Review of ATRA and ATO induction therapy in acute promyelocytic leukemia with RNA sequencing insights
Why PCR Missed This Leukemia
This case report and literature review examines induction therapy using all-trans retinoic acid and arsenic trioxide in acute promyelocytic …
A standard blood test missed a dangerous leukemia because the disease had a unique genetic pattern that routine screening overlooked until a…
Case report of ATRA and VAH regimen in refractory EVI1-positive AML
New hope for tough AML cases
This case report with a brief literature review describes a 42-year-old patient with refractory EVI1-positive AML.
A patient with high-risk AML and the tough EVI1 marker achieved complete remission after failing standard treatments, offering new hope for …
Review of observational data on vaccine antibody levels in children with acute lymphoblastic leukemia
Do routine vaccines work normally for children fighting acute lymphoblastic leukemia?
This narrative review synthesizes observational data regarding routine childhood measles and varicella zoster virus vaccines in children wit…
Children with leukemia have lower antibody levels after measles and chickenpox vaccines, but their immune cells still function well, suggest…
FDA Approves Vanflyta (quizartinib) for Newly Diagnosed FLT3-ITD-Positive AML in Adults
FDA approves new drug called Vanflyta for a specific type of blood cancer in adults
Vanflyta is approved in combination with induction and consolidation chemotherapy, and as maintenance monotherapy, for adult patients with n…
FDA approves Vanflyta to treat acute myeloid leukemia in adults with a specific genetic change that makes the cancer harder to manage.
Registry-based systematic review maps non-pharmacological cancer trials in Africa
Are lifestyle changes for cancer in Africa being studied enough, or do we need more local trials?
This registry-based systematic review analyzed 53 trials of lifestyle and non-pharmacological interventions for cancer patients in Africa.
Advice from wealthy nations may not work in Africa, where most cancer lifestyle trials happen in Egypt while Kenya and Nigeria are largely i…
Reiki reduced pain and improved quality of life in hospitalized children with leukemia aged 5-7
Reiki Helps Kids With Leukemia Feel Less Pain
This double-blind randomized controlled trial of 66 hospitalized children with leukemia aged 5-7 years compared Reiki with pseudo-Reiki and …
A gentle hand on the forehead helped children aged five to seven with leukemia feel less pain and improve their quality of life during hospi…
Narrative review explores immune monitoring for relapse prediction after AML stem cell transplant
Can better immune monitoring help predict relapse in leukemia patients after stem cell transplants?
This narrative review examines immune monitoring methodologies for predicting relapse in acute myeloid leukemia patients after allogeneic he…
New immune monitoring tools could spot leukemia relapse risks earlier than standard tests after stem cell transplants, helping doctors tailo…
Prehabilitation program improves physical and psychological outcomes in leukemia patients before chemotherapy
Getting Ready Before Chemotherapy Starts May Change How You Come Through It
A single-blind RCT of 86 newly diagnosed leukemia patients in China found a 12-week prehabilitation program integrating exercise, nutrition,…
Leukemia patients prepared with exercise and nutrition before chemotherapy walked farther and reported less anxiety and depression throughou…
Pediatric ALL outcomes at Muhimbili National Hospital show 72% 12-month survival with no significant differences by demographic or care pathway factors
The Long Road to a Leukemia Diagnosis in Tanzania
This retrospective observational cohort study evaluated 64 pediatric patients with acute lymphoblastic leukemia admitted to Muhimbili Nation…
In Tanzania, children with leukemia wait nearly a month for specialist care, and most die during the first weeks of treatment.
Ibrutinib monotherapy showed durable progression-free survival in patients with TP53 aberrations or advanced age
Ten Years on One Pill: What Long-Term Ibrutinib Revealed
This investigator-sponsored phase 2 study evaluated single-agent ibrutinib in 84 patients with chronic lymphocytic leukemia (CLL) harboring …
A decade of follow-up shows a daily pill can give high-risk leukemia patients years of control, but staying on it is not easy.
Itacitinib plus standard therapy in acute leukemia or myelofibrosis patients undergoing reduced-intensity conditioning donor stem cell transplantation
Early trial explores itacitinib for stem cell transplant patients with blood disorders
This Phase IIa trial evaluated itacitinib combined with tacrolimus and sirolimus in patients with acute leukemia, myelodysplastic syndrome, …
A new trial adds itacitinib to standard care for stem cell transplant patients with blood disorders to help prevent graft-versus-host diseas…
Dasatinib Added to Intensive Chemotherapy Fails to Improve Survival in CBF-AML
Adding Dasatinib to Chemo Does Not Help CBF-AML Patients
A phase 3 randomized trial in 202 adults with core-binding factor acute myeloid leukemia (CBF-AML) found adding dasatinib to intensive chemo…
Adding dasatinib to standard chemotherapy did not improve survival for adults with core-binding factor acute myeloid leukemia and increased …
Research across Cancer
Related studies from across the Cancer family.
Multitarget designs and microenvironment remodeling may overcome resistance to CAR T-cell therapy in B-cell malignancies
New Strategies Identified to Overcome CAR T-cell Therapy Resistance
This systematic review synthesizes current knowledge regarding resistance mechanisms and overcoming strategies for CAR T-cell therapy in rel…
Researchers identified specific ways to overcome resistance in CAR T-cell therapy for patients with certain types of blood cancers.
Review discusses pharmacogenomic biomarkers for pediatric B-ALL chemotherapy dosing
New review looks at using genetic tests to adjust cancer drug doses for kids
This narrative review examines the role of pharmacogenomic biomarkers and genotype-guided dose adjustments in pediatric B-cell acute lymphob…
A recent review suggests that checking specific genes before treatment can help doctors give the right amount of chemotherapy to children wi…
Review of a case of Down syndrome T-ALL with complex karyotype and treatment response
Boy with Down syndrome beats rare leukemia after tailored chemo
This narrative review and case report describes a 7-year-old boy with Down syndrome and T-cell acute lymphoblastic leukemia treated with AIE…
A 7-year-old with Down syndrome and a rare T-cell leukemia achieved remission after tailored chemotherapy, despite severe complications.
Combining pegylated interferon with nilotinib improves early molecular response in newly diagnosed chronic phase chronic myeloid leukaemia
Adding a weekly shot to a daily leukemia pill boosts deep remission rates
This phase 3 trial compared nilotinib monotherapy against nilotinib combined with pegylated interferon alfa-2a in patients with newly diagno…
A weekly injection added to a daily pill helped more newly diagnosed CML patients reach deep remission, but it also caused more side effects…
PD-L1-armored CAR-T followed by allo-HSCT yields 7-year remission in refractory B-cell ALL
New Leukemia Treatment Keeps Adult Patient Cancer Free For Seven Years
This retrospective observational analysis of a single clinical case describes an adult patient with early-relapsed, chemorefractory B-cell a…
A new dual-targeted therapy helped an adult with tough leukemia stay cancer-free for seven years after standard treatments failed.
Review compares 68Ga-pentixafor and 18F-FDG PET/CT in a single CLL patient
A New Scan Spots a Tricky Blood Cancer Far More Clearly
This case report and review of literature evaluates diagnostic performance of 68Ga-pentixafor versus 18F-FDG PET/CT in a 60-year-old woman w…
A new PET scan tracer spots chronic lymphocytic leukemia more clearly than standard imaging, helping doctors see disease extent in patients …
Case report and literature review on concurrent t-AML and LNTB treated with chemoimmunotherapy
Two Rare Diseases Strike After Lung Cancer Treatment
This case report and literature review describes the management of a 54-year-old male with locally advanced lung squamous cell carcinoma, th…
A lung cancer patient treated with chemo and immunotherapy developed two rare diseases simultaneously: a new blood cancer and tuberculosis.
Meta-analysis of HSCT with treosulfan in Ataxia Telangiectasia patients shows mixed survival outcomes and significant toxicities
A Teen With a Rare Disease Beat Leukemia After a Risky Transplant
This systematic review and meta-analysis evaluated hematopoietic stem cell transplantation (HSCT) using treosulfan in 16 patients with Ataxi…
A 16-year-old with a rare genetic disease survived leukemia after a tailored stem cell transplant, offering new hope for others with this fr…
Meta-analysis finds global BLV prevalence of 23.24% in cattle, with decline after 2018
Cattle Virus Hides in China While Global Numbers Drop
This meta-analysis of 44 studies synthesizes global and Chinese data on bovine leukemia virus (BLV) prevalence in cattle.
A hidden outbreak of a cancer-causing virus in Chinese cattle farms is growing fast even as the rest of the world sees fewer cases.
Review supports Allo-HSCT for BCR-ABL(+) AML with TKI and chemotherapy
A New Hope for Rare Blood Cancer Patients
This case report and literature review addresses the treatment of BCR-ABL(+) acute myeloid leukemia.
Doctors helped a patient with rare BCR-ABL positive leukemia survive by combining drugs, chemotherapy, and a stem cell transplant.
Drug Response Profiling in pediatric ALL yields 68% objective responses and bridges to cellular therapies
Can a simple test find the right drug to save children with tough leukemia?
A prospective, multicenter Drug Response Profiling registry of 340 children with relapsed or refractory acute lymphoblastic leukemia in 17 E…
A simple test matching leukemia drugs to patient cells helped 68% of children respond to treatment and gave 28 of 42 patients a chance to su…
Review of pediatric B-ALL CAR-T therapy identifies RAS mutation outcome predictor
New Test Predicts CAR-T Success in Kids
This narrative review synthesizes observational data from 86 pediatric patients with relapsed or refractory B-cell acute lymphoblastic leuke…
A new test can spot hidden genetic risks before a child starts powerful CAR-T cancer therapy.
Questions about leukemia
Can perinatal factors increase the risk of childhood acute leukemia?
Research shows that high birth weight, maternal diabetes, hypertension, history of abortion, and cesarean sections are linked to a higher risk of childhood acute leukemia.
Full answer →How does a prehabilitation program help leukemia patients before chemotherapy starts?
A prehabilitation program combining exercise, nutrition, and psychological care helps leukemia patients before chemotherapy by improving walking distance, reducing fatigue, and lowering anxiety and depression.
Full answer →