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Home › Conditions › Critical Illness

Critical Illness

15 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Critical Illness

60 trials tracked for Critical Illness: 10 in phase 3 or 4 and 5 with published results. The most-cited published study has 301 citations.

60Trials tracked
10Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 4 2 Phase 3 8 Phase 2 7 Other / NA 43
  1. Phase 3 Vitamin D to Improve Outcomes by Leveraging Early Treatment Completed · 301 cited
  2. Phase 3 Ketamine / Propofol Admixture "Ketofol" at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial Completed · 103 cited
  3. Phase 3 Midodrine for the Treatment of Refractory Hypotension Completed · 38 cited
  4. Phase 3 Hypovitaminosis D in Neurocritical Patients Completed · 21 cited
  5. Phase 3 Self-management of Sedative Therapy by Ventilated Patients Completed · 4 cited
  6. Phase 4 Effects of Intravenous Acetaminophen on Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults Completed
Show 44 more trials
  1. Phase 4 Levofloxacin Pharmacokinetics (PK) in the Severely Obese Completed
  2. Phase 3 Supplemental Enteral Protein in Critical Illness Completed
  3. Phase 3 Efficacy and Mechanisms of GLN Dipeptide in the SICU Completed
  4. Phase 3 Computerized Glucose Control in Critically Ill Patients Completed
  5. Phase 2 Code Status Video in the Intensive Care Unit: Video Assisted Patient Education Completed
  6. Phase 2 Inulin for Infections in the Intensive Care Unit Completed
  7. Phase 2 Maximizing trEatment of Neurological Dysfunction Using INtravenous Guanfacine Study Completed
  8. Phase 2 Practical Anemia Bundle for SusTained Blood Recovery Completed
  9. Phase 2 Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin Completed
  10. Phase 2 Safety and Dose Escalation Study of Zinc Supplementation in Critically Ill Children Completed
  11. Phase 2 Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery Completed
  12. N/A A Study Promoting Critical Illness Recovery in the Elderly Completed
  13. N/A Trial of Glutamine and Antioxidant Supplementation in Critically Ill Patients Completed
  14. N/A A Needs-focused Palliative Care Intervention for Older Adults in ICUs Completed
  15. N/A Continuous Glucose Monitoring for Hyperglycemia in Critically Ill Patients Completed
  16. N/A Improving Communication About Serious Illness Completed
  17. N/A Combining Objective and Subjective Sedation Assessment Tools Completed
  18. N/A Second Survey of Intensive Care in India Completed
  19. N/A A Open Study to Evaluate the Performance of Dressing on Subject With High Risk of Skin Breakdown Completed
  20. N/A Daily Checklists and Outcome in the Intensive Care Unit Completed
  21. N/A Pilot Study Assessing Oxidative Stress in Children Completed
  22. N/A Animal Assisted Interactions With Animal Robot in the Intensive Care Unit (ICU) Completed
  23. N/A European Mortality & Length Of Intensive Care Unit (ICU) Stay Evaluation (ELOISE) Completed
  24. N/A Isotonic Solutions and Major Adverse Renal Events Trial in the Non-Medical Intensive Care Unit (SMART-SURG) Completed
  25. N/A Dexmedetomidine Versus Midazolam for Facilitating Extubation Completed
  26. N/A Exploration of Investigating ICU Mobilisation With Vasoactive Drugs Completed
  27. N/A Development of a Rehabilitation Strengthening and Mobility Program for Ventilator Dependent Older Patients Completed
  28. N/A Use of Nudges To Enhance Enrollment in Critical Care Research Completed
  29. N/A Giving Information Systematically and Transparently in Lung and GI Cancer Phase 1 Completed
  30. N/A Giving Information Systematically and Transparently in Lung and GI Cancer Phase 2 Completed
  31. N/A Pilot Study of Targeted Normoxia in Critically Ill Trauma Patients Completed
  32. N/A Vidatalk Communication Application: Usability, Acceptability and Efficacy Study Completed
  33. N/A LOGIC-Insulin Algorithm-guided Versus Nurse-directed Blood Glucose Control During Critical Illness Completed
  34. N/A Implementation of Nudges to Promote Utilization of Low Tidal Volume Ventilation (INPUT) Study Completed
  35. N/A Sleep and Circadian Rhythms in Mechanically Ventilated Patients Completed
  36. N/A Personalized Nutrition Delivery to Improve Resilience in Older Adult Trauma Patients Completed
  37. N/A Improving Family Meetings in the Pediatric Cardiac Intensive Care Unit Completed
  38. N/A Optimizing Vancomycin Therapy in Children Completed
  39. N/A Continuous Glucose Monitoring With a Subcutaneous Sensor During Critical Illness and Surgery Completed
  40. N/A Family Satisfaction (FS) in the Intensive Care Unit Completed
  41. N/A Enhancing & Mobilizing the POtential for Wellness & Emotional Resilience Among Surrogate Decision-Makers of ICU Patients Completed
  42. N/A Improving Outcomes After PICU Admission: A Pilot Study Completed
  43. N/A Isotonic Solutions and Major Adverse Renal Events Trial in the Medical Intensive Care Unit Completed
  44. N/A Musical Intervention and Physiological Stress and Inflammatory Biomarkers in Mechanically Ventilated ICU Patients Completed

Showing the 50 most-cited and recently-updated of 60 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Meta-analysis finds diaphragmatic atrophy and weakness in critically ill patients on ventilation or with sepsis
Emergency Medicine Meta-analysis
Meta-analysis finds diaphragmatic atrophy and weakness in critically ill patients on ventilation or with sepsis Why do critically ill patients struggle to breathe on their own? Their diaphragm muscles shrink and weaken
A systematic review and meta-analysis of 187 critically ill patients requiring mechanical ventilation or with sepsis found diaphragmatic fib…
Critically ill patients on ventilators have diaphragm muscles that are 30% smaller and dramatically weaker than normal, explaining their str…
Apr 3, 2026
Testosterone gel fails to normalize serum levels in critically ill ICU patients in pilot RCT
Emergency Medicine RCT
Testosterone gel fails to normalize serum levels in critically ill ICU patients in pilot RCT Can testosterone gel help critically ill men? A small study finds no clear benefit
A pilot RCT of 30 critically ill ICU patients on vasopressors and mechanical ventilation found 14-day testosterone gel administration did no…
Testosterone gel did not improve hormone levels or safety in critically ill men needing breathing machines and blood pressure support.
Apr 2, 2026
Inspiratory muscle training shows no clear effect on physical function in critically ill adults on mechanical ventilation
Emergency Medicine Meta-analysis
Inspiratory muscle training shows no clear effect on physical function in critically ill adults on mechanical ventilation Breathing muscle training shows uncertain effect on physical function in ICU patients
A systematic review and meta-analysis of 18 studies in adults requiring invasive mechanical ventilation for ≥24 hours found inspiratory musc…
Breathing muscle training for ICU patients on ventilators may not improve their ability to move and perform daily activities, with effects r…
Apr 2, 2026

Questions about Critical Illness

Do buffered solutions lower mortality better than regular saline in critical illness?

No, a large meta-analysis found buffered solutions do not lower mortality compared to 0.9% saline in critically ill patients.

Full answer →
Can ultrasound muscle index predict how long a critically ill patient will live?

Yes, ultrasound muscle index, especially the tibialis anterior pennation angle (TA-PA), can help predict 60-day mortality in critically ill patients.

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Is melatonin a good sleep aid for ICU patients with critical illness?

Melatonin may modestly improve sleep in ICU patients, but evidence is limited and experts recommend trying non-drug measures first.

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Can continuous glucose monitoring lower mortality for patients in the ICU?

Continuous glucose monitoring may reduce mortality and hypoglycemia in ICU patients, but the evidence is very uncertain and more research is needed.

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Does using endoscopic guidance for tracheostomy reduce complications in critical illness?

A large randomized trial found no significant difference in perioperative complications between endoscopic-guided and nonendoscopic-guided percutaneous tracheostomy in critically ill patients.

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See all 5 questions about Critical Illness →