Immune dysregulation score predicts mortality and identifies hydrocortisone responders in community-acquired pneumonia
Three Blood Markers May Pick Who Benefits From Sepsis Steroids
A multicohort analysis and reanalysis of an RCT developed and validated an immune dysregulation score using three plasma biomarkers in 398 d…
A simple three-blood-test model may finally pick which sepsis patients benefit most from steroid treatment, using biology instead of guesswo…
A 1-hour sepsis bundle is associated with reduced short-term mortality compared to non-bundle care in a meta-analysis of 4435 patients
One Hour Saves Lives in Sepsis
This systematic review and meta-analysis evaluated the association between a 1-hour sepsis bundle and short-term mortality in 4435 patients …
A specific 1-hour checklist for treating sepsis significantly lowers short-term death rates compared to standard care, offering a simple way…
Maternal preeclampsia modestly increases neonatal sepsis risk in infants up to 28 days of age
A Mother’s High Blood Pressure May Raise Her Newborn’s Infection Risk
This systematic review and meta-analysis evaluated 1,513,008 neonates to assess the association between maternal preeclampsia and neonatal s…
Babies born to mothers with preeclampsia face a 27% higher risk of serious infection in the first month of life, prompting doctors to watch …
RDW trajectories during sepsis hospitalization predict 30- and 90-day mortality in retrospective study
Why a simple blood test predicts who gets sicker
A retrospective cohort study of 3,813 sepsis patients found that specific red blood cell distribution width (RDW) trajectories over the firs…
Tracking how your red blood cell size changes day by day reveals who is most likely to die from sepsis within 30 days.
CytoSorb hemoadsorption shows no benefit and potential harm in small septic shock trial
A Promising Sepsis Treatment May Do More Harm Than Good
A single-center RCT of 31 adults with septic shock and high IL-6 found no significant difference in cumulative norepinephrine dose (primary …
A high-tech blood filter for sepsis failed to help patients and may have worsened early survival rates in a new study.
AI applications in acute care showed potential but face significant implementation challenges
AI Is Quietly Changing How ERs Save Lives. Here’s How
This narrative review examined artificial intelligence (AI) applications in patients within emergency departments and intensive care units.
Artificial intelligence is moving into emergency rooms to help doctors spot life-threatening problems faster, but it’s not ready to run the …
Macrophage glycolysis interactions modulate inflammation and polarization in sepsis
A Hidden Switch in Your Immune System Could Change Sepsis Treatment
This systematic review examined mechanisms linking macrophage glycolysis and inflammation in sepsis.
Understanding this biological energy switch gives researchers a clear new target to stop sepsis in its tracks.
Red blood cell parameters predict sepsis in children with ALL and chemotherapy-induced neutropenia
A Simple Blood Test Could Warn of Sepsis in Children on Chemotherapy
This retrospective cohort study evaluated red blood cell parameters in children with acute lymphoblastic leukemia who developed chemotherapy…
Doctors may have found a faster, simpler way to spot a deadly infection in children undergoing cancer treatment.
NTIS subtypes and thyroid antibodies associated with higher in-hospital mortality in sepsis cohort
Thyroid Antibodies Signal Higher Death Risk in Sepsis
A retrospective cohort study of 871 sepsis patients at a Shanghai tertiary hospital found non-thyroidal illness syndrome (NTIS) was independ…
Thyroid antibodies found in sepsis patients signal a higher risk of death, offering doctors a critical warning sign beyond standard infectio…
Meta-analysis identifies clinical signs associated with sepsis and mortality in young infants
Which signs in a newborn's cry or feeding best warn of life-threatening infection?
A systematic review and meta-analysis of 52 studies including 140,885 young infants in resource-limited settings found 16 clinical signs sig…
A weak cry, poor feeding, or a drowsy baby are the top five signs linked to life-threatening infection and death in newborns under two month…
Socioeconomic factors associated with increased mortality in adults with sepsis or septic shock
Study finds poverty and lack of insurance linked to higher death rates from sepsis
A systematic review and meta-analysis of 13 observational studies involving 3,951,677 adults with sepsis or septic shock found that several …
Poverty and lack of private insurance are linked to higher death rates from sepsis, affecting nearly 4 million adults in a major review.
Neostigmine infusion in septic shock linked to lower TNF-alpha and 28-day mortality in single-center RCT
Neostigmine infusion linked to lower inflammation and mortality in septic shock trial
A single-center randomized controlled trial in adult ICU patients with septic shock compared a 5-day neostigmine infusion (0.2 mg/hr) to pla…
Septic shock patients receiving neostigmine showed lower inflammation, better organ scores, and fewer deaths compared to those on placebo in…