Corticosteroids in cirrhotic shock show no mortality benefit but increase bleeding and organ failure risk
Corticosteroids help resolve shock in cirrhosis patients but don't improve survival
A meta-analysis of 514 cirrhotic patients with septic or distributive shock found low-dose corticosteroids did not reduce in-hospital mortal…
Low-dose corticosteroids help resolve shock in cirrhosis patients but do not improve overall survival and increase bleeding risks.
Observational study examines septicemia death rates in US adults aged 65 and older
Study examines septicemia death rates in older U.S. adults
An observational study examined septicemia death rates among persons aged 65 years and older in the United States.
Septicemia death rates in U.S. adults aged 65 and older are being examined in a new study.
Report describes sepsis program activities in US acute care hospitals
What are hospitals actually doing to fight sepsis? A new report looks inside
A report describes sepsis program activities in acute care hospitals across the United States.
A new report reveals what hospitals are doing to fight sepsis, but it doesn't say which programs save lives or which are safest.
Procalcitonin shows moderate accuracy for bloodstream infection detection in retrospective cohort
Blood test shows promise in detecting bacterial infections and identifying their type
A retrospective cohort study of 251 bacterial isolates from positively flagged blood cultures in South India found procalcitonin (PCT) had 7…
A blood test detected bloodstream infections with 83% accuracy, showing slightly higher levels for Gram-negative bacteria like E. coli and K…
Case-control study identifies K. pneumoniae proteins associated with lack of neonatal sepsis
Study identifies potential vaccine targets for deadly newborn infection in Africa
A case-control study of 100 mother-baby dyads in sub-Saharan Africa analyzed antibody responses to 161 K.
Specific bacterial proteins might protect newborns from deadly sepsis via maternal antibodies, paving the way for a vaccine in sub-Saharan A…
Meta-analysis finds diaphragmatic atrophy and weakness in critically ill patients on ventilation or with sepsis
Why do critically ill patients struggle to breathe on their own? Their diaphragm muscles shrink and weaken
A systematic review and meta-analysis of 187 critically ill patients requiring mechanical ventilation or with sepsis found diaphragmatic fib…
Critically ill patients on ventilators have diaphragm muscles that are 30% smaller and dramatically weaker than normal, explaining their str…
Procalcitonin-guided antibiotic protocols reduce therapy duration in critically ill sepsis patients
Blood test helps guide antibiotic use in sepsis patients, may shorten treatment
A rapid systematic review and meta-analysis of 19 trials (n=6,382) in critically ill adult sepsis patients found procalcitonin-guided antibi…
A blood test that measures procalcitonin may help doctors safely shorten antibiotic treatment for sepsis by about two days.
Systematic review explores pathogenesis and emerging treatments for sepsis-induced cardiomyopathy
Review explores potential new treatments for sepsis-related heart problems
A systematic review examined the pathogenesis and treatment landscape for sepsis-induced cardiomyopathy in patients with severe sepsis.
New approaches targeting inflammation, calcium, and energy metabolism show potential for treating heart damage in severe sepsis patients.
Network meta-analysis finds PMX and HA 330 blood purification may reduce mortality in severe septic shock
Two blood purification devices linked to lower death rates in severe septic shock
A Bayesian network meta-analysis of 31 RCTs involving 2678 patients with severe septic shock found that the TORAYMYXIN™ filter (PMX) and HA …
Two specific blood purification devices are linked to lower death rates for patients with severe septic shock compared to standard treatment…
PAC use in cardiogenic shock associated with lower mortality but higher sepsis risk in meta-analysis
Can a heart monitor help people survive cardiogenic shock?
A meta-analysis of 14 observational studies including 789,553 adults with cardiogenic shock found pulmonary artery catheterization (PAC) use…
A heart monitor linked to lower death rates in cardiogenic shock also raises infection risks and the need for stronger research.
Higher baseline chondroitin sulfate predicts greater mortality benefit from restrictive fluid strategy in sepsis
Blood marker may help predict which sepsis patients benefit from less fluid
A biomarker analysis within an RCT of 574 patients with sepsis-associated hypotension found that higher baseline plasma chondroitin sulfate …
A blood marker may help doctors decide which sepsis patients benefit most from receiving less intravenous fluid during treatment.
Balanced salt solution in pediatric septic shock linked to lower AKI and RRT rates versus normal saline
Balanced fluids may reduce kidney injury in children with septic shock, study finds
A meta-analysis of 5 RCTs involving 992 children with septic shock found balanced salt solution (BSS) was not associated with reduced mortal…
Using balanced salt solutions instead of normal saline helps children with septic shock avoid kidney injury and dialysis, a new analysis of …