastrointestinal injury and septic shock
A Chinese herbal therapy may protect the gut during septic shock
This narrative review examines Shenfu Injection for sepsis-induced acute gastrointestinal injury and septic shock.
A traditional Chinese herbal blend may help protect the gut during septic shock, offering a new angle on a deadly complication that often go…
Active sepsis prevention program reduces maternal infection-related complications in Malawi and Uganda
New program cuts deadly infections in mothers by 32%
This cluster-randomized trial in Malawi and Uganda involving 431,394 women found that an Active Prevention and Treatment of Maternal Sepsis …
A low-cost hospital program in Africa cut life-threatening infections in pregnant women by more than 30%, offering hope for safer childbirth…
Sarcopenia in older patients with sepsis is associated with specific plasma metabolomic changes
Metabolic changes link muscle loss to sepsis in older adults
In this prospective observational cohort study of 84 older patients with sepsis, researchers identified significant differences in plasma me…
New findings show how specific chemical changes in the blood connect muscle wasting to severe infections in older patients.
Systematic review identifies dual role of NLRP3 inflammasome in sepsis induced immune dysregulation
NLRP3 activation plays a dual role in sepsis
This systematic review examines the role of NLRP3 inflammasome activation and modulation in sepsis.
A review of research shows that a specific protein complex helps drive both inflammation and immune suppression during sepsis.
Large language models show varying accuracy for data extraction in sepsis guidelines
AI models show promise for extracting sepsis study data
This study evaluated the performance of large language models, including ChatGPT-4o, Claude 3 Sonnet, and Gemini 1.5 Pro, for data extractio…
New tests show AI can help pull patient details from medical papers, but extracting clinical results remains a major challenge.
Narrative review examines multimorbidity impact on sepsis morbidity and mortality outcomes
Sepsis Risk Skyrockets When You Have Multiple Chronic Conditions
This narrative review synthesizes evidence regarding sepsis in patients with multimorbidity including type 2 diabetes and heart failure.
Common chronic diseases like diabetes and heart failure create hidden traps that make sepsis much harder to fight and treat.
Narrative review of Dachengqi Decoction for sepsis-induced organ injury
Dachengqi Decoction may protect organs during dangerous sepsis attacks
This narrative review summarizes evidence that Dachengqi Decoction (DCQD) and its bioactive metabolites may protect against sepsis-induced i…
A traditional Chinese medicine formula shows promise for stopping organ damage in sepsis patients by calming the body's extreme immune react…
Non-invasive ultrasound defines snuffbox artery RI and PI reference ranges in healthy volunteers versus ICU patients with septic shock or hypertension
New blood flow numbers reveal hidden risks in shock patients
This prospective observational cohort study included 91 healthy volunteers and 55 ICU patients at a 4,900-bed tertiary care hospital in Chin…
A simple finger test now shows hidden blood flow problems that standard checks miss in sick patients.
Early enteral nutrition linked to favorable biomarker trajectories and lower mortality risk in adult ICU sepsis patients
Early feeding helps sick patients avoid dangerous metabolic spikes
This retrospective cohort study of 3,354 adult ICU patients with sepsis at West China Hospital examined early enteral nutrition (EEN).
Starting food early in the ICU helps patients avoid dangerous metabolic spikes and lowers the risk of dying within 28 days.