Deucravacitinib modulates up to 2529 genes and SLE-relevant gene sets including interferon-regulated genes
Trial Shows Deucravacitinib Modulates Gene Activity in Lupus Patients
This post hoc analysis of a Phase 2 trial in 363 patients with systemic lupus erythematosus (SLE) found that deucravacitinib modulated up to…
A Phase 2 trial shows that deucravacitinib may influence specific gene sets and immune cell activity in people with systemic lupus erythemat…
Belimumab plus standard therapy shows numerically greater reductions in IgA, IgM, and anti-dsDNA antibodies
Trial Shows Belimumab May Help Manage Lupus Nephritis Symptoms
This Phase 3 randomized controlled trial of 446 adults with active lupus nephritis found that intravenous belimumab plus standard therapy re…
A Phase 3 trial identifies specific markers that may help predict how patients with lupus nephritis respond to belimumab treatment.
Corticosteroid and cyclophosphamide exposure are associated with higher mortality in Middle Eastern and North African SLE
Specific Medications Linked to Survival Rates in Lupus Patients
This meta-analysis of 3,478 adult patients in the MENA region found an all-cause mortality rate of 9.9% (95% CI: 7.2%-14.0%). While corticos…
New data identifies how specific medications and health conditions impact long-term survival for patients with systemic lupus erythematosus.
Anti-DFS70 antibodies show high specificity but low sensitivity for excluding Systemic Lupus Erythematosus
Anti-DFS70 Antibodies May Help Rule Out Systemic Lupus Erythematoma
This meta-analysis evaluates the diagnostic performance of anti-DFS70 antibodies in patients with Systemic Lupus Erythematoma (SLE). The ana…
A large analysis suggests that specific antibodies could help doctors rule out systemic lupus, though more research is needed to confirm the…
Aerobic and resistance exercise improve fatigue, physical function, and pain in systemic lupus erythematosus
Exercise Eases Fatigue and Pain in Lupus Patients
This meta-analysis of 470 adults with SLE found that aerobic, resistance, or combined exercise leads to small-to-moderate improvements in fa…
A review of 470 lupus patients finds exercise improves fatigue, pain, and mood without worsening disease activity.
Small PNH clones in SLE linked to thrombotic events and hemolysis in case series
Small blood cell issues can impact patients with lupus and PNH
A systematic review of 8 cases found that 37.5% of SLE patients with PNH had thrombotic events and 87.5% had detectable hemolysis. The findi…
A review of cases shows that even small clusters of abnormal cells can cause serious blood complications in people with lupus and PNH.
Dapirolizumab pegol increases BICLA response rate by 14.6% over placebo in moderate-to-severe SLE
Trial shows dapirolizumab pegol improves symptoms for lupus patients
This Phase 3 randomized controlled trial of 321 patients with moderate-to-severe, active SLE found that dapirolizumab pegol added to standar…
A new clinical trial found that dapirolizumab pegol significantly improved disease activity for adults with moderate to severe systemic lupu…
SLE patients have a 2- to 3-fold higher risk of intracerebral hemorrhage compared to non-SLE populations
Lupus Patients Face Higher Risk of Brain Bleeding
This literature review and case report analyze the association between systemic lupus erythematosus (SLE) and intracranial hemorrhage (ICH).…
Patients with systemic lupus erythematosus may face a much higher risk of brain bleeds compared to those without the condition.
Systemic immune-inflammation index and systemic inflammation response index correlate with disease activity in systemic lupus erythematosus
Inflammation markers are higher in lupus patients than in healthy people
This meta-analysis of eleven studies involving individuals with systemic lupus erythematosus and healthy controls examined inflammatory mark…
A new analysis shows inflammation markers are much higher in people with lupus. These markers also track closely with how active the disease…
Stress-induced IL-6 upregulation impairs skeletal growth and bone health in children with inflammatory diseases
Stress hormones may harm bone growth in children with inflammatory conditions
This narrative review synthesizes evidence from animal models and pediatric inflammatory disorders showing that stress-induced IL-6 upregula…
A review suggests stress-induced IL-6 upregulation impairs skeletal growth and bone health in kids with inflammatory disorders, highlighting…
Adrenal insufficiency is first manifestation in 73.6% of APS patients with adrenal involvement
Review finds adrenal crisis common in lupus and antiphospholipid syndrome cases
This systematic review and pooled individual-patient analysis of 155 published APS/SLE-spectrum patients with adrenal involvement found that…
A review of 155 patients shows adrenal crisis is frequent in lupus and antiphospholipid syndrome, highlighting the need for urgent care.
STAT3 inhibition targets cytokine signaling and renal inflammation in systemic lupus erythematosus and lupus nephritis
New review suggests STAT3 inhibition could help lupus kidney disease
This narrative review examines the role of STAT3 in systemic lupus erythematosus and lupus nephritis. The authors argue that STAT3 integrate…
A narrative review suggests targeting STAT3 might treat lupus kidney inflammation, though direct drug targeting remains unproven in patients…
Questions about Systemic Lupus Erythematosus
How do biologics compare to targeted drugs for treating systemic lupus erythematosus?
Biologics (e.g., anifrolumab, belimumab) and targeted drugs (e.g., telitacicept, upadacitinib) both treat SLE, but network meta-analyses show telitacicept may outperform belimumab for SRI-4 response, while anifrolumab and deucravacitinib work better for skin symptoms. Safety prof
Full answer →How common is female sexual dysfunction in women with systemic lupus erythematosus according to recent studies?
Recent studies show that about 59% of women with systemic lupus erythematosus experience sexual dysfunction, which is significantly higher than in healthy women.
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