Telitacicept 160 mg plus standard therapy doubles SRI-4 response rate in adults with SLE
Telitacicept shows promise for adults with systemic lupus erythematosus
This meta-analysis of adults with systemic lupus erythematosus (SLE) found that telitacicept 160 mg plus standard therapy increased the SRI-…
A new treatment option, telitacicept, may improve response rates for adults with systemic lupus erythematosus and lupus nephritis.
Diagnostic codes and algorithms show 0.90 sensitivity for identifying systemic lupus erythematosus in electronic records
Electronic Records Help Identify Connective Tissue Diseases More Accurately
This meta-analysis of 38 studies evaluates the accuracy of electronic health record codes and algorithms for identifying connective tissue d…
New data shows that specific coding systems in electronic health records can accurately identify patients with several connective tissue dis…
Exercise and physical activity may reduce fatigue in adults with systemic lupus erythematosus
Exercise May Help Reduce Fatigue in People with Lupus
This umbrella review evaluates exercise and physical activity for managing fatigue and disease activity in adults with systemic lupus erythe…
Exercise and physical activity may help reduce fatigue for adults with lupus, though the current evidence is limited and not yet fully certa…
Targeted and biological therapies offer potential to reduce disease activity and organ damage in SLE
New targeted and biological therapies show promise for lupus patients
This systematic review identifies 90 targeted agents, including 70 bDMARDs and 20 tsDMARDs, for the treatment of systemic lupus erythematosu…
Newer targeted and biological treatments may help people with lupus reduce disease activity and lower their need for steroids.
SLE Tied to More Than Double Stroke Risk Across 25 Cohorts
People with lupus face significantly higher risk of stroke
A meta-analysis of 25 cohort studies finds systemic lupus erythematosus more than doubles stroke risk, with consistent elevations across str…
A large study of over 5 million people shows that those with systemic lupus erythematosus have a much higher risk of suffering a stroke.
Umbilical cord-derived mesenchymal stromal cells balance immune homeostasis and offer potential for inflammatory disease treatment
Mesenchymal Stromal Cells Show Promise for Autoimmune and Immune Disorders
This systematic review examines the immunomodulatory properties and translational challenges of umbilical cord-derived mesenchymal stromal c…
Umbilical cord cells may help balance the immune system in conditions like lupus and rheumatoid arthritis, though long-term safety data is s…
Ivarmacitinib shows significant clinical improvement in a patient with alopecia areata and systemic lupus erythematosus
Ivarmacitinib Shows Promise for Alopecia Areata and Lupus Hair Loss
This case report and literature review describes a 35-year-old woman with severe patchy alopecia and systemic lupus erythematosus who showed…
A new treatment may help patients with overlapping hair loss conditions like alopecia areata and systemic lupus erythematosus.
Deep learning models show high sensitivity and specificity for SLE and lupus nephritis diagnosis
Machine Learning Models Show Promise for Diagnosing Lupus Conditions
This meta-analysis of 29 studies evaluated the diagnostic performance of machine learning and deep learning models for SLE, lupus nephritis,…
New analysis shows deep learning models may offer high accuracy in identifying various types of lupus and related kidney or neurological con…
Voclosporin doubles proteinuria reduction in lupus nephritis but raises adverse events
Voclosporin Shows Better Results for Lupus Nephritis Protein Reduction
This meta-analysis of randomized controlled trials in 770 adults with lupus nephritis found that adding voclosporin to standard treatment si…
Adding voclosporin to standard treatment may help reduce protein in the urine for adults with Lupus Nephritis, though it carries higher safe…
No direct evidence exists regarding altered ncRNA levels in breast milk from mothers with SLE
Breast Milk RNA in Lupus Mothers: What We Know
This literature review examines the presence of ncRNA molecules in human breast milk and their potential impact on the neonatal immune syste…
A review finds no direct proof that lupus changes RNA in breast milk, but highlights the need for more research on infant immunity.
High disease activity in paediatric SLE is associated with increased risk of multisystem involvement
High disease activity linked to organ damage in children with lupus
This meta-analysis of 4934 paediatric patients with systemic lupus erythematosus (pSLE) indicates that high disease activity is associated w…
Children with high disease activity in lupus are much more likely to experience serious complications like kidney damage and neurological is…
Obinutuzumab improves SRI-4 response by 23.1 percentage points in active systemic lupus erythematosus
Trial shows obinutuzumab improves outcomes for systemic lupus erythematosus
This Phase 3 randomized controlled trial of 303 adults with active systemic lupus erythematosus found obinutuzumab significantly superior to…
A new clinical trial shows that obinutuzumab significantly improved response rates for adults with active systemic lupus erythematosus compa…
Questions about Systemic Lupus Erythematosus
How do biologics compare to targeted drugs for treating systemic lupus erythematosus?
Biologics (e.g., anifrolumab, belimumab) and targeted drugs (e.g., telitacicept, upadacitinib) both treat SLE, but network meta-analyses show telitacicept may outperform belimumab for SRI-4 response, while anifrolumab and deucravacitinib work better for skin symptoms. Safety prof
Full answer →How common is female sexual dysfunction in women with systemic lupus erythematosus according to recent studies?
Recent studies show that about 59% of women with systemic lupus erythematosus experience sexual dysfunction, which is significantly higher than in healthy women.
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