CSF α-synuclein SAA detects Lewy body dementia with 95% sensitivity in multicenter cohort
Researchers find new test spots Lewy body dementia
This prospective cohort study of 398 patients from memory clinics found that CSF α-synuclein seed amplification assay (SAA) had 95% sensitiv…
A new blood and spinal fluid test accurately identifies Lewy body dementia, even when Alzheimer’s is also present, helping clarify diagnosis…
Review of MRI radiomic features aids Alzheimer's disease classification and progression modeling in 382 participants.
MRI Scan Finds Alzheimer's Signs Before Memory Loss Starts
This observational review synthesizes findings from 382 participants across three cognitive stages regarding MRI-derived radiomic features. …
New imaging tools might catch Alzheimer's changes years before memory fades.
Elevated Plasma P-tau217 Associated with Cognitive Impairment Onset Up to Four Years Before in Preclinical Alzheimer's
Alzheimer’s May Be Predicted Years in Advance
This observational cohort study evaluated individuals with preclinical cognitive decline in Alzheimer's Disease. Elevated plasma P-tau217 le…
Maria started forgetting names. Not just once or twice—her daughter noticed a pattern.
AI-assisted Bayesian framework identifies Alzheimer's gene pathways in single-cell RNA data
AI finds hidden Alzheimer's genes in brain data
This observational study applied a generative AI-assisted Bayesian-frequentist hybrid framework to single-cell RNA sequencing data from the …
A new AI method uncovered Alzheimer's-related genes that standard analysis missed, pointing to fresh biological pathways.
Rare CNV dosage associated with Alzheimer's disease risk in exome case-control study
Rare DNA Errors Found Linked to Higher Alzheimer's Risk
This case-control study analyzed exome data from individuals with Alzheimer's disease and controls. It found that 22q11.21 duplication carri…
Scientists found specific DNA changes that may make some people more likely to develop Alzheimer's.
Menopausal hormone therapy initiation around menopause linked to increased Alzheimer's risk
Hormone Therapy and Dementia: The Truth About Timing
This systematic review and meta-analysis of 213,678 menopausal women found that initiating systemic menopausal hormone therapy (MHT) around …
Many women look to hormone therapy to ease the hot flashes and mood swings of menopause.
Meta-analysis finds trivial cognitive effects of amyloid antibodies in mild Alzheimer's disease
Alzheimer’s Drugs Clear Plaques But Don’t Help Memory
This meta-analysis of 17 randomized trials found amyloid-beta-targeting monoclonal antibodies probably have little to no effect on cognitive…
This review shows that even when Alzheimer’s drugs clear amyloid from the brain, patients don’t see meaningful improvements in memory or dai…
Narrative review examines resveratrol in Alzheimer's, Parkinson's, MS, and cerebral ischemia with noted limitations.
This Common Food Compound May Shield Your Brain From Damage
This narrative review evaluates resveratrol across Alzheimer's disease, Parkinson's disease, multiple sclerosis, and cerebral ischemia. The …
A natural compound found in berries shows promise for protecting brain cells, but human proof is still missing.
Meta-analysis finds association between dentition defects and Alzheimer's disease risk
Tooth loss linked to higher Alzheimer's risk in new analysis
This meta-analysis synthesizes observational studies on dentition defects and Alzheimer's disease risk. It reports a significant association…
A review of past studies found a link between tooth loss and a higher risk of Alzheimer's disease, suggesting oral health may matter for bra…
Observational review of phenoconversion rates and biomarker alignment in Parkinson's disease genetic cohorts
Do your symptoms match the biology, or is the disease hiding in plain sight?
This observational cohort analysis reviews phenoconversion rates and biomarker alignment in Parkinson's Progression Markers Initiative parti…
In people at genetic risk for Parkinson's, symptoms and biological markers often don't align, with nearly one-third showing advanced brain c…
Literature review synthesizes Schisandra chinensis effects on gut microbiota and metabolic pathways across multiple conditions.
This Ancient Berry May Quiet Inflammation From Your Gut to Your Brain
This literature review examines the potential of Schisandra chinensis regarding gut health and metabolic regulation. The authors synthesize …
An ancient berry used for centuries may rebalance gut bacteria to calm inflammation linked to digestive issues, liver disease, diabetes, and…
Plasma proteomics profiling reveals differential protein expression in Alzheimer's and frontotemporal dementia
Can a simple blood test tell Alzheimer's from frontotemporal dementia?
An observational cohort study of 101 Asian individuals with known pTau217 status used plasma proteomics profiling to identify 1,168 proteins…
A simple blood test could distinguish Alzheimer's from frontotemporal dementia by spotting unique protein patterns linked to brain inflammat…