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Postoperative Complications

Subtypes of Postoperative Complications

Surgical Site Infection 12 Ischemia-Reperfusion Injury 10 Postoperative hemorrhage 2 Anastomotic Leak 1 Low Anterior Resection Syndrome 1

26 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Postoperative Complications

36 trials tracked for Postoperative Complications: 10 in phase 3 or 4 and 5 with published results. The most-cited published study has 162 citations.

36Trials tracked

10Phase 3 & 4

0Recruiting

5With published results

Phase distribution

Phase 4 8 Phase 3 2 Phase 2 2 Other / NA 24

Phase 4 Dexmedetomidine and Delirium in Patients After Cardiac Surgery Completed · 162 cited
Phase 4 The Effect of Sugammadex Versus Neostigmine on Postoperative Pulmonary Complications Completed · 142 cited
Phase 3 Glutamate for Metabolic Intervention in Coronary Surgery II Completed · 18 cited
Phase 4 High vs Low Dose Dexamethasone on Complications in the Immediate Postoperative Phase Completed · 12 cited
Phase 4 Sugammadex To IMprove Bowel Function Completed · 3 cited
Phase 4 Local Anesthesia Versus Saline Serum in Surgical Incision of Colorectal or Hepatic Surgery Completed

Show 30 more trials

Phase 4 Effect of Neuromuscular Blockade on Pulmonary Complications in Elective Cardiac Surgery Completed
Phase 4 High vs Low Dose Dexamethasone on Complications in the Immediate Postoperative Phase After Mastectomy Completed
Phase 4 Effect of Low-Dose Dexamethasone on the Incidence of Hyperglycemia Following Surgery Completed
Phase 3 Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic Meniscus Surgery Completed
Phase 2 The Effect of Caffeine on Postextubation Adverse Respiratory Events in Children With Obstructive Sleep Apnea (OSA). Completed
Phase 2 Does a Transabdominal Plane Block Decrease Patient Pain After Ventral Hernia Repair? Completed
N/A Low Pressure Pneumoperitoneum and Deep Neuromuscular Block vs. Standard During RARP to Improve Quality of Recovery; a Randomized Controlled Study. Completed
N/A Fast-track Surgery After Gynecological Oncology Surgery Completed
N/A Dilute Betadine Soak and Scrub for Foot and Ankle Surgery Completed
N/A A Study to Determine if Carbon Dioxide Lavage During Total Knee Surgery Reduces Intraoperative Embolic Events Completed
N/A Prospective Clinical Evaluation of High-Purity Type I Collagen in Select High-Risk Hernia Repair Scenarios Completed
N/A Patient Morbidity After Palatal Free Gingival Grafts With or Without PRF Membranes Coverage Completed
N/A Visits Versus Telephone Calls for Postoperative Care Completed
N/A Effect of Goal-directed Crystalloid Versus Colloid Administration on Major Postoperative Morbidity Completed
N/A Using Dexpanthenol Cream to Prevent Lip Corner Cracks in Children After Tonsil/Adenoid Surgery Completed
N/A Closed Incision Negative Pressure Therapy Versus Standard of Care Surgical Dressing in Revision Total Knee Arthroplasty Completed
N/A Closed-Loop Fluid Administration System Using Hemodynamic Monitors Completed
N/A Clinical Trial Comparing Conventional and Robot-assisted(Da Vinci®)Laparoscopic Interventions for Hysterectomy Completed
N/A Spontaneous Void Requirements for Patients Undergoing Ambulatory Anorectal Surgery Completed
N/A Postoperative Delirium: Brain Vulnerability and Recovery Completed
N/A Negative Pressure Wound Therapy in Obese Gynecologic Oncology Patients Completed
N/A Efficacy Side-effect Score (ESS): Development and Evaluation of a New Tool for Patients After Surgery Completed
N/A TAPP Inguinal Hernia Repair With Self-fixating Parietex™ ProGrip™ Mesh Completed
N/A Hemodynamic and Respiratory Variations During Laparoscopic Surgery With and Without Deep Neuromuscular Blockade. Completed
N/A Trendelenburg's Slide Prevention Study Completed
N/A Impact of Anesthesiology Interventions on Postoperative Outcomes in Adult Patients Undergoing Shoulder Surgery Completed
N/A Risk Factors Predicting Serious Complications With Laparoscopic Gastric Bypass Surgery Completed
N/A A Trial To Assess Risk of Delirium in Older Adults Undergoing Hip Fracture Surgery With Spinal or General Anesthesia Completed
N/A Comparative Effectiveness of Peripheral Nerve Blocks for Outpatient Shoulder Surgery Completed
N/A REPLACE: Implantable Cardiac Pulse Generator Replacement Registry Completed

Showing the 36 most-cited and recently-updated of 36 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Postoperative Complications: what the trials found

Clinical trials evaluating dexmedetomidine hydrochloride for injection showed no significant differences in the incidence of postoperative delirium (p=0.341), cognitive function (p=0.830), or non-delirium complications after surgery (p=0.214) ².

The administration of Sugammadex resulted in a significantly faster time to reach a Train of Four (TOF) ratio of ≥ 0.9 compared to the comparison group (5.2 vs. 17.5 minutes; p<0.001), while showing no significant difference in gastric emptying (p=0.58) or gastrointestinal complications (p=0.087) ⁵.

Dexamethasone did not significantly impact the number of participants with moderate to severe postoperative pain (p=0.248), length of stay in the PACU (p=0.519), or hospital length of stay (p=0.468) ⁴. Additionally, dexamethasone showed no significant difference in transfer to the PACU (p=1) or discharge scores at both the operating room and PACU arrival ⁶.

Succinylcholine was associated with significantly different surgical conditions (p=0.02), but did not show a statistically significant difference in the number of participants with postoperative pulmonary complications (p=1.00) ⁷.

Glutamate infusion showed no significant difference in postoperative plasma levels of NT-proBNP (p=0.36) or the postoperative increase of plasma NT-proBNP (p=0.86) ¹⁰.

Recent results — preliminary, needs further review

High-Purity Type I Collagen Mesh was associated with a decrease in Visual Analog Scale (VAS) pain scores from 6.0 to 2.9 ¹.
Dexpanthenol 5% Topical Ointment was associated with lower postoperative pain scores compared to the control group (4.48 vs. 2.38) ¹⁴.

For the clinician treating this condition

Dexmedetomidine hydrochloride does not appear to significantly alter delirium rates or cognitive outcomes in the postoperative period ².
Sugammadex provides a statistically significant reduction in time to reach a TOF ratio of ≥ 0.9 following administration ⁵.
Dexamethasone did not demonstrate significant clinical impact on pain severity, PACU stay, or total hospital length of stay [4, 6].

AI synthesis of 8 cited trials, updated Jun 21, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

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